Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 194334015

GI number: 194334015

Start: 1305356

End: 1306162

Strand: Reverse

Name: trxA [H]

Synonym: Paes_1199

Alternate gene names: 194334015

Gene position: 1306162-1305356 (Counterclockwise)

Preceding gene: 194334024

Following gene: 194334014

Centisome position: 51.98

GC content: 49.44

Gene sequence:

>807_bases
ATGGATAACGAACAGTTTGATTTTAGCTGTGATGTTCTTGAGCAAAGTCATGACATTGCGGTTCTTGTTGATTTCTGGGC
GGAATGGTGTGGCCCATGCCGTATGCTTGCCCCTGTTCTTGAAAGCGTTGTCGCACGATTCAATGGCAAGGTTGTGCTTG
TCAAAATCAATACGGAAGAACATCCGGCAGTTGCGCAAAAATTCAATATCAGGAGCATTCCCAACGTCAAGCTGTTTATT
GACGGAAAGGTTGCCGATGAATTTACAGGAGCCCTTCCTGAAGCCCAGATTGAGCAGTGGCTACGCAAAGCATTGCCAAG
CCCCTATACCGGTGAGATCAGGCTTGCCAGGGGATTGGGCCAACAGGGCAAGCAACAGCAGGCGATCTCCATTCTTGAGG
AGGTTTTGCTCAACGAGCCGGACAATATCGAGGCAACGGCCTTGCTGGTTAGGCTTACGCTGTTTACAAAGCCGACTGAG
GCGGGCAAGCTCATCGGGAGGCTCGAAGGGGAGTCGGAATACGCTGAATTTGCCGGATCGGTCAGGGAGCTTGTTTCGAT
GCTCGTTAAAAAGATTGATGAACTTCCCGAGGACCATGTTCGGGATCGATATGCAGCAGCTCTTCTTCAATTGCAGGCGC
AGGATTTTAATGCCGCTCTGGACGGATTTATCAAGGTAATAAAGGAGAACAGGTACTATGATGATGATGGTTCCCGAAAA
GCCTGTATTGCGATTTTCAAGTACCTGGGCGAGGATCACACGGTAACCTTGAAGCATCGCAGAGTTTTTGATCGGGCGCT
CTATTGA

Upstream 100 bases:

>100_bases
GCAGTTTTATTCCAGCCCCCGCGGTTGAAAAGGCCGGTACCTTTCAGTCTCATTGACGGGCGTCCGGCGAAGTATTGTTA
ACGATTATTTATTGTGTTTC

Downstream 100 bases:

>100_bases
ACTGCATTCGATTGTTTGTCGTATTGCTGCGGTTAGCTTTGCGGGGGAATCGTTCGTGATACGGGCTTGAGATACTACTG
GAGATTGATCATGCAAGAGA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MDNEQFDFSCDVLEQSHDIAVLVDFWAEWCGPCRMLAPVLESVVARFNGKVVLVKINTEEHPAVAQKFNIRSIPNVKLFI
DGKVADEFTGALPEAQIEQWLRKALPSPYTGEIRLARGLGQQGKQQQAISILEEVLLNEPDNIEATALLVRLTLFTKPTE
AGKLIGRLEGESEYAEFAGSVRELVSMLVKKIDELPEDHVRDRYAAALLQLQAQDFNAALDGFIKVIKENRYYDDDGSRK
ACIAIFKYLGEDHTVTLKHRRVFDRALY

Sequences:

>Translated_268_residues
MDNEQFDFSCDVLEQSHDIAVLVDFWAEWCGPCRMLAPVLESVVARFNGKVVLVKINTEEHPAVAQKFNIRSIPNVKLFI
DGKVADEFTGALPEAQIEQWLRKALPSPYTGEIRLARGLGQQGKQQQAISILEEVLLNEPDNIEATALLVRLTLFTKPTE
AGKLIGRLEGESEYAEFAGSVRELVSMLVKKIDELPEDHVRDRYAAALLQLQAQDFNAALDGFIKVIKENRYYDDDGSRK
ACIAIFKYLGEDHTVTLKHRRVFDRALY
>Mature_268_residues
MDNEQFDFSCDVLEQSHDIAVLVDFWAEWCGPCRMLAPVLESVVARFNGKVVLVKINTEEHPAVAQKFNIRSIPNVKLFI
DGKVADEFTGALPEAQIEQWLRKALPSPYTGEIRLARGLGQQGKQQQAISILEEVLLNEPDNIEATALLVRLTLFTKPTE
AGKLIGRLEGESEYAEFAGSVRELVSMLVKKIDELPEDHVRDRYAAALLQLQAQDFNAALDGFIKVIKENRYYDDDGSRK
ACIAIFKYLGEDHTVTLKHRRVFDRALY

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG3118

COG function: function code O; Thioredoxin domain-containing protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=90, Percent_Identity=38.8888888888889, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI87082331, Length=98, Percent_Identity=44.8979591836735, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1788936, Length=88, Percent_Identity=46.5909090909091, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87081747, Length=275, Percent_Identity=29.4545454545455, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI212646193, Length=101, Percent_Identity=36.6336633663366, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=85, Percent_Identity=34.1176470588235, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573567, Length=91, Percent_Identity=39.5604395604396, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639826, Length=76, Percent_Identity=32.8947368421053, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17648013, Length=71, Percent_Identity=38.0281690140845, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583090, Length=71, Percent_Identity=38.0281690140845, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 30280; Mature: 30280

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNEQFDFSCDVLEQSHDIAVLVDFWAEWCGPCRMLAPVLESVVARFNGKVVLVKINTEE
CCCCCCCCCHHHHCCCCCEEHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEEECCCC
HPAVAQKFNIRSIPNVKLFIDGKVADEFTGALPEAQIEQWLRKALPSPYTGEIRLARGLG
CCHHHHHCCCCCCCCEEEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCC
QQGKQQQAISILEEVLLNEPDNIEATALLVRLTLFTKPTEAGKLIGRLEGESEYAEFAGS
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHH
VRELVSMLVKKIDELPEDHVRDRYAAALLQLQAQDFNAALDGFIKVIKENRYYDDDGSRK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
ACIAIFKYLGEDHTVTLKHRRVFDRALY
HHHHHHHHHCCCCEEEHHHHHHHHHHCC
>Mature Secondary Structure
MDNEQFDFSCDVLEQSHDIAVLVDFWAEWCGPCRMLAPVLESVVARFNGKVVLVKINTEE
CCCCCCCCCHHHHCCCCCEEHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEEEEEECCCC
HPAVAQKFNIRSIPNVKLFIDGKVADEFTGALPEAQIEQWLRKALPSPYTGEIRLARGLG
CCHHHHHCCCCCCCCEEEEECCCHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCC
QQGKQQQAISILEEVLLNEPDNIEATALLVRLTLFTKPTEAGKLIGRLEGESEYAEFAGS
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHH
VRELVSMLVKKIDELPEDHVRDRYAAALLQLQAQDFNAALDGFIKVIKENRYYDDDGSRK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
ACIAIFKYLGEDHTVTLKHRRVFDRALY
HHHHHHHHHCCCCEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]