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The map label for this gene is selA

Identifier: 194733974

GI number: 194733974

Start: 3752167

End: 3753558

Strand: Reverse

Name: selA

Synonym: SeSA_A3883

Alternate gene names: 194733974

Gene position: 3753558-3752167 (Counterclockwise)

Preceding gene: 194734715

Following gene: 194735632

Centisome position: 79.71

GC content: 59.41

Gene sequence:

>1392_bases
ATGACAAGCGAAACGCGTACACTCTACAGCCAGCTTCCTGCTATCGATCGCTTATTGCACGATAGCGCTTTTCTTTCTCT
GCGCGATCGGTATGGCCATACCCAGGTGGTTGATCTGCTTAGGCGGATGCTTGACGACGCGCGCGACGTCATACGGAATA
CGCAAACGCTTCCCGACTGGTACGCAGACTGGGCGCAAGAGGCGAAACTCCGGCTGGAAAATGCGGCGCAAAGCGCGCTG
CGCCCGGTGATTAACCTGACGGGGACGGTGCTGCACACCAATCTTGGCCGCGCATTGCAGGCGCAAGAAGCGATTGAGGC
GGTAACGCAGGCGATGCGCGCGCCGGTGACGCTGGAATACGATTTGGATGGCGCCGGGCGGGGGCATCGCGACCGGGCGC
TGGCGACGCTATTATGCCGTATCACCGGGGCGGAAGACGCCTGTATCGTCAATAACAATGCGGCGGCGGTATTGCTGATG
CTGGCGGCGACCGCCAGCGGCAAAGAGGTAGTGGTTTCGCGTGGCGAGCTGGTCGAAATCGGCGGCGCGTTTCGTATTCC
GGATGTTATGCGCCAGGCGGGCTGTACGCTGCATGAAGTGGGCACCACCAACCGGACGCACGCGAAAGATTACCGTCAGG
CGGTAAATGAAAATACCGGGCTGTTGATGAAGGTGCATACCAGTAATTACAGCATTGAGGGCTTTACCAAAACGGTAGAG
GAAGCGGAACTGGCGGAAATCGGGCGAGAGCTGGATATTCCGGTGGTGGCGGATCTGGGCAGCGGTTCGCTGGTGGATTT
AAGTCAATATGGCTTACCCAAAGAGCCGATGCCGCAGCAGCTCATTGCCGCAGGCGTCAGCCTGGTAAGCTTCTCCGGCG
ATAAGTTGCTGGGCGGGCCGCAGGCCGGGATCATCGTCGGCAAAAAAGCGATGATTGCCCAACTGCAAAGCCATCCGCTG
AAACGCGCTCTGCGCGCGGATAAAATGACGCTGGCGGCGCTGGAGGCCACGTTACGTCTGTATCTGCACCCGGAAGCGTT
GGCGGAGAAATTACCCACCCTGCGTCTGTTAACCCGCAGTGAAGCGTCGATTCGCGAACAAGCGCAGCGGTTACAGGCGC
GGCTGGCGGCACGTTACGGCGATGAATTTGCGCTGGAGGTTAAACCCTGCCTGTCGCAAATCGGCAGCGGTTCATTACCG
GTAGACCGCCTTCCCAGCGCCGCCATGACCTTTACCCCGCACGACGGGCGCGGTAGTCGGCTGGAGGCGCTGGCGGCTCG
CTGGCGCACGCTGCCTGTACCGGTCATTGGCCGAATTTATGATGGCCGTTTATGGCTGGATATGCGCTGTCTTGAAGACG
AAAGCCGGTTTATGGAGATGATGCTGAAATGA

Upstream 100 bases:

>100_bases
GACGCGCATTATGTCCGCCTGAGCAAACTCACGTTACAATCCCCCTTATGTCGATATCCCTCTCCCGCCAGGAGAGGGCC
ACCAACAGCCAGGCATTTTC

Downstream 100 bases:

>100_bases
TTATTGCAACTGCCGGACACGTAGACCACGGTAAAACAACGTTGCTCCAGGCGATTACCGGGGTCAATGCCGACCGTCTG
CCGGAAGAGAAAAAACGCGG

Product: selenocysteine synthase

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTSETRTLYSQLPAIDRLLHDSAFLSLRDRYGHTQVVDLLRRMLDDARDVIRNTQTLPDWYADWAQEAKLRLENAAQSAL
RPVINLTGTVLHTNLGRALQAQEAIEAVTQAMRAPVTLEYDLDGAGRGHRDRALATLLCRITGAEDACIVNNNAAAVLLM
LAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHAKDYRQAVNENTGLLMKVHTSNYSIEGFTKTVE
EAELAEIGRELDIPVVADLGSGSLVDLSQYGLPKEPMPQQLIAAGVSLVSFSGDKLLGGPQAGIIVGKKAMIAQLQSHPL
KRALRADKMTLAALEATLRLYLHPEALAEKLPTLRLLTRSEASIREQAQRLQARLAARYGDEFALEVKPCLSQIGSGSLP
VDRLPSAAMTFTPHDGRGSRLEALAARWRTLPVPVIGRIYDGRLWLDMRCLEDESRFMEMMLK

Sequences:

>Translated_463_residues
MTSETRTLYSQLPAIDRLLHDSAFLSLRDRYGHTQVVDLLRRMLDDARDVIRNTQTLPDWYADWAQEAKLRLENAAQSAL
RPVINLTGTVLHTNLGRALQAQEAIEAVTQAMRAPVTLEYDLDGAGRGHRDRALATLLCRITGAEDACIVNNNAAAVLLM
LAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHAKDYRQAVNENTGLLMKVHTSNYSIEGFTKTVE
EAELAEIGRELDIPVVADLGSGSLVDLSQYGLPKEPMPQQLIAAGVSLVSFSGDKLLGGPQAGIIVGKKAMIAQLQSHPL
KRALRADKMTLAALEATLRLYLHPEALAEKLPTLRLLTRSEASIREQAQRLQARLAARYGDEFALEVKPCLSQIGSGSLP
VDRLPSAAMTFTPHDGRGSRLEALAARWRTLPVPVIGRIYDGRLWLDMRCLEDESRFMEMMLK
>Mature_462_residues
TSETRTLYSQLPAIDRLLHDSAFLSLRDRYGHTQVVDLLRRMLDDARDVIRNTQTLPDWYADWAQEAKLRLENAAQSALR
PVINLTGTVLHTNLGRALQAQEAIEAVTQAMRAPVTLEYDLDGAGRGHRDRALATLLCRITGAEDACIVNNNAAAVLLML
AATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHAKDYRQAVNENTGLLMKVHTSNYSIEGFTKTVEE
AELAEIGRELDIPVVADLGSGSLVDLSQYGLPKEPMPQQLIAAGVSLVSFSGDKLLGGPQAGIIVGKKAMIAQLQSHPLK
RALRADKMTLAALEATLRLYLHPEALAEKLPTLRLLTRSEASIREQAQRLQARLAARYGDEFALEVKPCLSQIGSGSLPV
DRLPSAAMTFTPHDGRGSRLEALAARWRTLPVPVIGRIYDGRLWLDMRCLEDESRFMEMMLK

Specific function: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis

COG id: COG1921

COG function: function code E; Selenocysteine synthase [seryl-tRNASer selenium transferase]

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the selA family

Homologues:

Organism=Escherichia coli, GI2367248, Length=463, Percent_Identity=86.1771058315335, Blast_Score=777, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SELA_SALA4 (B5EX94)

Other databases:

- EMBL:   CP001138
- RefSeq:   YP_002148612.1
- ProteinModelPortal:   B5EX94
- GeneID:   6795307
- GenomeReviews:   CP001138_GR
- KEGG:   sea:SeAg_B3897
- HOGENOM:   HBG564950
- OMA:   KRGDRDD
- ProtClustDB:   PRK04311
- GO:   GO:0005737
- HAMAP:   MF_00423
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR018319
- InterPro:   IPR004534
- Gene3D:   G3DSA:3.40.640.10
- TIGRFAMs:   TIGR00474

Pfam domain/function: PF03841 SelA; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.9.1.1

Molecular weight: Translated: 50829; Mature: 50698

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSETRTLYSQLPAIDRLLHDSAFLSLRDRYGHTQVVDLLRRMLDDARDVIRNTQTLPDW
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
YADWAQEAKLRLENAAQSALRPVINLTGTVLHTNLGRALQAQEAIEAVTQAMRAPVTLEY
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
DLDGAGRGHRDRALATLLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEI
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCEEEEECCCEEEE
GGAFRIPDVMRQAGCTLHEVGTTNRTHAKDYRQAVNENTGLLMKVHTSNYSIEGFTKTVE
CCCCCCHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCEEECHHHHHHH
EAELAEIGRELDIPVVADLGSGSLVDLSQYGLPKEPMPQQLIAAGVSLVSFSGDKLLGGP
HHHHHHCCCCCCCCEEEECCCCCEEEHHHCCCCCCCCHHHHHHHCHHHEEECCCCCCCCC
QAGIIVGKKAMIAQLQSHPLKRALRADKMTLAALEATLRLYLHPEALAEKLPTLRLLTRS
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHCCHHHHHHCC
EASIREQAQRLQARLAARYGDEFALEVKPCLSQIGSGSLPVDRLPSAAMTFTPHDGRGSR
HHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCCCCCHHHCCCCEEEECCCCCCCHH
LEALAARWRTLPVPVIGRIYDGRLWLDMRCLEDESRFMEMMLK
HHHHHHHHCCCCCCHHCEEECCEEEEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSETRTLYSQLPAIDRLLHDSAFLSLRDRYGHTQVVDLLRRMLDDARDVIRNTQTLPDW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHH
YADWAQEAKLRLENAAQSALRPVINLTGTVLHTNLGRALQAQEAIEAVTQAMRAPVTLEY
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEE
DLDGAGRGHRDRALATLLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEI
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHCCCCCEEEEECCCEEEE
GGAFRIPDVMRQAGCTLHEVGTTNRTHAKDYRQAVNENTGLLMKVHTSNYSIEGFTKTVE
CCCCCCHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCEEECHHHHHHH
EAELAEIGRELDIPVVADLGSGSLVDLSQYGLPKEPMPQQLIAAGVSLVSFSGDKLLGGP
HHHHHHCCCCCCCCEEEECCCCCEEEHHHCCCCCCCCHHHHHHHCHHHEEECCCCCCCCC
QAGIIVGKKAMIAQLQSHPLKRALRADKMTLAALEATLRLYLHPEALAEKLPTLRLLTRS
CCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHCCHHHHHHCC
EASIREQAQRLQARLAARYGDEFALEVKPCLSQIGSGSLPVDRLPSAAMTFTPHDGRGSR
HHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCCCCCHHHCCCCEEEECCCCCCCHH
LEALAARWRTLPVPVIGRIYDGRLWLDMRCLEDESRFMEMMLK
HHHHHHHHCCCCCCHHCEEECCEEEEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA