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The map label for this gene is lpd [H]

Identifier: 194334246

GI number: 194334246

Start: 1570209

End: 1571618

Strand: Reverse

Name: lpd [H]

Synonym: Paes_1439

Alternate gene names: 194334246

Gene position: 1571618-1570209 (Counterclockwise)

Preceding gene: 194334253

Following gene: 194334245

Centisome position: 62.54

GC content: 56.03

Gene sequence:

>1410_bases
ATGGAAGAGCATGATATGCATACGCAATCAGATTTCGATCTTGCCGTTATTGGCTCCGGTCCCGGTGGATTCGAGGCCGC
AGTGCGTGCGGCCCGCAAAGGGTTAACGGTCTGTGTGATAGAGCGGGGGGCGCTTGGCGGGGTTTGCGTCAACTGGGGCT
GTATTCCAACCAAGGCATTGCTGCGAAGTGCGGAGATTTTCCGCCTTGCCGGAGAGTCGTCAGCATTCGGGCTCGATATC
GAAGCATCGAGTATTGATCTTGCCCGGGCAGTCAAGCGGAGCCGAAAGGTGGTCCTTCTGGCGTCGAAAGGTGTTGAATC
GGCATTGAAAAAAAACAAGGTTACCGTTTTTCAGGGTGAGGCGACGTTTGTCGATGAGCGAACGCTCAGAGTCAGCCGGG
ACGGTCAGGAGGATGAGAGACTTACCGCAAAACATATCATTATCGCAAGTGGCGCTCGCCCACGCGAGATTCCTGTTCTT
CCTGTTGATGGACGCCATATTATGACAAGCCGAGAGGCGCTGGCGCTTAAAAGCGCTCCTGAACGAATGATCGTTGTCGG
TGGCGGGGCTATTGGTCTTGAAATGGCCTGGTACTATCATTCGGCCGGGACAAAGGTGACGGTTCTTGAGATGCTGCCAC
GTCTTCTTCCTCTTGAGGACAAGGAGGTTTCGGAGGGCCTGGAACGGCTTCTGAAGAAAGCGGGAATATCAATACACTGT
GAGGCGGCGGTTGTGTCGGCTTCGGCAGGGGACGACGGTATTGTCGATGCCGTTGTTCGAATGAAGGACGGTTCCGAGCA
GAAGATGCAGGGAGAGTGCCTGCTTGTGGCAGCAGGAGTTGTGCCGAATAGCGGAGGACTTCAGCTCGATGCTGCAGGCG
TGATCCTTGAGAGAGGTTTTATTGCGACCGACGCGCAGTGCAGAACCAATGTGGATCATATCTATGCTATCGGTGACGTC
CGTGGCGGAATGCAGCTTGCCCATAAAGCCTCCGCCGAGGCCGTTATTGCCGTTGAGTCAATAACAGGCGGCAATCCCAT
GCCGATCGACGACGCTATGGTTCCTCGATGCGTCTATGTCGAGCCTGCTGTGGCAGCTATCGGTGCCAGCCAAGAGGATG
CGGCAGCAGAAGGGCGTGAGGTGATGGTCGGACGGGCCATGTTTGCGGCTTCTGGCAAGGCGAGCGCCTACGGATTTCGC
GACGGCTTCGTCAAGCTGATTTTTGATGCAGGAAGCGGTGTGATGATTGGTGGTCATGTGCTCGGTCACGGGGCTGTGGA
ACTGATCGGCGAACTGAGCCTTGCCATGCGGCTTGGAGCTACAGCCGATCAGATCGCAAGCACTATCCATGCTCACCCGA
CACTTTCGGAAACGGTCAGGGAAGCGGCTGAAAATGCAGTGGTCGCATGA

Upstream 100 bases:

>100_bases
TTTTTAACGGCTGATTTTGCATTTTTGGTAAACTGTTGCAGACCCCTCTTCATCGTCAATACGGGGTAGTATACTAAAAA
CTGTTTGATATTATAGAGCT

Downstream 100 bases:

>100_bases
CGGCTTGCCTTGATAAATTAAATCAGGGAAAGTCCTTTCCTTTTTGGTAAAGCATTTTCTATTGTCTTTCTAAAAACATA
AATTCAAGGTTTAAAATTGT

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MEEHDMHTQSDFDLAVIGSGPGGFEAAVRAARKGLTVCVIERGALGGVCVNWGCIPTKALLRSAEIFRLAGESSAFGLDI
EASSIDLARAVKRSRKVVLLASKGVESALKKNKVTVFQGEATFVDERTLRVSRDGQEDERLTAKHIIIASGARPREIPVL
PVDGRHIMTSREALALKSAPERMIVVGGGAIGLEMAWYYHSAGTKVTVLEMLPRLLPLEDKEVSEGLERLLKKAGISIHC
EAAVVSASAGDDGIVDAVVRMKDGSEQKMQGECLLVAAGVVPNSGGLQLDAAGVILERGFIATDAQCRTNVDHIYAIGDV
RGGMQLAHKASAEAVIAVESITGGNPMPIDDAMVPRCVYVEPAVAAIGASQEDAAAEGREVMVGRAMFAASGKASAYGFR
DGFVKLIFDAGSGVMIGGHVLGHGAVELIGELSLAMRLGATADQIASTIHAHPTLSETVREAAENAVVA

Sequences:

>Translated_469_residues
MEEHDMHTQSDFDLAVIGSGPGGFEAAVRAARKGLTVCVIERGALGGVCVNWGCIPTKALLRSAEIFRLAGESSAFGLDI
EASSIDLARAVKRSRKVVLLASKGVESALKKNKVTVFQGEATFVDERTLRVSRDGQEDERLTAKHIIIASGARPREIPVL
PVDGRHIMTSREALALKSAPERMIVVGGGAIGLEMAWYYHSAGTKVTVLEMLPRLLPLEDKEVSEGLERLLKKAGISIHC
EAAVVSASAGDDGIVDAVVRMKDGSEQKMQGECLLVAAGVVPNSGGLQLDAAGVILERGFIATDAQCRTNVDHIYAIGDV
RGGMQLAHKASAEAVIAVESITGGNPMPIDDAMVPRCVYVEPAVAAIGASQEDAAAEGREVMVGRAMFAASGKASAYGFR
DGFVKLIFDAGSGVMIGGHVLGHGAVELIGELSLAMRLGATADQIASTIHAHPTLSETVREAAENAVVA
>Mature_469_residues
MEEHDMHTQSDFDLAVIGSGPGGFEAAVRAARKGLTVCVIERGALGGVCVNWGCIPTKALLRSAEIFRLAGESSAFGLDI
EASSIDLARAVKRSRKVVLLASKGVESALKKNKVTVFQGEATFVDERTLRVSRDGQEDERLTAKHIIIASGARPREIPVL
PVDGRHIMTSREALALKSAPERMIVVGGGAIGLEMAWYYHSAGTKVTVLEMLPRLLPLEDKEVSEGLERLLKKAGISIHC
EAAVVSASAGDDGIVDAVVRMKDGSEQKMQGECLLVAAGVVPNSGGLQLDAAGVILERGFIATDAQCRTNVDHIYAIGDV
RGGMQLAHKASAEAVIAVESITGGNPMPIDDAMVPRCVYVEPAVAAIGASQEDAAAEGREVMVGRAMFAASGKASAYGFR
DGFVKLIFDAGSGVMIGGHVLGHGAVELIGELSLAMRLGATADQIASTIHAHPTLSETVREAAENAVVA

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=458, Percent_Identity=35.3711790393013, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI22035672, Length=477, Percent_Identity=30.188679245283, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=26.6375545851528, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI148277065, Length=475, Percent_Identity=26.7368421052632, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI33519430, Length=475, Percent_Identity=26.7368421052632, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI33519428, Length=475, Percent_Identity=26.7368421052632, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI33519426, Length=475, Percent_Identity=26.7368421052632, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI148277071, Length=475, Percent_Identity=26.7368421052632, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI291045266, Length=432, Percent_Identity=24.537037037037, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI291045268, Length=424, Percent_Identity=24.2924528301887, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1786307, Length=462, Percent_Identity=38.3116883116883, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=29.0948275862069, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1789915, Length=436, Percent_Identity=29.3577981651376, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=28.2608695652174, Blast_Score=164, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=37.6623376623377, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=26.7223382045929, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71983429, Length=455, Percent_Identity=27.6923076923077, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=456, Percent_Identity=27.8508771929825, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=24.5322245322245, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17559934, Length=188, Percent_Identity=28.1914893617021, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=462, Percent_Identity=37.6623376623377, Blast_Score=283, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6325240, Length=486, Percent_Identity=29.4238683127572, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6325166, Length=468, Percent_Identity=25.4273504273504, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI21358499, Length=455, Percent_Identity=38.021978021978, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=27.9317697228145, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=27.9317697228145, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24640551, Length=470, Percent_Identity=27.4468085106383, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17737741, Length=477, Percent_Identity=28.0922431865828, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49106; Mature: 49106

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEHDMHTQSDFDLAVIGSGPGGFEAAVRAARKGLTVCVIERGALGGVCVNWGCIPTKAL
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHH
LRSAEIFRLAGESSAFGLDIEASSIDLARAVKRSRKVVLLASKGVESALKKNKVTVFQGE
HHHHHHEEECCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCHHHHHHCCCEEEEECC
ATFVDERTLRVSRDGQEDERLTAKHIIIASGARPREIPVLPVDGRHIMTSREALALKSAP
EEEECCEEEEECCCCCHHHHEEEEEEEEECCCCCCCCCEEECCCCEEECCCHHHHCCCCC
ERMIVVGGGAIGLEMAWYYHSAGTKVTVLEMLPRLLPLEDKEVSEGLERLLKKAGISIHC
CEEEEEECCEEEEEEEEEEECCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEE
EAAVVSASAGDDGIVDAVVRMKDGSEQKMQGECLLVAAGVVPNSGGLQLDAAGVILERGF
EEEEEECCCCCCCCEEHHEEECCCCCCCCCCCEEEEEECCCCCCCCEEEEECCEEEECCE
IATDAQCRTNVDHIYAIGDVRGGMQLAHKASAEAVIAVESITGGNPMPIDDAMVPRCVYV
EECCCHHHCCCCEEEEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEEEE
EPAVAAIGASQEDAAAEGREVMVGRAMFAASGKASAYGFRDGFVKLIFDAGSGVMIGGHV
CCHHHHHCCCCCHHHCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEECCEE
LGHGAVELIGELSLAMRLGATADQIASTIHAHPTLSETVREAAENAVVA
ECCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEEHDMHTQSDFDLAVIGSGPGGFEAAVRAARKGLTVCVIERGALGGVCVNWGCIPTKAL
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHH
LRSAEIFRLAGESSAFGLDIEASSIDLARAVKRSRKVVLLASKGVESALKKNKVTVFQGE
HHHHHHEEECCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCHHHHHHCCCEEEEECC
ATFVDERTLRVSRDGQEDERLTAKHIIIASGARPREIPVLPVDGRHIMTSREALALKSAP
EEEECCEEEEECCCCCHHHHEEEEEEEEECCCCCCCCCEEECCCCEEECCCHHHHCCCCC
ERMIVVGGGAIGLEMAWYYHSAGTKVTVLEMLPRLLPLEDKEVSEGLERLLKKAGISIHC
CEEEEEECCEEEEEEEEEEECCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEE
EAAVVSASAGDDGIVDAVVRMKDGSEQKMQGECLLVAAGVVPNSGGLQLDAAGVILERGF
EEEEEECCCCCCCCEEHHEEECCCCCCCCCCCEEEEEECCCCCCCCEEEEECCEEEECCE
IATDAQCRTNVDHIYAIGDVRGGMQLAHKASAEAVIAVESITGGNPMPIDDAMVPRCVYV
EECCCHHHCCCCEEEEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCEEEEE
EPAVAAIGASQEDAAAEGREVMVGRAMFAASGKASAYGFRDGFVKLIFDAGSGVMIGGHV
CCHHHHHCCCCCHHHCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEECCEE
LGHGAVELIGELSLAMRLGATADQIASTIHAHPTLSETVREAAENAVVA
ECCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA