Click here to switch to the map view.

The map label for this gene is hemL [H]

Identifier: 194734166

GI number: 194734166

Start: 236441

End: 237721

Strand: Reverse

Name: hemL [H]

Synonym: SeSA_A0224

Alternate gene names: 194734166

Gene position: 237721-236441 (Counterclockwise)

Preceding gene: 194737595

Following gene: 194735647

Centisome position: 5.05

GC content: 59.02

Gene sequence:

>1281_bases
ATGAGTAAGTCTGAAAATCTCTATAGCGCGGCCCGCGAGCTGATCCCCGGCGGTGTGAACTCCCCTGTTCGCGCCTTCAC
TGGCGTGGGCGGCACCCCGCTGTTTATCGAAAAAGCGGACGGCGCGTATCTGTACGATGTCGATGGCAAAGCGTATATCG
ACTATGTCGGTTCCTGGGGGCCAATGGTACTGGGGCATAACCACCCGGCTATCCGCAATGCGGTGATCGAAGCTGCGGAG
CGCGGTTTAAGCTTCGGCGCGCCAACCGAAATGGAAGTGAAAATGGCGGAACTGGTCACCAACCTGGTGCCGACCATGGA
CATGGTGCGCATGGTGAACTCCGGTACCGAAGCGACGATGAGCGCTATTCGCCTGGCGCGTGGTTTTACTGGCCGCGATA
AGATTATCAAATTCGAAGGCTGCTACCACGGCCACGCAGACTGTCTGCTGGTCAAAGCCGGTTCTGGCGCGCTGACGCTC
GGTCAGCCGAACTCGCCGGGCGTGCCGGCAGATTTCGCGAAACATACGCTGACCTGCACTTATAACGATCTGGCGTCAGT
GCGCGCGGCGTTTGAACAATATCCGCAGGAAATCGCCTGTATCATCGTCGAACCCGTGGCGGGCAATATGAACTGCGTCC
CGCCGCTGCCGGAATTCCTGCCCGGTCTGCGCGCCTTGTGCGATGAGTTCGGCGCGCTGCTGATTATCGACGAAGTGATG
ACCGGTTTTCGCGTAGCGCTGGCCGGAGCCCAGGATTACTACGGCGTCGTGCCGGACCTGACCTGTCTGGGTAAAATCAT
CGGCGGCGGGATGCCGGTAGGCGCGTTTGGCGGTCGTCGCGATGTAATGGATGCGCTGGCGCCGACGGGCCCGGTTTACC
AGGCGGGCACCCTTTCCGGCAACCCGATTGCGATGGCGGCCGGTTTCGCCTGCCTGAATGAAGTCGCCCAGCCCGGCATT
CATGAAACGCTGGATGAGCTCACCACCCGTCTGGCGGAAGGTTTGCTGGAAGCTGCCGAAGAAGCGAATATTCCGCTGGT
GGTTAACCATGTCGGCGGCATGTTCGGGATTTTCTTCACCGACGCTGAGAGCGTAACTTGCTATCAGGACGTGATGGCGT
GCGACGTGGAACGCTTTAAGCGTTTCTTCCACCTGATGCTGGAGGAAGGCGTATATCTGGCGCCATCGGCGTTTGAGGCG
GGCTTTATGTCGGTCGCACACAGCATGGACGACATTAATAATACTATTGACGCCGCGCGTCGGGTGTTTGCGAAATTGTA
A

Upstream 100 bases:

>100_bases
TGCAAATCGTATTGTTTCAAATGCGTAAAACTTTCATAACCTTCTCTGAATAACTTAGAATAGCGGGTATTCACTTTTTC
TACGAACCAGGAATCTTTCC

Downstream 100 bases:

>100_bases
AGGATGAATTGCCGGGTGACGCTTACGCTTACCCGGCCTACATTCTACACCGCAGGCCGGATAAGGCATTTATGCCGCCA
TCCGGCAAACTCAGCGGCTC

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSKSENLYSAARELIPGGVNSPVRAFTGVGGTPLFIEKADGAYLYDVDGKAYIDYVGSWGPMVLGHNHPAIRNAVIEAAE
RGLSFGAPTEMEVKMAELVTNLVPTMDMVRMVNSGTEATMSAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTL
GQPNSPGVPADFAKHTLTCTYNDLASVRAAFEQYPQEIACIIVEPVAGNMNCVPPLPEFLPGLRALCDEFGALLIIDEVM
TGFRVALAGAQDYYGVVPDLTCLGKIIGGGMPVGAFGGRRDVMDALAPTGPVYQAGTLSGNPIAMAAGFACLNEVAQPGI
HETLDELTTRLAEGLLEAAEEANIPLVVNHVGGMFGIFFTDAESVTCYQDVMACDVERFKRFFHLMLEEGVYLAPSAFEA
GFMSVAHSMDDINNTIDAARRVFAKL

Sequences:

>Translated_426_residues
MSKSENLYSAARELIPGGVNSPVRAFTGVGGTPLFIEKADGAYLYDVDGKAYIDYVGSWGPMVLGHNHPAIRNAVIEAAE
RGLSFGAPTEMEVKMAELVTNLVPTMDMVRMVNSGTEATMSAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTL
GQPNSPGVPADFAKHTLTCTYNDLASVRAAFEQYPQEIACIIVEPVAGNMNCVPPLPEFLPGLRALCDEFGALLIIDEVM
TGFRVALAGAQDYYGVVPDLTCLGKIIGGGMPVGAFGGRRDVMDALAPTGPVYQAGTLSGNPIAMAAGFACLNEVAQPGI
HETLDELTTRLAEGLLEAAEEANIPLVVNHVGGMFGIFFTDAESVTCYQDVMACDVERFKRFFHLMLEEGVYLAPSAFEA
GFMSVAHSMDDINNTIDAARRVFAKL
>Mature_425_residues
SKSENLYSAARELIPGGVNSPVRAFTGVGGTPLFIEKADGAYLYDVDGKAYIDYVGSWGPMVLGHNHPAIRNAVIEAAER
GLSFGAPTEMEVKMAELVTNLVPTMDMVRMVNSGTEATMSAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLG
QPNSPGVPADFAKHTLTCTYNDLASVRAAFEQYPQEIACIIVEPVAGNMNCVPPLPEFLPGLRALCDEFGALLIIDEVMT
GFRVALAGAQDYYGVVPDLTCLGKIIGGGMPVGAFGGRRDVMDALAPTGPVYQAGTLSGNPIAMAAGFACLNEVAQPGIH
ETLDELTTRLAEGLLEAAEEANIPLVVNHVGGMFGIFFTDAESVTCYQDVMACDVERFKRFFHLMLEEGVYLAPSAFEAG
FMSVAHSMDDINNTIDAARRVFAKL

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=315, Percent_Identity=30.1587301587302, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI13994255, Length=373, Percent_Identity=27.0777479892761, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI284507298, Length=230, Percent_Identity=30.4347826086957, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786349, Length=426, Percent_Identity=98.1220657276995, Blast_Score=858, Evalue=0.0,
Organism=Escherichia coli, GI1789016, Length=446, Percent_Identity=30.2690582959641, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1787560, Length=346, Percent_Identity=32.3699421965318, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1788044, Length=312, Percent_Identity=33.0128205128205, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789759, Length=320, Percent_Identity=31.25, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI145693181, Length=334, Percent_Identity=29.6407185628743, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1786991, Length=384, Percent_Identity=26.0416666666667, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71992977, Length=360, Percent_Identity=28.6111111111111, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=305, Percent_Identity=28.5245901639344, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=330, Percent_Identity=25.7575757575758, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25144274, Length=148, Percent_Identity=32.4324324324324, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=340, Percent_Identity=28.8235294117647, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324432, Length=348, Percent_Identity=26.4367816091954, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357415, Length=301, Percent_Identity=27.5747508305648, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356575, Length=321, Percent_Identity=28.0373831775701, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 45380; Mature: 45248

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSENLYSAARELIPGGVNSPVRAFTGVGGTPLFIEKADGAYLYDVDGKAYIDYVGSWG
CCCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEEECCCEEEEECCCCEEEEEECCCC
PMVLGHNHPAIRNAVIEAAERGLSFGAPTEMEVKMAELVTNLVPTMDMVRMVNSGTEATM
CEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPADFAKHTLTCT
HHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCHHHHHCEEEEE
YNDLASVRAAFEQYPQEIACIIVEPVAGNMNCVPPLPEFLPGLRALCDEFGALLIIDEVM
HHHHHHHHHHHHHCCHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEHHHHH
TGFRVALAGAQDYYGVVPDLTCLGKIIGGGMPVGAFGGRRDVMDALAPTGPVYQAGTLSG
HHHHHHEECCCHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPIAMAAGFACLNEVAQPGIHETLDELTTRLAEGLLEAAEEANIPLVVNHVGGMFGIFFT
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEE
DAESVTCYQDVMACDVERFKRFFHLMLEEGVYLAPSAFEAGFMSVAHSMDDINNTIDAAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHH
RVFAKL
HHHHCC
>Mature Secondary Structure 
SKSENLYSAARELIPGGVNSPVRAFTGVGGTPLFIEKADGAYLYDVDGKAYIDYVGSWG
CCCCHHHHHHHHHCCCCCCCCHHHHHCCCCCEEEEEECCCEEEEECCCCEEEEEECCCC
PMVLGHNHPAIRNAVIEAAERGLSFGAPTEMEVKMAELVTNLVPTMDMVRMVNSGTEATM
CEEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
SAIRLARGFTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPADFAKHTLTCT
HHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEECCCEEECCCCCCCCCCHHHHHCEEEEE
YNDLASVRAAFEQYPQEIACIIVEPVAGNMNCVPPLPEFLPGLRALCDEFGALLIIDEVM
HHHHHHHHHHHHHCCHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEHHHHH
TGFRVALAGAQDYYGVVPDLTCLGKIIGGGMPVGAFGGRRDVMDALAPTGPVYQAGTLSG
HHHHHHEECCCHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCC
NPIAMAAGFACLNEVAQPGIHETLDELTTRLAEGLLEAAEEANIPLVVNHVGGMFGIFFT
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEE
DAESVTCYQDVMACDVERFKRFFHLMLEEGVYLAPSAFEAGFMSVAHSMDDINNTIDAAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHH
RVFAKL
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA