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The map label for this gene is sthA [H]

Identifier: 194734506

GI number: 194734506

Start: 4211192

End: 4212604

Strand: Reverse

Name: sthA [H]

Synonym: SeSA_A4336

Alternate gene names: 194734506

Gene position: 4212604-4211192 (Counterclockwise)

Preceding gene: 194737076

Following gene: 194735342

Centisome position: 89.46

GC content: 52.51

Gene sequence:

>1413_bases
GTGAGTAATACCATGCCACATTCTTGGGATTATGATGCAGTCGTCATAGGGTCAGGCCCCGGCGGTGAAGGCGCTGCAAT
GGGTCTGGTTAAGCAAGGAGCACGCGTCGCGGTGATTGAGCGTTATCATAACGTTGGCGGCGGATGTACCCACTGGGGCA
CCATTCCATCCAAAGCCCTTCGCCACGCCGTCAGCCGCATTATTGAATTTAATCAAAACCCGCTCTATAGCGACCACTCC
CGTCTCCTTCGATCTTCTTTCGCCGATATCCTTAATCATGCCGATAACGTGATTAATCAACAAACGCGTATGCGTCAGGG
GTTTTATGAGCGTAACCACTGTGAAATCTTGCAGGGCAACGCCCATTTTATTGACGAACATACCCTGGCGCTGGAATGCC
ATGACGGCACGGTTGAAACCCTGACGGCAGAAAAATTTGTTATTGCCTGTGGTTCGCGTCCTTACCATCCCAATGATGTG
GATTTCTCGCATCCGCGCATTTATGACAGCGACTCAATCCTGAGTCTCCACCATGAACCGCGCCACGTTATTATTTACGG
CGCCGGCGTTATCGGCTGCGAATATGCGTCCATCTTCCGCGGTATGGATGTGAAAGTGGATCTGATCAACACCCGCGATC
GCCTGCTGGCCTTTCTCGATCAGGAGATGTCCGACTCTCTCTCTTACCATTTCTGGAATAGCGGCGTGGTTATTCGCCAC
AATGAAGAGTATGAGAAAATCGAAGGCTGCGATGATGGCGTCATCATGCACCTGAAATCCGGTAAAAAACTGAAGGCTGA
CTGCCTGCTCTATGCTAATGGCCGTACCGGTAACACCGATTCGCTGGCGCTGGAGAATATTGGTCTGGAAACAGACAGCC
GTGGACAGCTCAAAGTCAACAGTATGTACCAGACCGCCCTGCCGCACGTCTATGCGGTGGGCGACGTGATTGGCTATCCC
AGTCTGGCCTCCGCCGCCTACGATCAGGGGCGTATTGCAGCGCAGGCGCTGGTGAAAGGCGAAGCGACCGCGCATCTTAT
CGAAGATATCCCCACCGGGATTTATACCATTCCGGAAATCAGTTCTGTCGGCAAAACCGAGCAGCAGTTAACGGCAATGA
AAGTGCCTTACGAAGTGGGCCGCGCGCAGTTTAAGCATCTGGCGCGAGCGCAAATCGTCGGCATGAACGTCGGCACGCTA
AAAATTCTCTTCCACCGCGAAACCAAAGAAATTCTGGGGATTCACTGCTTTGGCGAACGCGCCGCCGAAATTATTCATAT
CGGCCAGGCGATCATGGAGCAGAAAGGTGGCGGTAACACCATTGAATACTTCGTTAACACCACCTTTAACTACCCAACCA
TGGCGGAAGCTTATCGGGTTGCGGCGTTGAACGGCTTAAACCGCCTGTTTTAA

Upstream 100 bases:

>100_bases
TACAGACAGTTTGTGCTCCGGCTTCGCAAAAAAGCACAACGATAATTGGGTTAAAGCTGGGCAAATGTTATCATCGTGTT
TATTTTATGTATAAAAACAG

Downstream 100 bases:

>100_bases
CGCCTTGTCGAAATGGCCATCCATTGCGCCACGGATGGCCTCTGCCAGTTGCTCATAACGGCTACGCAGCGGCGATCCCG
GGCGATAAACCAGCCCCACG

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MSNTMPHSWDYDAVVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHS
RLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNAHFIDEHTLALECHDGTVETLTAEKFVIACGSRPYHPNDV
DFSHPRIYDSDSILSLHHEPRHVIIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRH
NEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALENIGLETDSRGQLKVNSMYQTALPHVYAVGDVIGYP
SLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTL
KILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Sequences:

>Translated_470_residues
MSNTMPHSWDYDAVVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHS
RLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNAHFIDEHTLALECHDGTVETLTAEKFVIACGSRPYHPNDV
DFSHPRIYDSDSILSLHHEPRHVIIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRH
NEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALENIGLETDSRGQLKVNSMYQTALPHVYAVGDVIGYP
SLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTL
KILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
>Mature_469_residues
SNTMPHSWDYDAVVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSR
LLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNAHFIDEHTLALECHDGTVETLTAEKFVIACGSRPYHPNDVD
FSHPRIYDSDSILSLHHEPRHVIIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHN
EEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALENIGLETDSRGQLKVNSMYQTALPHVYAVGDVIGYPS
LASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEISSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLK
ILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=474, Percent_Identity=28.9029535864979, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=26.5795206971678, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI22035672, Length=491, Percent_Identity=26.4765784114053, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI148277071, Length=400, Percent_Identity=25.75, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI33519430, Length=400, Percent_Identity=25.75, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI33519428, Length=400, Percent_Identity=25.75, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI33519426, Length=400, Percent_Identity=25.75, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI148277065, Length=400, Percent_Identity=25.75, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI291045266, Length=431, Percent_Identity=23.6658932714617, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI291045268, Length=350, Percent_Identity=24.8571428571429, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI226437568, Length=288, Percent_Identity=26.7361111111111, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI65787454, Length=270, Percent_Identity=27.4074074074074, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI21389617, Length=270, Percent_Identity=27.4074074074074, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=96.9957081545064, Blast_Score=947, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=458, Percent_Identity=28.1659388646288, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI87081717, Length=464, Percent_Identity=27.801724137931, Blast_Score=158, Evalue=9e-40,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=27.2517321016166, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI32565766, Length=465, Percent_Identity=29.6774193548387, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=24.8936170212766, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=367, Percent_Identity=26.9754768392371, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71983429, Length=367, Percent_Identity=26.9754768392371, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71982272, Length=344, Percent_Identity=24.1279069767442, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17559934, Length=286, Percent_Identity=24.4755244755245, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=489, Percent_Identity=28.0163599182004, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6325166, Length=471, Percent_Identity=25.0530785562633, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=471, Percent_Identity=26.1146496815287, Blast_Score=133, Evalue=5e-32,
Organism=Drosophila melanogaster, GI21358499, Length=471, Percent_Identity=29.9363057324841, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24640553, Length=487, Percent_Identity=29.3634496919918, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24640549, Length=487, Percent_Identity=29.3634496919918, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24640551, Length=487, Percent_Identity=29.3634496919918, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI17737741, Length=493, Percent_Identity=26.1663286004057, Blast_Score=132, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 52043; Mature: 51911

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTMPHSWDYDAVVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKAL
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCEEEEEHHHHCCCCCCCCCCCCHHHHH
RHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGN
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
AHFIDEHTLALECHDGTVETLTAEKFVIACGSRPYHPNDVDFSHPRIYDSDSILSLHHEP
CEEEECEEEEEEECCCCEEEEECCEEEEEECCCCCCCCCCCCCCCEEECCCCEEEEECCC
RHVIIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRH
CEEEEEECCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCEEEEE
NEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALENIGLETDSRGQLKVN
CCCHHHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCEEEC
SMYQTALPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEI
CHHHHHCCHHEEHHHHHCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHCCCCEEECCCC
SSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGER
HHCCCCHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCEEEEEEEECCHHHEEEEECCHH
AAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNTMPHSWDYDAVVIGSGPGGEGAAMGLVKQGARVAVIERYHNVGGGCTHWGTIPSKAL
CCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCEEEEEHHHHCCCCCCCCCCCCHHHHH
RHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGN
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
AHFIDEHTLALECHDGTVETLTAEKFVIACGSRPYHPNDVDFSHPRIYDSDSILSLHHEP
CEEEECEEEEEEECCCCEEEEECCEEEEEECCCCCCCCCCCCCCCEEECCCCEEEEECCC
RHVIIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRH
CEEEEEECCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCEEEEE
NEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALENIGLETDSRGQLKVN
CCCHHHHCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCEEEECCCCCCCCCCCEEEC
SMYQTALPHVYAVGDVIGYPSLASAAYDQGRIAAQALVKGEATAHLIEDIPTGIYTIPEI
CHHHHHCCHHEEHHHHHCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHCCCCEEECCCC
SSVGKTEQQLTAMKVPYEVGRAQFKHLARAQIVGMNVGTLKILFHRETKEILGIHCFGER
HHCCCCHHHHHHHCCCHHHHHHHHHHHHHHEEEECCCCEEEEEEEECCHHHEEEEECCHH
AAEIIHIGQAIMEQKGGGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
HHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA