Click here to switch to the map view.

The map label for this gene is purL [H]

Identifier: 194333822

GI number: 194333822

Start: 1094914

End: 1097190

Strand: Reverse

Name: purL [H]

Synonym: Paes_0996

Alternate gene names: 194333822

Gene position: 1097190-1094914 (Counterclockwise)

Preceding gene: 194333823

Following gene: 194333821

Centisome position: 43.66

GC content: 53.14

Gene sequence:

>2277_bases
ATGACACAGACAGAACCAGAAGTCAATCTTAATCTTGCAAGAGAACACGGTCTGAATGAAGACGAGTACCGCACGATAGT
CGACGTTCTCCAAAGAACGCCCACCTTTACGGAATTAGGTATTTATTCAGTCATGTGGTCCGAGCACTGCAGCTACAAAA
ACTCAATCGCTGTCCTGAAAACCCTGCCAAGAGAAGGGGGACGCCTCCTGACAAGCGCAGGAGAAGAAAACGCAGGACTT
GTCGATATCGGAGACAATCTGGCCGTCGCCTTCAAAATTGAATCGCACAATCACCCGTCCGCCGTCGAACCCTATCAGGG
AGCGGCAACCGGTGTTGGCGGAATTCATCGCGATATTTTCACCATGGGGGCGCGCCCTGTCGCTGCACTCAACTCACTTC
GCTTCGGATCCCCCAAAGACCCCAGAGTACGCTACCTCGTCGACGGCGTCGTCAGGGGAATCGGCGATTACGGCAACTCA
TTCGGCGTTCCTACCGTCGGCGGAGAAATCTATTTCGAAGATGCCTATACCGGCAACCCGCTCGTCAATGCCATGTCGGT
GGGCCTGGTCGAACACCACAAAACCGTCAGTGCAACCGCTGAAGGGCAAGGCAATCCGGTCCTGATTGTCGGATCAGCCA
CCGGGCGGGACGGCATTCATGGAGCGACATTCGCCTCGGAAGATCTGAGTGAGGCATCTGAAGACAAACGGCCGAGTGTT
CAGGTCGGTGACCCCTTCGCAGAAAAACTGCTGCTCGAAGCAACATTGGAAGCCATTGCATCCGGCTTCGTTGCCGGTTT
ACAGGATATGGGCGCAGCCGGTATCACCAGTTCGACATCGGAAATGAGCGCAAGAGGGATCGACAAACACGGGCACGGAG
GAATCGACATCAATCTTGACCATGTTCCCACCCGTGAAGATGCCATGTCGGCATATGAAATCATGCTTTCTGAATCCCAG
GAACGCATGCTGCTGGTCGCAGAGAAAGGTCATGAAGAGGATATCATCGATATCTATCGCAAGTGGGATATTCACGCCGT
TGTTATCGGCAGCGTGACCAACGACAACATGCTGCGTATCCGTCATAGAGGCAAAGTTGTCGCTGAAATACCGGCAACCT
CGCTCGTGCTTGGAGGAGGAGCTCCGGTCTATATCCGTGAAGCGACCGAAAAGAAACCCGAAACACCTGATGCACAGATC
GTTGCAGACAGTGAACTTGATCTGCATGAAACCACGATACAGCTCCTCTCGAGGCCGAATATAGCCAGCAAGCAATGGGT
CTACCAGCAGTATGATTCCATGGTCCAGACCAATACCGTCACCGCGACAGGAACGTCCGACGCAGCGGTCATCCGCATAA
AAGGCTCCAACAAGGGTCTGGCAATGCAGACCGACTGCAATGCCAGATACGTCTATCTCAATCCCCGTGAAGGAGGCATG
ATTGCCGTAGCTGAATGCGCCCGCAACATAGCCTGCTCCGGAGCACGGCCGCTGGCAATCACCAACTGCCTGAACTTCGG
CAATCCATACAAGCCTGAAGTATACTATCAGTTCAAAACATCGGTCGAAGGCATGGGTGCAGCCTGCCGGGCGTTCAACA
CACCGGTCACAGGAGGAAACGTCAGTTTCTACAATGAATCATCCCTTACCGGCACAGCGATTTACCCGACGCCCGTCATC
GGCATGATCGGTCTTCTCGACAATATCGACAACCTGACCGGCTCGACATTCCAGAACGCCGGCGATGCGATTCTTCTGCT
TGGAGACCCCAATCTCACCCTCGATGGATCAGAATATCTTGTCATGCAGTATGCAACGCCGGGCAAAACGACTCCAACAT
TCGATCTTGAACTTGAACAACGACTGCAGGAACTGCTGATTGAACTTTCCGCAGAAGGCCTTCTCAGCTCAGCTCATGAT
ATTTCAGACGGAGGAATGATTACTGCTCTTGCTGAAAAAGCCATCATGAAAAAAGAGAGCCCGATGGGCTTTGCCGTTAA
CCTGGAAACAAGCCAGCGACATGAGAGCTTCATGCAGGAACTGTTCTACTCAGAAGCCCAGGGACGGGTACTGCTGAGTC
TGCCCGCAGAAAATGCCGCCAGAGTAATCGACATGGCAATGCACCACCAGATACCGGCAAAAGCCATCGGGAAAGTCCAG
GAATCGGGAGCATCAGTTGAGGTCAACGGCAAGCCCATCGTCAGTTTTTCAACTGAAGAACTCATCGCGGCGTACTATCC
TGCCCTGGAAAACGCACTGCACCTTGACGAACTTTGA

Upstream 100 bases:

>100_bases
GAAAAAAATATAAAAACTGCTGCGGCAGGTAAACGACAATCTTTCAGGGGATCCCAAAAAAAGATCCCCCTCAATCAGCT
GAACAGTCAAAGCCCAGAAC

Downstream 100 bases:

>100_bases
TTGCAATAAGCACGACAGCCATGGATGCGATACTCACAGCCGAAGAAATGGCCCTGGCAGACCGGGCCGCGATTGCAACG
CTGCGTACCAGTGAAACGCG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 758; Mature: 757

Protein sequence:

>758_residues
MTQTEPEVNLNLAREHGLNEDEYRTIVDVLQRTPTFTELGIYSVMWSEHCSYKNSIAVLKTLPREGGRLLTSAGEENAGL
VDIGDNLAVAFKIESHNHPSAVEPYQGAATGVGGIHRDIFTMGARPVAALNSLRFGSPKDPRVRYLVDGVVRGIGDYGNS
FGVPTVGGEIYFEDAYTGNPLVNAMSVGLVEHHKTVSATAEGQGNPVLIVGSATGRDGIHGATFASEDLSEASEDKRPSV
QVGDPFAEKLLLEATLEAIASGFVAGLQDMGAAGITSSTSEMSARGIDKHGHGGIDINLDHVPTREDAMSAYEIMLSESQ
ERMLLVAEKGHEEDIIDIYRKWDIHAVVIGSVTNDNMLRIRHRGKVVAEIPATSLVLGGGAPVYIREATEKKPETPDAQI
VADSELDLHETTIQLLSRPNIASKQWVYQQYDSMVQTNTVTATGTSDAAVIRIKGSNKGLAMQTDCNARYVYLNPREGGM
IAVAECARNIACSGARPLAITNCLNFGNPYKPEVYYQFKTSVEGMGAACRAFNTPVTGGNVSFYNESSLTGTAIYPTPVI
GMIGLLDNIDNLTGSTFQNAGDAILLLGDPNLTLDGSEYLVMQYATPGKTTPTFDLELEQRLQELLIELSAEGLLSSAHD
ISDGGMITALAEKAIMKKESPMGFAVNLETSQRHESFMQELFYSEAQGRVLLSLPAENAARVIDMAMHHQIPAKAIGKVQ
ESGASVEVNGKPIVSFSTEELIAAYYPALENALHLDEL

Sequences:

>Translated_758_residues
MTQTEPEVNLNLAREHGLNEDEYRTIVDVLQRTPTFTELGIYSVMWSEHCSYKNSIAVLKTLPREGGRLLTSAGEENAGL
VDIGDNLAVAFKIESHNHPSAVEPYQGAATGVGGIHRDIFTMGARPVAALNSLRFGSPKDPRVRYLVDGVVRGIGDYGNS
FGVPTVGGEIYFEDAYTGNPLVNAMSVGLVEHHKTVSATAEGQGNPVLIVGSATGRDGIHGATFASEDLSEASEDKRPSV
QVGDPFAEKLLLEATLEAIASGFVAGLQDMGAAGITSSTSEMSARGIDKHGHGGIDINLDHVPTREDAMSAYEIMLSESQ
ERMLLVAEKGHEEDIIDIYRKWDIHAVVIGSVTNDNMLRIRHRGKVVAEIPATSLVLGGGAPVYIREATEKKPETPDAQI
VADSELDLHETTIQLLSRPNIASKQWVYQQYDSMVQTNTVTATGTSDAAVIRIKGSNKGLAMQTDCNARYVYLNPREGGM
IAVAECARNIACSGARPLAITNCLNFGNPYKPEVYYQFKTSVEGMGAACRAFNTPVTGGNVSFYNESSLTGTAIYPTPVI
GMIGLLDNIDNLTGSTFQNAGDAILLLGDPNLTLDGSEYLVMQYATPGKTTPTFDLELEQRLQELLIELSAEGLLSSAHD
ISDGGMITALAEKAIMKKESPMGFAVNLETSQRHESFMQELFYSEAQGRVLLSLPAENAARVIDMAMHHQIPAKAIGKVQ
ESGASVEVNGKPIVSFSTEELIAAYYPALENALHLDEL
>Mature_757_residues
TQTEPEVNLNLAREHGLNEDEYRTIVDVLQRTPTFTELGIYSVMWSEHCSYKNSIAVLKTLPREGGRLLTSAGEENAGLV
DIGDNLAVAFKIESHNHPSAVEPYQGAATGVGGIHRDIFTMGARPVAALNSLRFGSPKDPRVRYLVDGVVRGIGDYGNSF
GVPTVGGEIYFEDAYTGNPLVNAMSVGLVEHHKTVSATAEGQGNPVLIVGSATGRDGIHGATFASEDLSEASEDKRPSVQ
VGDPFAEKLLLEATLEAIASGFVAGLQDMGAAGITSSTSEMSARGIDKHGHGGIDINLDHVPTREDAMSAYEIMLSESQE
RMLLVAEKGHEEDIIDIYRKWDIHAVVIGSVTNDNMLRIRHRGKVVAEIPATSLVLGGGAPVYIREATEKKPETPDAQIV
ADSELDLHETTIQLLSRPNIASKQWVYQQYDSMVQTNTVTATGTSDAAVIRIKGSNKGLAMQTDCNARYVYLNPREGGMI
AVAECARNIACSGARPLAITNCLNFGNPYKPEVYYQFKTSVEGMGAACRAFNTPVTGGNVSFYNESSLTGTAIYPTPVIG
MIGLLDNIDNLTGSTFQNAGDAILLLGDPNLTLDGSEYLVMQYATPGKTTPTFDLELEQRLQELLIELSAEGLLSSAHDI
SDGGMITALAEKAIMKKESPMGFAVNLETSQRHESFMQELFYSEAQGRVLLSLPAENAARVIDMAMHHQIPAKAIGKVQE
SGASVEVNGKPIVSFSTEELIAAYYPALENALHLDEL

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=746, Percent_Identity=23.8605898123324, Blast_Score=91, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24582111, Length=644, Percent_Identity=23.2919254658385, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24582109, Length=644, Percent_Identity=23.2919254658385, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137292, Length=644, Percent_Identity=23.2919254658385, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 81542; Mature: 81411

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTEPEVNLNLAREHGLNEDEYRTIVDVLQRTPTFTELGIYSVMWSEHCSYKNSIAVLK
CCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEE
TLPREGGRLLTSAGEENAGLVDIGDNLAVAFKIESHNHPSAVEPYQGAATGVGGIHRDIF
CCCCCCCEEEECCCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
TMGARPVAALNSLRFGSPKDPRVRYLVDGVVRGIGDYGNSFGVPTVGGEIYFEDAYTGNP
HCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCC
LVNAMSVGLVEHHKTVSATAEGQGNPVLIVGSATGRDGIHGATFASEDLSEASEDKRPSV
HHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCE
QVGDPFAEKLLLEATLEAIASGFVAGLQDMGAAGITSSTSEMSARGIDKHGHGGIDINLD
EECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCEEEEEC
HVPTREDAMSAYEIMLSESQERMLLVAEKGHEEDIIDIYRKWDIHAVVIGSVTNDNMLRI
CCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCEEEEEEEECCCCCEEEE
RHRGKVVAEIPATSLVLGGGAPVYIREATEKKPETPDAQIVADSELDLHETTIQLLSRPN
EECCCEEEECCCEEEEECCCCCEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCC
IASKQWVYQQYDSMVQTNTVTATGTSDAAVIRIKGSNKGLAMQTDCNARYVYLNPREGGM
CCHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEECCCCCEEEEECCCEEEEEEECCCCCE
IAVAECARNIACSGARPLAITNCLNFGNPYKPEVYYQFKTSVEGMGAACRAFNTPVTGGN
EEHHHHHHHHCCCCCCCEEEEHHHHCCCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCC
VSFYNESSLTGTAIYPTPVIGMIGLLDNIDNLTGSTFQNAGDAILLLGDPNLTLDGSEYL
EEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEECCCCEE
VMQYATPGKTTPTFDLELEQRLQELLIELSAEGLLSSAHDISDGGMITALAEKAIMKKES
EEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCC
PMGFAVNLETSQRHESFMQELFYSEAQGRVLLSLPAENAARVIDMAMHHQIPAKAIGKVQ
CCCEEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHH
ESGASVEVNGKPIVSFSTEELIAAYYPALENALHLDEL
HCCCEEEECCEEEEEECHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TQTEPEVNLNLAREHGLNEDEYRTIVDVLQRTPTFTELGIYSVMWSEHCSYKNSIAVLK
CCCCCCCEEEEHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEE
TLPREGGRLLTSAGEENAGLVDIGDNLAVAFKIESHNHPSAVEPYQGAATGVGGIHRDIF
CCCCCCCEEEECCCCCCCCEEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHH
TMGARPVAALNSLRFGSPKDPRVRYLVDGVVRGIGDYGNSFGVPTVGGEIYFEDAYTGNP
HCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCC
LVNAMSVGLVEHHKTVSATAEGQGNPVLIVGSATGRDGIHGATFASEDLSEASEDKRPSV
HHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCE
QVGDPFAEKLLLEATLEAIASGFVAGLQDMGAAGITSSTSEMSARGIDKHGHGGIDINLD
EECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCEEEEEC
HVPTREDAMSAYEIMLSESQERMLLVAEKGHEEDIIDIYRKWDIHAVVIGSVTNDNMLRI
CCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCEEEEEEEECCCCCEEEE
RHRGKVVAEIPATSLVLGGGAPVYIREATEKKPETPDAQIVADSELDLHETTIQLLSRPN
EECCCEEEECCCEEEEECCCCCEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCC
IASKQWVYQQYDSMVQTNTVTATGTSDAAVIRIKGSNKGLAMQTDCNARYVYLNPREGGM
CCHHHHHHHHHHHHHHCCEEEEECCCCEEEEEEECCCCCEEEEECCCEEEEEEECCCCCE
IAVAECARNIACSGARPLAITNCLNFGNPYKPEVYYQFKTSVEGMGAACRAFNTPVTGGN
EEHHHHHHHHCCCCCCCEEEEHHHHCCCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCC
VSFYNESSLTGTAIYPTPVIGMIGLLDNIDNLTGSTFQNAGDAILLLGDPNLTLDGSEYL
EEEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCEEECCCCEE
VMQYATPGKTTPTFDLELEQRLQELLIELSAEGLLSSAHDISDGGMITALAEKAIMKKES
EEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHCCC
PMGFAVNLETSQRHESFMQELFYSEAQGRVLLSLPAENAARVIDMAMHHQIPAKAIGKVQ
CCCEEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHH
ESGASVEVNGKPIVSFSTEELIAAYYPALENALHLDEL
HCCCEEEECCEEEEEECHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]