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The map label for this gene is pyrC [H]

Identifier: 194333864

GI number: 194333864

Start: 1140380

End: 1141702

Strand: Reverse

Name: pyrC [H]

Synonym: Paes_1038

Alternate gene names: 194333864

Gene position: 1141702-1140380 (Counterclockwise)

Preceding gene: 194333865

Following gene: 194333863

Centisome position: 45.43

GC content: 52.23

Gene sequence:

>1323_bases
ATGAGCATCATTTTTCATCAGGCGAGAATCATCAATCCCGCCCAGAACCTTGATACGACAGGATCGATCCGTATTTCCGA
TTCAGGCCGGATTGAAACCATCGTTACAGGAAACGATCCCCTGCCCCCTCAGGATACCGACCGCGTCATTGATATGAACG
GCAAACTTCTCGTTCCGGGCCTGTTCGATATGCACTGCCACTTCAGAGAGCCTGGACAGGAATACAAAGAAACACTCGAA
ACAGGATCAAGAGCCGCTGTCGCAGGAGGATTTACGGGTGTGGCTCTTATGCCGAATACCAAACCCGTCATCGACAACCC
GCAGGGAGTCGCCTATATCCGTCAGACGGCCATGGAGCTGCCGATCGACATCGAAGTCATCTCGGCGATGACCAAAGAAA
GCAGGGGGGAAACTCTGGCCCCTTTCGGAAAACTCTTTGCAAGCGGCGTCAAAGCCGTATCGGATGACGGAACCGCTATT
CAGAACAGCCAGATCATGCGCCTGGCGTTTGAGTACGCCGCCAACTTCAACTTACTCTTCATCCAGCACTGTGAAGACAC
CAGCCTTACCTCGGGCGGGGTCATGAATGAAGGTGAATATTCTGCGATGATGGGTCTTAAAGGAATTCCCGACGTCGCAG
AAGCAATCACGCTCAGCCGTGACCTGCTGCTTATCGACTACCTCCGAAAACATAAACTCTCACCGCCTCTGACTGCACCA
CGTTATCATGTCGCCCATATCAGCACAAGAAGCGCCCTGGATCTTGTACGCAAAGCAAGGAAAGAAGGCATGGCAATAAC
CTGCGAAGTCACGCCGCATCATTTCACCCTCACCGAAGAGGCCCTTTTCAAGGCAGAGCACAAAGGCAACTTCATCATGA
AACCGCCACTCTGCAGCCTTGATAACCACGCAGCAATCCTTGAAGCGATTGTCGACGGCACGATCGACGCCATTGCAACC
GATCACGCGCCACATGCCGAACATGAAAAGCAATGCCCTCCCGATCAGGCATCATTCGGCATCATCGGTCTGGAAACAGC
GGTGGGACTGACCTTCAGCGAACTGGTCCACACAGGACGCATATCCGTCAGCCGGGCTATAGAGATGCTCTCAGTCAACC
CAAGACGGATTATGGATATTGAACCTGTGCTTTTCGAACCCCAGAGAGCGGCTAACTTTACGCTGATAGATCCCGATGCC
ACCTGGACCTGGAAGAGCGAGCATATCAAGTCGAAAGCAAAAAACTCTCCGTTTATCGGCCGAACAATGAAAGGCAAAGC
GATCGGTATCTGTCATAAAGGAAAACTGCTTGGACTTGACTGA

Upstream 100 bases:

>100_bases
CAGCCCTGACGCATTTCGAAGCAACAATCCATGAACCCGGCACATAAGAGCCTGCCGTCATCCAAACAAAACTTTTCCGT
TAACACTACAGCGAGCAAGC

Downstream 100 bases:

>100_bases
TCAGAAAGTCGCCGATCGCGAAAAGAAAAAACATTGTCATTTACGACTGTTTTTATTACATTGGTTTTCTATGTATTTTA
CCGGATTATTACCGGCAGAA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSIIFHQARIINPAQNLDTTGSIRISDSGRIETIVTGNDPLPPQDTDRVIDMNGKLLVPGLFDMHCHFREPGQEYKETLE
TGSRAAVAGGFTGVALMPNTKPVIDNPQGVAYIRQTAMELPIDIEVISAMTKESRGETLAPFGKLFASGVKAVSDDGTAI
QNSQIMRLAFEYAANFNLLFIQHCEDTSLTSGGVMNEGEYSAMMGLKGIPDVAEAITLSRDLLLIDYLRKHKLSPPLTAP
RYHVAHISTRSALDLVRKARKEGMAITCEVTPHHFTLTEEALFKAEHKGNFIMKPPLCSLDNHAAILEAIVDGTIDAIAT
DHAPHAEHEKQCPPDQASFGIIGLETAVGLTFSELVHTGRISVSRAIEMLSVNPRRIMDIEPVLFEPQRAANFTLIDPDA
TWTWKSEHIKSKAKNSPFIGRTMKGKAIGICHKGKLLGLD

Sequences:

>Translated_440_residues
MSIIFHQARIINPAQNLDTTGSIRISDSGRIETIVTGNDPLPPQDTDRVIDMNGKLLVPGLFDMHCHFREPGQEYKETLE
TGSRAAVAGGFTGVALMPNTKPVIDNPQGVAYIRQTAMELPIDIEVISAMTKESRGETLAPFGKLFASGVKAVSDDGTAI
QNSQIMRLAFEYAANFNLLFIQHCEDTSLTSGGVMNEGEYSAMMGLKGIPDVAEAITLSRDLLLIDYLRKHKLSPPLTAP
RYHVAHISTRSALDLVRKARKEGMAITCEVTPHHFTLTEEALFKAEHKGNFIMKPPLCSLDNHAAILEAIVDGTIDAIAT
DHAPHAEHEKQCPPDQASFGIIGLETAVGLTFSELVHTGRISVSRAIEMLSVNPRRIMDIEPVLFEPQRAANFTLIDPDA
TWTWKSEHIKSKAKNSPFIGRTMKGKAIGICHKGKLLGLD
>Mature_439_residues
SIIFHQARIINPAQNLDTTGSIRISDSGRIETIVTGNDPLPPQDTDRVIDMNGKLLVPGLFDMHCHFREPGQEYKETLET
GSRAAVAGGFTGVALMPNTKPVIDNPQGVAYIRQTAMELPIDIEVISAMTKESRGETLAPFGKLFASGVKAVSDDGTAIQ
NSQIMRLAFEYAANFNLLFIQHCEDTSLTSGGVMNEGEYSAMMGLKGIPDVAEAITLSRDLLLIDYLRKHKLSPPLTAPR
YHVAHISTRSALDLVRKARKEGMAITCEVTPHHFTLTEEALFKAEHKGNFIMKPPLCSLDNHAAILEAIVDGTIDAIATD
HAPHAEHEKQCPPDQASFGIIGLETAVGLTFSELVHTGRISVSRAIEMLSVNPRRIMDIEPVLFEPQRAANFTLIDPDAT
WTWKSEHIKSKAKNSPFIGRTMKGKAIGICHKGKLLGLD

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=405, Percent_Identity=28.1481481481481, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1786722, Length=415, Percent_Identity=26.0240963855422, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI87082175, Length=442, Percent_Identity=25.3393665158371, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI193204318, Length=389, Percent_Identity=26.4781491002571, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322218, Length=399, Percent_Identity=23.3082706766917, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24642586, Length=200, Percent_Identity=32, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48105; Mature: 47974

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIIFHQARIINPAQNLDTTGSIRISDSGRIETIVTGNDPLPPQDTDRVIDMNGKLLVPG
CCEEEECCEECCHHHCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCEEECCCCEEECC
LFDMHCHFREPGQEYKETLETGSRAAVAGGFTGVALMPNTKPVIDNPQGVAYIRQTAMEL
CEECCCCCCCCCHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHCC
PIDIEVISAMTKESRGETLAPFGKLFASGVKAVSDDGTAIQNSQIMRLAFEYAANFNLLF
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCEECCCHHHHHHHHHHCCCCEEE
IQHCEDTSLTSGGVMNEGEYSAMMGLKGIPDVAEAITLSRDLLLIDYLRKHKLSPPLTAP
EEECCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCCCCCC
RYHVAHISTRSALDLVRKARKEGMAITCEVTPHHFTLTEEALFKAEHKGNFIMKPPLCSL
CEEEEEECHHHHHHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHCCCEEECCCCCCC
DNHAAILEAIVDGTIDAIATDHAPHAEHEKQCPPDQASFGIIGLETAVGLTFSELVHTGR
CCHHHHHHHHHHCCHHHHCCCCCCCCCHHCCCCCCCCCCCEEEEHHHHCCCHHHHHHHCC
ISVSRAIEMLSVNPRRIMDIEPVLFEPQRAANFTLIDPDATWTWKSEHIKSKAKNSPFIG
CCHHHHHHHHCCCCHHEEECCCEEECCCCCCCEEEECCCCCEEECHHHHHHHHCCCCCCC
RTMKGKAIGICHKGKLLGLD
EECCCCEEEEEECCEEECCC
>Mature Secondary Structure 
SIIFHQARIINPAQNLDTTGSIRISDSGRIETIVTGNDPLPPQDTDRVIDMNGKLLVPG
CEEEECCEECCHHHCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCEEECCCCEEECC
LFDMHCHFREPGQEYKETLETGSRAAVAGGFTGVALMPNTKPVIDNPQGVAYIRQTAMEL
CEECCCCCCCCCHHHHHHHHCCCCEEEECCCCEEEECCCCCCCCCCCCCHHHHHHHHHCC
PIDIEVISAMTKESRGETLAPFGKLFASGVKAVSDDGTAIQNSQIMRLAFEYAANFNLLF
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCEECCCHHHHHHHHHHCCCCEEE
IQHCEDTSLTSGGVMNEGEYSAMMGLKGIPDVAEAITLSRDLLLIDYLRKHKLSPPLTAP
EEECCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCCCCCC
RYHVAHISTRSALDLVRKARKEGMAITCEVTPHHFTLTEEALFKAEHKGNFIMKPPLCSL
CEEEEEECHHHHHHHHHHHHHCCCEEEEEECCCEEEECHHHHHHHHHCCCEEECCCCCCC
DNHAAILEAIVDGTIDAIATDHAPHAEHEKQCPPDQASFGIIGLETAVGLTFSELVHTGR
CCHHHHHHHHHHCCHHHHCCCCCCCCCHHCCCCCCCCCCCEEEEHHHHCCCHHHHHHHCC
ISVSRAIEMLSVNPRRIMDIEPVLFEPQRAANFTLIDPDATWTWKSEHIKSKAKNSPFIG
CCHHHHHHHHCCCCHHEEECCCEEECCCCCCCEEEECCCCCEEECHHHHHHHHCCCCCCC
RTMKGKAIGICHKGKLLGLD
EECCCCEEEEEECCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]