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The map label for this gene is yjcE [H]

Identifier: 194733933

GI number: 194733933

Start: 4398206

End: 4399852

Strand: Direct

Name: yjcE [H]

Synonym: SeSA_A4521

Alternate gene names: 194733933

Gene position: 4398206-4399852 (Clockwise)

Preceding gene: 194735883

Following gene: 194737181

Centisome position: 93.4

GC content: 55.92

Gene sequence:

>1647_bases
ATGGAAATTTTCTTCACAATACTCATCATGACCCTTGTGGTCTCGCTGTCGGGGGTTTTTACGCGTGTATTACCCTTCCA
GCTTCCTTTACCCCTTATGCAGATCGCCGTTGGCGCGCTGTTGGCGTGGCCGACGTTTGGTTTGCATGTGGAATTCGACC
CGGAACTCTTCCTGGTGCTGTTTATTCCGCCGCTGCTGTTTGCGGATGGCTGGAAGACGCCGACCCGTGAATTTCTTGAG
CATGGACGAGAGATTTTCGGGCTGGCGCTGGCGCTGGTCCTGGTAACGGTCGTGGGAATCGGCTTCCTGATTTATTGGCT
GGTGCCCGGCATTCCGCTGATCCCCGCCTTTGCGCTGGCCGCCGTGCTGTCGCCGACCGATGCGGTAGCGCTCTCCGGAA
TTGTGGGCGAGGGGCGTATCCCGAAAAAAATCATGGGCATTCTGCAGGGAGAGGCGTTAATGAACGACGCCTCCGGTCTG
GTATCGCTGAAATTCGCCGTCGCGGTGGCGATGGGGACGATGGTCTTTACCGTCGGCGGCGCGACGCTGGAATTTTTTAA
GGTCGCTATCGGCGGTATTCTGGCGGGTTTTGTGGTCAGTTGGCTGTATGGCCGCTCGCTGCGTTTTTTGAGCCGCTGGG
GCGGCGATGAACCCGCGACGCAAATTGTCCTGCTGTTTCTGCTGCCCTTCGCGTCTTACCTGATTGCCGAGCATATTGGC
GTCTCAGGCATCCTGGCCGCGGTTGCCGCCGGGATGACCATCACCCGTTCTGGCGTAATGCGCCGCGCGCCGCTGGCAAT
GCGTTTGCGCGCGAACAGTACCTGGGCGATGCTGGAATTTGTCTTTAACGGTATGGTCTTTCTGCTGTTGGGACTGCAAT
TGCCGGGTATTCTGGAATCTTCGCTGGCGGCGGCGGAAGCTGACCCGAATGTCGAAACCTGGATGCTCTTTACCGATATC
GTGCTGATTTATGCGGCATTGATGCTGGTTCGCTTCGGCTGGCTGTGGGCCATGAAAAAGTTCAGCCTGCGTTTTTTGAA
GAAGAAACCGATGGAGTTCGCCAGCTGGACGTCGCGTGAAATTCTGATTGCTTCCTTCGCTGGCGTTCGTGGGGCGATCA
CCCTGGCTGGTGTGCTCTCTATACCGTTACTTTTGCCGGATGGCAGCGGATTTCCGGCGCGTTATGAACTGGTATTCCTG
GCGGCTGGCGTCATTCTGTTCTCGTTATTTGTCGGCGTGATCATGCTGCCGCTGCTGTTGCAACATCTGGAAGTCGCCGA
TCATGCGCAACAGTTGAAAGAGGAGCGTATCGCCCGTGCGGCGACGGCGGAGGTGGCAATTGTCGCCATTCAGAAAATGG
AAGAGCGTTTGGCGGCGGATACCGAAGAAAACATCGATAATCAGTTGCTTACTGAAGTAAGCTCGCGTGTCATTGGTAAC
TTGCGTCGCCGTGCCGATGGGCGAAACGATGTCGAAAGCTCCATACAGGAAGAAAATCTGGAGCGACGTTTCCGTCTTGC
CGCGCTGCGTTCTGAACGCGCCGAGTTGTATCATCTGCGCGCCACACGAGAAATCAGCAATGAAACATTGCAAAAGCTGC
TGCACGACCTGGATTTGATGGAAGCGCTACTGATAGAAAATCAGTAG

Upstream 100 bases:

>100_bases
TTCAGGACACATCACGTTACCTTTTGCGTTAATCTGAAGAAGGTGAAACCGAGGCATGATGCCTTTCTCCATCATAAAAA
ACATCGCAAACAGGGAACGC

Downstream 100 bases:

>100_bases
TCCTTGTGGCCCGGTGGCGCCATGCTTACCGGGTCTACAAGTAGGCCGGATAAGGTGCTTGCGCCGCCATCCGGCAAGGG
TTTTAACCTATGGCTTACGG

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 548; Mature: 548

Protein sequence:

>548_residues
MEIFFTILIMTLVVSLSGVFTRVLPFQLPLPLMQIAVGALLAWPTFGLHVEFDPELFLVLFIPPLLFADGWKTPTREFLE
HGREIFGLALALVLVTVVGIGFLIYWLVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGL
VSLKFAVAVAMGTMVFTVGGATLEFFKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
VSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGILESSLAAAEADPNVETWMLFTDI
VLIYAALMLVRFGWLWAMKKFSLRFLKKKPMEFASWTSREILIASFAGVRGAITLAGVLSIPLLLPDGSGFPARYELVFL
AAGVILFSLFVGVIMLPLLLQHLEVADHAQQLKEERIARAATAEVAIVAIQKMEERLAADTEENIDNQLLTEVSSRVIGN
LRRRADGRNDVESSIQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLMEALLIENQ

Sequences:

>Translated_548_residues
MEIFFTILIMTLVVSLSGVFTRVLPFQLPLPLMQIAVGALLAWPTFGLHVEFDPELFLVLFIPPLLFADGWKTPTREFLE
HGREIFGLALALVLVTVVGIGFLIYWLVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGL
VSLKFAVAVAMGTMVFTVGGATLEFFKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
VSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGILESSLAAAEADPNVETWMLFTDI
VLIYAALMLVRFGWLWAMKKFSLRFLKKKPMEFASWTSREILIASFAGVRGAITLAGVLSIPLLLPDGSGFPARYELVFL
AAGVILFSLFVGVIMLPLLLQHLEVADHAQQLKEERIARAATAEVAIVAIQKMEERLAADTEENIDNQLLTEVSSRVIGN
LRRRADGRNDVESSIQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLMEALLIENQ
>Mature_548_residues
MEIFFTILIMTLVVSLSGVFTRVLPFQLPLPLMQIAVGALLAWPTFGLHVEFDPELFLVLFIPPLLFADGWKTPTREFLE
HGREIFGLALALVLVTVVGIGFLIYWLVPGIPLIPAFALAAVLSPTDAVALSGIVGEGRIPKKIMGILQGEALMNDASGL
VSLKFAVAVAMGTMVFTVGGATLEFFKVAIGGILAGFVVSWLYGRSLRFLSRWGGDEPATQIVLLFLLPFASYLIAEHIG
VSGILAAVAAGMTITRSGVMRRAPLAMRLRANSTWAMLEFVFNGMVFLLLGLQLPGILESSLAAAEADPNVETWMLFTDI
VLIYAALMLVRFGWLWAMKKFSLRFLKKKPMEFASWTSREILIASFAGVRGAITLAGVLSIPLLLPDGSGFPARYELVFL
AAGVILFSLFVGVIMLPLLLQHLEVADHAQQLKEERIARAATAEVAIVAIQKMEERLAADTEENIDNQLLTEVSSRVIGN
LRRRADGRNDVESSIQEENLERRFRLAALRSERAELYHLRATREISNETLQKLLHDLDLMEALLIENQ

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=463, Percent_Identity=25.7019438444924, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI148727259, Length=434, Percent_Identity=24.8847926267281, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI194239733, Length=500, Percent_Identity=24, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI27734935, Length=342, Percent_Identity=23.0994152046784, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI14211919, Length=348, Percent_Identity=23.5632183908046, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI4759144, Length=360, Percent_Identity=26.1111111111111, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI294997330, Length=269, Percent_Identity=22.6765799256506, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI110227626, Length=269, Percent_Identity=22.6765799256506, Blast_Score=66, Evalue=7e-11,
Organism=Homo sapiens, GI5454070, Length=269, Percent_Identity=22.6765799256506, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1790501, Length=549, Percent_Identity=94.8998178506375, Blast_Score=1016, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25150332, Length=388, Percent_Identity=23.7113402061856, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71980847, Length=401, Percent_Identity=24.1895261845387, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71999817, Length=455, Percent_Identity=23.5164835164835, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71999819, Length=455, Percent_Identity=23.5164835164835, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999821, Length=431, Percent_Identity=24.3619489559165, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71990932, Length=407, Percent_Identity=23.0958230958231, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71992107, Length=337, Percent_Identity=21.6617210682493, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71992101, Length=337, Percent_Identity=21.6617210682493, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71990924, Length=407, Percent_Identity=23.0958230958231, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71993590, Length=400, Percent_Identity=22.5, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6320663, Length=370, Percent_Identity=23.5135135135135, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281364513, Length=440, Percent_Identity=21.1363636363636, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221473222, Length=440, Percent_Identity=21.1363636363636, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221510734, Length=403, Percent_Identity=22.8287841191067, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221510738, Length=403, Percent_Identity=22.8287841191067, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221473215, Length=442, Percent_Identity=21.0407239819005, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221473212, Length=454, Percent_Identity=20.4845814977974, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI221510732, Length=403, Percent_Identity=22.8287841191067, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI221510736, Length=403, Percent_Identity=22.8287841191067, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24585580, Length=403, Percent_Identity=22.8287841191067, Blast_Score=66, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24585578, Length=403, Percent_Identity=22.8287841191067, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 60243; Mature: 60243

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCC
>Mature Secondary Structure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HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]