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The map label for this gene is uraA [H]

Identifier: 194734259

GI number: 194734259

Start: 2613741

End: 2615030

Strand: Reverse

Name: uraA [H]

Synonym: SeSA_A2734

Alternate gene names: 194734259

Gene position: 2615030-2613741 (Counterclockwise)

Preceding gene: 194734892

Following gene: 194735099

Centisome position: 55.53

GC content: 56.28

Gene sequence:

>1290_bases
ATGACGCGCCGTGCTATCGGGGTGAGTGAAAGACCGCCGCTTTTACAGACAATCCCGCTTAGTTTACAGCACCTTTTCGC
CATGTTTGGCGCGACCGTGCTGGTGCCAGTTCTGTTTCATATCAACCCCGCGACGGTGCTGCTGTTTAACGGTATCGGAA
CGCTGCTGTATCTCTTTATCTGCAAAGGTAAAATTCCGGCCTACCTCGGATCGAGCTTTGCCTTTATTTCCCCGGTACTA
CTGCTGTTGCCGCTGGGTTATGAAGTGGCGCTGGGCGGTTTTATTATGTGCGGCGTGTTGTTCTGTCTGGTTTCTTTCAT
CGTTAAAAAAGCGGGCACCGGCTGGCTGGATGTGATGTTCCCGCCTGCGGCAATGGGCGCAATCGTTGCCGTCATCGGTC
TGGAGCTGGCTGGCGTCGCGGCGGGGATGGCCGGATTGCTGCCTGCGCAAGGGCAGTCGCCGGACACGAAAACAATTATC
ATCTCCATGGTCACGCTGGCGGTGACGGTGTTCGGCTCCGTACTGTTTCGCGGTTTCCTGGCGATCATTCCGATTTTGAT
CGGCGTGCTGGCAGGCTATGCGCTGTCATTCGCGCTGGGAGTGGTCGATACCACGCCCATTGCCCAGGCACACTGGTTTG
CGCTGCCGACCTTCTATACGCCGCGTTTTGAATGGTTCGCGATCCTGACGATTCTGCCCGCGGCGTTGGTCGTGATCGCC
GAGCATGTCGGTCATCTGGTGGTGACGGCGAATATCGTCAAAAAAGATCTGGTGCGCGATCCCGGTTTGCACCGCTCGAT
GTTCGCTAACGGACTGTCGACGATCGTCTCCGGTTTCTTCGGCTCCACGCCGAATACCACCTATGGGGAAAATATTGGCG
TCATGGCGATCACCCGCGTTTACAGTACCTGGGTTATCGGCGGCGCGGCGATTTTCGCCATTCTGCTTTCCTGCGTCGGC
AAACTGGCGGCGGCGATTCAGATTATCCCGTTACCCGTGATGGGCGGCGTCTCACTGCTGTTGTACGGCGTTATCGGCGC
GTCGGGGATTCGCGTCTTGATCGAATCGAAAGTCGATTACAACAAAGCGCAAAACCTGATCCTCACCTCGGTGATTTTGA
TCATCGGCGTGAGCGGCGCGAAAGTGCATATCGGCGCGGCAGAATTGAAAGGGATGGCGCTGGCGACCATCGTCGGGATT
TGCCTGAGCCTGATTTTTAAACTGATTAGCCTGTTGCGTCCGGAAGAAGTGGTACTGGAGGCAAATGATGCGGAGTCTCC
GCATCAGTAA

Upstream 100 bases:

>100_bases
TGGTACCAAGTAAGTGAATAAATAATTAAAAGCCGACTTTAAGAGTCGGCTTTTTTTTGAATAAAACAACTCATAACAAA
CACACTTAGAGGAAAACACT

Downstream 100 bases:

>100_bases
CGGGTTGCCGGGCAGCGATGCTGCCCGGTTCTATCTCAAGGGAATTATGTGGTAAACTCAGCGCGATTTTATGTCATCCT
GGGTTGAGGTATCTCTGAAC

Product: uracil transporter

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVL
LLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVMFPPAAMGAIVAVIGLELAGVAAGMAGLLPAQGQSPDTKTII
ISMVTLAVTVFGSVLFRGFLAIIPILIGVLAGYALSFALGVVDTTPIAQAHWFALPTFYTPRFEWFAILTILPAALVVIA
EHVGHLVVTANIVKKDLVRDPGLHRSMFANGLSTIVSGFFGSTPNTTYGENIGVMAITRVYSTWVIGGAAIFAILLSCVG
KLAAAIQIIPLPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGI
CLSLIFKLISLLRPEEVVLEANDAESPHQ

Sequences:

>Translated_429_residues
MTRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVL
LLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVMFPPAAMGAIVAVIGLELAGVAAGMAGLLPAQGQSPDTKTII
ISMVTLAVTVFGSVLFRGFLAIIPILIGVLAGYALSFALGVVDTTPIAQAHWFALPTFYTPRFEWFAILTILPAALVVIA
EHVGHLVVTANIVKKDLVRDPGLHRSMFANGLSTIVSGFFGSTPNTTYGENIGVMAITRVYSTWVIGGAAIFAILLSCVG
KLAAAIQIIPLPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGI
CLSLIFKLISLLRPEEVVLEANDAESPHQ
>Mature_428_residues
TRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVLL
LLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVMFPPAAMGAIVAVIGLELAGVAAGMAGLLPAQGQSPDTKTIII
SMVTLAVTVFGSVLFRGFLAIIPILIGVLAGYALSFALGVVDTTPIAQAHWFALPTFYTPRFEWFAILTILPAALVVIAE
HVGHLVVTANIVKKDLVRDPGLHRSMFANGLSTIVSGFFGSTPNTTYGENIGVMAITRVYSTWVIGGAAIFAILLSCVGK
LAAAIQIIPLPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGIC
LSLIFKLISLLRPEEVVLEANDAESPHQ

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=238, Percent_Identity=27.3109243697479, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI40316845, Length=238, Percent_Identity=27.3109243697479, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI44680143, Length=221, Percent_Identity=25.3393665158371, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI44680145, Length=221, Percent_Identity=25.3393665158371, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1788843, Length=425, Percent_Identity=94.5882352941177, Blast_Score=795, Evalue=0.0,
Organism=Escherichia coli, GI87081818, Length=425, Percent_Identity=36.2352941176471, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87082181, Length=429, Percent_Identity=26.3403263403263, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1790087, Length=445, Percent_Identity=26.0674157303371, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17541904, Length=233, Percent_Identity=26.1802575107296, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558856, Length=173, Percent_Identity=29.4797687861272, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=185, Percent_Identity=29.1891891891892, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356175, Length=435, Percent_Identity=23.9080459770115, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45130; Mature: 44999

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
CKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVMF
HCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PPAAMGAIVAVIGLELAGVAAGMAGLLPAQGQSPDTKTIIISMVTLAVTVFGSVLFRGFL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AIIPILIGVLAGYALSFALGVVDTTPIAQAHWFALPTFYTPRFEWFAILTILPAALVVIA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHH
EHVGHLVVTANIVKKDLVRDPGLHRSMFANGLSTIVSGFFGSTPNTTYGENIGVMAITRV
HHHCHHEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
YSTWVIGGAAIFAILLSCVGKLAAAIQIIPLPVMGGVSLLLYGVIGASGIRVLIESKVDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCH
NKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGICLSLIFKLISLLRPEEVVLE
HHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ANDAESPHQ
CCCCCCCCC
>Mature Secondary Structure 
TRRAIGVSERPPLLQTIPLSLQHLFAMFGATVLVPVLFHINPATVLLFNGIGTLLYLFI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
CKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGVLFCLVSFIVKKAGTGWLDVMF
HCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PPAAMGAIVAVIGLELAGVAAGMAGLLPAQGQSPDTKTIIISMVTLAVTVFGSVLFRGFL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AIIPILIGVLAGYALSFALGVVDTTPIAQAHWFALPTFYTPRFEWFAILTILPAALVVIA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHH
EHVGHLVVTANIVKKDLVRDPGLHRSMFANGLSTIVSGFFGSTPNTTYGENIGVMAITRV
HHHCHHEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
YSTWVIGGAAIFAILLSCVGKLAAAIQIIPLPVMGGVSLLLYGVIGASGIRVLIESKVDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCH
NKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGICLSLIFKLISLLRPEEVVLE
HHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
ANDAESPHQ
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]