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The map label for this gene is map [H]

Identifier: 194334840

GI number: 194334840

Start: 2236973

End: 2237764

Strand: Reverse

Name: map [H]

Synonym: Paes_2043

Alternate gene names: 194334840

Gene position: 2237764-2236973 (Counterclockwise)

Preceding gene: 194334841

Following gene: 194334839

Centisome position: 89.05

GC content: 50.63

Gene sequence:

>792_bases
ATGATAACGATTAAAAGTGAACGCGAAATTGATTTGATGAGAGAGTCTGGTGCGGCAACGTCACTGGTTCTTGATATGAT
AGAGAGGGAAATAAAGCCAGGCATGACGACGCTCCAGCTCGACACGCTTGCCGAGGCCTTTATCCGTGATAACGGAGGTG
TTCCCAGCTTTCTGCATTATGCCCCAAAAGGAGACCCGGATGTTACTCCTTATCCGGCAACCCTCTGTGTTTCTATCAAT
GAAGAGGTCGTCCATGGAGTGCCTGATGCGAAGCGAGTCATTAGAGAAGGCGACATAGTCTCTGTTGACTGCGGGGTTTA
CAAGGGAGGTTACCACGGTGATTCAGCCCGGACATACCTCATAGGAGAGGTCAATCCAAAAGTACGCAAGTTGGTAACCG
TCACCAGAGAATGTCTATACCTTGGTATTGAGCAGGCTGTGGAGGGCAACCGGCTTCACGATATTTCTGCGGCTATTGAG
CGCCATGCCCGTTCATTCGGATACAGTGTTATAGAGAATATGGTCGGTCATGGAATCGGCAGCGAACTTCACGAGGAGCC
CCCGGTTCCGAACTACGGTCGGAGGAAGACCGGGATACGGTTACGCGAAGGTATGGCACTGGCAATAGAGCCCATGATCG
CTATGGGACGTTCCCGGAACGCAGTTTCACGAAATGGCCAGTGGGTTGCCGTTACAGAAGATGGCAAACCGTCTGCACAT
TTCGAGCATACGATCATAGTAAGAAAAGAGAAGGCCGAGATTATGACACTCTCTCCCTCTGAACGGAAATGA

Upstream 100 bases:

>100_bases
CTTCAGCAGGTAGAAAGCCATCTCCTGATGAGGCATTATGACGGATTTATGAAATCAGGCAAAACACGCGGCCGTCGATA
AGCCGCCGTAAAGAGATTGT

Downstream 100 bases:

>100_bases
ACCATTAAAAAAGGAGCTGATTTCATTGGCAAAGGAAGATTCAATTGAGGTCGAGGGCGTCATTCTTGAAGCCCTGCCGA
ATGCACAGTTCAAAGTGGAA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MITIKSEREIDLMRESGAATSLVLDMIEREIKPGMTTLQLDTLAEAFIRDNGGVPSFLHYAPKGDPDVTPYPATLCVSIN
EEVVHGVPDAKRVIREGDIVSVDCGVYKGGYHGDSARTYLIGEVNPKVRKLVTVTRECLYLGIEQAVEGNRLHDISAAIE
RHARSFGYSVIENMVGHGIGSELHEEPPVPNYGRRKTGIRLREGMALAIEPMIAMGRSRNAVSRNGQWVAVTEDGKPSAH
FEHTIIVRKEKAEIMTLSPSERK

Sequences:

>Translated_263_residues
MITIKSEREIDLMRESGAATSLVLDMIEREIKPGMTTLQLDTLAEAFIRDNGGVPSFLHYAPKGDPDVTPYPATLCVSIN
EEVVHGVPDAKRVIREGDIVSVDCGVYKGGYHGDSARTYLIGEVNPKVRKLVTVTRECLYLGIEQAVEGNRLHDISAAIE
RHARSFGYSVIENMVGHGIGSELHEEPPVPNYGRRKTGIRLREGMALAIEPMIAMGRSRNAVSRNGQWVAVTEDGKPSAH
FEHTIIVRKEKAEIMTLSPSERK
>Mature_263_residues
MITIKSEREIDLMRESGAATSLVLDMIEREIKPGMTTLQLDTLAEAFIRDNGGVPSFLHYAPKGDPDVTPYPATLCVSIN
EEVVHGVPDAKRVIREGDIVSVDCGVYKGGYHGDSARTYLIGEVNPKVRKLVTVTRECLYLGIEQAVEGNRLHDISAAIE
RHARSFGYSVIENMVGHGIGSELHEEPPVPNYGRRKTGIRLREGMALAIEPMIAMGRSRNAVSRNGQWVAVTEDGKPSAH
FEHTIIVRKEKAEIMTLSPSERK

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=255, Percent_Identity=38.4313725490196, Blast_Score=176, Evalue=1e-44,
Organism=Homo sapiens, GI40385867, Length=260, Percent_Identity=33.0769230769231, Blast_Score=147, Evalue=9e-36,
Organism=Escherichia coli, GI1786364, Length=257, Percent_Identity=37.7431906614786, Blast_Score=187, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI71996291, Length=257, Percent_Identity=32.6848249027237, Blast_Score=147, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6323273, Length=256, Percent_Identity=35.546875, Blast_Score=168, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24583427, Length=253, Percent_Identity=35.1778656126482, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21355531, Length=255, Percent_Identity=34.9019607843137, Blast_Score=154, Evalue=4e-38,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29016; Mature: 29016

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIKSEREIDLMRESGAATSLVLDMIEREIKPGMTTLQLDTLAEAFIRDNGGVPSFLHY
CEEECCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCHHHCC
APKGDPDVTPYPATLCVSINEEVVHGVPDAKRVIREGDIVSVDCGVYKGGYHGDSARTYL
CCCCCCCCCCCCEEEEEECCHHHHHCCCHHHHHHHCCCEEEEECCEEECCCCCCCCCEEE
IGEVNPKVRKLVTVTRECLYLGIEQAVEGNRLHDISAAIERHARSFGYSVIENMVGHGIG
EECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SELHEEPPVPNYGRRKTGIRLREGMALAIEPMIAMGRSRNAVSRNGQWVAVTEDGKPSAH
CHHHCCCCCCCCCCCCCCCEECCCCEEEEHHHHHHCCCCCCCCCCCCEEEEECCCCCCCC
FEHTIIVRKEKAEIMTLSPSERK
EEEEEEEEECCCEEEECCCCCCC
>Mature Secondary Structure
MITIKSEREIDLMRESGAATSLVLDMIEREIKPGMTTLQLDTLAEAFIRDNGGVPSFLHY
CEEECCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCHHHCC
APKGDPDVTPYPATLCVSINEEVVHGVPDAKRVIREGDIVSVDCGVYKGGYHGDSARTYL
CCCCCCCCCCCCEEEEEECCHHHHHCCCHHHHHHHCCCEEEEECCEEECCCCCCCCCEEE
IGEVNPKVRKLVTVTRECLYLGIEQAVEGNRLHDISAAIERHARSFGYSVIENMVGHGIG
EECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SELHEEPPVPNYGRRKTGIRLREGMALAIEPMIAMGRSRNAVSRNGQWVAVTEDGKPSAH
CHHHCCCCCCCCCCCCCCCEECCCCEEEEHHHHHHCCCCCCCCCCCCEEEEECCCCCCCC
FEHTIIVRKEKAEIMTLSPSERK
EEEEEEEEECCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]