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The map label for this gene is menA [H]

Identifier: 194334414

GI number: 194334414

Start: 1753191

End: 1754114

Strand: Reverse

Name: menA [H]

Synonym: Paes_1609

Alternate gene names: 194334414

Gene position: 1754114-1753191 (Counterclockwise)

Preceding gene: 194334415

Following gene: 194334413

Centisome position: 69.8

GC content: 51.3

Gene sequence:

>924_bases
ATGACCATGCAGTCAGATCATTCTTCCACTGTTCCTTCGCATTATCAGGCCTGGATGATGGCGGTGCGCCCCAAAACGCT
TCCTGCAGGAGCGGTTCCCGTTCTTCTCGGCACAGCTCTTGCCTACACTGATGGCTTTTTTCGTCCCCTTCCTGCGCTGG
TTGCGCTGATCTGCGCTCTGGGAATCCAGATCGCGACCAATTTCATCAATGAAATCTATGACTTTCGCAAGGGGGCCGAT
AGCGGCGAGCGTCTCGGTCCAACAAGGACGGTCGCTGCCGGTCTCATTACCGAGAAAACCATGATCGCGGCTTCGGTGAG
TCTTCTTGTATCGGTTTTTCTGCTCGGACTCTATCTCGTCTGGATTGGCGGATGGGTTATTCTCGCTATTGGTCTCTTTT
CCATGCTTTTTGCCTGGGCCTATACCGGAGGGCCCTACCCGATAGCCTATTCAGGGCTCGGTGATCTTTTTGTTTTTATT
TTTTTCGGCCTTGTCGCTGTCGGTGGAACCTATTTCGTTCAGGCTCGGGAGGTGACCTTTCCGGTTATGACGGCAGCTAT
TGCTCCCGGTGTTTTTTCAGTCAATATTCTGCTTTGTAACAATATTCGAGATATTGAAACCGACCGTAAGGTCGGAAAGA
TGACCCTTCCGGCAAGAATCGGCGGGGCCAATGCAAGGCAGCTCTACTTCGGGCTGACACTGGTTGCGTATTTTGTGCCG
ATATGGATGTGGATGACAGGTTATTCATCAATGGTGATGCTTTCATGGCTCTCTCTTCCTCTTGCGCTGGTTCAGGTCCG
CAAGCTTTTCAAGAGCGAAGGCCGGGCTCTGAACGATGTCCTTGCCGCTACAGGCAAGGTTATGACCCTCCACGCTCTTT
TGCTTTCGGCAGGATTGCTTTTAACAACGATTTTAGCGTTTTAA

Upstream 100 bases:

>100_bases
ATGCGACAATGGCTGTTCGGCACAGTCTCAGTTATATTAAACCTGGTGAGAAAATCCGGCATCAGTTCAGCAGTGTCAAG
ATGGCCAAAGAGAAAAAATA

Downstream 100 bases:

>100_bases
CCATATGCGTTCCGATCAAGTGCGAATAGCCCTGGTTCAGATGAGCTGTACTTCAGAGCCTGAAACAAATCTCGATGCCG
CCTGCAGTCGGATCATGGAT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTMQSDHSSTVPSHYQAWMMAVRPKTLPAGAVPVLLGTALAYTDGFFRPLPALVALICALGIQIATNFINEIYDFRKGAD
SGERLGPTRTVAAGLITEKTMIAASVSLLVSVFLLGLYLVWIGGWVILAIGLFSMLFAWAYTGGPYPIAYSGLGDLFVFI
FFGLVAVGGTYFVQAREVTFPVMTAAIAPGVFSVNILLCNNIRDIETDRKVGKMTLPARIGGANARQLYFGLTLVAYFVP
IWMWMTGYSSMVMLSWLSLPLALVQVRKLFKSEGRALNDVLAATGKVMTLHALLLSAGLLLTTILAF

Sequences:

>Translated_307_residues
MTMQSDHSSTVPSHYQAWMMAVRPKTLPAGAVPVLLGTALAYTDGFFRPLPALVALICALGIQIATNFINEIYDFRKGAD
SGERLGPTRTVAAGLITEKTMIAASVSLLVSVFLLGLYLVWIGGWVILAIGLFSMLFAWAYTGGPYPIAYSGLGDLFVFI
FFGLVAVGGTYFVQAREVTFPVMTAAIAPGVFSVNILLCNNIRDIETDRKVGKMTLPARIGGANARQLYFGLTLVAYFVP
IWMWMTGYSSMVMLSWLSLPLALVQVRKLFKSEGRALNDVLAATGKVMTLHALLLSAGLLLTTILAF
>Mature_306_residues
TMQSDHSSTVPSHYQAWMMAVRPKTLPAGAVPVLLGTALAYTDGFFRPLPALVALICALGIQIATNFINEIYDFRKGADS
GERLGPTRTVAAGLITEKTMIAASVSLLVSVFLLGLYLVWIGGWVILAIGLFSMLFAWAYTGGPYPIAYSGLGDLFVFIF
FGLVAVGGTYFVQAREVTFPVMTAAIAPGVFSVNILLCNNIRDIETDRKVGKMTLPARIGGANARQLYFGLTLVAYFVPI
WMWMTGYSSMVMLSWLSLPLALVQVRKLFKSEGRALNDVLAATGKVMTLHALLLSAGLLLTTILAF

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=297, Percent_Identity=31.3131313131313, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1790365, Length=300, Percent_Identity=36.3333333333333, Blast_Score=157, Evalue=8e-40,
Organism=Drosophila melanogaster, GI17737429, Length=278, Percent_Identity=29.4964028776978, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 33207; Mature: 33076

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMQSDHSSTVPSHYQAWMMAVRPKTLPAGAVPVLLGTALAYTDGFFRPLPALVALICAL
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
GIQIATNFINEIYDFRKGADSGERLGPTRTVAAGLITEKTMIAASVSLLVSVFLLGLYLV
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIGGWVILAIGLFSMLFAWAYTGGPYPIAYSGLGDLFVFIFFGLVAVGGTYFVQAREVTF
HHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCHHEEEEHHHHH
PVMTAAIAPGVFSVNILLCNNIRDIETDRKVGKMTLPARIGGANARQLYFGLTLVAYFVP
HHHHHHHCCCHHEEEEEEECCCHHHHHHHHHCCEECCHHCCCCCHHHHHHHHHHHHHHHH
IWMWMTGYSSMVMLSWLSLPLALVQVRKLFKSEGRALNDVLAATGKVMTLHALLLSAGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHH
LTTILAF
HHHHHHC
>Mature Secondary Structure 
TMQSDHSSTVPSHYQAWMMAVRPKTLPAGAVPVLLGTALAYTDGFFRPLPALVALICAL
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
GIQIATNFINEIYDFRKGADSGERLGPTRTVAAGLITEKTMIAASVSLLVSVFLLGLYLV
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WIGGWVILAIGLFSMLFAWAYTGGPYPIAYSGLGDLFVFIFFGLVAVGGTYFVQAREVTF
HHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCHHEEEEHHHHH
PVMTAAIAPGVFSVNILLCNNIRDIETDRKVGKMTLPARIGGANARQLYFGLTLVAYFVP
HHHHHHHCCCHHEEEEEEECCCHHHHHHHHHCCEECCHHCCCCCHHHHHHHHHHHHHHHH
IWMWMTGYSSMVMLSWLSLPLALVQVRKLFKSEGRALNDVLAATGKVMTLHALLLSAGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHH
LTTILAF
HHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]