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The map label for this gene is cycA [H]

Identifier: 194734481

GI number: 194734481

Start: 4533794

End: 4535203

Strand: Direct

Name: cycA [H]

Synonym: SeSA_A4666

Alternate gene names: 194734481

Gene position: 4533794-4535203 (Clockwise)

Preceding gene: 194734970

Following gene: 194738061

Centisome position: 96.28

GC content: 53.62

Gene sequence:

>1410_bases
ATGGTAGATCAGGTAAAAGTCGCAGCCGACGAACAGGCTCCGGCTGAACAGTCGCTACGGCGCAATCTTACAAACCGTCA
TATACAGCTTATCGCTATTGGCGGCGCTATTGGTACCGGTCTGTTTATGGGATCGGGTAAAACGATCAGTCTCGCCGGAC
CGTCGATCATTTTTGTGTATATGATCATCGGTTTTATGCTTTTTTTCGTGATGCGCGCCATGGGGGAATTGCTGCTCTCG
AATCTGGAATATAAATCGTTTAGCGATTTTGCTTCCGACCTGCTTGGCCCCTGGGCGGGATATTTCACCGGCTGGACGTA
CTGGTTTTGCTGGGTAGTGACCGGTATGGCTGACGTGGTGGCGATTACCGCCTACGCGCAGTTCTGGTTTCCCGGCCTTT
CCGATTGGGTCGCCTCGCTGGCGGTAGTGATCCTGCTGCTAAGCCTCAACCTCGCCACCGTTAAAATGTTTGGTGAAATG
GAATTTTGGTTTGCTATGGTCAAAATCGTCGCCATCGTGGCGTTGATTGTGGTCGGGCTGGTCATGATTGCGATGCACTT
TAAATCGCCGACAGGCGTTGAAGCGTCTTTTGCGCATCTGTGGAATGACGGCGGCTGGTTCCCGAAAGGTATTAGCGGGT
TCTTTGCCGGTTTCCAGATTGCGGTGTTCGCCTTCGTGGGCATTGAGCTGGTCGGTACTACCGCCGCAGAAACTAAAGAT
CCGGAAAAATCGCTGCCGCGCGCGATTAACTCAATACCGATCCGTATCATCATGTTCTACGTCTTTGCGCTGATTGTCAT
TATGTCGGTGACGCCGTGGAGTTCCGTGGTGCCGGATAAGAGCCCGTTTGTTGAGCTGTTTGTACTGGTGGGTCTGCCTG
CCGCCGCTAGCGTGATCAACTTTGTTGTGCTGACCTCGGCGGCGTCTTCCGCCAACAGCGGCGTCTTCTCGACCAGCCGT
ATGCTGTTTGGCCTGGCGCAAGAAGGCGTGGCGCCAAAAGCGTTCGCTAAGCTATCGAAACGCGCGGTACCGGCGAAAGG
CCTGACCTTCTCCTGTATCTGCCTGCTGGGCGGCGTGGTTATGCTGATGGTCAACCCGAGCGTGATTGGCGCATTCACCA
TGATCACTACGGTTTCGGCTATCCTGTTTATGTTTGTCTGGACCATCATTCTGTGTTCATACCTGGTGTACCGCAAAAAG
CGTCCCCACTTGCATGAAAAATCCATCTATAAGATGCCGCTCGGTAAGCTGATGTGCTGGGTCTGTATGGCGTTCTTTGC
GTTCGTGCTGGTATTACTGACGCTGGAAGACGATACGCGCCAGGCGCTGATCGTGACGCCGCTGTGGTTTATCGCGTTGG
GTCTGGGCTGGCTGTTGATAGGTAAGAAACGGATGGCGGGAATGCGTTAA

Upstream 100 bases:

>100_bases
ATTCTTACCTAATATCGATGAGTCCTGATAACAGGATCGTCGTATCATAGACCAAAGGCCGTAGAGCCCGCACAACACAG
ACAGGTACAGGAAGAAAAAC

Downstream 100 bases:

>100_bases
TTGTTTTGCCCGGTAGCGCTGGCGCTTACCGGGCTTACAGCGTAGCGTTGATTTGTAGGCCGGATAAGGCGCGGTTTACA
GCCGCCACCCGGCAAAATGC

Product: D-alanine/D-serine/glycine permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MVDQVKVAADEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLAVVILLLSLNLATVKMFGEM
EFWFAMVKIVAIVALIVVGLVMIAMHFKSPTGVEASFAHLWNDGGWFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPDKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLMVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKK
RPHLHEKSIYKMPLGKLMCWVCMAFFAFVLVLLTLEDDTRQALIVTPLWFIALGLGWLLIGKKRMAGMR

Sequences:

>Translated_469_residues
MVDQVKVAADEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLAVVILLLSLNLATVKMFGEM
EFWFAMVKIVAIVALIVVGLVMIAMHFKSPTGVEASFAHLWNDGGWFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPDKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLMVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKK
RPHLHEKSIYKMPLGKLMCWVCMAFFAFVLVLLTLEDDTRQALIVTPLWFIALGLGWLLIGKKRMAGMR
>Mature_469_residues
MVDQVKVAADEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVYMIIGFMLFFVMRAMGELLLS
NLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVVAITAYAQFWFPGLSDWVASLAVVILLLSLNLATVKMFGEM
EFWFAMVKIVAIVALIVVGLVMIAMHFKSPTGVEASFAHLWNDGGWFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPDKSPFVELFVLVGLPAAASVINFVVLTSAASSANSGVFSTSR
MLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVVMLMVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKK
RPHLHEKSIYKMPLGKLMCWVCMAFFAFVLVLLTLEDDTRQALIVTPLWFIALGLGWLLIGKKRMAGMR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=358, Percent_Identity=22.6256983240223, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI114326544, Length=367, Percent_Identity=22.6158038147139, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI114326550, Length=367, Percent_Identity=22.6158038147139, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI115648063, Length=463, Percent_Identity=25.2699784017279, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI115648022, Length=463, Percent_Identity=25.2699784017279, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI258645169, Length=363, Percent_Identity=22.5895316804408, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI181337167, Length=346, Percent_Identity=21.3872832369942, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790653, Length=469, Percent_Identity=95.5223880597015, Blast_Score=910, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=457, Percent_Identity=40.4814004376368, Blast_Score=347, Evalue=9e-97,
Organism=Escherichia coli, GI1786789, Length=466, Percent_Identity=37.3390557939914, Blast_Score=337, Evalue=9e-94,
Organism=Escherichia coli, GI1786602, Length=454, Percent_Identity=40.7488986784141, Blast_Score=330, Evalue=8e-92,
Organism=Escherichia coli, GI48994972, Length=456, Percent_Identity=39.0350877192982, Blast_Score=319, Evalue=3e-88,
Organism=Escherichia coli, GI87081915, Length=455, Percent_Identity=36.7032967032967, Blast_Score=287, Evalue=9e-79,
Organism=Escherichia coli, GI87081708, Length=473, Percent_Identity=32.9809725158562, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1788480, Length=455, Percent_Identity=34.5054945054945, Blast_Score=238, Evalue=7e-64,
Organism=Escherichia coli, GI1789017, Length=447, Percent_Identity=30.8724832214765, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87082023, Length=351, Percent_Identity=22.5071225071225, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI2367353, Length=333, Percent_Identity=23.7237237237237, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=362, Percent_Identity=24.8618784530387, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17531343, Length=442, Percent_Identity=21.9457013574661, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=422, Percent_Identity=32.4644549763033, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324924, Length=428, Percent_Identity=30.607476635514, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6320772, Length=446, Percent_Identity=29.1479820627803, Blast_Score=182, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=419, Percent_Identity=31.2649164677804, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322892, Length=404, Percent_Identity=29.7029702970297, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324553, Length=408, Percent_Identity=29.1666666666667, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324059, Length=456, Percent_Identity=28.5087719298246, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321629, Length=421, Percent_Identity=27.5534441805226, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6320717, Length=414, Percent_Identity=25.8454106280193, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=446, Percent_Identity=26.9058295964126, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320251, Length=403, Percent_Identity=27.2952853598015, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319608, Length=420, Percent_Identity=26.4285714285714, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319824, Length=399, Percent_Identity=26.0651629072682, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6319542, Length=404, Percent_Identity=25.2475247524752, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321053, Length=411, Percent_Identity=27.007299270073, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=419, Percent_Identity=29.1169451073986, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324981, Length=420, Percent_Identity=28.0952380952381, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320364, Length=471, Percent_Identity=24.416135881104, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24666159, Length=399, Percent_Identity=21.0526315789474, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI221512776, Length=403, Percent_Identity=20.8436724565757, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI45550968, Length=424, Percent_Identity=25.9433962264151, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921172, Length=424, Percent_Identity=25.9433962264151, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51342; Mature: 51342

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDQVKVAADEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSDWVASLAVVILLLSLNLATVKMFGEMEFWFAMVKIVAIVALIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMIAMHFKSPTGVEASFAHLWNDGGWFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPDKSPFVELFVLVGLPAAASVIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLMVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKKRPHLHEKSIYKMPLGKLMCW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHH
VCMAFFAFVLVLLTLEDDTRQALIVTPLWFIALGLGWLLIGKKRMAGMR
HHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVDQVKVAADEQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
CCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHEEECCCCEEEECCHHHHHHH
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AITAYAQFWFPGLSDWVASLAVVILLLSLNLATVKMFGEMEFWFAMVKIVAIVALIVVGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMIAMHFKSPTGVEASFAHLWNDGGWFPKGISGFFAGFQIAVFAFVGIELVGTTAAETKD
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPDKSPFVELFVLVGLPAAASVIN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHCCCHHHHHHH
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
HHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
MLMVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKKRPHLHEKSIYKMPLGKLMCW
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHH
VCMAFFAFVLVLLTLEDDTRQALIVTPLWFIALGLGWLLIGKKRMAGMR
HHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]