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The map label for this gene is frmA [H]

Identifier: 194734098

GI number: 194734098

Start: 1688393

End: 1689511

Strand: Reverse

Name: frmA [H]

Synonym: SeSA_A1746

Alternate gene names: 194734098

Gene position: 1689511-1688393 (Counterclockwise)

Preceding gene: 194737103

Following gene: 194736223

Centisome position: 35.88

GC content: 53.62

Gene sequence:

>1119_bases
ATGAAATCACGTGCAGCAGTTGCTTTTGGTCCCGGTCAGCCGCTAAAAATTGTCGAGATTGACGTTGCGCCGCCGAAAAA
AGGCGAAGTTCTGGTCAAAATCACCCATACCGGCGTTTGCCATACCGATGCTTTTACCCTTTCCGGCGATGATCCGGAAG
GCGTATTCCCGGCAGTCCTGGGTCACGAAGGCGGCGGCGTGGTAGTCGAGGTCGGCGAGGGGGTCACCAGCCTGAAACCC
GGCGACCATGTTATTCCACTGTATACGGCGGAATGCGGCGAGTGTAAGTTCTGTAAGTCCGGTAAAACTAACCTTTGTCA
GGCCGTACGCGCCACTCAGGGAAAAGGGCTGATGCCGGATGGCACTACCCGCTTTTCTTATAACGGCGAACCCGTTTATC
ACTATATGGGAACCAGCACGTTCAGCGAATATACCGTTTGCGCGGAAATTTCTCTGGCGAAAGTGAACCCGCAGGCGCCG
CTGGATAAAGTGTGTCTGTTGGGCTGCGGCGTGACGACGGGTATTGGCGCCGTCCATAACACCGCTAAAGTGAAAGCGGG
CGACACCGTTGCCGTTTTTGGTTTAGGCGGTATTGGGCTGGCGGTTATTCAGGGCGCGGTTCAGGCTAAAGCCGGGCGTA
TTTTAGCTGTCGACACGAATCCGGAAAAATTTACGCTGGCGGGCGAAATGGGGGCTACGGACTTTATTAATCCGAATGAT
TACGACAAACCGATCCAGGACGTTATTGTTGAGCTTACTGATGGCGGCGTAGATTTCAGTTTTGAATGTATCGGCAACGT
TAACGTGATGCGAGCGGCGCTGGAATGTTGTCATAAAGGCTGGGGCGAAAGCATTATTATTGGCGTAGCGGGAGCAGGGC
AGGAAATCAAAACCCGTCCCTTCCAGCTAGTGACCGGTCGCGTCTGGCGTGGCTCCGCCTTTGGCGGCGTGAAAGGGCGC
ACGCAGCTGCCAGGGATGGTCGAAGATGCGATGAACGGTAAAATCCGTTTAGATCCTTTTATTACTCACCGCCTGCCGCT
GGAGCAGATTAACGATGCCTTTGAACTGATGCATCAGGGTAAATCCATCCGTACTGTTATCCACTTTAGCGATAACTGA

Upstream 100 bases:

>100_bases
ACTACGCCAGATCAGCGCGCGGTTCGGATGGCGGAAATCGGCCATCTTCTTCGCGCTTATCTAAAATAACAATTTCCCTC
ACCGTAACAGGAAGAGATAT

Downstream 100 bases:

>100_bases
TTCATCCGCCAGCGGATTTTCCGCTGGCGCTTTTCTGAATTTTCTGGAATGAATGTTGTGAAAATGTGACGAAGGCGATG
CTTTTCGCGGTAAGCAAACG

Product: S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKSRAAVAFGPGQPLKIVEIDVAPPKKGEVLVKITHTGVCHTDAFTLSGDDPEGVFPAVLGHEGGGVVVEVGEGVTSLKP
GDHVIPLYTAECGECKFCKSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPVYHYMGTSTFSEYTVCAEISLAKVNPQAP
LDKVCLLGCGVTTGIGAVHNTAKVKAGDTVAVFGLGGIGLAVIQGAVQAKAGRILAVDTNPEKFTLAGEMGATDFINPND
YDKPIQDVIVELTDGGVDFSFECIGNVNVMRAALECCHKGWGESIIIGVAGAGQEIKTRPFQLVTGRVWRGSAFGGVKGR
TQLPGMVEDAMNGKIRLDPFITHRLPLEQINDAFELMHQGKSIRTVIHFSDN

Sequences:

>Translated_372_residues
MKSRAAVAFGPGQPLKIVEIDVAPPKKGEVLVKITHTGVCHTDAFTLSGDDPEGVFPAVLGHEGGGVVVEVGEGVTSLKP
GDHVIPLYTAECGECKFCKSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPVYHYMGTSTFSEYTVCAEISLAKVNPQAP
LDKVCLLGCGVTTGIGAVHNTAKVKAGDTVAVFGLGGIGLAVIQGAVQAKAGRILAVDTNPEKFTLAGEMGATDFINPND
YDKPIQDVIVELTDGGVDFSFECIGNVNVMRAALECCHKGWGESIIIGVAGAGQEIKTRPFQLVTGRVWRGSAFGGVKGR
TQLPGMVEDAMNGKIRLDPFITHRLPLEQINDAFELMHQGKSIRTVIHFSDN
>Mature_372_residues
MKSRAAVAFGPGQPLKIVEIDVAPPKKGEVLVKITHTGVCHTDAFTLSGDDPEGVFPAVLGHEGGGVVVEVGEGVTSLKP
GDHVIPLYTAECGECKFCKSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPVYHYMGTSTFSEYTVCAEISLAKVNPQAP
LDKVCLLGCGVTTGIGAVHNTAKVKAGDTVAVFGLGGIGLAVIQGAVQAKAGRILAVDTNPEKFTLAGEMGATDFINPND
YDKPIQDVIVELTDGGVDFSFECIGNVNVMRAALECCHKGWGESIIIGVAGAGQEIKTRPFQLVTGRVWRGSAFGGVKGR
TQLPGMVEDAMNGKIRLDPFITHRLPLEQINDAFELMHQGKSIRTVIHFSDN

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=65.0406504065041, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=50.4043126684636, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=49.3261455525606, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=49.3224932249323, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=49.0616621983914, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=47.6839237057221, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=47.9224376731302, Blast_Score=360, Evalue=1e-100,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=47.4254742547426, Blast_Score=351, Evalue=5e-97,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=47.4254742547426, Blast_Score=351, Evalue=6e-97,
Organism=Homo sapiens, GI156627571, Length=372, Percent_Identity=25.5376344086022, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=80.7588075880759, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI87082125, Length=384, Percent_Identity=26.0416666666667, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI87081918, Length=348, Percent_Identity=32.183908045977, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788073, Length=381, Percent_Identity=26.509186351706, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1787863, Length=368, Percent_Identity=26.3586956521739, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790045, Length=359, Percent_Identity=26.4623955431755, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786825, Length=247, Percent_Identity=29.9595141700405, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI226510992, Length=369, Percent_Identity=24.9322493224932, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790718, Length=330, Percent_Identity=24.8484848484848, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788407, Length=230, Percent_Identity=28.2608695652174, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1786518, Length=371, Percent_Identity=26.9541778975741, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=59.2493297587131, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=58.9333333333333, Blast_Score=453, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=58.8921282798834, Blast_Score=423, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17562584, Length=364, Percent_Identity=28.021978021978, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=373, Percent_Identity=26.8096514745308, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=373, Percent_Identity=27.0777479892761, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=60.9164420485175, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6323729, Length=366, Percent_Identity=28.9617486338798, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=31.0469314079422, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=275, Percent_Identity=30.5454545454545, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=264, Percent_Identity=31.0606060606061, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=377, Percent_Identity=28.1167108753316, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6319257, Length=307, Percent_Identity=28.0130293159609, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=63.8586956521739, Blast_Score=495, Evalue=1e-140,
Organism=Drosophila melanogaster, GI17137530, Length=347, Percent_Identity=26.5129682997118, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17737897, Length=347, Percent_Identity=24.4956772334294, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39286; Mature: 39286

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRAAVAFGPGQPLKIVEIDVAPPKKGEVLVKITHTGVCHTDAFTLSGDDPEGVFPAVL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCEEECCEEEECCCCCCCCCCCEE
GHEGGGVVVEVGEGVTSLKPGDHVIPLYTAECGECKFCKSGKTNLCQAVRATQGKGLMPD
CCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCEEECCCCCHHHHHHHHHCCCCCCCCC
GTTRFSYNGEPVYHYMGTSTFSEYTVCAEISLAKVNPQAPLDKVCLLGCGVTTGIGAVHN
CCEEEECCCCEEEEEECCCCCCCEEEEEEEEEEECCCCCCHHHHHEEECCHHHCCCHHCC
TAKVKAGDTVAVFGLGGIGLAVIQGAVQAKAGRILAVDTNPEKFTLAGEMGATDFINPND
CEEEECCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCCC
YDKPIQDVIVELTDGGVDFSFECIGNVNVMRAALECCHKGWGESIIIGVAGAGQEIKTRP
CCCCHHHHEEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRVWRGSAFGGVKGRTQLPGMVEDAMNGKIRLDPFITHRLPLEQINDAFELMHQG
EEEEECEEEECCCCCCCCCCCCCCCHHHHHCCCEEEECCCEECCCCHHHHHHHHHHHHCC
KSIRTVIHFSDN
CCEEEEEEECCC
>Mature Secondary Structure
MKSRAAVAFGPGQPLKIVEIDVAPPKKGEVLVKITHTGVCHTDAFTLSGDDPEGVFPAVL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCEEECCEEEECCCCCCCCCCCEE
GHEGGGVVVEVGEGVTSLKPGDHVIPLYTAECGECKFCKSGKTNLCQAVRATQGKGLMPD
CCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCEEECCCCCHHHHHHHHHCCCCCCCCC
GTTRFSYNGEPVYHYMGTSTFSEYTVCAEISLAKVNPQAPLDKVCLLGCGVTTGIGAVHN
CCEEEECCCCEEEEEECCCCCCCEEEEEEEEEEECCCCCCHHHHHEEECCHHHCCCHHCC
TAKVKAGDTVAVFGLGGIGLAVIQGAVQAKAGRILAVDTNPEKFTLAGEMGATDFINPND
CEEEECCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCCCCCCCCCCC
YDKPIQDVIVELTDGGVDFSFECIGNVNVMRAALECCHKGWGESIIIGVAGAGQEIKTRP
CCCCHHHHEEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRVWRGSAFGGVKGRTQLPGMVEDAMNGKIRLDPFITHRLPLEQINDAFELMHQG
EEEEECEEEECCCCCCCCCCCCCCCHHHHHCCCEEEECCCEECCCCHHHHHHHHHHHHCC
KSIRTVIHFSDN
CCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]