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The map label for this gene is yhdN [H]

Identifier: 194333729

GI number: 194333729

Start: 982691

End: 983650

Strand: Reverse

Name: yhdN [H]

Synonym: Paes_0899

Alternate gene names: 194333729

Gene position: 983650-982691 (Counterclockwise)

Preceding gene: 194333730

Following gene: 194333728

Centisome position: 39.14

GC content: 54.79

Gene sequence:

>960_bases
ATGAACACTGTCCGGTTAGGCAGAACAGATCTGGATATCACTCCCGTTGGATTCGGCTGCTGGGCGATCGGCGGCGGAAA
CTGGGCCTATGGCTGGGGTCCCCAGAATGACCATCAGGCAATTGAGGCCATCATTGCAGCGACAGAACTCGGCATCAACT
GGATAGACACTGCAGCAGTCTACGGCCTCGGCCATGCAGAAGAACTTGTCGGAGAAGCCCTCCGGGGAATGAACAACAGA
CCCCTTATCTTCACGAAATGCTCTCTCGTATGGGATACCTCCCGAAACGTCACCAACTGCCTCAAAGCGGACTCCATTTT
GCGGGAATGCGAAGCAAGCCTCAAACGGCTTGGCATTGAGGCTATCGATCTCTACCAGGTCCACTGGCCGAACCCCGATG
AAGATATTGAAGAGGGATGGCAGACCCTGGCGAAACTGCAGGAAGAAGGGCTTGTTCGCCATATAGGTGTCTCGAATTTT
TCAGTCGAGCAGATGCAGCGTGCCGAAGCGATCGCACCGGTCGCCTCCCTTCAGCCACCTTACTCGATGCTCAGACGGGG
AATCGAAGAAAAGATTCTGCCCTACTGCCAGGAGCACAACATCGGGGTCATCGTCTATTCTCCGATGCTTTCCGGCATGC
TTTCGGGGGCAATGACCCTCGATCGAGCCCTCAACCTTCCAAAGAATGACTGGAGAAGAAACAACAAGGAGTTTCAGGAA
CCCCGGCTCTCGAAGAATATTGCGCTGGTAGAACTGCTCCGCTCAATCGGCAGAGCCTACGAAGCCTCACCGGGAGAAGT
AGCCATCGCCTGGACCCTCAACAACCCGGCTGTAACCGGCGCTATTGTCGGAGGCCGGAGCGCTGAACAGGTCAAAGGAA
CCTATGGCGCAGCGTCACTACGACTTACCGACGAGGATATACAGGCAATCGAAAAATTCATTGCATCCGTAGCGGAGTAA

Upstream 100 bases:

>100_bases
AGACAAATGATGTACTCCTGTTCTTCGTCACCTGAACAAAAGATTTCCTATTTTGCAAAGAAAGAGATAACCCCCTCCTG
CAACAAACAAAGAGATCGAC

Downstream 100 bases:

>100_bases
CTAACAACGATCCATGAGACGTCATTCACCGACAAAAGAGGAACATAACCATGAATGGCAGCATCTACGAAACAAAACTC
AGAGAGCTTCTCGAATCAGC

Product: aldo/keto reductase

Products: NA

Alternate protein names: GSP69; AKR11B [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MNTVRLGRTDLDITPVGFGCWAIGGGNWAYGWGPQNDHQAIEAIIAATELGINWIDTAAVYGLGHAEELVGEALRGMNNR
PLIFTKCSLVWDTSRNVTNCLKADSILRECEASLKRLGIEAIDLYQVHWPNPDEDIEEGWQTLAKLQEEGLVRHIGVSNF
SVEQMQRAEAIAPVASLQPPYSMLRRGIEEKILPYCQEHNIGVIVYSPMLSGMLSGAMTLDRALNLPKNDWRRNNKEFQE
PRLSKNIALVELLRSIGRAYEASPGEVAIAWTLNNPAVTGAIVGGRSAEQVKGTYGAASLRLTDEDIQAIEKFIASVAE

Sequences:

>Translated_319_residues
MNTVRLGRTDLDITPVGFGCWAIGGGNWAYGWGPQNDHQAIEAIIAATELGINWIDTAAVYGLGHAEELVGEALRGMNNR
PLIFTKCSLVWDTSRNVTNCLKADSILRECEASLKRLGIEAIDLYQVHWPNPDEDIEEGWQTLAKLQEEGLVRHIGVSNF
SVEQMQRAEAIAPVASLQPPYSMLRRGIEEKILPYCQEHNIGVIVYSPMLSGMLSGAMTLDRALNLPKNDWRRNNKEFQE
PRLSKNIALVELLRSIGRAYEASPGEVAIAWTLNNPAVTGAIVGGRSAEQVKGTYGAASLRLTDEDIQAIEKFIASVAE
>Mature_319_residues
MNTVRLGRTDLDITPVGFGCWAIGGGNWAYGWGPQNDHQAIEAIIAATELGINWIDTAAVYGLGHAEELVGEALRGMNNR
PLIFTKCSLVWDTSRNVTNCLKADSILRECEASLKRLGIEAIDLYQVHWPNPDEDIEEGWQTLAKLQEEGLVRHIGVSNF
SVEQMQRAEAIAPVASLQPPYSMLRRGIEEKILPYCQEHNIGVIVYSPMLSGMLSGAMTLDRALNLPKNDWRRNNKEFQE
PRLSKNIALVELLRSIGRAYEASPGEVAIAWTLNNPAVTGAIVGGRSAEQVKGTYGAASLRLTDEDIQAIEKFIASVAE

Specific function: Unknown

COG id: COG0667

COG function: function code C; Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldo/keto reductase 2 family [H]

Homologues:

Organism=Homo sapiens, GI4504825, Length=328, Percent_Identity=26.8292682926829, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI27436969, Length=328, Percent_Identity=26.8292682926829, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI27436964, Length=330, Percent_Identity=24.8484848484848, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI27436962, Length=325, Percent_Identity=24.9230769230769, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI27436966, Length=325, Percent_Identity=24.9230769230769, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI27436971, Length=331, Percent_Identity=23.2628398791541, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI223718702, Length=280, Percent_Identity=27.5, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI41152114, Length=283, Percent_Identity=26.8551236749117, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI41327764, Length=275, Percent_Identity=27.6363636363636, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI24497577, Length=306, Percent_Identity=26.797385620915, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI5174391, Length=306, Percent_Identity=26.797385620915, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1788070, Length=320, Percent_Identity=33.125, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI87081735, Length=315, Percent_Identity=29.5238095238095, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1788081, Length=294, Percent_Identity=27.2108843537415, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1789199, Length=351, Percent_Identity=26.7806267806268, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1789375, Length=330, Percent_Identity=26.3636363636364, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082198, Length=290, Percent_Identity=26.551724137931, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1786400, Length=294, Percent_Identity=25.5102040816327, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787674, Length=318, Percent_Identity=24.2138364779874, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI48994888, Length=287, Percent_Identity=26.4808362369338, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI212645785, Length=307, Percent_Identity=26.0586319218241, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17550248, Length=307, Percent_Identity=25.7328990228013, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17537075, Length=327, Percent_Identity=24.7706422018349, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17537077, Length=325, Percent_Identity=24.3076923076923, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6325169, Length=338, Percent_Identity=26.3313609467456, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320079, Length=177, Percent_Identity=31.0734463276836, Blast_Score=76, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319958, Length=297, Percent_Identity=24.9158249158249, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323998, Length=325, Percent_Identity=24.6153846153846, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646155, Length=225, Percent_Identity=28, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24662789, Length=205, Percent_Identity=30.7317073170732, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640980, Length=340, Percent_Identity=24.7058823529412, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45549126, Length=340, Percent_Identity=24.7058823529412, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR018170
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 35097; Mature: 35097

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00062 ALDOKETO_REDUCTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVRLGRTDLDITPVGFGCWAIGGGNWAYGWGPQNDHQAIEAIIAATELGINWIDTAAV
CCCCCCCCCCCCEEECCCEEEEECCCCEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
YGLGHAEELVGEALRGMNNRPLIFTKCSLVWDTSRNVTNCLKADSILRECEASLKRLGIE
HCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
AIDLYQVHWPNPDEDIEEGWQTLAKLQEEGLVRHIGVSNFSVEQMQRAEAIAPVASLQPP
EEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCC
YSMLRRGIEEKILPYCQEHNIGVIVYSPMLSGMLSGAMTLDRALNLPKNDWRRNNKEFQE
HHHHHHCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHC
PRLSKNIALVELLRSIGRAYEASPGEVAIAWTLNNPAVTGAIVGGRSAEQVKGTYGAASL
CHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCHHHHCCCCCCEEE
RLTDEDIQAIEKFIASVAE
EECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTVRLGRTDLDITPVGFGCWAIGGGNWAYGWGPQNDHQAIEAIIAATELGINWIDTAAV
CCCCCCCCCCCCEEECCCEEEEECCCCEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
YGLGHAEELVGEALRGMNNRPLIFTKCSLVWDTSRNVTNCLKADSILRECEASLKRLGIE
HCCCCHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCC
AIDLYQVHWPNPDEDIEEGWQTLAKLQEEGLVRHIGVSNFSVEQMQRAEAIAPVASLQPP
EEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHCCCC
YSMLRRGIEEKILPYCQEHNIGVIVYSPMLSGMLSGAMTLDRALNLPKNDWRRNNKEFQE
HHHHHHCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHC
PRLSKNIALVELLRSIGRAYEASPGEVAIAWTLNNPAVTGAIVGGRSAEQVKGTYGAASL
CHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCHHHHCCCCCCEEE
RLTDEDIQAIEKFIASVAE
EECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 9298659 [H]