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The map label for this gene is purC

Identifier: 194334183

GI number: 194334183

Start: 1496497

End: 1497204

Strand: Reverse

Name: purC

Synonym: Paes_1375

Alternate gene names: 194334183

Gene position: 1497204-1496497 (Counterclockwise)

Preceding gene: 194334184

Following gene: 194334182

Centisome position: 59.58

GC content: 47.18

Gene sequence:

>708_bases
ATGAATAAAGTGTCACTTCTTCACGAAGGAAAGGCCAAAAAGGTGTTTCTGACCGATAACAGCGATCTTGTTATACAGGA
ATTCAAAGATGATGCGACAGCCTTCAATGCGAAGAAAAAAGGTTCCATTCAGAACAAGGGCGTCGTCAATAATGCGATTT
CGTGTACCTTGTTTACCTTTCTTGGCGAGAATGGCATTCCAACGCACTATGTCGAGCAGCTCTCCGATCGCGATATGCTC
TGCAAGCATCTCGACATTATCAAAGTCGAGGTTGTCGTCCGCAATGTTGCGGCAGGTTCTCTTGTCCGTCGCTATGGGTT
CAAGGAGGGCTTCGTCCTTGAAACCCCTATCATCGAACTCTATCTCAAAGACGACGATCTCGATGATCCGCTTATGAACG
AAAGCCATGCTGTTGCCCTTGGTCTTGCTTCCTATGAAGAACTTGACCGTCTTAAAGAACTTGCGGCTGCAATCAACACG
CTTCTCCGCTCCTTTTTTGCTGATCGCAAACTTAATCTGGTTGATTTTAAACTTGAGTTCGGCCGTCACAACGGAACCAT
TCTTCTTGGCGATGAGATAAGCCCGGATACCTGTCGTTTCTGGGACCTCGATTCCGGAGAGAAGATGGATAAAGACCGTT
TCCGGTTCGATATGGGCGGCGTTGAAGATGCTTATTCTGAAGTGCAGCGCCGGGTTCTGGAACTTTAA

Upstream 100 bases:

>100_bases
CAATAGATAGTACATGTATTTGCAGCGCTGCCGTCAGGCTCAACATCCTGAATGAGCGGCGGTGTTTTTTATTTATTCTT
TTAACCATAGTTCAACCATT

Downstream 100 bases:

>100_bases
TGTGCAAGCAGGACTATTGCTTTAATTACATGAGCAGATGCTGGAATCAGTCATAGCCTATTTACAGACAGCCGATCCGT
TAACGGTCTATCTGTTTCTG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MNKVSLLHEGKAKKVFLTDNSDLVIQEFKDDATAFNAKKKGSIQNKGVVNNAISCTLFTFLGENGIPTHYVEQLSDRDML
CKHLDIIKVEVVVRNVAAGSLVRRYGFKEGFVLETPIIELYLKDDDLDDPLMNESHAVALGLASYEELDRLKELAAAINT
LLRSFFADRKLNLVDFKLEFGRHNGTILLGDEISPDTCRFWDLDSGEKMDKDRFRFDMGGVEDAYSEVQRRVLEL

Sequences:

>Translated_235_residues
MNKVSLLHEGKAKKVFLTDNSDLVIQEFKDDATAFNAKKKGSIQNKGVVNNAISCTLFTFLGENGIPTHYVEQLSDRDML
CKHLDIIKVEVVVRNVAAGSLVRRYGFKEGFVLETPIIELYLKDDDLDDPLMNESHAVALGLASYEELDRLKELAAAINT
LLRSFFADRKLNLVDFKLEFGRHNGTILLGDEISPDTCRFWDLDSGEKMDKDRFRFDMGGVEDAYSEVQRRVLEL
>Mature_235_residues
MNKVSLLHEGKAKKVFLTDNSDLVIQEFKDDATAFNAKKKGSIQNKGVVNNAISCTLFTFLGENGIPTHYVEQLSDRDML
CKHLDIIKVEVVVRNVAAGSLVRRYGFKEGFVLETPIIELYLKDDDLDDPLMNESHAVALGLASYEELDRLKELAAAINT
LLRSFFADRKLNLVDFKLEFGRHNGTILLGDEISPDTCRFWDLDSGEKMDKDRFRFDMGGVEDAYSEVQRRVLEL

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=220, Percent_Identity=32.7272727272727, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI5453539, Length=220, Percent_Identity=32.7272727272727, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI119220559, Length=227, Percent_Identity=31.7180616740088, Blast_Score=107, Evalue=6e-24,
Organism=Escherichia coli, GI1788820, Length=232, Percent_Identity=47.4137931034483, Blast_Score=215, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17531275, Length=220, Percent_Identity=33.1818181818182, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24583917, Length=205, Percent_Identity=30.7317073170732, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI18860083, Length=222, Percent_Identity=30.1801801801802, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_PROA2 (B4S8K9)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002016043.1
- ProteinModelPortal:   B4S8K9
- SMR:   B4S8K9
- GeneID:   6460497
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_1375
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 26612; Mature: 26612

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKVSLLHEGKAKKVFLTDNSDLVIQEFKDDATAFNAKKKGSIQNKGVVNNAISCTLFTF
CCCCCCEECCCCCEEEEECCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
LGENGIPTHYVEQLSDRDMLCKHLDIIKVEVVVRNVAAGSLVRRYGFKEGFVLETPIIEL
HCCCCCCHHHHHHHCCHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCCCCCEEEECCEEEE
YLKDDDLDDPLMNESHAVALGLASYEELDRLKELAAAINTLLRSFFADRKLNLVDFKLEF
EECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
GRHNGTILLGDEISPDTCRFWDLDSGEKMDKDRFRFDMGGVEDAYSEVQRRVLEL
CCCCCEEEECCCCCCCCEEEEECCCCCCCCCHHHEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKVSLLHEGKAKKVFLTDNSDLVIQEFKDDATAFNAKKKGSIQNKGVVNNAISCTLFTF
CCCCCCEECCCCCEEEEECCCCEEEEECCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
LGENGIPTHYVEQLSDRDMLCKHLDIIKVEVVVRNVAAGSLVRRYGFKEGFVLETPIIEL
HCCCCCCHHHHHHHCCHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCCCCCEEEECCEEEE
YLKDDDLDDPLMNESHAVALGLASYEELDRLKELAAAINTLLRSFFADRKLNLVDFKLEF
EECCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
GRHNGTILLGDEISPDTCRFWDLDSGEKMDKDRFRFDMGGVEDAYSEVQRRVLEL
CCCCCEEEECCCCCCCCEEEEECCCCCCCCCHHHEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA