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The map label for this gene is dcuA [H]

Identifier: 194734295

GI number: 194734295

Start: 4469417

End: 4470718

Strand: Reverse

Name: dcuA [H]

Synonym: SeSA_A4595

Alternate gene names: 194734295

Gene position: 4470718-4469417 (Counterclockwise)

Preceding gene: 194736630

Following gene: 194734784

Centisome position: 94.94

GC content: 54.22

Gene sequence:

>1302_bases
ATGATAGTTGTCGAACTTATCATTGTTTTGCTGGCAATCTTTTTGGGCGCCAGACTTGGGGGCATCGGTATTGGATTCGC
TGGTGGGCTGGGTGTTCTGGTACTTGCCGCCATCGGCGTGAAGCCAGGGACAATTCCATTCGATGTCATTTCCATCATCA
TGGCGGTTATCGCCGCGATCTCTGCTATGCAGGTCGCGGGCGGTCTGGATTATTTGGTAAACCAGACGGAAAAACTGCTG
CGTAAGAACCCGAAATACATCACTATCCTCGCACCGATTGTGACCTATTTCCTGACTATTTTTGCTGGTACCGGGAACAT
TTCCCTGGCAACGCTGCCGGTTATTGCTGAAGTCGCGAAGGAGCAGGGAATCAAACCTTGCCGTCCGCTCTCGACCGCCG
TGGTATCCGCGCAGATTGCGATTACCGCCTCGCCGATTTCTGCGGCCGTGGTGTATATGTCTTCTGTTATGGAAGGTCAT
GGCATTAGCTACATTCACCTGCTGTCCGTGGTTATCCCCTCTACGCTGCTGGCGGTGCTGGTGATGTCCTTCCTGGTCAC
GATGCTGTTCAACTCCAAACTGTCGGACGACCCGATTTACCGCAAGCGTCTGGAAGAAGGGCTGATTGAACTGCGTGGTG
AAAAGCAGATTGAAATCAAACCGATGGCAAAAAATTCCGTCTGGCTGTTCCTGCTGGGCGTTATCTGCGTGGTTGTTTAT
GCGATTGTCAACAGTCCGAGCCTCGGCCTGGTTGAAAAACCGCTGATGAACACCACCAACGCTATTTTGATCATCATGTT
GAGCGTCGCAACGCTGACCACCATCCTGTGTAAAGTGGAAACTGACGCCATCCTCAACTCCAGCACCTTTAAAGCAGGGA
TGAGCGCCTGTATCTGTATTCTGGGCGTGGCGTGGCTGGGCGATACCTTCGTATCCGCTAACATCGACTGGATCAAAGAC
ACTGCGGGTAGCGTCATCCAGGGTCATCCGTGGCTGCTGGCCGTCATCTTCTTCTTTGCTTCCGCGCTGCTCTACTCTCA
GGCGGCAACGGCGAAAGCGCTGATGCCGATGGCGCTGGCGCTGAACGTCTCTCCGCTGACGGCAGTCGCTTCCTTCGCCG
CCGTTTCCGGCCTGTTCATTCTGCCGACCTACCCGACTCTGGTTGCGGCGGTACAGATGGATGACACCGGTACAACCCGT
ATCGGTAAATTCGTCTTTAACCACCCGTTCTTCATCCCAGGCACCCTGGGCGTCGTTCTGGCTGTCTGCTTCGGCTTCCT
GCTGGGCAGCTTTATGCTGTAA

Upstream 100 bases:

>100_bases
ACCAAAGAGGCACGTCACGATGACGTGCCTTTTTTCTTACAAGAAGTTACCAAATAACAACAATTTAATATCAACTTGTT
AAACAACAAGGAAGGCTAAT

Downstream 100 bases:

>100_bases
GTGTTTCACCCGCGGGGCGTATCACGCCCCGCATTCTCCCGCCCTTTGACTAACATCCTGCCCTCGTCCGTTGTATAGTG
ACCGTTCACTTGCGGGTCTT

Product: anaerobic C4-dicarboxylate transporter

Products: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MIVVELIIVLLAIFLGARLGGIGIGFAGGLGVLVLAAIGVKPGTIPFDVISIIMAVIAAISAMQVAGGLDYLVNQTEKLL
RKNPKYITILAPIVTYFLTIFAGTGNISLATLPVIAEVAKEQGIKPCRPLSTAVVSAQIAITASPISAAVVYMSSVMEGH
GISYIHLLSVVIPSTLLAVLVMSFLVTMLFNSKLSDDPIYRKRLEEGLIELRGEKQIEIKPMAKNSVWLFLLGVICVVVY
AIVNSPSLGLVEKPLMNTTNAILIIMLSVATLTTILCKVETDAILNSSTFKAGMSACICILGVAWLGDTFVSANIDWIKD
TAGSVIQGHPWLLAVIFFFASALLYSQAATAKALMPMALALNVSPLTAVASFAAVSGLFILPTYPTLVAAVQMDDTGTTR
IGKFVFNHPFFIPGTLGVVLAVCFGFLLGSFML

Sequences:

>Translated_433_residues
MIVVELIIVLLAIFLGARLGGIGIGFAGGLGVLVLAAIGVKPGTIPFDVISIIMAVIAAISAMQVAGGLDYLVNQTEKLL
RKNPKYITILAPIVTYFLTIFAGTGNISLATLPVIAEVAKEQGIKPCRPLSTAVVSAQIAITASPISAAVVYMSSVMEGH
GISYIHLLSVVIPSTLLAVLVMSFLVTMLFNSKLSDDPIYRKRLEEGLIELRGEKQIEIKPMAKNSVWLFLLGVICVVVY
AIVNSPSLGLVEKPLMNTTNAILIIMLSVATLTTILCKVETDAILNSSTFKAGMSACICILGVAWLGDTFVSANIDWIKD
TAGSVIQGHPWLLAVIFFFASALLYSQAATAKALMPMALALNVSPLTAVASFAAVSGLFILPTYPTLVAAVQMDDTGTTR
IGKFVFNHPFFIPGTLGVVLAVCFGFLLGSFML
>Mature_433_residues
MIVVELIIVLLAIFLGARLGGIGIGFAGGLGVLVLAAIGVKPGTIPFDVISIIMAVIAAISAMQVAGGLDYLVNQTEKLL
RKNPKYITILAPIVTYFLTIFAGTGNISLATLPVIAEVAKEQGIKPCRPLSTAVVSAQIAITASPISAAVVYMSSVMEGH
GISYIHLLSVVIPSTLLAVLVMSFLVTMLFNSKLSDDPIYRKRLEEGLIELRGEKQIEIKPMAKNSVWLFLLGVICVVVY
AIVNSPSLGLVEKPLMNTTNAILIIMLSVATLTTILCKVETDAILNSSTFKAGMSACICILGVAWLGDTFVSANIDWIKD
TAGSVIQGHPWLLAVIFFFASALLYSQAATAKALMPMALALNVSPLTAVASFAAVSGLFILPTYPTLVAAVQMDDTGTTR
IGKFVFNHPFFIPGTLGVVLAVCFGFLLGSFML

Specific function: Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane [H]

COG id: COG2704

COG function: function code R; Anaerobic C4-dicarboxylate transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dcuA/dcuB transporter (TC 2.A.13.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790580, Length=433, Percent_Identity=94.6882217090069, Blast_Score=789, Evalue=0.0,
Organism=Escherichia coli, GI1790565, Length=404, Percent_Identity=36.6336633663366, Blast_Score=240, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004668 [H]

Pfam domain/function: PF03605 DcuA_DcuB [H]

EC number: NA

Molecular weight: Translated: 45769; Mature: 45769

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVVELIIVLLAIFLGARLGGIGIGFAGGLGVLVLAAIGVKPGTIPFDVISIIMAVIAAI
CHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
SAMQVAGGLDYLVNQTEKLLRKNPKYITILAPIVTYFLTIFAGTGNISLATLPVIAEVAK
HHHHHHCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EQGIKPCRPLSTAVVSAQIAITASPISAAVVYMSSVMEGHGISYIHLLSVVIPSTLLAVL
HCCCCCCCCHHHHHHHEEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VMSFLVTMLFNSKLSDDPIYRKRLEEGLIELRGEKQIEIKPMAKNSVWLFLLGVICVVVY
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHH
AIVNSPSLGLVEKPLMNTTNAILIIMLSVATLTTILCKVETDAILNSSTFKAGMSACICI
HHHCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LGVAWLGDTFVSANIDWIKDTAGSVIQGHPWLLAVIFFFASALLYSQAATAKALMPMALA
HHHHHHCCHHHCCCCHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNVSPLTAVASFAAVSGLFILPTYPTLVAAVQMDDTGTTRIGKFVFNHPFFIPGTLGVVL
CCCCHHHHHHHHHHHCCEEEECCCHHHHEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHH
AVCFGFLLGSFML
HHHHHHHHHHHCC
>Mature Secondary Structure
MIVVELIIVLLAIFLGARLGGIGIGFAGGLGVLVLAAIGVKPGTIPFDVISIIMAVIAAI
CHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
SAMQVAGGLDYLVNQTEKLLRKNPKYITILAPIVTYFLTIFAGTGNISLATLPVIAEVAK
HHHHHHCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
EQGIKPCRPLSTAVVSAQIAITASPISAAVVYMSSVMEGHGISYIHLLSVVIPSTLLAVL
HCCCCCCCCHHHHHHHEEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VMSFLVTMLFNSKLSDDPIYRKRLEEGLIELRGEKQIEIKPMAKNSVWLFLLGVICVVVY
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHH
AIVNSPSLGLVEKPLMNTTNAILIIMLSVATLTTILCKVETDAILNSSTFKAGMSACICI
HHHCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
LGVAWLGDTFVSANIDWIKDTAGSVIQGHPWLLAVIFFFASALLYSQAATAKALMPMALA
HHHHHHCCHHHCCCCHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNVSPLTAVASFAAVSGLFILPTYPTLVAAVQMDDTGTTRIGKFVFNHPFFIPGTLGVVL
CCCCHHHHHHHHHHHCCEEEECCCHHHHEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHH
AVCFGFLLGSFML
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Specific reaction: C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] = C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]