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The map label for this gene is fsr [H]

Identifier: 194734415

GI number: 194734415

Start: 560480

End: 561700

Strand: Reverse

Name: fsr [H]

Synonym: SeSA_A0556

Alternate gene names: 194734415

Gene position: 561700-560480 (Counterclockwise)

Preceding gene: 194735308

Following gene: 194735414

Centisome position: 11.93

GC content: 55.12

Gene sequence:

>1221_bases
ATGGCCATGAGTGAACCAACCCAGCCGTTAGCCGGCGCGCCCGCAGCGGCCGCTAAAGCACGTACTTCGTTTGGTATTTT
GGGCGCGATCAGTCTTTCCCATCTGCTGAACGATATGATCCAGTCGCTAATCTTAGCCATTTATCCCCTGTTGCAGGCGG
AGTTCTCGCTGACCTTCGTCCAGATAGGTTTGATCACCCTGACGTTCCAGCTCGCCTCATCGCTACTGCAACCGGTCGTC
GGCTACTGGACGGATAAATATCCCATGCCGTGGTCGCTGCCTGTCGGCATGTGTTTTACCCTGAGCGGGTTGGTACTGCT
GGCAATGGCGGGAAGTTTTGGCGGCGTATTGCTCGCTGCGGCGCTGGTGGGTACCGGCTCGTCCGTTTTTCACCCGGAAT
CGTCCCGCGTGGCGCGCATGGCCTCCGGCGGACGTCATGGTCTGGCGCAGTCTATCTTCCAGGTCGGAGGTAACTTCGGC
AGTTCATTGGGCCCGCTGCTGGCCGCCGTGATTATCGCGCCCTATGGCAAAGGGAATGTCGCCTGGTTTGTGCTGGCCGC
GCTGCTGGCGATCGTGGTGCTGGCGCAGATCAGCCGCTGGTATGCAGCCCAGCACCGGATAGCGAAAGGCAAGCCAAAAG
CGATAATCGCTAACCCGCTGCCGCGCAATAAAGTCGTGCTGGCGGTCAGCGTATTATTGCTACTCATTTTCTCGAAATAT
TTTTATATGGCGAGCATCAGTAGCTACTACACCTTTTATCTGATGCAAAAATTCGGATTATCAATACAAAACGCGCAGCT
CCATCTGTTTGCCTTCCTGTTTGCGGTGGCTGCCGGGACGGTAATCGGCGGGCCGGTGGGCGATAAAATCGGCAGAAAAT
ATGTGATTTGGGGCTCTATTCTCGGCGTCGCGCCGTTTACCCTTGTTTTACCCTACGCCACGCTGTACTGGACGGGGATT
TTAACGGTGATTATCGGCTTTATTCTCGCGTCGGCGTTTTCCGCCATTCTGGTGTATGCCCAGGAGCTGCTGCCAGGACG
CATCGGTATGGTTTCCGGCCTGTTTTTCGGGTTTGCCTTCGGAATGGGAGGCTTGGGCGCAGCGGTGTTGGGGCTGATTG
CCGACCATACCAGTATCTATTTAGTTTATAAAATCTGTGCTTTCCTGCCGCTTCTGGGGATACTGACCATATTCTTACCT
GATAATCGACATAAAGCATGA

Upstream 100 bases:

>100_bases
AATTGAGACTTCCTTCAAACACATTTCACAGGTATGTTAGGCAAGTAATAATTACACATCCTACTATCTCCAACATCGCA
TAAAATTTAAGTGACTTTCT

Downstream 100 bases:

>100_bases
TTTTATGGCGGTTAAAGGTACGCTTTAACCGCCTGTACATCCTGATGCCATCTTGCTTTGTCCATCCCATACTTATCACT
TTTACGTTCCGTGCTCTTTT

Product: fosmidomycin resistance protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MAMSEPTQPLAGAPAAAAKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGLITLTFQLASSLLQPVV
GYWTDKYPMPWSLPVGMCFTLSGLVLLAMAGSFGGVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSIFQVGGNFG
SSLGPLLAAVIIAPYGKGNVAWFVLAALLAIVVLAQISRWYAAQHRIAKGKPKAIIANPLPRNKVVLAVSVLLLLIFSKY
FYMASISSYYTFYLMQKFGLSIQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYATLYWTGI
LTVIIGFILASAFSAILVYAQELLPGRIGMVSGLFFGFAFGMGGLGAAVLGLIADHTSIYLVYKICAFLPLLGILTIFLP
DNRHKA

Sequences:

>Translated_406_residues
MAMSEPTQPLAGAPAAAAKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGLITLTFQLASSLLQPVV
GYWTDKYPMPWSLPVGMCFTLSGLVLLAMAGSFGGVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSIFQVGGNFG
SSLGPLLAAVIIAPYGKGNVAWFVLAALLAIVVLAQISRWYAAQHRIAKGKPKAIIANPLPRNKVVLAVSVLLLLIFSKY
FYMASISSYYTFYLMQKFGLSIQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYATLYWTGI
LTVIIGFILASAFSAILVYAQELLPGRIGMVSGLFFGFAFGMGGLGAAVLGLIADHTSIYLVYKICAFLPLLGILTIFLP
DNRHKA
>Mature_405_residues
AMSEPTQPLAGAPAAAAKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFVQIGLITLTFQLASSLLQPVVG
YWTDKYPMPWSLPVGMCFTLSGLVLLAMAGSFGGVLLAAALVGTGSSVFHPESSRVARMASGGRHGLAQSIFQVGGNFGS
SLGPLLAAVIIAPYGKGNVAWFVLAALLAIVVLAQISRWYAAQHRIAKGKPKAIIANPLPRNKVVLAVSVLLLLIFSKYF
YMASISSYYTFYLMQKFGLSIQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSILGVAPFTLVLPYATLYWTGIL
TVIIGFILASAFSAILVYAQELLPGRIGMVSGLFFGFAFGMGGLGAAVLGLIADHTSIYLVYKICAFLPLLGILTIFLPD
NRHKA

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=405, Percent_Identity=93.5802469135802, Blast_Score=721, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43058; Mature: 42927

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMSEPTQPLAGAPAAAAKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIGLITLTFQLASSLLQPVVGYWTDKYPMPWSLPVGMCFTLSGLVLLAMAGSFGGVLLAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
ALVGTGSSVFHPESSRVARMASGGRHGLAQSIFQVGGNFGSSLGPLLAAVIIAPYGKGNV
HHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCH
AWFVLAALLAIVVLAQISRWYAAQHRIAKGKPKAIIANPLPRNKVVLAVSVLLLLIFSKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
FYMASISSYYTFYLMQKFGLSIQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSI
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCEEEEEHHH
LGVAPFTLVLPYATLYWTGILTVIIGFILASAFSAILVYAQELLPGRIGMVSGLFFGFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GMGGLGAAVLGLIADHTSIYLVYKICAFLPLLGILTIFLPDNRHKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AMSEPTQPLAGAPAAAAKARTSFGILGAISLSHLLNDMIQSLILAIYPLLQAEFSLTFV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIGLITLTFQLASSLLQPVVGYWTDKYPMPWSLPVGMCFTLSGLVLLAMAGSFGGVLLAA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
ALVGTGSSVFHPESSRVARMASGGRHGLAQSIFQVGGNFGSSLGPLLAAVIIAPYGKGNV
HHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCH
AWFVLAALLAIVVLAQISRWYAAQHRIAKGKPKAIIANPLPRNKVVLAVSVLLLLIFSKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
FYMASISSYYTFYLMQKFGLSIQNAQLHLFAFLFAVAAGTVIGGPVGDKIGRKYVIWGSI
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCEEEEEHHH
LGVAPFTLVLPYATLYWTGILTVIIGFILASAFSAILVYAQELLPGRIGMVSGLFFGFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
GMGGLGAAVLGLIADHTSIYLVYKICAFLPLLGILTIFLPDNRHKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]