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The map label for this gene is cobD [H]

Identifier: 194334081

GI number: 194334081

Start: 1371586

End: 1372680

Strand: Reverse

Name: cobD [H]

Synonym: Paes_1268

Alternate gene names: 194334081

Gene position: 1372680-1371586 (Counterclockwise)

Preceding gene: 194334082

Following gene: 194334080

Centisome position: 54.62

GC content: 49.68

Gene sequence:

>1095_bases
ATGAGCAGAGACAATCTTTATCATCATGAACACGGAGGAGAACCGGAGCGCTACTGCGTTACAGGAACTCAGCCACTCCT
TGATTTCAGCGTCAATATCAGTCCGCTTTCTCCATCGCTTCCGGAGGTTTCTCTCGACGCGTTTTCTCTTCATTGTTACC
CTTCCATTGATGGACGTGGTATACGGGAATTCTACTCGAACCGTTTCAGTCTTGACGATGAAACGCTGCTGCCTCTCAAT
GGCGCTATCGAAGGGATCTATCTTGTTCCCAGAGCGCTGCGTTTGCAACGGGTTATGGTGCTTGCCCCATCATTTTTCGA
CTACGAACGGGCCTGCCGGATTGCAGGGGCGAAGGTCAGCTATCTGAGACTTCAGGAAAAGGAGCTGTTTCTTCTGCCCG
GCATCGACGAGATTGCAGAGCAACTGCAGGATGCCGACGCGCTGTTTGCCGCAAACCCCAATAATCCCACCGGGACGAGA
TTTCCGAAGGAGCTTGTCATGGCGCTTGCAAGCCGGTTCCCTGATAAATGGTTCATTATCGATGAAGCTTTTATCCAGTT
CGTTGACGATTTTCCCGGTGCTTCGCTGATGCGTGATGTTCGGGCTTTCCGCAATATTGTCGTGATCAATTCCCTGACGA
AATTTTATGCGTTGCCCGGGCTTCGGCTGGGAGCAGCTATTGCTCATCCGGATGTTATCAAAATCCTTCTTGATTTCAAG
GAACCCTGGACGGTCAATGCCATTGCGGAAGCTGTTGCCTTAGAGCTGCTTCATGCTGGTGATTTCGAGGAGGATGTCCG
TCGCCTGATCACGGTGGAGCGGGCTAAAATTTATAAACGTATGAAAAACGTCCCGGACATCGCGATCCGTGGATATGCCG
CAAACTTTTTTCTTGCTCAGTGGAACAGTGGATCAAGCCTCAATGATCTTCTCGATTTCCTGATCGCAAAAAATATCTAT
GTCAGGGATTGTCGGAATTTTCCCGGTCTTGAGGATAATTATTTCAGGTTTGCTATCCGTAAACCGGAAGAAAACGACTA
TATGCTCGATCAGCTTCAGCTTGTCGGCGGCGAGGTCGGGATGGTTGAGAAATGA

Upstream 100 bases:

>100_bases
CTTGCGCGACATGTTGCAGCTCATCTTGATCTTGATAAGCTGTACAGGATTATCGAAAAATAGGAGTAAGTTGTTTTTTT
CGAATACCGAACAGGGGACA

Downstream 100 bases:

>100_bases
TGTATCCAGTTGAATACCAGATTGCAGCTGCTTTTCTTGTTGACTTTCTTGCCGGTGATCCGCGTTTTCTGCCGCATCCT
GTCAGGGCAATAGGGTGGCT

Product: L-threonine-O-3-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MSRDNLYHHEHGGEPERYCVTGTQPLLDFSVNISPLSPSLPEVSLDAFSLHCYPSIDGRGIREFYSNRFSLDDETLLPLN
GAIEGIYLVPRALRLQRVMVLAPSFFDYERACRIAGAKVSYLRLQEKELFLLPGIDEIAEQLQDADALFAANPNNPTGTR
FPKELVMALASRFPDKWFIIDEAFIQFVDDFPGASLMRDVRAFRNIVVINSLTKFYALPGLRLGAAIAHPDVIKILLDFK
EPWTVNAIAEAVALELLHAGDFEEDVRRLITVERAKIYKRMKNVPDIAIRGYAANFFLAQWNSGSSLNDLLDFLIAKNIY
VRDCRNFPGLEDNYFRFAIRKPEENDYMLDQLQLVGGEVGMVEK

Sequences:

>Translated_364_residues
MSRDNLYHHEHGGEPERYCVTGTQPLLDFSVNISPLSPSLPEVSLDAFSLHCYPSIDGRGIREFYSNRFSLDDETLLPLN
GAIEGIYLVPRALRLQRVMVLAPSFFDYERACRIAGAKVSYLRLQEKELFLLPGIDEIAEQLQDADALFAANPNNPTGTR
FPKELVMALASRFPDKWFIIDEAFIQFVDDFPGASLMRDVRAFRNIVVINSLTKFYALPGLRLGAAIAHPDVIKILLDFK
EPWTVNAIAEAVALELLHAGDFEEDVRRLITVERAKIYKRMKNVPDIAIRGYAANFFLAQWNSGSSLNDLLDFLIAKNIY
VRDCRNFPGLEDNYFRFAIRKPEENDYMLDQLQLVGGEVGMVEK
>Mature_363_residues
SRDNLYHHEHGGEPERYCVTGTQPLLDFSVNISPLSPSLPEVSLDAFSLHCYPSIDGRGIREFYSNRFSLDDETLLPLNG
AIEGIYLVPRALRLQRVMVLAPSFFDYERACRIAGAKVSYLRLQEKELFLLPGIDEIAEQLQDADALFAANPNNPTGTRF
PKELVMALASRFPDKWFIIDEAFIQFVDDFPGASLMRDVRAFRNIVVINSLTKFYALPGLRLGAAIAHPDVIKILLDFKE
PWTVNAIAEAVALELLHAGDFEEDVRRLITVERAKIYKRMKNVPDIAIRGYAANFFLAQWNSGSSLNDLLDFLIAKNIYV
RDCRNFPGLEDNYFRFAIRKPEENDYMLDQLQLVGGEVGMVEK

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=324, Percent_Identity=25, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322075, Length=319, Percent_Identity=24.7648902821317, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 41317; Mature: 41186

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRDNLYHHEHGGEPERYCVTGTQPLLDFSVNISPLSPSLPEVSLDAFSLHCYPSIDGRG
CCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCH
IREFYSNRFSLDDETLLPLNGAIEGIYLVPRALRLQRVMVLAPSFFDYERACRIAGAKVS
HHHHHCCCCCCCCCEEECCCCCCCHHEECHHHHHHHHHHHHCCCHHCHHHHHHHCCCEEE
YLRLQEKELFLLPGIDEIAEQLQDADALFAANPNNPTGTRFPKELVMALASRFPDKWFII
EEEECCCCEEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEH
DEAFIQFVDDFPGASLMRDVRAFRNIVVINSLTKFYALPGLRLGAAIAHPDVIKILLDFK
HHHHHHHHHCCCCHHHHHHHHHHHHEEHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCC
EPWTVNAIAEAVALELLHAGDFEEDVRRLITVERAKIYKRMKNVPDIAIRGYAANFFLAQ
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEE
WNSGSSLNDLLDFLIAKNIYVRDCRNFPGLEDNYFRFAIRKPEENDYMLDQLQLVGGEVG
CCCCCCHHHHHHHHHHCCHHEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCC
MVEK
CCCC
>Mature Secondary Structure 
SRDNLYHHEHGGEPERYCVTGTQPLLDFSVNISPLSPSLPEVSLDAFSLHCYPSIDGRG
CCCCCCCCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCH
IREFYSNRFSLDDETLLPLNGAIEGIYLVPRALRLQRVMVLAPSFFDYERACRIAGAKVS
HHHHHCCCCCCCCCEEECCCCCCCHHEECHHHHHHHHHHHHCCCHHCHHHHHHHCCCEEE
YLRLQEKELFLLPGIDEIAEQLQDADALFAANPNNPTGTRFPKELVMALASRFPDKWFII
EEEECCCCEEEECCHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEH
DEAFIQFVDDFPGASLMRDVRAFRNIVVINSLTKFYALPGLRLGAAIAHPDVIKILLDFK
HHHHHHHHHCCCCHHHHHHHHHHHHEEHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCC
EPWTVNAIAEAVALELLHAGDFEEDVRRLITVERAKIYKRMKNVPDIAIRGYAANFFLAQ
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEE
WNSGSSLNDLLDFLIAKNIYVRDCRNFPGLEDNYFRFAIRKPEENDYMLDQLQLVGGEVG
CCCCCCHHHHHHHHHHCCHHEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCC
MVEK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]