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The map label for this gene is hisB

Identifier: 194333653

GI number: 194333653

Start: 900711

End: 901313

Strand: Reverse

Name: hisB

Synonym: Paes_0820

Alternate gene names: 194333653

Gene position: 901313-900711 (Counterclockwise)

Preceding gene: 194333654

Following gene: 194333652

Centisome position: 35.87

GC content: 48.26

Gene sequence:

>603_bases
ATGTCTCAACCTGACAACCATTCCTCAAGAAGTGCCAGCGTAAGCCGCAGAACGTCTGAAACAGATATATCCATCGATCT
CAATCTGGACGGCACGGGCACACATTCGATCAGCTCCGGCGTGGTTTTTCTCGACCATATGCTCGCCAACTTCAGCAAGC
ATGCTCAAATCGATATCACCCTCACATGCAAGGGAGATACCGATGTCGACGACCATCACTCCGTTGAAGATATCGCCCTT
GTCCTGGGAAGCGCCCTGCTGCAGTCGCTCGGTGACAAAAAAGGAATCAAACGTTACGGCTGGAGCATGATACCGATGGA
TGAAGCCCTTGCCCGATGCGCACTTGATCTCGGAGGCAGAAGTTACTCGGTCTTCAACGCAACCTTTAACAGAAGCGTTG
TCAATGGATTTTCCACTGAGATGGTAGAGCATTTCTTTCTCTCACTTTCAAGAACCCTCCACGCCAATATCCATATATCA
ATTCTTGAAGGCCAGAATACTCATCACAAGATTGAAGCAATATTCAAAGCCTTCGCTTACGCGCTCAAGGATGCCATATC
GATAAGCGGAACCGGCATTCCTTCAACAAAAGGAGTTATTTGA

Upstream 100 bases:

>100_bases
ATTTCCGGTTTTATTTTCCAGTGGGAACATCAATAACAGTCTCACTTCTCCTCACCATTCTTATCTACTGCTTCAATAAA
TTCATCCATTAACGCACCCT

Downstream 100 bases:

>100_bases
ATAGTGCCGAACCGATGCATTGTGTGGCGGAGGAATTCACTGTTCGTTACCTGTTATTCGTGACCAGTGAAGAGGAAATT
ACCCCATCCCGTAACCCCTC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MSQPDNHSSRSASVSRRTSETDISIDLNLDGTGTHSISSGVVFLDHMLANFSKHAQIDITLTCKGDTDVDDHHSVEDIAL
VLGSALLQSLGDKKGIKRYGWSMIPMDEALARCALDLGGRSYSVFNATFNRSVVNGFSTEMVEHFFLSLSRTLHANIHIS
ILEGQNTHHKIEAIFKAFAYALKDAISISGTGIPSTKGVI

Sequences:

>Translated_200_residues
MSQPDNHSSRSASVSRRTSETDISIDLNLDGTGTHSISSGVVFLDHMLANFSKHAQIDITLTCKGDTDVDDHHSVEDIAL
VLGSALLQSLGDKKGIKRYGWSMIPMDEALARCALDLGGRSYSVFNATFNRSVVNGFSTEMVEHFFLSLSRTLHANIHIS
ILEGQNTHHKIEAIFKAFAYALKDAISISGTGIPSTKGVI
>Mature_199_residues
SQPDNHSSRSASVSRRTSETDISIDLNLDGTGTHSISSGVVFLDHMLANFSKHAQIDITLTCKGDTDVDDHHSVEDIALV
LGSALLQSLGDKKGIKRYGWSMIPMDEALARCALDLGGRSYSVFNATFNRSVVNGFSTEMVEHFFLSLSRTLHANIHISI
LEGQNTHHKIEAIFKAFAYALKDAISISGTGIPSTKGVI

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=191, Percent_Identity=47.1204188481675, Blast_Score=183, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=36.697247706422, Blast_Score=148, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_PROA2 (B4S729)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002015513.1
- ProteinModelPortal:   B4S729
- SMR:   B4S729
- GeneID:   6460021
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_0820
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21691; Mature: 21559

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPDNHSSRSASVSRRTSETDISIDLNLDGTGTHSISSGVVFLDHMLANFSKHAQIDIT
CCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEE
LTCKGDTDVDDHHSVEDIALVLGSALLQSLGDKKGIKRYGWSMIPMDEALARCALDLGGR
EEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCC
SYSVFNATFNRSVVNGFSTEMVEHFFLSLSRTLHANIHISILEGQNTHHKIEAIFKAFAY
EEEEEECHHHHHHHCCHHHHHHHHHHHHHHHHEECEEEEEEEECCCCHHHHHHHHHHHHH
ALKDAISISGTGIPSTKGVI
HHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQPDNHSSRSASVSRRTSETDISIDLNLDGTGTHSISSGVVFLDHMLANFSKHAQIDIT
CCCCCCCCCCCHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEE
LTCKGDTDVDDHHSVEDIALVLGSALLQSLGDKKGIKRYGWSMIPMDEALARCALDLGGR
EEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHCCCC
SYSVFNATFNRSVVNGFSTEMVEHFFLSLSRTLHANIHISILEGQNTHHKIEAIFKAFAY
EEEEEECHHHHHHHCCHHHHHHHHHHHHHHHHEECEEEEEEEECCCCHHHHHHHHHHHHH
ALKDAISISGTGIPSTKGVI
HHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA