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The map label for this gene is accC [H]

Identifier: 193214424

GI number: 193214424

Start: 824712

End: 826046

Strand: Direct

Name: accC [H]

Synonym: Ctha_0707

Alternate gene names: 193214424

Gene position: 824712-826046 (Clockwise)

Preceding gene: 193214423

Following gene: 193214427

Centisome position: 25.04

GC content: 47.87

Gene sequence:

>1335_bases
TTGTTTAAAAAGATTCTCATTGCCAATCGCGGTGAAATAGCCATGCGCATTATTCGCACGTGCCGTGAGCTTGGCGTCAA
TACCGTTGCGGTGTACTCAACTGCCGATACCGAATCGCTTCACGTCAAATATGCGGACGAAGCCATTTGCATCGGCGCAC
CGTCAGGAAAAGACAGTTACTTAAACGTTTCGCGAATTATTGCCGCTGCCGAAATCACCAACGCCGACGCGATTCACCCC
GGTTACGGATTTCTGGCTGAAAACGCAGACTTTGCTGAAGTTTGCCAATCTTCTGGCATTAAATTTATTGGGCCTTCAGC
GGAGATGATCCGCAAAATGGGGGACAAAATTACGGCCAAAGAAAGCATGAAAATTGCACAGGTGCCGGTTGTCCCTGGAA
GCGATGGCCTGGTGGAAGATGTTTCAGAGGCAAAACGCTTAGCAGCCCAAATCGGACTGCCCGTAATCATTAAAGCCACA
GCTGGCGGCGGCGGAAAAGGCATGAGAATCGTTCATAAAATGGATGATTTAGAGAAAGCGTTTGTCACGGCACAATCCGA
AGCCGAAAAATCGTTTGGCAATAGCGGTGTCTACATTGAAAAGTTTGTTGAAGAGCCGCGTCACGTTGAAATTCAGGTGA
TGGGCGACCAATACGGCAATGTGTTTCACCTTGGCGAACGCGATTGCACCGTTCAGCGCCGGCATCAAAAGCTCATCGAA
GAATCGCCCTCGCCCGTCATGAATGAAGCGCTTCGCGACAAAATGGGCGACGCAGCGGTAAATGCGGCAAAAGCCATCCA
ATACGAAGGCGCCGGAACCGTGGAATTTCTGGTTGATAAGTACATGAATTTTTATTTCATGGAAATGAATACCCGCATTC
AAGTGGAGCATCCTGTCACTGAGGAAGTTTATGATGTGGATTTGATTCGCGACCAGATTTTAGTTGCTGCTGGCGAGACA
CTCGCAGAAAGATGCTACATTCGAAAAGGCCATTCCATTGAATGCCGAATTAATGCGGAAGATCCCGACTACGGATTTCG
CCCAAGTCCGGGAGTTGTGCAAGTTTTTCACACACCGGGCGGCCATGGCGTAAGAGTTGAAACACACGCGTATGCCGGCT
ATAAAATTCCGCCGTACTACGATTCTATGATTGCAAAGCTGATTGTTCATGCAGCTGACCGCACGCAGGCAATAGAACGA
ATGGTTCGTGCTTTGGATGAATTTATCATTGAAGGCATTAAAACGACCATTCCATTCCACAAGCGCGTGATGCAATCGGA
AGTTTTTAGAAGCGGCAATTTTGATACTTCGTTTTTGGAGAAAACAAAACTTTAG

Upstream 100 bases:

>100_bases
TTTTGGTAGAAAACGGACAGCCAGTAGAATATGACCAAGTGCTCTTTCTTGTTGAGCCAGCATGATGAATTTTCAATTTA
ACTAAATCGCGCCACCGACA

Downstream 100 bases:

>100_bases
TTTCTCGTTTTTTCAAGGAAAAAAAACAGAGCGCGGCTCTTGTTTCTCAAGCAAATTTTTACATTTTTCAATAAAAAAGG
GGCGTTCTATGAAGCCCCTT

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MFKKILIANRGEIAMRIIRTCRELGVNTVAVYSTADTESLHVKYADEAICIGAPSGKDSYLNVSRIIAAAEITNADAIHP
GYGFLAENADFAEVCQSSGIKFIGPSAEMIRKMGDKITAKESMKIAQVPVVPGSDGLVEDVSEAKRLAAQIGLPVIIKAT
AGGGGKGMRIVHKMDDLEKAFVTAQSEAEKSFGNSGVYIEKFVEEPRHVEIQVMGDQYGNVFHLGERDCTVQRRHQKLIE
ESPSPVMNEALRDKMGDAAVNAAKAIQYEGAGTVEFLVDKYMNFYFMEMNTRIQVEHPVTEEVYDVDLIRDQILVAAGET
LAERCYIRKGHSIECRINAEDPDYGFRPSPGVVQVFHTPGGHGVRVETHAYAGYKIPPYYDSMIAKLIVHAADRTQAIER
MVRALDEFIIEGIKTTIPFHKRVMQSEVFRSGNFDTSFLEKTKL

Sequences:

>Translated_444_residues
MFKKILIANRGEIAMRIIRTCRELGVNTVAVYSTADTESLHVKYADEAICIGAPSGKDSYLNVSRIIAAAEITNADAIHP
GYGFLAENADFAEVCQSSGIKFIGPSAEMIRKMGDKITAKESMKIAQVPVVPGSDGLVEDVSEAKRLAAQIGLPVIIKAT
AGGGGKGMRIVHKMDDLEKAFVTAQSEAEKSFGNSGVYIEKFVEEPRHVEIQVMGDQYGNVFHLGERDCTVQRRHQKLIE
ESPSPVMNEALRDKMGDAAVNAAKAIQYEGAGTVEFLVDKYMNFYFMEMNTRIQVEHPVTEEVYDVDLIRDQILVAAGET
LAERCYIRKGHSIECRINAEDPDYGFRPSPGVVQVFHTPGGHGVRVETHAYAGYKIPPYYDSMIAKLIVHAADRTQAIER
MVRALDEFIIEGIKTTIPFHKRVMQSEVFRSGNFDTSFLEKTKL
>Mature_444_residues
MFKKILIANRGEIAMRIIRTCRELGVNTVAVYSTADTESLHVKYADEAICIGAPSGKDSYLNVSRIIAAAEITNADAIHP
GYGFLAENADFAEVCQSSGIKFIGPSAEMIRKMGDKITAKESMKIAQVPVVPGSDGLVEDVSEAKRLAAQIGLPVIIKAT
AGGGGKGMRIVHKMDDLEKAFVTAQSEAEKSFGNSGVYIEKFVEEPRHVEIQVMGDQYGNVFHLGERDCTVQRRHQKLIE
ESPSPVMNEALRDKMGDAAVNAAKAIQYEGAGTVEFLVDKYMNFYFMEMNTRIQVEHPVTEEVYDVDLIRDQILVAAGET
LAERCYIRKGHSIECRINAEDPDYGFRPSPGVVQVFHTPGGHGVRVETHAYAGYKIPPYYDSMIAKLIVHAADRTQAIER
MVRALDEFIIEGIKTTIPFHKRVMQSEVFRSGNFDTSFLEKTKL

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=47.6614699331849, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=47.6614699331849, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=47.6614699331849, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=50.3401360544218, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=48.6425339366516, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=48.6425339366516, Blast_Score=414, Evalue=1e-116,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=48.6425339366516, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI38679960, Length=503, Percent_Identity=31.8091451292247, Blast_Score=261, Evalue=7e-70,
Organism=Homo sapiens, GI38679974, Length=503, Percent_Identity=31.8091451292247, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI38679977, Length=503, Percent_Identity=31.8091451292247, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI38679967, Length=503, Percent_Identity=31.8091451292247, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI38679971, Length=503, Percent_Identity=31.8091451292247, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI134142062, Length=503, Percent_Identity=31.2127236580517, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=55.0561797752809, Blast_Score=465, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=45.2115812917595, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=49.5475113122172, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=46.7268623024831, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI133931226, Length=486, Percent_Identity=31.0699588477366, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI71997163, Length=505, Percent_Identity=29.9009900990099, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI71997168, Length=505, Percent_Identity=29.9009900990099, Blast_Score=211, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6319685, Length=442, Percent_Identity=45.0226244343891, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319695, Length=451, Percent_Identity=45.4545454545455, Blast_Score=378, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321376, Length=451, Percent_Identity=45.4545454545455, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=31.9607843137255, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6323863, Length=453, Percent_Identity=32.2295805739514, Blast_Score=232, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=48.6547085201794, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=48.6547085201794, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=48.6547085201794, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=48.6547085201794, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=48.6547085201794, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=48.6547085201794, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=48.6547085201794, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=48.6547085201794, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=48.6547085201794, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=48.6547085201794, Blast_Score=427, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24651757, Length=442, Percent_Identity=49.7737556561086, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=48.0295566502463, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=31.58953722334, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=31.58953722334, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=31.58953722334, Blast_Score=245, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=31.58953722334, Blast_Score=245, Evalue=4e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49134; Mature: 49134

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILIANRGEIAMRIIRTCRELGVNTVAVYSTADTESLHVKYADEAICIGAPSGKDSY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEEECCCCCCCC
LNVSRIIAAAEITNADAIHPGYGFLAENADFAEVCQSSGIKFIGPSAEMIRKMGDKITAK
EEHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCCEEECCCHHHHHHHCCCCCHH
ESMKIAQVPVVPGSDGLVEDVSEAKRLAAQIGLPVIIKATAGGGGKGMRIVHKMDDLEKA
HCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHHHHH
FVTAQSEAEKSFGNSGVYIEKFVEEPRHVEIQVMGDQYGNVFHLGERDCTVQRRHQKLIE
HHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHH
ESPSPVMNEALRDKMGDAAVNAAKAIQYEGAGTVEFLVDKYMNFYFMEMNTRIQVEHPVT
CCCCHHHHHHHHHHCCHHHHHHHHHEEECCCCHHHHHHHHHCCEEEEEECCEEEECCCCC
EEVYDVDLIRDQILVAAGETLAERCYIRKGHSIECRINAEDPDYGFRPSPGVVQVFHTPG
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCC
GHGVRVETHAYAGYKIPPYYDSMIAKLIVHAADRTQAIERMVRALDEFIIEGIKTTIPFH
CCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KRVMQSEVFRSGNFDTSFLEKTKL
HHHHHHHHHHCCCCCHHHHHHCCC
>Mature Secondary Structure
MFKKILIANRGEIAMRIIRTCRELGVNTVAVYSTADTESLHVKYADEAICIGAPSGKDSY
CCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEEECCCCCCCC
LNVSRIIAAAEITNADAIHPGYGFLAENADFAEVCQSSGIKFIGPSAEMIRKMGDKITAK
EEHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCCEEECCCHHHHHHHCCCCCHH
ESMKIAQVPVVPGSDGLVEDVSEAKRLAAQIGLPVIIKATAGGGGKGMRIVHKMDDLEKA
HCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHHHHH
FVTAQSEAEKSFGNSGVYIEKFVEEPRHVEIQVMGDQYGNVFHLGERDCTVQRRHQKLIE
HHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHH
ESPSPVMNEALRDKMGDAAVNAAKAIQYEGAGTVEFLVDKYMNFYFMEMNTRIQVEHPVT
CCCCHHHHHHHHHHCCHHHHHHHHHEEECCCCHHHHHHHHHCCEEEEEECCEEEECCCCC
EEVYDVDLIRDQILVAAGETLAERCYIRKGHSIECRINAEDPDYGFRPSPGVVQVFHTPG
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCC
GHGVRVETHAYAGYKIPPYYDSMIAKLIVHAADRTQAIERMVRALDEFIIEGIKTTIPFH
CCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KRVMQSEVFRSGNFDTSFLEKTKL
HHHHHHHHHHCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]