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The map label for this gene is ccmA [H]

Identifier: 194734013

GI number: 194734013

Start: 3899763

End: 3900380

Strand: Reverse

Name: ccmA [H]

Synonym: SeSA_A4030

Alternate gene names: 194734013

Gene position: 3900380-3899763 (Counterclockwise)

Preceding gene: 194737894

Following gene: 194734379

Centisome position: 82.83

GC content: 72.33

Gene sequence:

>618_bases
ATGCTTGAAGCCAGAGATCTGTACTGCGAGCGGGACGAGAGGACGCTGTTCAGCGGGCTGTCGTTCACCGTGGAGGCCGG
GGAGTGGGTGCAGGTCACCGGCGGCAACGGCGCCGGAAAAACCACCCTGCTGCGCCTGCTGACCGGGCTGGCGCGCCCGG
ACGGCGGCGAGGTGTACTGGCAGGGCGAACCCCTGCGCCGCGTGCGCGACAGCTTCCATTCCGGCCTGCTGTGGATAGGG
CACCAGCCGGGGATTAAAACCCGCCTGACGGCGCGGGAGAACCTGCATTTCTTCCACCCCGGCGACGGCGCGCGTCTCCC
GGAGGCGCTGGCGCAGGCCGGGCTGGCGGGATTTGAGGACGTGCCGGTCGCCCGGCTTTCGGCCGGGCAGCAGCGCCGGG
TGGCGCTGGCCCGCCTGTGGCTGACCCGCGCCGCGCTGTGGGTGCTCGACGAGCCGTTCACCGCCATTGACGTTAACGGC
GTGGCGCGCCTCACCCGGCGGATGGCGGCGCACACGGCGCAGGGCGGGATGGTCATTCTCACCACCCACCAGCCGTTGCC
GGGGGCCGCGGACACCGTCCGCCGCCTGGCGCTGACCGGCGGGGAGGCTGGGCTGTGA

Upstream 100 bases:

>100_bases
CAGATCTGCCGCAAAACGATATTGACGATATCGTCGCCTTCCTGGAAAGCCTGACCGGTGTTTATACGCCATATCAACCT
GAATATGCGCAATGACAATG

Downstream 100 bases:

>100_bases
TGTGGCGTGTCTTCTGTCTCGAACTGCGCGTGGCGTTCCGCCACGGCGCGGACATCGCCGGCCCGCTGTGGTTCTTCCTG
ATGGTCATCACCCTGTTTCC

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Cytochrome c biogenesis ATP-binding export protein CcmA 2; Heme exporter protein A 2; Cytochrome c-type biogenesis protein CcmE 2; Cytochrome c maturation protein E 2; Heme chaperone CcmE 2 [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MLEARDLYCERDERTLFSGLSFTVEAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYWQGEPLRRVRDSFHSGLLWIG
HQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFEDVPVARLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNG
VARLTRRMAAHTAQGGMVILTTHQPLPGAADTVRRLALTGGEAGL

Sequences:

>Translated_205_residues
MLEARDLYCERDERTLFSGLSFTVEAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYWQGEPLRRVRDSFHSGLLWIG
HQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFEDVPVARLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNG
VARLTRRMAAHTAQGGMVILTTHQPLPGAADTVRRLALTGGEAGL
>Mature_205_residues
MLEARDLYCERDERTLFSGLSFTVEAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYWQGEPLRRVRDSFHSGLLWIG
HQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFEDVPVARLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNG
VARLTRRMAAHTAQGGMVILTTHQPLPGAADTVRRLALTGGEAGL

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27436953, Length=193, Percent_Identity=30.5699481865285, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI11967969, Length=189, Percent_Identity=29.1005291005291, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI153792144, Length=193, Percent_Identity=29.0155440414508, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI9665248, Length=210, Percent_Identity=27.1428571428571, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI73747915, Length=164, Percent_Identity=28.6585365853659, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI73747917, Length=164, Percent_Identity=28.6585365853659, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI27477115, Length=195, Percent_Identity=27.1794871794872, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI150417984, Length=177, Percent_Identity=31.0734463276836, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI87082064, Length=200, Percent_Identity=79.5, Blast_Score=305, Evalue=2e-84,
Organism=Escherichia coli, GI87081709, Length=174, Percent_Identity=32.7586206896552, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI87081791, Length=195, Percent_Identity=28.7179487179487, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1789891, Length=188, Percent_Identity=29.2553191489362, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788165, Length=154, Percent_Identity=34.4155844155844, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1787370, Length=187, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789873, Length=203, Percent_Identity=27.0935960591133, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1787041, Length=183, Percent_Identity=27.3224043715847, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1789991, Length=197, Percent_Identity=27.9187817258883, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1789586, Length=197, Percent_Identity=28.9340101522843, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790544, Length=201, Percent_Identity=29.3532338308458, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI87081834, Length=198, Percent_Identity=26.7676767676768, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1790190, Length=186, Percent_Identity=26.3440860215054, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1786563, Length=205, Percent_Identity=28.2926829268293, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786253, Length=193, Percent_Identity=30.0518134715026, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI48994943, Length=163, Percent_Identity=28.2208588957055, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787112, Length=187, Percent_Identity=29.9465240641711, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1787113, Length=197, Percent_Identity=31.9796954314721, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1786703, Length=204, Percent_Identity=28.4313725490196, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787105, Length=220, Percent_Identity=27.7272727272727, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1788897, Length=199, Percent_Identity=26.6331658291457, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787792, Length=203, Percent_Identity=23.6453201970443, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786345, Length=204, Percent_Identity=28.921568627451, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787164, Length=197, Percent_Identity=31.4720812182741, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI87081782, Length=195, Percent_Identity=29.2307692307692, Blast_Score=60, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI71992290, Length=189, Percent_Identity=27.5132275132275, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533608, Length=175, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193211017, Length=191, Percent_Identity=26.1780104712042, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193211015, Length=191, Percent_Identity=26.1780104712042, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71996809, Length=191, Percent_Identity=26.1780104712042, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17533971, Length=192, Percent_Identity=23.9583333333333, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25146777, Length=189, Percent_Identity=25.3968253968254, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI45550390, Length=197, Percent_Identity=26.9035532994924, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585091, Length=179, Percent_Identity=29.608938547486, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28574744, Length=187, Percent_Identity=27.807486631016, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI19920532, Length=183, Percent_Identity=26.2295081967213, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24580930, Length=183, Percent_Identity=26.2295081967213, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574533, Length=169, Percent_Identity=27.810650887574, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- InterPro:   IPR004329
- InterPro:   IPR012340 [H]

Pfam domain/function: PF00005 ABC_tran; PF03100 CcmE [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 22268; Mature: 22268

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEARDLYCERDERTLFSGLSFTVEAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYW
CCCCCCCHHCCCCHHHHCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEE
QGEPLRRVRDSFHSGLLWIGHQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFED
CCCHHHHHHHHHHCCEEEEECCCCCCEEEEHHCCEEEECCCCCCHHHHHHHHHCCCCCCC
VPVARLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNGVARLTRRMAAHTAQGGMVIL
CCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCCEEEE
TTHQPLPGAADTVRRLALTGGEAGL
EECCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLEARDLYCERDERTLFSGLSFTVEAGEWVQVTGGNGAGKTTLLRLLTGLARPDGGEVYW
CCCCCCCHHCCCCHHHHCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEE
QGEPLRRVRDSFHSGLLWIGHQPGIKTRLTARENLHFFHPGDGARLPEALAQAGLAGFED
CCCHHHHHHHHHHCCEEEEECCCCCCEEEEHHCCEEEECCCCCCHHHHHHHHHCCCCCCC
VPVARLSAGQQRRVALARLWLTRAALWVLDEPFTAIDVNGVARLTRRMAAHTAQGGMVIL
CCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHCCCCCEEEE
TTHQPLPGAADTVRRLALTGGEAGL
EECCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA