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The map label for this gene is hemN [H]

Identifier: 194334815

GI number: 194334815

Start: 2215899

End: 2217023

Strand: Reverse

Name: hemN [H]

Synonym: Paes_2018

Alternate gene names: 194334815

Gene position: 2217023-2215899 (Counterclockwise)

Preceding gene: 194334816

Following gene: 194334814

Centisome position: 88.22

GC content: 55.91

Gene sequence:

>1125_bases
ATGCTTCACTGTTACGTCCATATTCCTTTCTGCAGAAACCGCTGCAGCTACTGTGACTTTTTCCTGATAACCCGCGAGGG
ATTTCAGGAACCTTTTTTTCGTGCGCTCCGGGAGGAGACCCGCTCTCGCGCTATCCTGCTTGAGGGCAGGACGATCCGTT
CCGTTCATTTCGGCGGTGGAACCCCCTCGCTTGTCGACCCTCGGCACCTCGAAGCGTGGTTGAATCAGGTTGCCGGGTAT
GCGACCTTTCATCCTGAACTGGAGATCACCCTTGAAGCCAATCCGGAAGATCTTACCCCTCAATCCCTTGCGCTCTGGTC
ATCGATCGGTGTCAACCGCCTGAGTATCGGTATTCAGTCATACAACAGCAGGAAACTTCACGCTCTCGGGCGCGACCATG
ACGCCTTGTGCGCACGTCGCGTCACCGGGGAGGCGATGGAGCGCTTCCGGAATGTCAGCGTTGATCTGATCTGCGGGGTT
GAGGGGGAGTCGTCTGCCCTGTGGGGTGCCGATCTTGATGACGCCCTCTCATTCGGTCTGCAGCATCTGTCGGTCTATAT
GCTGACGGTCGAGCCTTCCACGCGGCTTGCCCGCGATGTCAGCAAAGGCCTCGTTCAGGTGCCGGGTGAGGGTGAGCTTG
CCTCGATGTACTCGATTGCCTCAGAACGGCTCTCATCATCGGGGTTCGAGCATTATGAGGTATCGAATTTCGCCAGGGCA
GGCTGTTTTTCACGCTATAATATGGGATGCTGGCAAAGGGAATCGTATCTTGGATTCGGTCCTTCTGCCCATTCGCTCTA
TACACTGGGGGCAGCTGAGTGGCGCAGTGCCAATGTGACGAGTCTGACACGCTATATTGCTGAACCCCGTGAGCTCTCTT
CACAGAGAGAGTTTCTCTCAGAAAAGGATCGTCGCAATGAGCAGATTTTTCTTTCCCTTCGCCTGAAGACCGGTCTCGAT
GCCGGCCTTCTGCAAAGGTGGCATTCGTTCGATCCGAGGATCGATGCGGCAGTCGATGCATTCAGACAACGAGGGTGGCT
CGATGTGAACGGCCGGACCCTCAAGGTGACCCGGAAAGGGTTTCTTTTCGCCGATCTCATTGCTGAGGAACTGCTGCTCG
GATGA

Upstream 100 bases:

>100_bases
AAAAACCTTCTTCCCGAATATGTTGCCGATGACCTTTACGATGCCGTTGCCGGTTATATCCTTTCACAACAGCTCACTTG
ACTCGCCTGACACTCCCGGG

Downstream 100 bases:

>100_bases
ATTTTACAGATGGTATAAGGAGGGTATTTGAAGCATCGTGATGTAAACAGACTTTTTGCAGCGTTACTGTTTCTGCTTTC
AGGGGCGGTCTATCTTATGA

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MLHCYVHIPFCRNRCSYCDFFLITREGFQEPFFRALREETRSRAILLEGRTIRSVHFGGGTPSLVDPRHLEAWLNQVAGY
ATFHPELEITLEANPEDLTPQSLALWSSIGVNRLSIGIQSYNSRKLHALGRDHDALCARRVTGEAMERFRNVSVDLICGV
EGESSALWGADLDDALSFGLQHLSVYMLTVEPSTRLARDVSKGLVQVPGEGELASMYSIASERLSSSGFEHYEVSNFARA
GCFSRYNMGCWQRESYLGFGPSAHSLYTLGAAEWRSANVTSLTRYIAEPRELSSQREFLSEKDRRNEQIFLSLRLKTGLD
AGLLQRWHSFDPRIDAAVDAFRQRGWLDVNGRTLKVTRKGFLFADLIAEELLLG

Sequences:

>Translated_374_residues
MLHCYVHIPFCRNRCSYCDFFLITREGFQEPFFRALREETRSRAILLEGRTIRSVHFGGGTPSLVDPRHLEAWLNQVAGY
ATFHPELEITLEANPEDLTPQSLALWSSIGVNRLSIGIQSYNSRKLHALGRDHDALCARRVTGEAMERFRNVSVDLICGV
EGESSALWGADLDDALSFGLQHLSVYMLTVEPSTRLARDVSKGLVQVPGEGELASMYSIASERLSSSGFEHYEVSNFARA
GCFSRYNMGCWQRESYLGFGPSAHSLYTLGAAEWRSANVTSLTRYIAEPRELSSQREFLSEKDRRNEQIFLSLRLKTGLD
AGLLQRWHSFDPRIDAAVDAFRQRGWLDVNGRTLKVTRKGFLFADLIAEELLLG
>Mature_374_residues
MLHCYVHIPFCRNRCSYCDFFLITREGFQEPFFRALREETRSRAILLEGRTIRSVHFGGGTPSLVDPRHLEAWLNQVAGY
ATFHPELEITLEANPEDLTPQSLALWSSIGVNRLSIGIQSYNSRKLHALGRDHDALCARRVTGEAMERFRNVSVDLICGV
EGESSALWGADLDDALSFGLQHLSVYMLTVEPSTRLARDVSKGLVQVPGEGELASMYSIASERLSSSGFEHYEVSNFARA
GCFSRYNMGCWQRESYLGFGPSAHSLYTLGAAEWRSANVTSLTRYIAEPRELSSQREFLSEKDRRNEQIFLSLRLKTGLD
AGLLQRWHSFDPRIDAAVDAFRQRGWLDVNGRTLKVTRKGFLFADLIAEELLLG

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=376, Percent_Identity=35.1063829787234, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI1789325, Length=385, Percent_Identity=28.5714285714286, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI87082341, Length=241, Percent_Identity=26.1410788381743, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42211; Mature: 42211

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHCYVHIPFCRNRCSYCDFFLITREGFQEPFFRALREETRSRAILLEGRTIRSVHFGGG
CEEEEEECHHHCCCCCCCEEEEEEHHCCCCHHHHHHHHHHCCCEEEEECCEEEEEEECCC
TPSLVDPRHLEAWLNQVAGYATFHPELEITLEANPEDLTPQSLALWSSIGVNRLSIGIQS
CCCCCCHHHHHHHHHHHCCCEEECCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEC
YNSRKLHALGRDHDALCARRVTGEAMERFRNVSVDLICGVEGESSALWGADLDDALSFGL
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCHHHHHHHHH
QHLSVYMLTVEPSTRLARDVSKGLVQVPGEGELASMYSIASERLSSSGFEHYEVSNFARA
HEEEEEEEEECCHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GCFSRYNMGCWQRESYLGFGPSAHSLYTLGAAEWRSANVTSLTRYIAEPRELSSQREFLS
HHHHHCCCCCCCCCCCCCCCCCCCCEEEECCHHCCCCCHHHHHHHHCCHHHHHHHHHHHH
EKDRRNEQIFLSLRLKTGLDAGLLQRWHSFDPRIDAAVDAFRQRGWLDVNGRTLKVTRKG
HHHCCCCEEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEECCCEEEEEECC
FLFADLIAEELLLG
CHHHHHHHHHHHCC
>Mature Secondary Structure
MLHCYVHIPFCRNRCSYCDFFLITREGFQEPFFRALREETRSRAILLEGRTIRSVHFGGG
CEEEEEECHHHCCCCCCCEEEEEEHHCCCCHHHHHHHHHHCCCEEEEECCEEEEEEECCC
TPSLVDPRHLEAWLNQVAGYATFHPELEITLEANPEDLTPQSLALWSSIGVNRLSIGIQS
CCCCCCHHHHHHHHHHHCCCEEECCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEC
YNSRKLHALGRDHDALCARRVTGEAMERFRNVSVDLICGVEGESSALWGADLDDALSFGL
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEECCCCHHHHHHHHH
QHLSVYMLTVEPSTRLARDVSKGLVQVPGEGELASMYSIASERLSSSGFEHYEVSNFARA
HEEEEEEEEECCHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GCFSRYNMGCWQRESYLGFGPSAHSLYTLGAAEWRSANVTSLTRYIAEPRELSSQREFLS
HHHHHCCCCCCCCCCCCCCCCCCCCEEEECCHHCCCCCHHHHHHHHCCHHHHHHHHHHHH
EKDRRNEQIFLSLRLKTGLDAGLLQRWHSFDPRIDAAVDAFRQRGWLDVNGRTLKVTRKG
HHHCCCCEEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEECCCEEEEEECC
FLFADLIAEELLLG
CHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]