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The map label for this gene is macA [H]

Identifier: 194334025

GI number: 194334025

Start: 1315373

End: 1316542

Strand: Reverse

Name: macA [H]

Synonym: Paes_1210

Alternate gene names: 194334025

Gene position: 1316542-1315373 (Counterclockwise)

Preceding gene: 194334026

Following gene: 194334024

Centisome position: 52.39

GC content: 53.25

Gene sequence:

>1170_bases
ATGAAACTTTCTACAACACAGAAAATTGTTGCCGGGGTGACGGTTGTCGTCATCGCTATCCTGTTCATCCTGATGATGCC
GGCTCCATTGCCGGTTGATACCGAAATCGTTCGGCGAGGAGTATTGACGGTGAGGCTTGAAGGAGAGGGCAGGAGCAGGG
TAAAGGAGCGTTTTACGATATCATCGCCGGTGAATGGCAGGCTTGAGAGGATTCTCCTGGACGAAGGAGACTCTGTTACA
AGCAATGCCGTTGTAGCCCGCATCACCCCTCCATCGCTCAATACCCGTGAGTACACAAGGGCCGAGGCCGCAATGCGTTC
TTCGGAAGCTGCTCTGGGAGCTGCCGGTGCTCGAGAGCGACAGGTAAAGGTTGATCTTGAACAGGCCCGTCGGAAATATG
ATCGTTATACTGTTCTTTTTGAGCAGGGAGCGGTGTCGAAAGAGGAGTATGAAGAGGTCAAAGCCACCAGGGATATGCTT
GCCAAAGAGTACAGTGCTGCCACGATGACGACCCGTTCATCCCGGTTTGATGTTGATGCTGCTCGAGCAGTTGTTGATTC
TGCGCTTGAGGGCTCTTTTTTCGAAGTGCGTTCTCCCCGTGACGGTCTTGTTCTGAAGATACTTGAAAAGAGTGAGCGCA
TCATTGCGGCAGGAACGCCTCTGGTCGAAATTGGCGATGCCCATGATATCGAACTGGTGATAGATGTGCTTTCATCAGAT
GCGGTCAAGGTCGCTCCGGGTATGCAGGTCGTTATCGAGGAGTGGGGCGGTGGATCTGCTCTTCAGGGTCGTGTGCGCTT
TATCGAGCCTGCAGCGGTAACCAAAATTTCCTCTCTCGGGATTGAGGAGAAGCGGGTAAATATTATTATTGACCTCGATG
AGCCGGAGAGGAGGCTGGGAGATAATTACCGGGTACAGGCCGACATTGTTCTCTGGCGGGGAGACAATGTTTTGCAGGTT
CCTGTCAGCAGTCTTTTTCGTGGCGACGAGGACTGGGAGGTGTTTACGGTACGTCGCGGCAGGGCTATTGTGCAGCCGGT
CACTATCGGGCGGAGAGGGGCCTATGAAGCCGAAGTGATCGATGGGGTTCGGGAGGGGGATCTTGTTGTTGTCCATCCGA
CCAATGATCTTGAAGATGGCATGAGAGTCAAGACTCTCAAGGGTCGCTGA

Upstream 100 bases:

>100_bases
GATCTGATCGCTGTATTGAAAACAAGGGAGTAGACGACGTCGCAACGTCAGGTGGTTACACGAGTATGTCACAGGCTGCT
AAATTTGCTATACTGGTACT

Downstream 100 bases:

>100_bases
ATTCGATAGAAATTCAAATGCCAATTGAACACGCAATGAACACTATTTCGGAACGACATCGTGCCGATATTCTTATTATC
GGCGGCGGAGCAGCAGGTTT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKLSTTQKIVAGVTVVVIAILFILMMPAPLPVDTEIVRRGVLTVRLEGEGRSRVKERFTISSPVNGRLERILLDEGDSVT
SNAVVARITPPSLNTREYTRAEAAMRSSEAALGAAGARERQVKVDLEQARRKYDRYTVLFEQGAVSKEEYEEVKATRDML
AKEYSAATMTTRSSRFDVDAARAVVDSALEGSFFEVRSPRDGLVLKILEKSERIIAAGTPLVEIGDAHDIELVIDVLSSD
AVKVAPGMQVVIEEWGGGSALQGRVRFIEPAAVTKISSLGIEEKRVNIIIDLDEPERRLGDNYRVQADIVLWRGDNVLQV
PVSSLFRGDEDWEVFTVRRGRAIVQPVTIGRRGAYEAEVIDGVREGDLVVVHPTNDLEDGMRVKTLKGR

Sequences:

>Translated_389_residues
MKLSTTQKIVAGVTVVVIAILFILMMPAPLPVDTEIVRRGVLTVRLEGEGRSRVKERFTISSPVNGRLERILLDEGDSVT
SNAVVARITPPSLNTREYTRAEAAMRSSEAALGAAGARERQVKVDLEQARRKYDRYTVLFEQGAVSKEEYEEVKATRDML
AKEYSAATMTTRSSRFDVDAARAVVDSALEGSFFEVRSPRDGLVLKILEKSERIIAAGTPLVEIGDAHDIELVIDVLSSD
AVKVAPGMQVVIEEWGGGSALQGRVRFIEPAAVTKISSLGIEEKRVNIIIDLDEPERRLGDNYRVQADIVLWRGDNVLQV
PVSSLFRGDEDWEVFTVRRGRAIVQPVTIGRRGAYEAEVIDGVREGDLVVVHPTNDLEDGMRVKTLKGR
>Mature_389_residues
MKLSTTQKIVAGVTVVVIAILFILMMPAPLPVDTEIVRRGVLTVRLEGEGRSRVKERFTISSPVNGRLERILLDEGDSVT
SNAVVARITPPSLNTREYTRAEAAMRSSEAALGAAGARERQVKVDLEQARRKYDRYTVLFEQGAVSKEEYEEVKATRDML
AKEYSAATMTTRSSRFDVDAARAVVDSALEGSFFEVRSPRDGLVLKILEKSERIIAAGTPLVEIGDAHDIELVIDVLSSD
AVKVAPGMQVVIEEWGGGSALQGRVRFIEPAAVTKISSLGIEEKRVNIIIDLDEPERRLGDNYRVQADIVLWRGDNVLQV
PVSSLFRGDEDWEVFTVRRGRAIVQPVTIGRRGAYEAEVIDGVREGDLVVVHPTNDLEDGMRVKTLKGR

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=368, Percent_Identity=25.2717391304348, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42925; Mature: 42925

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSTTQKIVAGVTVVVIAILFILMMPAPLPVDTEIVRRGVLTVRLEGEGRSRVKERFTI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEEECCCCHHHHHHHEEE
SSPVNGRLERILLDEGDSVTSNAVVARITPPSLNTREYTRAEAAMRSSEAALGAAGARER
CCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCC
QVKVDLEQARRKYDRYTVLFEQGAVSKEEYEEVKATRDMLAKEYSAATMTTRSSRFDVDA
EEEECHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHH
ARAVVDSALEGSFFEVRSPRDGLVLKILEKSERIIAAGTPLVEIGDAHDIELVIDVLSSD
HHHHHHHHHCCCEEEECCCCCCEEEEEECCCCEEEEECCCEEEECCCCCHHHHHHHHCCC
AVKVAPGMQVVIEEWGGGSALQGRVRFIEPAAVTKISSLGIEEKRVNIIIDLDEPERRLG
CEEECCCCEEEEEECCCCCEECCEEEEECCHHHHHHHHCCCCCCEEEEEEECCCHHHHCC
DNYRVQADIVLWRGDNVLQVPVSSLFRGDEDWEVFTVRRGRAIVQPVTIGRRGAYEAEVI
CCEEEEEEEEEECCCCEEEECHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCHHHHH
DGVREGDLVVVHPTNDLEDGMRVKTLKGR
CCCCCCCEEEEECCCCCCCCCEEEEECCC
>Mature Secondary Structure
MKLSTTQKIVAGVTVVVIAILFILMMPAPLPVDTEIVRRGVLTVRLEGEGRSRVKERFTI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEEECCCCHHHHHHHEEE
SSPVNGRLERILLDEGDSVTSNAVVARITPPSLNTREYTRAEAAMRSSEAALGAAGARER
CCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCHHHCCCCCCCC
QVKVDLEQARRKYDRYTVLFEQGAVSKEEYEEVKATRDMLAKEYSAATMTTRSSRFDVDA
EEEECHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHH
ARAVVDSALEGSFFEVRSPRDGLVLKILEKSERIIAAGTPLVEIGDAHDIELVIDVLSSD
HHHHHHHHHCCCEEEECCCCCCEEEEEECCCCEEEEECCCEEEECCCCCHHHHHHHHCCC
AVKVAPGMQVVIEEWGGGSALQGRVRFIEPAAVTKISSLGIEEKRVNIIIDLDEPERRLG
CEEECCCCEEEEEECCCCCEECCEEEEECCHHHHHHHHCCCCCCEEEEEEECCCHHHHCC
DNYRVQADIVLWRGDNVLQVPVSSLFRGDEDWEVFTVRRGRAIVQPVTIGRRGAYEAEVI
CCEEEEEEEEEECCCCEEEECHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCHHHHH
DGVREGDLVVVHPTNDLEDGMRVKTLKGR
CCCCCCCEEEEECCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]