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The map label for this gene is galU [C]

Identifier: 194333642

GI number: 194333642

Start: 886587

End: 887567

Strand: Reverse

Name: galU [C]

Synonym: Paes_0809

Alternate gene names: 194333642

Gene position: 887567-886587 (Counterclockwise)

Preceding gene: 194333652

Following gene: 194333641

Centisome position: 35.32

GC content: 48.93

Gene sequence:

>981_bases
ATGAAAGCAATCATACCTGTTGCAGGAGTCGGAACCCGACTTCGCCCACATACCTTTTCACAGCCTAAAGTCCTGGTTAA
CGTCGCCGGAAAACCCATTATCGGCCACATCATGGACAAGCTCATCGCGTCAGGTATCGATGAAGCAATTGTCGTCGTCG
GATACCTCGGCGATATGATAGAAAGTTATCTCAAGAAAACCTACCCGATCAAATTCACCTTTGTAACCCAGAAACAGATG
CTCGGTCTGGCACACGCCATCTGGATCTGTAAAAAACACGTTCAGAACGACGAGCCGCTGTTTATCATACTCGGCGACAC
TATTTTCGATGTCGATCTTTCCGGAGTATTTAATAGCCAAAGTTCAACCCTCGGCGTCAGGGAGGTTGAAGACCCGAGAC
GATTCGGCATTGCCATTACTGAAGGCAGCCATATTACAAAGCTTATTGAAAAACCCGACACCCCTATCGGCAACCAGGCC
ATCGTCGGACTCTACTACCTCAAGAATGCCGGCACCCTCTTTTCAAGCCTCGATCACCTGATCTCGAATGAAATAAAAAC
AAAGGGAGAGTATCAGCTGACCGACGCCCTCCAGCATATGATAGAGTCAGGCGAAACATTCACGACATTTCCTGTCAAAA
ACTGGTATGACTGCGGCAAACCAGAAACACTGCTTGCAACCAACAGGGTCCTGCTTCAGACCATGAACAGCGATGCATCA
CTCTTTGCGGGATGCGTCATCAACGAACCGGTGTATATAGCCGCAAGCGCGACGGTTCAAAATGCGATAATAGGCCCCGA
TTCCACGATCGGCGAGAACGCCGTTATCACCGATGCCATTATCAAAGACTCCATCATCGGCAACAACGCCAAAGTTGAAA
AGGTGATGCTGAGCAGATCGATCGTCGGCAGCAATGCGCATATTTCAGGAAGTCATCAGGAAATCAACATAGGCGATTCT
TCCGAGATCAGACTGCGCTGA

Upstream 100 bases:

>100_bases
TTTCGGATTTACACCATATTTCACGTAACTTATTGACGGAAGCACAAACACTTTCAGCCCGATACGCGATAAAAAAACCA
CAACACTCCCTCATCGACCA

Downstream 100 bases:

>100_bases
AAGAACGGAAGCAATTGCATCAAGTCCCCGGAGGCGTTTCTGCAATGAGACGAAAGATGGCCTTGCAAGAATAAGAGCGA
ATGCTTACATTTTGGTCTTA

Product: Nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MKAIIPVAGVGTRLRPHTFSQPKVLVNVAGKPIIGHIMDKLIASGIDEAIVVVGYLGDMIESYLKKTYPIKFTFVTQKQM
LGLAHAIWICKKHVQNDEPLFIILGDTIFDVDLSGVFNSQSSTLGVREVEDPRRFGIAITEGSHITKLIEKPDTPIGNQA
IVGLYYLKNAGTLFSSLDHLISNEIKTKGEYQLTDALQHMIESGETFTTFPVKNWYDCGKPETLLATNRVLLQTMNSDAS
LFAGCVINEPVYIAASATVQNAIIGPDSTIGENAVITDAIIKDSIIGNNAKVEKVMLSRSIVGSNAHISGSHQEINIGDS
SEIRLR

Sequences:

>Translated_326_residues
MKAIIPVAGVGTRLRPHTFSQPKVLVNVAGKPIIGHIMDKLIASGIDEAIVVVGYLGDMIESYLKKTYPIKFTFVTQKQM
LGLAHAIWICKKHVQNDEPLFIILGDTIFDVDLSGVFNSQSSTLGVREVEDPRRFGIAITEGSHITKLIEKPDTPIGNQA
IVGLYYLKNAGTLFSSLDHLISNEIKTKGEYQLTDALQHMIESGETFTTFPVKNWYDCGKPETLLATNRVLLQTMNSDAS
LFAGCVINEPVYIAASATVQNAIIGPDSTIGENAVITDAIIKDSIIGNNAKVEKVMLSRSIVGSNAHISGSHQEINIGDS
SEIRLR
>Mature_326_residues
MKAIIPVAGVGTRLRPHTFSQPKVLVNVAGKPIIGHIMDKLIASGIDEAIVVVGYLGDMIESYLKKTYPIKFTFVTQKQM
LGLAHAIWICKKHVQNDEPLFIILGDTIFDVDLSGVFNSQSSTLGVREVEDPRRFGIAITEGSHITKLIEKPDTPIGNQA
IVGLYYLKNAGTLFSSLDHLISNEIKTKGEYQLTDALQHMIESGETFTTFPVKNWYDCGKPETLLATNRVLLQTMNSDAS
LFAGCVINEPVYIAASATVQNAIIGPDSTIGENAVITDAIIKDSIIGNNAKVEKVMLSRSIVGSNAHISGSHQEINIGDS
SEIRLR

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=324, Percent_Identity=26.5432098765432, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI11761619, Length=324, Percent_Identity=26.5432098765432, Blast_Score=118, Evalue=7e-27,
Organism=Escherichia coli, GI1787488, Length=266, Percent_Identity=29.6992481203008, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788355, Length=268, Percent_Identity=26.4925373134328, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790224, Length=264, Percent_Identity=27.6515151515151, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790168, Length=313, Percent_Identity=23.6421725239617, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788351, Length=264, Percent_Identity=26.1363636363636, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=334, Percent_Identity=30.5389221556886, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17509979, Length=345, Percent_Identity=27.8260869565217, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17509981, Length=340, Percent_Identity=27.0588235294118, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=347, Percent_Identity=24.207492795389, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21355443, Length=330, Percent_Identity=26.969696969697, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24644084, Length=330, Percent_Identity=26.969696969697, Blast_Score=111, Evalue=7e-25,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 35491; Mature: 35491

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIIPVAGVGTRLRPHTFSQPKVLVNVAGKPIIGHIMDKLIASGIDEAIVVVGYLGDMI
CCCEEECCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ESYLKKTYPIKFTFVTQKQMLGLAHAIWICKKHVQNDEPLFIILGDTIFDVDLSGVFNSQ
HHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEEEECCEECCC
SSTLGVREVEDPRRFGIAITEGSHITKLIEKPDTPIGNQAIVGLYYLKNAGTLFSSLDHL
CCCCCCCCCCCCHHEEEEEECCCHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHH
ISNEIKTKGEYQLTDALQHMIESGETFTTFPVKNWYDCGKPETLLATNRVLLQTMNSDAS
HHHHHCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEHHHHHEEEEECCCCHH
LFAGCVINEPVYIAASATVQNAIIGPDSTIGENAVITDAIIKDSIIGNNAKVEKVMLSRS
EEEHEEECCCEEEEEECHHHHEEECCCCCCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHH
IVGSNAHISGSHQEINIGDSSEIRLR
HCCCCCEECCCCCEEECCCCCCEEEC
>Mature Secondary Structure
MKAIIPVAGVGTRLRPHTFSQPKVLVNVAGKPIIGHIMDKLIASGIDEAIVVVGYLGDMI
CCCEEECCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ESYLKKTYPIKFTFVTQKQMLGLAHAIWICKKHVQNDEPLFIILGDTIFDVDLSGVFNSQ
HHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEEEEECCEECCC
SSTLGVREVEDPRRFGIAITEGSHITKLIEKPDTPIGNQAIVGLYYLKNAGTLFSSLDHL
CCCCCCCCCCCCHHEEEEEECCCHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHH
ISNEIKTKGEYQLTDALQHMIESGETFTTFPVKNWYDCGKPETLLATNRVLLQTMNSDAS
HHHHHCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCEEHHHHHEEEEECCCCHH
LFAGCVINEPVYIAASATVQNAIIGPDSTIGENAVITDAIIKDSIIGNNAKVEKVMLSRS
EEEHEEECCCEEEEEECHHHHEEECCCCCCCCCCEEEHHHHHHHHCCCCCHHHHHHHHHH
IVGSNAHISGSHQEINIGDSSEIRLR
HCCCCCEECCCCCEEECCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA