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The map label for this gene is betC [H]

Identifier: 194734352

GI number: 194734352

Start: 40130

End: 41623

Strand: Direct

Name: betC [H]

Synonym: SeSA_A0040

Alternate gene names: 194734352

Gene position: 40130-41623 (Clockwise)

Preceding gene: 194736972

Following gene: 194735938

Centisome position: 0.85

GC content: 52.48

Gene sequence:

>1494_bases
ATGAAAAGATCAGTCGTTGCCAGTATGATAGGGTTGGCGCTATGCGCTGGAAGCGTATTATCAACCGCGCAAGCGGCAAC
CGCAAAGCGTCCTAACTTAGTCATTATTCTGGCAGATGATTTAGGGTATGGCGATCTCGCCACCTACGGGCACCGCATCG
TTAAAACACCTAACATAGACAAATTGGCGCAGGAGGGGGTGAAGTTTACCGACTATTATGCGCCAGCGCCTCTGTGTTCT
CCTTCCCGCGCGGGCCTGTTAACCGGCCGTATGCCGTTCCGTACCGGAATCCGTTCCTGGATACCGGAAGGCAAAGATGT
TGCGCTGGGGCGTAATGAACTGACTATCGCCAACCTGCTAAAACAGCAGGGCTACGATACGGCGATGATGGGGAAATTAC
ACCTGAATGCGGGCGGCGATCGCACCGATCAGCCGCAGGCGAAAGACATGGGCTTTGACTATACGTTGGTTAATCCGGCG
GGATTTGTCACCGATGCTACGTTGGACAACGCCAAGGAGCGCCCGCGCTATGGCGTGGTGCATCCTACGGGGTGGATTCG
TAATGGCCAACATATTGGCCGCGCAGATAAGATGAGCGGCGAGTTTGTGAGCTCTGAAGTGGTGAACTGGCTGGATAATA
AGAAAGACGATAATCCGTTCTTCTTATATGTCGCCTTTACCGAAGTCCATAGCCCGCTGGCGTCGCCGAAAAAATACCTT
GATATGTATTCGCAGTACATGACCGACTACCAGAAGCAGCATCCGGATCTGTTCTACGGCGACTGGGCAGACAAACCGTG
GCGCGGCACCGGCGAATATTACGCCAATATCAGCTACATGGATGAGCAGGTCGGTAAAGTGCTGGATAAAATTAAGGCGA
TGGGCGAGGAAGATAACACCATCGTCATCTTTACCAGCGACAACGGCCCTGTCACGCGTGAAGCGCGTAAGGTATACGAG
CTGAACCTGGCCGGGGAAACCGACGGTCTGCGCGGGCGTAAAGACAACCTGTGGGAAGGCGGCATTCGCGTACCGGCAAT
CATCAAATACGGCAAGCACATTCCACAGGGGATGGTAACGGACACGCCGGTATATGGTCTTGACTGGCTGCCGACGCTGG
CCAACATGATGGACTTTAAACTTCCGACCGATCGTACCTACGACGGTCAGTCTTTAGTTCCGCTCCTGAAGGACAAGACT
TTAAAACGCCAGAAACCGCTGATCTTCGGTATCGATATGCCGTTCCAGGATGATCCGACGGATGAGTGGGCGATCCGCGA
CGGCGACTGGAAGATGATCATCGATCGCCAGAATAAACCTAAATATCTCTATAACCTGAAAACCGATCGTTTCGAGACGC
TCAATCAAATTGGTAAACAGCCGCAGATTGAGAAACAGCTCTACGGTAAGTTCCTGAAGTATAAAAAGGATATTGATAAC
GATTCTCTGATGAAAGCCCGTGGCGATAAGCCGACGCCTGTCACCTGGGGCTAA

Upstream 100 bases:

>100_bases
TCGAATATATATAGTGCAATTAATTCAGGCTGTATTCCGCAGCCGGGTCTATCGGCAAATATATCGTAATCAGACCGTGC
GATAACTCAAAGGAGTTGAA

Downstream 100 bases:

>100_bases
TGGAATAATTATAAAAAATTAAGTATGCCACTTAGGGCGATGCCCACCTGATCCGGTCACTCTGTGCCGGATCAGGTTCT
TTTATTTCAGGGAAGGTAAT

Product: sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MKRSVVASMIGLALCAGSVLSTAQAATAKRPNLVIILADDLGYGDLATYGHRIVKTPNIDKLAQEGVKFTDYYAPAPLCS
PSRAGLLTGRMPFRTGIRSWIPEGKDVALGRNELTIANLLKQQGYDTAMMGKLHLNAGGDRTDQPQAKDMGFDYTLVNPA
GFVTDATLDNAKERPRYGVVHPTGWIRNGQHIGRADKMSGEFVSSEVVNWLDNKKDDNPFFLYVAFTEVHSPLASPKKYL
DMYSQYMTDYQKQHPDLFYGDWADKPWRGTGEYYANISYMDEQVGKVLDKIKAMGEEDNTIVIFTSDNGPVTREARKVYE
LNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHIPQGMVTDTPVYGLDWLPTLANMMDFKLPTDRTYDGQSLVPLLKDKT
LKRQKPLIFGIDMPFQDDPTDEWAIRDGDWKMIIDRQNKPKYLYNLKTDRFETLNQIGKQPQIEKQLYGKFLKYKKDIDN
DSLMKARGDKPTPVTWG

Sequences:

>Translated_497_residues
MKRSVVASMIGLALCAGSVLSTAQAATAKRPNLVIILADDLGYGDLATYGHRIVKTPNIDKLAQEGVKFTDYYAPAPLCS
PSRAGLLTGRMPFRTGIRSWIPEGKDVALGRNELTIANLLKQQGYDTAMMGKLHLNAGGDRTDQPQAKDMGFDYTLVNPA
GFVTDATLDNAKERPRYGVVHPTGWIRNGQHIGRADKMSGEFVSSEVVNWLDNKKDDNPFFLYVAFTEVHSPLASPKKYL
DMYSQYMTDYQKQHPDLFYGDWADKPWRGTGEYYANISYMDEQVGKVLDKIKAMGEEDNTIVIFTSDNGPVTREARKVYE
LNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHIPQGMVTDTPVYGLDWLPTLANMMDFKLPTDRTYDGQSLVPLLKDKT
LKRQKPLIFGIDMPFQDDPTDEWAIRDGDWKMIIDRQNKPKYLYNLKTDRFETLNQIGKQPQIEKQLYGKFLKYKKDIDN
DSLMKARGDKPTPVTWG
>Mature_497_residues
MKRSVVASMIGLALCAGSVLSTAQAATAKRPNLVIILADDLGYGDLATYGHRIVKTPNIDKLAQEGVKFTDYYAPAPLCS
PSRAGLLTGRMPFRTGIRSWIPEGKDVALGRNELTIANLLKQQGYDTAMMGKLHLNAGGDRTDQPQAKDMGFDYTLVNPA
GFVTDATLDNAKERPRYGVVHPTGWIRNGQHIGRADKMSGEFVSSEVVNWLDNKKDDNPFFLYVAFTEVHSPLASPKKYL
DMYSQYMTDYQKQHPDLFYGDWADKPWRGTGEYYANISYMDEQVGKVLDKIKAMGEEDNTIVIFTSDNGPVTREARKVYE
LNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHIPQGMVTDTPVYGLDWLPTLANMMDFKLPTDRTYDGQSLVPLLKDKT
LKRQKPLIFGIDMPFQDDPTDEWAIRDGDWKMIIDRQNKPKYLYNLKTDRFETLNQIGKQPQIEKQLYGKFLKYKKDIDN
DSLMKARGDKPTPVTWG

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI53831991, Length=452, Percent_Identity=30.7522123893805, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI146229331, Length=465, Percent_Identity=30.9677419354839, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI146229329, Length=465, Percent_Identity=30.9677419354839, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI6005990, Length=465, Percent_Identity=30.9677419354839, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI146229324, Length=465, Percent_Identity=30.9677419354839, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI38569405, Length=443, Percent_Identity=30.2483069977427, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI38569407, Length=404, Percent_Identity=31.6831683168317, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI4503899, Length=428, Percent_Identity=28.7383177570093, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI59797060, Length=488, Percent_Identity=26.2295081967213, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI109389362, Length=426, Percent_Identity=28.6384976525822, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI157266309, Length=453, Percent_Identity=26.4900662251656, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI45430057, Length=510, Percent_Identity=28.4313725490196, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI58743319, Length=157, Percent_Identity=42.0382165605096, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI71852586, Length=153, Percent_Identity=42.483660130719, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI71852584, Length=153, Percent_Identity=42.483660130719, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI31742482, Length=173, Percent_Identity=41.6184971098266, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI146229327, Length=380, Percent_Identity=26.3157894736842, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI5360208, Length=342, Percent_Identity=27.1929824561404, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4557659, Length=338, Percent_Identity=27.2189349112426, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI4506919, Length=412, Percent_Identity=24.5145631067961, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI87081924, Length=572, Percent_Identity=25.5244755244755, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1790112, Length=381, Percent_Identity=28.6089238845144, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1790233, Length=385, Percent_Identity=29.6103896103896, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI115533416, Length=477, Percent_Identity=25.5765199161426, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17559078, Length=235, Percent_Identity=34.0425531914894, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI115533418, Length=463, Percent_Identity=25.0539956803456, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24666109, Length=421, Percent_Identity=30.166270783848, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI281366397, Length=456, Percent_Identity=28.2894736842105, Blast_Score=152, Evalue=8e-37,
Organism=Drosophila melanogaster, GI281366395, Length=456, Percent_Identity=28.2894736842105, Blast_Score=152, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24666163, Length=456, Percent_Identity=28.2894736842105, Blast_Score=152, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24666175, Length=422, Percent_Identity=28.436018957346, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI281363223, Length=422, Percent_Identity=28.436018957346, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24647401, Length=444, Percent_Identity=23.4234234234234, Blast_Score=87, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 56065; Mature: 56065

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00523 SULFATASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRSVVASMIGLALCAGSVLSTAQAATAKRPNLVIILADDLGYGDLATYGHRIVKTPNID
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHCCEEEECCCHH
KLAQEGVKFTDYYAPAPLCSPSRAGLLTGRMPFRTGIRSWIPEGKDVALGRNELTIANLL
HHHHCCCEEEECCCCCCCCCCCCCCEEECCCHHHHHHHHHCCCCCCEECCCCCHHHHHHH
KQQGYDTAMMGKLHLNAGGDRTDQPQAKDMGFDYTLVNPAGFVTDATLDNAKERPRYGVV
HHCCCCEEEEEEEEECCCCCCCCCCCHHHCCCCEEEECCCCCEECCHHHCHHCCCCCEEE
HPTGWIRNGQHIGRADKMSGEFVSSEVVNWLDNKKDDNPFFLYVAFTEVHSPLASPKKYL
CCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHCCCCCHHHHH
DMYSQYMTDYQKQHPDLFYGDWADKPWRGTGEYYANISYMDEQVGKVLDKIKAMGEEDNT
HHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCE
IVIFTSDNGPVTREARKVYELNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHIPQGMVT
EEEEECCCCCCCHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
DTPVYGLDWLPTLANMMDFKLPTDRTYDGQSLVPLLKDKTLKRQKPLIFGIDMPFQDDPT
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCHHHHCCCEEEEECCCCCCCCC
DEWAIRDGDWKMIIDRQNKPKYLYNLKTDRFETLNQIGKQPQIEKQLYGKFLKYKKDIDN
CCCEEECCCEEEEEECCCCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
DSLMKARGDKPTPVTWG
CHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKRSVVASMIGLALCAGSVLSTAQAATAKRPNLVIILADDLGYGDLATYGHRIVKTPNID
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHCCEEEECCCHH
KLAQEGVKFTDYYAPAPLCSPSRAGLLTGRMPFRTGIRSWIPEGKDVALGRNELTIANLL
HHHHCCCEEEECCCCCCCCCCCCCCEEECCCHHHHHHHHHCCCCCCEECCCCCHHHHHHH
KQQGYDTAMMGKLHLNAGGDRTDQPQAKDMGFDYTLVNPAGFVTDATLDNAKERPRYGVV
HHCCCCEEEEEEEEECCCCCCCCCCCHHHCCCCEEEECCCCCEECCHHHCHHCCCCCEEE
HPTGWIRNGQHIGRADKMSGEFVSSEVVNWLDNKKDDNPFFLYVAFTEVHSPLASPKKYL
CCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHCCCCCHHHHH
DMYSQYMTDYQKQHPDLFYGDWADKPWRGTGEYYANISYMDEQVGKVLDKIKAMGEEDNT
HHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCE
IVIFTSDNGPVTREARKVYELNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHIPQGMVT
EEEEECCCCCCCHHHHEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCC
DTPVYGLDWLPTLANMMDFKLPTDRTYDGQSLVPLLKDKTLKRQKPLIFGIDMPFQDDPT
CCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCHHHHCCCEEEEECCCCCCCCC
DEWAIRDGDWKMIIDRQNKPKYLYNLKTDRFETLNQIGKQPQIEKQLYGKFLKYKKDIDN
CCCEEECCCEEEEEECCCCCCEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
DSLMKARGDKPTPVTWG
CHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]