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The map label for this gene is atpB2

Identifier: 194335035

GI number: 194335035

Start: 2425248

End: 2426222

Strand: Reverse

Name: atpB2

Synonym: Paes_2247

Alternate gene names: 194335035

Gene position: 2426222-2425248 (Counterclockwise)

Preceding gene: 194335036

Following gene: 194335034

Centisome position: 96.55

GC content: 49.33

Gene sequence:

>975_bases
ATGAAACGGGTAAATGTTTTCAGATCAGGAGTTTTTTCAAGGCTTTTCGCGCTCCTTCTTCCTTTTCTGCTTGGAATCAA
TGGTCTTGTTTATGCTTCGGCTGAAGCGCCTGCTGAAGCAGTTCATGCGGAAGCGGCAGCTCATGCGGAAGGCGGCCATG
AGAGTGCTGGCGACGTCATCATGCATCATATTCTTGATACCGGGGTTATGTCCTTCGAACCTTTCGGAGAGGTTCATCTT
CCTCAGATCGTCATCGGGGGCTTTGATATTTCCATCACCAGGCATGTCGTCATGATGTGGATAGCATCAGCGATTCTTCT
GGTTGTCTTTTTACTGGTAGGAAACCGTTACAAGACGATGACCAGTCGTCAGGCTCCTGGCGGGATGGCAAATGCTATGG
AGGCTCTTGTAGAGTTTATCCGTCTCGACGTCGCAAAATCCAATATCGGCGCAGGTTACGAGAAGCATCTTCCCTATCTT
CTTACTGTCTTTGCTTTTATCCTTCTGCTGAACCTGCTTGGTCTTGTGCCGTATGGCGCTACAGCCACAGGCAACATCAA
TGTAACACTGACGCTCGCTGTCTTCACGTTTTTCATTACCCAGGTCGCTTCGCTGAAGGCCCATGGAATCAAGGGTTATC
TTGCGCATCTTACTGCCGGGACGCACTGGGCGCTGTGGATTATCATGATCCCGATCGAGATTATCGGTCTGTTCACCAAG
CCGTTCGCGCTGACCGTTCGACTTTTTGCCAACATGACCGCCGGCCACATCGTGATCCTGAGTCTTATCTTCATCAGTTT
CATTCTCAAGAGCTATATCGTGGCAATGTTCGTGTCCGTGCCATTCTCGATTTTTATCTATCTTCTTGAGATTTTCGTTG
CCTTCCTGCAGGCATTTATCTTTACCATGCTTTCAGCGCTCTTCATCGGTCTGGCAACAGCTCATGAAGGTCACGAAGGC
GAGGCAGCACACTGA

Upstream 100 bases:

>100_bases
TGAGCGATTTCATTCTTTCGTTTTTCGCATTCTACTGTATCTACGTGATTATTGAAATTCTCGGATATCAAAACAGGAAT
AAACAGAAAAAGAAAGTTGC

Downstream 100 bases:

>100_bases
TCCTTCTGGAGGATTTAGTTTATAGTTTTTTTTTAGTACTTTTGTCAAGGTTTTAAACCGCTTTTAGCATTCAACACTTA
ATAAACTAACGGAGGTATTT

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a 2; F-ATPase subunit 6 2

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKRVNVFRSGVFSRLFALLLPFLLGINGLVYASAEAPAEAVHAEAAAHAEGGHESAGDVIMHHILDTGVMSFEPFGEVHL
PQIVIGGFDISITRHVVMMWIASAILLVVFLLVGNRYKTMTSRQAPGGMANAMEALVEFIRLDVAKSNIGAGYEKHLPYL
LTVFAFILLLNLLGLVPYGATATGNINVTLTLAVFTFFITQVASLKAHGIKGYLAHLTAGTHWALWIIMIPIEIIGLFTK
PFALTVRLFANMTAGHIVILSLIFISFILKSYIVAMFVSVPFSIFIYLLEIFVAFLQAFIFTMLSALFIGLATAHEGHEG
EAAH

Sequences:

>Translated_324_residues
MKRVNVFRSGVFSRLFALLLPFLLGINGLVYASAEAPAEAVHAEAAAHAEGGHESAGDVIMHHILDTGVMSFEPFGEVHL
PQIVIGGFDISITRHVVMMWIASAILLVVFLLVGNRYKTMTSRQAPGGMANAMEALVEFIRLDVAKSNIGAGYEKHLPYL
LTVFAFILLLNLLGLVPYGATATGNINVTLTLAVFTFFITQVASLKAHGIKGYLAHLTAGTHWALWIIMIPIEIIGLFTK
PFALTVRLFANMTAGHIVILSLIFISFILKSYIVAMFVSVPFSIFIYLLEIFVAFLQAFIFTMLSALFIGLATAHEGHEG
EAAH
>Mature_324_residues
MKRVNVFRSGVFSRLFALLLPFLLGINGLVYASAEAPAEAVHAEAAAHAEGGHESAGDVIMHHILDTGVMSFEPFGEVHL
PQIVIGGFDISITRHVVMMWIASAILLVVFLLVGNRYKTMTSRQAPGGMANAMEALVEFIRLDVAKSNIGAGYEKHLPYL
LTVFAFILLLNLLGLVPYGATATGNINVTLTLAVFTFFITQVASLKAHGIKGYLAHLTAGTHWALWIIMIPIEIIGLFTK
PFALTVRLFANMTAGHIVILSLIFISFILKSYIVAMFVSVPFSIFIYLLEIFVAFLQAFIFTMLSALFIGLATAHEGHEG
EAAH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=209, Percent_Identity=29.1866028708134, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP62_PROA2 (B4S6E6)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002016895.1
- ProteinModelPortal:   B4S6E6
- SMR:   B4S6E6
- GeneID:   6459625
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_2247
- HOGENOM:   HBG734175
- OMA:   RFANTVE
- ProtClustDB:   PRK13419
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 35260; Mature: 35260

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1f6b5308)-; HASH(0x1f2f3320)-; HASH(0x1e0f09bc)-; HASH(0x1ee23f74)-; HASH(0x1e723c9c)-; HASH(0x1f126708)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVNVFRSGVFSRLFALLLPFLLGINGLVYASAEAPAEAVHAEAAAHAEGGHESAGDVI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHH
MHHILDTGVMSFEPFGEVHLPQIVIGGFDISITRHVVMMWIASAILLVVFLLVGNRYKTM
HHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
TSRQAPGGMANAMEALVEFIRLDVAKSNIGAGYEKHLPYLLTVFAFILLLNLLGLVPYGA
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCC
TATGNINVTLTLAVFTFFITQVASLKAHGIKGYLAHLTAGTHWALWIIMIPIEIIGLFTK
CCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
PFALTVRLFANMTAGHIVILSLIFISFILKSYIVAMFVSVPFSIFIYLLEIFVAFLQAFI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTMLSALFIGLATAHEGHEGEAAH
HHHHHHHHHHHHHCCCCCCCCCCH
>Mature Secondary Structure
MKRVNVFRSGVFSRLFALLLPFLLGINGLVYASAEAPAEAVHAEAAAHAEGGHESAGDVI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHH
MHHILDTGVMSFEPFGEVHLPQIVIGGFDISITRHVVMMWIASAILLVVFLLVGNRYKTM
HHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
TSRQAPGGMANAMEALVEFIRLDVAKSNIGAGYEKHLPYLLTVFAFILLLNLLGLVPYGA
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHCCCCC
TATGNINVTLTLAVFTFFITQVASLKAHGIKGYLAHLTAGTHWALWIIMIPIEIIGLFTK
CCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
PFALTVRLFANMTAGHIVILSLIFISFILKSYIVAMFVSVPFSIFIYLLEIFVAFLQAFI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTMLSALFIGLATAHEGHEGEAAH
HHHHHHHHHHHHHCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA