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The map label for this gene is pkn1 [H]

Identifier: 194335022

GI number: 194335022

Start: 2413592

End: 2414788

Strand: Reverse

Name: pkn1 [H]

Synonym: Paes_2233

Alternate gene names: 194335022

Gene position: 2414788-2413592 (Counterclockwise)

Preceding gene: 194335023

Following gene: 194335021

Centisome position: 96.09

GC content: 54.72

Gene sequence:

>1197_bases
ATGAGCGATATTTTTATCAGTTACGCCCGCGAGGATGAGCGTCGGGTTAAGCCTATCGTGCAGCATCTCCAGCAACTGGG
TTGGCGAGTATTCTGGGATCGGAATATTCCGCCGGGCCAGAGCTGGGATGAATACATAGAACAGCATCTGGAGGCTTCAC
GCTGTGTGGTGGTCGTCTGGTCGAAGCACTCTGTGGGCTCCCGATGGGTGAAGGCAGAAGCCGAAGAGGCAAAAAACAGG
AATATTCTTGTGCCCCTGTTACTTGACAAGGTAAAACTCAGTCTGGGATTCAGGTACATCCAGGCAGCCGACCTGACCTC
ATGGAACCATGATGATAGAACGCATCCCCAATACAGGGCATGTATCGATGCTATTGCCCGTATGATCCCGCAGTCAGGGC
CGTTAGAGCCGGCTTCTCCGGATGTGTTCGTTACTCCGGTTGAGCCTCCTGCTTCCAGGCCGCAGCTTCCGGAAAACTTC
GTCCTGATAAAGGGTGGGCAGTTCAGCATGGGCAGCCCTGAAGACGAACATGGTCATGAGTCTGATGAAACCCTGCACGA
AGTGAAGGTGAGCGACTTTGCTCTCTGCAGGTATGCGGTGACGGTCGGAGAGTATCTTGAATTTACCGAAGAGGCCAAGA
TCAATTATGACGCTGGCACGGAGGGCGATCGTTATCCTGTGGTCAATGTTTCGTGGAATGATGCAGTTGCCTATTGCCGG
TGGTTATCCGAAAAGCGGGGCGAGCTTTTCCGGTTACCGACAGAGGCAGAGTGGGAGTATGCGTGTCGCGGTGGGACCAC
AACTCCTTTCAGCACAGGAGAGAACCTGACCACCGATGAGGCAAACTATGACGGGAACTACCCATACCGTAATAATTCTA
AGGGGAAGTATCGCGAAGCAACGGTGCCGGTGGACAGCTTCGAACCCAACAGTTACGGATTGTACAACATGCACGGCAAT
GTATGGGAGTGGTGCGGTGACTGGTATGGGGAGAAATACTATGAAGAGTGCCGGAAGAAAGGTGTGGTGGAGAATCCGCA
GGGGCCGAAAGAGGGTTCGCGCCGTGTTCTTCGTGGTGGTGGCTGGACCTACTATGCGCGGTACTGCCGGTCGGCTGATC
GCAGCAGCGGCGGCCCCGGCTATCGCGGCAACAATGTGGGCTTCCGCCTTGTGTTCGTCCCGCAGTTCAAAGGGTAG

Upstream 100 bases:

>100_bases
GTTTTGTGAAAAAGGCGTTCTTGATGGTTTCCTGATTTGTGAAAAATAAGTAAGATGCCGTTATATTGAGTGAAGTGTTC
TCATTTCAGATCAAATTCTT

Downstream 100 bases:

>100_bases
CTCATCCGGCAAAAAAGGAGTGAGATGACGAGCCGGGGGCAGGCGGCGCAAGGGCCGCGGCGCCAGAAGCCCCTGGAACG
GCATTGAACGGTCGTGGTGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MSDIFISYAREDERRVKPIVQHLQQLGWRVFWDRNIPPGQSWDEYIEQHLEASRCVVVVWSKHSVGSRWVKAEAEEAKNR
NILVPLLLDKVKLSLGFRYIQAADLTSWNHDDRTHPQYRACIDAIARMIPQSGPLEPASPDVFVTPVEPPASRPQLPENF
VLIKGGQFSMGSPEDEHGHESDETLHEVKVSDFALCRYAVTVGEYLEFTEEAKINYDAGTEGDRYPVVNVSWNDAVAYCR
WLSEKRGELFRLPTEAEWEYACRGGTTTPFSTGENLTTDEANYDGNYPYRNNSKGKYREATVPVDSFEPNSYGLYNMHGN
VWEWCGDWYGEKYYEECRKKGVVENPQGPKEGSRRVLRGGGWTYYARYCRSADRSSGGPGYRGNNVGFRLVFVPQFKG

Sequences:

>Translated_398_residues
MSDIFISYAREDERRVKPIVQHLQQLGWRVFWDRNIPPGQSWDEYIEQHLEASRCVVVVWSKHSVGSRWVKAEAEEAKNR
NILVPLLLDKVKLSLGFRYIQAADLTSWNHDDRTHPQYRACIDAIARMIPQSGPLEPASPDVFVTPVEPPASRPQLPENF
VLIKGGQFSMGSPEDEHGHESDETLHEVKVSDFALCRYAVTVGEYLEFTEEAKINYDAGTEGDRYPVVNVSWNDAVAYCR
WLSEKRGELFRLPTEAEWEYACRGGTTTPFSTGENLTTDEANYDGNYPYRNNSKGKYREATVPVDSFEPNSYGLYNMHGN
VWEWCGDWYGEKYYEECRKKGVVENPQGPKEGSRRVLRGGGWTYYARYCRSADRSSGGPGYRGNNVGFRLVFVPQFKG
>Mature_397_residues
SDIFISYAREDERRVKPIVQHLQQLGWRVFWDRNIPPGQSWDEYIEQHLEASRCVVVVWSKHSVGSRWVKAEAEEAKNRN
ILVPLLLDKVKLSLGFRYIQAADLTSWNHDDRTHPQYRACIDAIARMIPQSGPLEPASPDVFVTPVEPPASRPQLPENFV
LIKGGQFSMGSPEDEHGHESDETLHEVKVSDFALCRYAVTVGEYLEFTEEAKINYDAGTEGDRYPVVNVSWNDAVAYCRW
LSEKRGELFRLPTEAEWEYACRGGTTTPFSTGENLTTDEANYDGNYPYRNNSKGKYREATVPVDSFEPNSYGLYNMHGNV
WEWCGDWYGEKYYEECRKKGVVENPQGPKEGSRRVLRGGGWTYYARYCRSADRSSGGPGYRGNNVGFRLVFVPQFKG

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI257470975, Length=273, Percent_Identity=33.6996336996337, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI38202250, Length=175, Percent_Identity=42.2857142857143, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI257470977, Length=172, Percent_Identity=39.5348837209302, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI194248087, Length=274, Percent_Identity=29.1970802919708, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI194248088, Length=289, Percent_Identity=27.681660899654, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI226437577, Length=173, Percent_Identity=34.6820809248555, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20130397, Length=174, Percent_Identity=38.5057471264368, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 45560; Mature: 45429

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50104 TIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIFISYAREDERRVKPIVQHLQQLGWRVFWDRNIPPGQSWDEYIEQHLEASRCVVVVW
CCCEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEE
SKHSVGSRWVKAEAEEAKNRNILVPLLLDKVKLSLGFRYIQAADLTSWNHDDRTHPQYRA
CCCCCCCHHHHCCHHHHCCCCEEEHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHH
CIDAIARMIPQSGPLEPASPDVFVTPVEPPASRPQLPENFVLIKGGQFSMGSPEDEHGHE
HHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCC
SDETLHEVKVSDFALCRYAVTVGEYLEFTEEAKINYDAGTEGDRYPVVNVSWNDAVAYCR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCEEEECCCHHHHHHH
WLSEKRGELFRLPTEAEWEYACRGGTTTPFSTGENLTTDEANYDGNYPYRNNSKGKYREA
HHHHHCCCEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
TVPVDSFEPNSYGLYNMHGNVWEWCGDWYGEKYYEECRKKGVVENPQGPKEGSRRVLRGG
ECCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
GWTYYARYCRSADRSSGGPGYRGNNVGFRLVFVPQFKG
CHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure 
SDIFISYAREDERRVKPIVQHLQQLGWRVFWDRNIPPGQSWDEYIEQHLEASRCVVVVW
CCEEEEECCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEE
SKHSVGSRWVKAEAEEAKNRNILVPLLLDKVKLSLGFRYIQAADLTSWNHDDRTHPQYRA
CCCCCCCHHHHCCHHHHCCCCEEEHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHH
CIDAIARMIPQSGPLEPASPDVFVTPVEPPASRPQLPENFVLIKGGQFSMGSPEDEHGHE
HHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCC
SDETLHEVKVSDFALCRYAVTVGEYLEFTEEAKINYDAGTEGDRYPVVNVSWNDAVAYCR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCEEEECCCHHHHHHH
WLSEKRGELFRLPTEAEWEYACRGGTTTPFSTGENLTTDEANYDGNYPYRNNSKGKYREA
HHHHHCCCEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
TVPVDSFEPNSYGLYNMHGNVWEWCGDWYGEKYYEECRKKGVVENPQGPKEGSRRVLRGG
ECCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCC
GWTYYARYCRSADRSSGGPGYRGNNVGFRLVFVPQFKG
CHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]