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The map label for this gene is cysG [H]

Identifier: 194334105

GI number: 194334105

Start: 1411914

End: 1412675

Strand: Reverse

Name: cysG [H]

Synonym: Paes_1293

Alternate gene names: 194334105

Gene position: 1412675-1411914 (Counterclockwise)

Preceding gene: 194334106

Following gene: 194334104

Centisome position: 56.22

GC content: 57.74

Gene sequence:

>762_bases
ATGTCTGAAACACACAACGGGGGACGGGTGGTGATTGCCGGTGCAGGCCCGGGAGATCCGGAGTTGCTGACCGTGAAGGC
CGCCAGACGGCTGCAGCAGGCCGATGCCGTCCTGTATGATTCCCTGGTGACAAGGGAAATCCTCGATCTTGCCGCAAAGG
GAGCCGATATGGTGCCTGTCGGAAAACGGTGCGGGGACGGGCAGGACCAGACACAACGGCAGAATGCCATCAATGAGCTC
ATGCTCGATTATGCCCGCAGGGGAGCGCTCTGTGTCCGGCTCAAGGCGGGAGATCCCTTCGTGTTCGGAAGAGGGGTCGA
AGAGGTTCGTTTTCTGACCGAACGCCAGGTCACGGTTGAGGTCATTCCCGGAATCAGTGCCGGCATAGCGGCTGCGAACC
TTTTTCACGTTCCTGTGACCGAGCGTTACAGAACCTCTTCGGTAATATTGAGTACAGGGCATACGTCCACCTGCTCGATG
GAGGAGTTCGATAGTGTGGTCGCGTTGCTGAAACAGGGTACTCCGCTTGTGCTGTACATGGGAATGAAACATCTCGAGTG
TATCTGCCAGCGGTTGCTGGACGCCGGATTTTCGCCGGATTTTCCGCTCTGCGCAGCATCACGGGTGTCCATGCCCGATC
AGCAGCTGATCTGTGCAACGCTGGGGACGATCTGCTTGCTTCTGGTCAAAACACCGTTGCCGACACCTGTCGTGTTTTTC
GTGGGGGAGCATGCCGTCCCCATATCGCAGCAGACCGTATAA

Upstream 100 bases:

>100_bases
TACAGCCGAGCTCGATATCTCCCTGCTGCGCAACAAGCATTTTTATGACAGGCTGGAGTTCGATCTCCTCCTTGGAAAAC
AGAATTAAGAACGATGTATC

Downstream 100 bases:

>100_bases
TAAAGAGTTACCATCATCATGTCAAGAACCTATCCAAAGAGAAAACAGATAAACCGCAAGGCGATCCTGCTTGCGCATTT
CGGCACGTCCTTCGTATCTG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MSETHNGGRVVIAGAGPGDPELLTVKAARRLQQADAVLYDSLVTREILDLAAKGADMVPVGKRCGDGQDQTQRQNAINEL
MLDYARRGALCVRLKAGDPFVFGRGVEEVRFLTERQVTVEVIPGISAGIAAANLFHVPVTERYRTSSVILSTGHTSTCSM
EEFDSVVALLKQGTPLVLYMGMKHLECICQRLLDAGFSPDFPLCAASRVSMPDQQLICATLGTICLLLVKTPLPTPVVFF
VGEHAVPISQQTV

Sequences:

>Translated_253_residues
MSETHNGGRVVIAGAGPGDPELLTVKAARRLQQADAVLYDSLVTREILDLAAKGADMVPVGKRCGDGQDQTQRQNAINEL
MLDYARRGALCVRLKAGDPFVFGRGVEEVRFLTERQVTVEVIPGISAGIAAANLFHVPVTERYRTSSVILSTGHTSTCSM
EEFDSVVALLKQGTPLVLYMGMKHLECICQRLLDAGFSPDFPLCAASRVSMPDQQLICATLGTICLLLVKTPLPTPVVFF
VGEHAVPISQQTV
>Mature_252_residues
SETHNGGRVVIAGAGPGDPELLTVKAARRLQQADAVLYDSLVTREILDLAAKGADMVPVGKRCGDGQDQTQRQNAINELM
LDYARRGALCVRLKAGDPFVFGRGVEEVRFLTERQVTVEVIPGISAGIAAANLFHVPVTERYRTSSVILSTGHTSTCSME
EFDSVVALLKQGTPLVLYMGMKHLECICQRLLDAGFSPDFPLCAASRVSMPDQQLICATLGTICLLLVKTPLPTPVVFFV
GEHAVPISQQTV

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=232, Percent_Identity=36.6379310344828, Blast_Score=145, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6322922, Length=236, Percent_Identity=29.2372881355932, Blast_Score=100, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 27251; Mature: 27120

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETHNGGRVVIAGAGPGDPELLTVKAARRLQQADAVLYDSLVTREILDLAAKGADMVPV
CCCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GKRCGDGQDQTQRQNAINELMLDYARRGALCVRLKAGDPFVFGRGVEEVRFLTERQVTVE
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCHHHHHHHHHCCEEEE
VIPGISAGIAAANLFHVPVTERYRTSSVILSTGHTSTCSMEEFDSVVALLKQGTPLVLYM
EECCCHHHHHHHHEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEC
GMKHLECICQRLLDAGFSPDFPLCAASRVSMPDQQLICATLGTICLLLVKTPLPTPVVFF
CHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
VGEHAVPISQQTV
ECCCCCCCCCCCC
>Mature Secondary Structure 
SETHNGGRVVIAGAGPGDPELLTVKAARRLQQADAVLYDSLVTREILDLAAKGADMVPV
CCCCCCCEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
GKRCGDGQDQTQRQNAINELMLDYARRGALCVRLKAGDPFVFGRGVEEVRFLTERQVTVE
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCHHHHHHHHHCCEEEE
VIPGISAGIAAANLFHVPVTERYRTSSVILSTGHTSTCSMEEFDSVVALLKQGTPLVLYM
EECCCHHHHHHHHEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEC
GMKHLECICQRLLDAGFSPDFPLCAASRVSMPDQQLICATLGTICLLLVKTPLPTPVVFF
CHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
VGEHAVPISQQTV
ECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA