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The map label for this gene is gatD [H]

Identifier: 194734003

GI number: 194734003

Start: 3332157

End: 3333200

Strand: Direct

Name: gatD [H]

Synonym: SeSA_A3450

Alternate gene names: 194734003

Gene position: 3332157-3333200 (Clockwise)

Preceding gene: 194734480

Following gene: 194735688

Centisome position: 70.76

GC content: 55.08

Gene sequence:

>1044_bases
ATGAAATCAGTGGTTATTCACGCTGAGGGAGACGTGCGCGTTGAAGAACGCCCCTTACCACAACTGCAAGCCGAGGACGA
TGTGTTGGTCAAAGTCGTTAGCTCAGGGCTTTGCGGGTCGGATATCCCGCGTATTTTCGCGCAGGGCGCCCATTATTATC
CTATTACGTTAGGCCATGAATTCAGCGGCTACGTAGAATCCTACGGCACAGGCGTAACGGATATGCAGCCCGGCGATGCC
GTCGCTTGTGTCCCGCTTCTTCCCTGCTTTCACTGTCCGCAATGCGAACGCGGTTACTTTTCTTTATGCAGACAGTATCA
GTTTGTAGGATCGCGCAGCGAAGGCGGTAATGCGGAATATGTGGTGGTCAAACGGGCCAATCTTTTCCGCTTGCCGTCTG
ATATGCCGATTGAAGATGGCGCGTTTATCGAACCGATTACCGTGGGCTTACACGCCTTTCATCTGGCGCAGGGCTGCGAG
GGGAAAAACGTAATTATCGTCGGTGCCGGGACAATTGGCCTGCTGGCCTTACAATGCGCGCGGGAACTGGGCGCTCGAAG
CGTAACGGCGATTGATATCAATCCGCAGAAACTGGAACTGGCGAAAGCGCTCGGCGCAACGCATACCTGTAATAGCCGGG
AAATGACCGCCGACGACATCCAGACCGCGTTGTCCGGCATTCAGTTTGATCAACTGGTTCTCGAAACGGCAGGAACTCCC
CAGACCGTCTCGCTGGCTATCGATATCGCCGGGCCGCGCGCGCAACTGGCGCTGGTGGGGACGTTACATCACGATCTCAC
CCTGACAACGCGTACATTCGGATTAATTTTGCGTAAAGAGCTCACGCTCCTCGGCAGTTGGATGAACTACTCCGCGCCAT
GGCCAGGAGAAGAATGGGAAACCGCAGCGCGCCTGTTGGCTGAAAAACGTCTTCAACTGACCCCTCTCATTGCCCATCGC
GGCGATGCGGAAAGCTTTGCAGAAGCAGTCAAAGCGCTTAATGGCGCGCCCATGCAGGGCAAAATCTTACTTCAACTTTC
CTGA

Upstream 100 bases:

>100_bases
CAGTTTGTCGCGGCTGAGAAAGCCACGGCGCTACAGCAAAGTCAAATCGCCTCTTAATTTTAGGGGAGCAATCGCTCCCC
TCACCTTCCTGGAGAATGTT

Downstream 100 bases:

>100_bases
TGGTACGAGCCAGCAACCTGCGCTGGCTCACATTTCCTTTCGAAATTTAGCGTTCACCTTTCGCAATCCTTCGATTAAAC
TAGTTACAGTTAATTATCAG

Product: galactitol-1-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MKSVVIHAEGDVRVEERPLPQLQAEDDVLVKVVSSGLCGSDIPRIFAQGAHYYPITLGHEFSGYVESYGTGVTDMQPGDA
VACVPLLPCFHCPQCERGYFSLCRQYQFVGSRSEGGNAEYVVVKRANLFRLPSDMPIEDGAFIEPITVGLHAFHLAQGCE
GKNVIIVGAGTIGLLALQCARELGARSVTAIDINPQKLELAKALGATHTCNSREMTADDIQTALSGIQFDQLVLETAGTP
QTVSLAIDIAGPRAQLALVGTLHHDLTLTTRTFGLILRKELTLLGSWMNYSAPWPGEEWETAARLLAEKRLQLTPLIAHR
GDAESFAEAVKALNGAPMQGKILLQLS

Sequences:

>Translated_347_residues
MKSVVIHAEGDVRVEERPLPQLQAEDDVLVKVVSSGLCGSDIPRIFAQGAHYYPITLGHEFSGYVESYGTGVTDMQPGDA
VACVPLLPCFHCPQCERGYFSLCRQYQFVGSRSEGGNAEYVVVKRANLFRLPSDMPIEDGAFIEPITVGLHAFHLAQGCE
GKNVIIVGAGTIGLLALQCARELGARSVTAIDINPQKLELAKALGATHTCNSREMTADDIQTALSGIQFDQLVLETAGTP
QTVSLAIDIAGPRAQLALVGTLHHDLTLTTRTFGLILRKELTLLGSWMNYSAPWPGEEWETAARLLAEKRLQLTPLIAHR
GDAESFAEAVKALNGAPMQGKILLQLS
>Mature_347_residues
MKSVVIHAEGDVRVEERPLPQLQAEDDVLVKVVSSGLCGSDIPRIFAQGAHYYPITLGHEFSGYVESYGTGVTDMQPGDA
VACVPLLPCFHCPQCERGYFSLCRQYQFVGSRSEGGNAEYVVVKRANLFRLPSDMPIEDGAFIEPITVGLHAFHLAQGCE
GKNVIIVGAGTIGLLALQCARELGARSVTAIDINPQKLELAKALGATHTCNSREMTADDIQTALSGIQFDQLVLETAGTP
QTVSLAIDIAGPRAQLALVGTLHHDLTLTTRTFGLILRKELTLLGSWMNYSAPWPGEEWETAARLLAEKRLQLTPLIAHR
GDAESFAEAVKALNGAPMQGKILLQLS

Specific function: Converts galactitol 1-phosphate to tagatose 6-phosphate [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=348, Percent_Identity=29.5977011494253, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI156523966, Length=349, Percent_Identity=27.2206303724928, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501939, Length=339, Percent_Identity=27.1386430678466, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI4501929, Length=211, Percent_Identity=27.9620853080569, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI71743840, Length=212, Percent_Identity=26.4150943396226, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI262073058, Length=212, Percent_Identity=26.4150943396226, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI34577061, Length=216, Percent_Identity=27.7777777777778, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI4501933, Length=216, Percent_Identity=28.2407407407407, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI71565154, Length=214, Percent_Identity=26.1682242990654, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1788407, Length=344, Percent_Identity=68.6046511627907, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=31.6109422492401, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=27.6162790697674, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1787863, Length=331, Percent_Identity=29.607250755287, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI226510992, Length=324, Percent_Identity=28.7037037037037, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790718, Length=360, Percent_Identity=26.6666666666667, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI87082125, Length=207, Percent_Identity=31.4009661835749, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788075, Length=342, Percent_Identity=25.4385964912281, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786825, Length=233, Percent_Identity=28.3261802575107, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87081918, Length=231, Percent_Identity=30.7359307359307, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1786552, Length=277, Percent_Identity=28.158844765343, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786518, Length=275, Percent_Identity=28.7272727272727, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=360, Percent_Identity=31.1111111111111, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17562878, Length=254, Percent_Identity=33.4645669291339, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI25146526, Length=346, Percent_Identity=24.8554913294798, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=319, Percent_Identity=25.3918495297806, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17565904, Length=318, Percent_Identity=25.4716981132075, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=194, Percent_Identity=31.9587628865979, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=338, Percent_Identity=30.1775147928994, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6322619, Length=338, Percent_Identity=30.1775147928994, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323099, Length=349, Percent_Identity=28.9398280802292, Blast_Score=150, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6319258, Length=234, Percent_Identity=29.4871794871795, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319257, Length=314, Percent_Identity=24.5222929936306, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320033, Length=309, Percent_Identity=25.5663430420712, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17137530, Length=349, Percent_Identity=32.0916905444126, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI17737897, Length=350, Percent_Identity=30, Blast_Score=148, Evalue=6e-36,
Organism=Drosophila melanogaster, GI17737895, Length=296, Percent_Identity=28.0405405405405, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI221457811, Length=173, Percent_Identity=28.9017341040462, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550770, Length=173, Percent_Identity=28.9017341040462, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45551930, Length=173, Percent_Identity=28.9017341040462, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.251 [H]

Molecular weight: Translated: 37431; Mature: 37431

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVVIHAEGDVRVEERPLPQLQAEDDVLVKVVSSGLCGSDIPRIFAQGAHYYPITLGHE
CCEEEEECCCCEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCC
FSGYVESYGTGVTDMQPGDAVACVPLLPCFHCPQCERGYFSLCRQYQFVGSRSEGGNAEY
HHHHHHHHCCCCCCCCCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
VVVKRANLFRLPSDMPIEDGAFIEPITVGLHAFHLAQGCEGKNVIIVGAGTIGLLALQCA
EEEEECCEEECCCCCCCCCCCEECHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHH
RELGARSVTAIDINPQKLELAKALGATHTCNSREMTADDIQTALSGIQFDQLVLETAGTP
HHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHEECCCCC
QTVSLAIDIAGPRAQLALVGTLHHDLTLTTRTFGLILRKELTLLGSWMNYSAPWPGEEWE
CEEEEEEEECCCCEEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
TAARLLAEKRLQLTPLIAHRGDAESFAEAVKALNGAPMQGKILLQLS
HHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure
MKSVVIHAEGDVRVEERPLPQLQAEDDVLVKVVSSGLCGSDIPRIFAQGAHYYPITLGHE
CCEEEEECCCCEEECCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEECCC
FSGYVESYGTGVTDMQPGDAVACVPLLPCFHCPQCERGYFSLCRQYQFVGSRSEGGNAEY
HHHHHHHHCCCCCCCCCCCCEEHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
VVVKRANLFRLPSDMPIEDGAFIEPITVGLHAFHLAQGCEGKNVIIVGAGTIGLLALQCA
EEEEECCEEECCCCCCCCCCCEECHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHH
RELGARSVTAIDINPQKLELAKALGATHTCNSREMTADDIQTALSGIQFDQLVLETAGTP
HHHCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHEECCCCC
QTVSLAIDIAGPRAQLALVGTLHHDLTLTTRTFGLILRKELTLLGSWMNYSAPWPGEEWE
CEEEEEEEECCCCEEEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
TAARLLAEKRLQLTPLIAHRGDAESFAEAVKALNGAPMQGKILLQLS
HHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]