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The map label for this gene is hmuU [H]

Identifier: 194334079

GI number: 194334079

Start: 1369581

End: 1370615

Strand: Reverse

Name: hmuU [H]

Synonym: Paes_1266

Alternate gene names: 194334079

Gene position: 1370615-1369581 (Counterclockwise)

Preceding gene: 194334080

Following gene: 194334078

Centisome position: 54.54

GC content: 53.72

Gene sequence:

>1035_bases
ATGAAAACTGGTGTAAACAATGATATACAGCCGACCGTACTCTTTGGCATCAGCAGTGTGTCGAGATGGCGTATCGTGCT
TTTTCTTCTCGCGGTTCCGCTCCTGCTTGCACTCTCTCTGCTTTTAGGTCCCAGCAGTCTGGGGCTGCCGGATCTGCAGA
GCCCTGTGGGCCGGGCGATTCTGAATCTCCGTTTCAATCGGCTGGTGATGGGACTGCTTGTCGGTTCTGCACTTTCGGTA
TCGGGGGTGGTCTTTCAGGCTATTCTGCGTAATCCGCTTGCTGAACCCTATGTGCTTGGGGTGAGCGGGGGAGCCGGTCT
CGGGGCGACGCTGGCCATCCTTTTCGGAGCCGTGGCTTTTATTCCACTCAGTCTGCCCGTTGCCGCATTTTTTGCCGCCA
TCGTCACCCTGTTGCTTGTCTACGGGATTGCCAGGACAGGGAGCGGGGGTTCTCCTTCGGTCTATAGCCTCATTCTCAGT
GGTGTGATTATCAGTGCGATCTGCTCGAGCCTGATCATGTTTCTTGTCTCAAGCGCCAGCGTTGAGGGGCTTCATAACGT
TATCTGGTGGATGCTCGGAAACCTGCAACCGGTGCCTCTTCAGCAGAGAATTATGTCGTCGATTCTTATCGTTGCCGGTT
TTATTGTCGTATGGATGCTTGCATCGCGTTTCAACGCATTGACGCTTGGTCGTGAAATGGCCCACTATCAGGGTATGAAC
GCTGACCTTATCATACTTGTCGGACTGCTTGCATCAACGCTGATGGCCGCGACAGCCGTTTCGGTTGGTGGAATGATCGG
TTTTGTCGGCCTGATCGTACCGCATGTAACAAGGGCTATGTTCGGCCCTGATCATCGCTGGCTTATTCCTCTTTCCGCGT
TGTCAGGTGGAACTTTCCTGGTTCTGTGCGATGCGTTTGCACGGACGGTTCTCGCTCCTGTGGAAATTCCGGTCGGTGTT
ATCACCGCCCTTGCCGGAGGTCCGTTTTTTCTCCTGATATTGCAGCGAAAAATGAAGAATGCGTGGATAGCCTGA

Upstream 100 bases:

>100_bases
AACAGGCGGTTGTTCTCATGCTGCTTTCTTCAGGTGTTTTTCTTGTGACGGGAGTTTTTTTGCGCCTTGTTGTTCAGGCG
GCAATGCTTTATCTGATGTG

Downstream 100 bases:

>100_bases
AAAAGCCGAAAGCAAAACGGACTTGATAGTTCCTGAACGAGCTCATATTTTCTTAGCACTTAGCACTTAGCACTTAGCAC
TTAGCACTTAGCACTTAGCA

Product: transport system permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MKTGVNNDIQPTVLFGISSVSRWRIVLFLLAVPLLLALSLLLGPSSLGLPDLQSPVGRAILNLRFNRLVMGLLVGSALSV
SGVVFQAILRNPLAEPYVLGVSGGAGLGATLAILFGAVAFIPLSLPVAAFFAAIVTLLLVYGIARTGSGGSPSVYSLILS
GVIISAICSSLIMFLVSSASVEGLHNVIWWMLGNLQPVPLQQRIMSSILIVAGFIVVWMLASRFNALTLGREMAHYQGMN
ADLIILVGLLASTLMAATAVSVGGMIGFVGLIVPHVTRAMFGPDHRWLIPLSALSGGTFLVLCDAFARTVLAPVEIPVGV
ITALAGGPFFLLILQRKMKNAWIA

Sequences:

>Translated_344_residues
MKTGVNNDIQPTVLFGISSVSRWRIVLFLLAVPLLLALSLLLGPSSLGLPDLQSPVGRAILNLRFNRLVMGLLVGSALSV
SGVVFQAILRNPLAEPYVLGVSGGAGLGATLAILFGAVAFIPLSLPVAAFFAAIVTLLLVYGIARTGSGGSPSVYSLILS
GVIISAICSSLIMFLVSSASVEGLHNVIWWMLGNLQPVPLQQRIMSSILIVAGFIVVWMLASRFNALTLGREMAHYQGMN
ADLIILVGLLASTLMAATAVSVGGMIGFVGLIVPHVTRAMFGPDHRWLIPLSALSGGTFLVLCDAFARTVLAPVEIPVGV
ITALAGGPFFLLILQRKMKNAWIA
>Mature_344_residues
MKTGVNNDIQPTVLFGISSVSRWRIVLFLLAVPLLLALSLLLGPSSLGLPDLQSPVGRAILNLRFNRLVMGLLVGSALSV
SGVVFQAILRNPLAEPYVLGVSGGAGLGATLAILFGAVAFIPLSLPVAAFFAAIVTLLLVYGIARTGSGGSPSVYSLILS
GVIISAICSSLIMFLVSSASVEGLHNVIWWMLGNLQPVPLQQRIMSSILIVAGFIVVWMLASRFNALTLGREMAHYQGMN
ADLIILVGLLASTLMAATAVSVGGMIGFVGLIVPHVTRAMFGPDHRWLIPLSALSGGTFLVLCDAFARTVLAPVEIPVGV
ITALAGGPFFLLILQRKMKNAWIA

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=286, Percent_Identity=34.2657342657343, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1788004, Length=289, Percent_Identity=34.9480968858132, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1790741, Length=283, Percent_Identity=31.8021201413428, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786805, Length=294, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786347, Length=276, Percent_Identity=29.3478260869565, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1786804, Length=283, Percent_Identity=30.3886925795053, Blast_Score=90, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36091; Mature: 36091

Theoretical pI: Translated: 10.77; Mature: 10.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTGVNNDIQPTVLFGISSVSRWRIVLFLLAVPLLLALSLLLGPSSLGLPDLQSPVGRAI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
LNLRFNRLVMGLLVGSALSVSGVVFQAILRNPLAEPYVLGVSGGAGLGATLAILFGAVAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHH
IPLSLPVAAFFAAIVTLLLVYGIARTGSGGSPSVYSLILSGVIISAICSSLIMFLVSSAS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEGLHNVIWWMLGNLQPVPLQQRIMSSILIVAGFIVVWMLASRFNALTLGREMAHYQGMN
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ADLIILVGLLASTLMAATAVSVGGMIGFVGLIVPHVTRAMFGPDHRWLIPLSALSGGTFL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHCCCCHHE
VLCDAFARTVLAPVEIPVGVITALAGGPFFLLILQRKMKNAWIA
EHHHHHHHHHHCCHHCHHHHHHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTGVNNDIQPTVLFGISSVSRWRIVLFLLAVPLLLALSLLLGPSSLGLPDLQSPVGRAI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
LNLRFNRLVMGLLVGSALSVSGVVFQAILRNPLAEPYVLGVSGGAGLGATLAILFGAVAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHH
IPLSLPVAAFFAAIVTLLLVYGIARTGSGGSPSVYSLILSGVIISAICSSLIMFLVSSAS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEGLHNVIWWMLGNLQPVPLQQRIMSSILIVAGFIVVWMLASRFNALTLGREMAHYQGMN
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ADLIILVGLLASTLMAATAVSVGGMIGFVGLIVPHVTRAMFGPDHRWLIPLSALSGGTFL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHCCCCHHE
VLCDAFARTVLAPVEIPVGVITALAGGPFFLLILQRKMKNAWIA
EHHHHHHHHHHCCHHCHHHHHHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]