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The map label for this gene is pepD [H]

Identifier: 194334037

GI number: 194334037

Start: 1330536

End: 1331996

Strand: Reverse

Name: pepD [H]

Synonym: Paes_1222

Alternate gene names: 194334037

Gene position: 1331996-1330536 (Counterclockwise)

Preceding gene: 194334039

Following gene: 194334034

Centisome position: 53.01

GC content: 52.02

Gene sequence:

>1461_bases
ATGAATGATGATATTCTTTCCTTAGAGCCCCAGGCGGTATGGAAACATTTTTACGGCCTGACCCGGATAGCCCGTCCTTC
AGGCAACGAGGAGAAAGTCCGGAGATTTATTGCTGGTTTCGGGCAGTCTCTTGGATTGGAAACGATTGTTGACGAGTCGG
GTAACGTTCTTATCCGTAAACCGGCGACATCCGGCATGGCTGATCGGAAGGGCGTTATTCTTCAGGCTCATGTTGATATG
GTTCCCCAGAAGAACAGTGGTACGGTTCACGATTTTGACAAAGATCCTATTGAACCCATTGTCGATGGTCAATGGGTGCG
GGCAAGGGGAACGACGCTCGGAGCCGATAACGGCATTGGCGTTGCAGCGATCATGGCTGTGCTGGAATCGACGGAAATGC
GTCATGGCCCTCTTGAAGCGCTCTTTACCAGTAACGAAGAGAGCGGTATGACCGGTGCATTCGGACTGAAATCCGGTGTG
CTCAGGGGCAGCATTCTTCTCAACCTGGATTCGGAAAATGAGGGAGAGCTGTGTATCGGTTGCGCTGGCGGCCTCGATGC
AACGATGAGGTTCAGCTACGAAGAGCAGGCCGTCCCGGATGGACACACTGGGTTCACGATCAGTGTGGGCGGTTTGAGAG
GCGGTCACAGTGGCATGGATATTGCACTTGGGCGCGGCAATGCAAACAAGATCCTGACCCGCCTGCTCTCTACCGGATAT
ACATGTCATGATATGCTGTTGGCCTCGATCGACGGAGGTAGCCTTCGCAATGCAATTCCCCGAGAATCGAATGCAACGGT
CGCTGTTCCCTCCTTGAATGCTGAGTGTTTCGTGGAGGGGCTTGCTTGCCTGGCTGCTGATATGCGGCGGGAGTTGACGA
CCGCTGATCCGTCGCTCAGAATTGATGTGTTTCCTGCCACGCTTCCGGACAGGGTGGTTGAGAATGGTGTTGCCGGGAGG
CTGCTTAAAGCGCTTTATGCCTGTCCGAACGGTGTGATGCGAATGAGCGATGAGATGCCTGGTCTGGTTGAGACATCCAA
TAATCTTGCTGTCGTCAGATCCAAAAATGGATTGATTTGCGTTGAATGTCTGCTTCGAAGTTCCGTGGATTCAGCTCGTG
ATGATCTGGAATCGATGATAAGAAGCTGTTTTGAACTCGCAGGAGCCAGTACGCTCTTCGATGGAGGATATCCTGGATGG
AAACCGAATCCTGAGTCGGCTATGCTGCAACGCATGCGGGAAATCTATTGGAAGATGTTTGGTGAAAATCCTGCTATTCA
GGCTGTTCATGCAGGTCTGGAATGCGGAATTATAGGGGCAACGTACCCTGAACTCGATATGATTTCTTTAGGACCGACCA
TTCGATACCCCCACTCTCCGGATGAAAAGGTCAATATCGCTTCAGTAGGCGCGTTTATGGATTTTCTGGTCGAGACGCTC
TCCGGAGTTCCCTGCCAATAA

Upstream 100 bases:

>100_bases
GATGATGCCTGTTGTTATCATTATAAATATACTATACTTGATTGAAGAAAAAGAGTCAAAACGTTCAACAATTTTTTTGT
TTTCAGGGAGTGTATGAGAG

Downstream 100 bases:

>100_bases
AAGAACGCCGGAGTTTTCCTGGTGGTTAGAGTCTCTTGTTGACCCTCTCTGACAGGTATGGTTTATGTTGTTTCAGGTAA
GGCTTTTTTGACTGCTTCGA

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MNDDILSLEPQAVWKHFYGLTRIARPSGNEEKVRRFIAGFGQSLGLETIVDESGNVLIRKPATSGMADRKGVILQAHVDM
VPQKNSGTVHDFDKDPIEPIVDGQWVRARGTTLGADNGIGVAAIMAVLESTEMRHGPLEALFTSNEESGMTGAFGLKSGV
LRGSILLNLDSENEGELCIGCAGGLDATMRFSYEEQAVPDGHTGFTISVGGLRGGHSGMDIALGRGNANKILTRLLSTGY
TCHDMLLASIDGGSLRNAIPRESNATVAVPSLNAECFVEGLACLAADMRRELTTADPSLRIDVFPATLPDRVVENGVAGR
LLKALYACPNGVMRMSDEMPGLVETSNNLAVVRSKNGLICVECLLRSSVDSARDDLESMIRSCFELAGASTLFDGGYPGW
KPNPESAMLQRMREIYWKMFGENPAIQAVHAGLECGIIGATYPELDMISLGPTIRYPHSPDEKVNIASVGAFMDFLVETL
SGVPCQ

Sequences:

>Translated_486_residues
MNDDILSLEPQAVWKHFYGLTRIARPSGNEEKVRRFIAGFGQSLGLETIVDESGNVLIRKPATSGMADRKGVILQAHVDM
VPQKNSGTVHDFDKDPIEPIVDGQWVRARGTTLGADNGIGVAAIMAVLESTEMRHGPLEALFTSNEESGMTGAFGLKSGV
LRGSILLNLDSENEGELCIGCAGGLDATMRFSYEEQAVPDGHTGFTISVGGLRGGHSGMDIALGRGNANKILTRLLSTGY
TCHDMLLASIDGGSLRNAIPRESNATVAVPSLNAECFVEGLACLAADMRRELTTADPSLRIDVFPATLPDRVVENGVAGR
LLKALYACPNGVMRMSDEMPGLVETSNNLAVVRSKNGLICVECLLRSSVDSARDDLESMIRSCFELAGASTLFDGGYPGW
KPNPESAMLQRMREIYWKMFGENPAIQAVHAGLECGIIGATYPELDMISLGPTIRYPHSPDEKVNIASVGAFMDFLVETL
SGVPCQ
>Mature_486_residues
MNDDILSLEPQAVWKHFYGLTRIARPSGNEEKVRRFIAGFGQSLGLETIVDESGNVLIRKPATSGMADRKGVILQAHVDM
VPQKNSGTVHDFDKDPIEPIVDGQWVRARGTTLGADNGIGVAAIMAVLESTEMRHGPLEALFTSNEESGMTGAFGLKSGV
LRGSILLNLDSENEGELCIGCAGGLDATMRFSYEEQAVPDGHTGFTISVGGLRGGHSGMDIALGRGNANKILTRLLSTGY
TCHDMLLASIDGGSLRNAIPRESNATVAVPSLNAECFVEGLACLAADMRRELTTADPSLRIDVFPATLPDRVVENGVAGR
LLKALYACPNGVMRMSDEMPGLVETSNNLAVVRSKNGLICVECLLRSSVDSARDDLESMIRSCFELAGASTLFDGGYPGW
KPNPESAMLQRMREIYWKMFGENPAIQAVHAGLECGIIGATYPELDMISLGPTIRYPHSPDEKVNIASVGAFMDFLVETL
SGVPCQ

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=489, Percent_Identity=46.4212678936605, Blast_Score=453, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52052; Mature: 52052

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDDILSLEPQAVWKHFYGLTRIARPSGNEEKVRRFIAGFGQSLGLETIVDESGNVLIRK
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHCCCHHEECCCCCEEEEC
PATSGMADRKGVILQAHVDMVPQKNSGTVHDFDKDPIEPIVDGQWVRARGTTLGADNGIG
CCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCH
VAAIMAVLESTEMRHGPLEALFTSNEESGMTGAFGLKSGVLRGSILLNLDSENEGELCIG
HHHHHHHHHHHHCCCCCCHHEEECCCCCCCEECHHHHCCCEEEEEEEEECCCCCCCEEEE
CAGGLDATMRFSYEEQAVPDGHTGFTISVGGLRGGHSGMDIALGRGNANKILTRLLSTGY
ECCCCCCEEEECCHHHCCCCCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHCCC
TCHDMLLASIDGGSLRNAIPRESNATVAVPSLNAECFVEGLACLAADMRRELTTADPSLR
CHHHHHEEECCCCHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
IDVFPATLPDRVVENGVAGRLLKALYACPNGVMRMSDEMPGLVETSNNLAVVRSKNGLIC
EEEECCCCHHHHHHCCHHHHHHHHHHHCCCCCEECCCCCCCCEECCCCEEEEECCCCEEH
VECLLRSSVDSARDDLESMIRSCFELAGASTLFDGGYPGWKPNPESAMLQRMREIYWKMF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
GENPAIQAVHAGLECGIIGATYPELDMISLGPTIRYPHSPDEKVNIASVGAFMDFLVETL
CCCCHHHHHHCCCCEEEEECCCCCCEEEECCCEEECCCCCCCCEEHHHHHHHHHHHHHHH
SGVPCQ
CCCCCC
>Mature Secondary Structure
MNDDILSLEPQAVWKHFYGLTRIARPSGNEEKVRRFIAGFGQSLGLETIVDESGNVLIRK
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHCCCHHEECCCCCEEEEC
PATSGMADRKGVILQAHVDMVPQKNSGTVHDFDKDPIEPIVDGQWVRARGTTLGADNGIG
CCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCH
VAAIMAVLESTEMRHGPLEALFTSNEESGMTGAFGLKSGVLRGSILLNLDSENEGELCIG
HHHHHHHHHHHHCCCCCCHHEEECCCCCCCEECHHHHCCCEEEEEEEEECCCCCCCEEEE
CAGGLDATMRFSYEEQAVPDGHTGFTISVGGLRGGHSGMDIALGRGNANKILTRLLSTGY
ECCCCCCEEEECCHHHCCCCCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHHCCC
TCHDMLLASIDGGSLRNAIPRESNATVAVPSLNAECFVEGLACLAADMRRELTTADPSLR
CHHHHHEEECCCCHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
IDVFPATLPDRVVENGVAGRLLKALYACPNGVMRMSDEMPGLVETSNNLAVVRSKNGLIC
EEEECCCCHHHHHHCCHHHHHHHHHHHCCCCCEECCCCCCCCEECCCCEEEEECCCCEEH
VECLLRSSVDSARDDLESMIRSCFELAGASTLFDGGYPGWKPNPESAMLQRMREIYWKMF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
GENPAIQAVHAGLECGIIGATYPELDMISLGPTIRYPHSPDEKVNIASVGAFMDFLVETL
CCCCHHHHHHCCCCEEEEECCCCCCEEEECCCEEECCCCCCCCEEHHHHHHHHHHHHHHH
SGVPCQ
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]