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The map label for this gene is atoC [H]

Identifier: 194333755

GI number: 194333755

Start: 1019146

End: 1020600

Strand: Reverse

Name: atoC [H]

Synonym: Paes_0925

Alternate gene names: 194333755

Gene position: 1020600-1019146 (Counterclockwise)

Preceding gene: 194333757

Following gene: 194333754

Centisome position: 40.61

GC content: 48.87

Gene sequence:

>1455_bases
ATGAACAGCAAACGAGCAAATGCAACCGTCCTGATAGCCGATGACAGTGCAGTTATGCGCACGCTCATCAGTCATGTCAT
CAAGCGTCTCGGTTATAAACATATTACAGCCGATGACGGCAACGCATGCATCCGGCTCCTGCAGGACAATAAAGTGGACC
TGCTTCTGCTCGATATCAATATGCCGGGGAAAAACGGTATCGATGTACTTGCGTACATGAAAGAGAACGGCCTTGAGATT
CCGGTTATCATGATTACCGCATCCGATGATATCAGTCAGGCTGTGCAGTGCATCAAGATGGGAGCCTATGAATACCTCAC
CAAACCTGTTGACAACGACCGGCTCGAAATCACGGCCAAAAACGCCCTTTCTGAACAAAGCCTGAAAAAAAAGGTGGAGC
TTCTTGAAAAAGAACTTCTGCAAAAAGATATTTTCAAGCGTATCTACGGTGAAAGCCAAGCCATCAAAGAGTGTATCGGA
CAGGCCACGCAGGTCATGGAAACCGATGTCAACGTCCTGATCAACGGAGAAAGCGGAACCGGAAAAGAGCTTTTTGCTCA
GGCGATCCACAACGGAAGCAAACGCAAAAACGGCCCCTTTGTGACAATCAACTGCGCAGCAATAACCAATGAACTTGCCG
ACAGTCTTCTGTTCGGGCACGTCAAGGGCTCTTTTACGGGCGCAAACAGCGATCATACAGGATTTTTCGAACAGGCTGAC
GGTGGCACGATTTTTCTGGATGAAATCGGAGACCTGAACATCGAGATTCAGGCAAAAGTACTTCGAGTGCTCCAGGAACA
CATCGTCAGACGTGTGGGAGAAAAAAAAGAACGCCCGGTGGACTTCCGCCTCATTTCTGCCACGCACAAGGATTTTTCCA
ATGCCATAGAAACAGGTTCCTTCAGGGCAGACCTCTACTACCGTCTTGAAGAGTATCCTCTCTATATACCGCCATTGAGA
GAACGAGGTGATGATATTTCGCTGCTCGCCAAACATTTTCTGGAAAGTTTCTGCATCGCAAACAACATCGAACCGCTCAC
GTTCAAACCTCTCGTCCTCGATCAGCTGAGCAGATATGACTGGCCGGGAAATATCAGAGAACTCCAGAATATCGTCAGAC
GATCTGCTATCAATCGCACTGGGAACGAAATCAATGCCCTTCCCGGATTCTTATCGGCTGATCACAAGCGCCCGAAAGAT
GCGCTTCCGGAACCCGAAGCTTCTCATCCGGAACCTGTAACGGATACAGAAATCAACCATCCCATTTCTGCACCGGTGGA
AACCTCCCTCAAGGATGCTGAACAGCAGGCTATAGCAAGGGCCTATGAGGCATGCAGAGGCAACCAGACCAAAACCGCCA
GAATTCTCGGCATAAGCCGCTCCTCGCTCTACAGAAAGCTGAAAAAATACGGTATGGAAAAATCCATCACCCTCTCTCTC
AACAAAACGCCCTGA

Upstream 100 bases:

>100_bases
CTGGATCCGCAGCCCCCTGATCTGTGGCAACTGATTCATTTGGTTGAGGATGCGAGGAATTCTATATTGAAAAAAAAGTG
ATCTCAACAGGCCCCCTCTG

Downstream 100 bases:

>100_bases
TATCGCTTATTCGTTTATGAAACACCGTGGAGCAAGCATACTCTTCTTCAACGAAAGTCGGCAGGTGCTGCTTCTTCTGC
GCGACGATATACCATCTATC

Product: Fis family two component sigma54 specific transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MNSKRANATVLIADDSAVMRTLISHVIKRLGYKHITADDGNACIRLLQDNKVDLLLLDINMPGKNGIDVLAYMKENGLEI
PVIMITASDDISQAVQCIKMGAYEYLTKPVDNDRLEITAKNALSEQSLKKKVELLEKELLQKDIFKRIYGESQAIKECIG
QATQVMETDVNVLINGESGTGKELFAQAIHNGSKRKNGPFVTINCAAITNELADSLLFGHVKGSFTGANSDHTGFFEQAD
GGTIFLDEIGDLNIEIQAKVLRVLQEHIVRRVGEKKERPVDFRLISATHKDFSNAIETGSFRADLYYRLEEYPLYIPPLR
ERGDDISLLAKHFLESFCIANNIEPLTFKPLVLDQLSRYDWPGNIRELQNIVRRSAINRTGNEINALPGFLSADHKRPKD
ALPEPEASHPEPVTDTEINHPISAPVETSLKDAEQQAIARAYEACRGNQTKTARILGISRSSLYRKLKKYGMEKSITLSL
NKTP

Sequences:

>Translated_484_residues
MNSKRANATVLIADDSAVMRTLISHVIKRLGYKHITADDGNACIRLLQDNKVDLLLLDINMPGKNGIDVLAYMKENGLEI
PVIMITASDDISQAVQCIKMGAYEYLTKPVDNDRLEITAKNALSEQSLKKKVELLEKELLQKDIFKRIYGESQAIKECIG
QATQVMETDVNVLINGESGTGKELFAQAIHNGSKRKNGPFVTINCAAITNELADSLLFGHVKGSFTGANSDHTGFFEQAD
GGTIFLDEIGDLNIEIQAKVLRVLQEHIVRRVGEKKERPVDFRLISATHKDFSNAIETGSFRADLYYRLEEYPLYIPPLR
ERGDDISLLAKHFLESFCIANNIEPLTFKPLVLDQLSRYDWPGNIRELQNIVRRSAINRTGNEINALPGFLSADHKRPKD
ALPEPEASHPEPVTDTEINHPISAPVETSLKDAEQQAIARAYEACRGNQTKTARILGISRSSLYRKLKKYGMEKSITLSL
NKTP
>Mature_484_residues
MNSKRANATVLIADDSAVMRTLISHVIKRLGYKHITADDGNACIRLLQDNKVDLLLLDINMPGKNGIDVLAYMKENGLEI
PVIMITASDDISQAVQCIKMGAYEYLTKPVDNDRLEITAKNALSEQSLKKKVELLEKELLQKDIFKRIYGESQAIKECIG
QATQVMETDVNVLINGESGTGKELFAQAIHNGSKRKNGPFVTINCAAITNELADSLLFGHVKGSFTGANSDHTGFFEQAD
GGTIFLDEIGDLNIEIQAKVLRVLQEHIVRRVGEKKERPVDFRLISATHKDFSNAIETGSFRADLYYRLEEYPLYIPPLR
ERGDDISLLAKHFLESFCIANNIEPLTFKPLVLDQLSRYDWPGNIRELQNIVRRSAINRTGNEINALPGFLSADHKRPKD
ALPEPEASHPEPVTDTEINHPISAPVETSLKDAEQQAIARAYEACRGNQTKTARILGISRSSLYRKLKKYGMEKSITLSL
NKTP

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=467, Percent_Identity=37.9014989293362, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1790437, Length=464, Percent_Identity=38.7931034482759, Blast_Score=313, Evalue=1e-86,
Organism=Escherichia coli, GI1790299, Length=471, Percent_Identity=36.5180467091295, Blast_Score=300, Evalue=2e-82,
Organism=Escherichia coli, GI1788905, Length=466, Percent_Identity=36.480686695279, Blast_Score=278, Evalue=7e-76,
Organism=Escherichia coli, GI87082117, Length=370, Percent_Identity=39.1891891891892, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1789087, Length=379, Percent_Identity=39.0501319261214, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87082152, Length=314, Percent_Identity=41.0828025477707, Blast_Score=236, Evalue=4e-63,
Organism=Escherichia coli, GI1789233, Length=330, Percent_Identity=37.2727272727273, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI87081872, Length=327, Percent_Identity=37.3088685015291, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1787583, Length=337, Percent_Identity=35.3115727002967, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1786524, Length=342, Percent_Identity=38.0116959064327, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI87081858, Length=315, Percent_Identity=30.1587301587302, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1789828, Length=223, Percent_Identity=34.5291479820628, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786599, Length=136, Percent_Identity=28.6764705882353, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=109, Percent_Identity=33.0275229357798, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787487, Length=144, Percent_Identity=29.8611111111111, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790863, Length=115, Percent_Identity=30.4347826086957, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1787229, Length=124, Percent_Identity=27.4193548387097, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 54000; Mature: 54000

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKRANATVLIADDSAVMRTLISHVIKRLGYKHITADDGNACIRLLQDNKVDLLLLDIN
CCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCHHEEEEEECCCEEEEEEEEC
MPGKNGIDVLAYMKENGLEIPVIMITASDDISQAVQCIKMGAYEYLTKPVDNDRLEITAK
CCCCCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEH
NALSEQSLKKKVELLEKELLQKDIFKRIYGESQAIKECIGQATQVMETDVNVLINGESGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKELFAQAIHNGSKRKNGPFVTINCAAITNELADSLLFGHVKGSFTGANSDHTGFFEQAD
CHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
GGTIFLDEIGDLNIEIQAKVLRVLQEHIVRRVGEKKERPVDFRLISATHKDFSNAIETGS
CCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCC
FRADLYYRLEEYPLYIPPLRERGDDISLLAKHFLESFCIANNIEPLTFKPLVLDQLSRYD
EEEHEEEEHHCCCEECCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHCC
WPGNIRELQNIVRRSAINRTGNEINALPGFLSADHKRPKDALPEPEASHPEPVTDTEINH
CCCCHHHHHHHHHHHHHHCCCCHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PISAPVETSLKDAEQQAIARAYEACRGNQTKTARILGISRSSLYRKLKKYGMEKSITLSL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEEE
NKTP
CCCC
>Mature Secondary Structure
MNSKRANATVLIADDSAVMRTLISHVIKRLGYKHITADDGNACIRLLQDNKVDLLLLDIN
CCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCHHEEEEEECCCEEEEEEEEC
MPGKNGIDVLAYMKENGLEIPVIMITASDDISQAVQCIKMGAYEYLTKPVDNDRLEITAK
CCCCCCCEEEEEECCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEH
NALSEQSLKKKVELLEKELLQKDIFKRIYGESQAIKECIGQATQVMETDVNVLINGESGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKELFAQAIHNGSKRKNGPFVTINCAAITNELADSLLFGHVKGSFTGANSDHTGFFEQAD
CHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECC
GGTIFLDEIGDLNIEIQAKVLRVLQEHIVRRVGEKKERPVDFRLISATHKDFSNAIETGS
CCEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCC
FRADLYYRLEEYPLYIPPLRERGDDISLLAKHFLESFCIANNIEPLTFKPLVLDQLSRYD
EEEHEEEEHHCCCEECCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHCC
WPGNIRELQNIVRRSAINRTGNEINALPGFLSADHKRPKDALPEPEASHPEPVTDTEINH
CCCCHHHHHHHHHHHHHHCCCCHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PISAPVETSLKDAEQQAIARAYEACRGNQTKTARILGISRSSLYRKLKKYGMEKSITLSL
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEEEE
NKTP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]