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The map label for this gene is folE [H]

Identifier: 193214206

GI number: 193214206

Start: 569411

End: 570124

Strand: Direct

Name: folE [H]

Synonym: Ctha_0487

Alternate gene names: 193214206

Gene position: 569411-570124 (Clockwise)

Preceding gene: 193214205

Following gene: 193214207

Centisome position: 17.29

GC content: 45.52

Gene sequence:

>714_bases
ATGAAGCACGCTGAAAAATCCCTTACCGATGCCCGTAACGGACATAGAACCGCAACCTCATTTATAGACGCCGTGACTGA
GGAAATTGGCGATGAACATATCAGCACGTCGGTGGATACACCGATTCGTCCTGATGCGTTTGATCAGGACGATGAACTCA
AAATGGAGCTAATTGCCGAGCACTTTGAAAAAATCATGCTGATTTTAGGCCTTGACCTAAAAGACGACAGCTTGCGCGGC
ACACCGAAGCGCGTGGCAAAAATGTATGTCAAAGAAATTTTCAGCGGACTCAATCCCGCCAATAAACCCAAAGTCGCGTT
GTTCGACAATTCTTACAAGTACAATGAAATGCTCATTGAAAAAGACATCATTGTGCATTCTACTTGTGAGCATCATTTTG
TTCCTATTCTCGGCAAGGCGCATGTCGGATACATTTCAAGCGGCAAGGTGATTGGTCTTTCAAAAATTAACCGGATCGTG
CAGTATTACGCCAAACGCCCGCAAGTTCAAGAGCGAATGACCATGCAAATTGTCAAAGAACTAAAGGAAACCTTGCAAAC
TGAGGATGTGGCTGTGGTTATTGATGCGCGGCATTTGTGCGTATCGGTTCGCGGGGTTGAAGATGTGGCCAGCTCAACTG
TGACTTCCAGCTACAATGGCAAGTTTTTGAACGAACAGACCCGCAACGAATTTCTGAAACATATCTACGGATGA

Upstream 100 bases:

>100_bases
TATGAGGTAAAGCTTTTCGAATCGGAACGGAACTTTGTCCGGTATCGTGGCGATTAATCATCTTGGAACAACTTTGAACA
TAACTGACATTTAAAACCTT

Downstream 100 bases:

>100_bases
ACTCATCCGAACCCAATTTTTCTTACAAGCAGGTTTTTCACAGCCTGCTTTTTTATTGCCATTTTTGAAATCTGCTATGT
GAACTCATCATCAAATTTCT

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKHAEKSLTDARNGHRTATSFIDAVTEEIGDEHISTSVDTPIRPDAFDQDDELKMELIAEHFEKIMLILGLDLKDDSLRG
TPKRVAKMYVKEIFSGLNPANKPKVALFDNSYKYNEMLIEKDIIVHSTCEHHFVPILGKAHVGYISSGKVIGLSKINRIV
QYYAKRPQVQERMTMQIVKELKETLQTEDVAVVIDARHLCVSVRGVEDVASSTVTSSYNGKFLNEQTRNEFLKHIYG

Sequences:

>Translated_237_residues
MKHAEKSLTDARNGHRTATSFIDAVTEEIGDEHISTSVDTPIRPDAFDQDDELKMELIAEHFEKIMLILGLDLKDDSLRG
TPKRVAKMYVKEIFSGLNPANKPKVALFDNSYKYNEMLIEKDIIVHSTCEHHFVPILGKAHVGYISSGKVIGLSKINRIV
QYYAKRPQVQERMTMQIVKELKETLQTEDVAVVIDARHLCVSVRGVEDVASSTVTSSYNGKFLNEQTRNEFLKHIYG
>Mature_237_residues
MKHAEKSLTDARNGHRTATSFIDAVTEEIGDEHISTSVDTPIRPDAFDQDDELKMELIAEHFEKIMLILGLDLKDDSLRG
TPKRVAKMYVKEIFSGLNPANKPKVALFDNSYKYNEMLIEKDIIVHSTCEHHFVPILGKAHVGYISSGKVIGLSKINRIV
QYYAKRPQVQERMTMQIVKELKETLQTEDVAVVIDARHLCVSVRGVEDVASSTVTSSYNGKFLNEQTRNEFLKHIYG

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=245, Percent_Identity=36.3265306122449, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI4503949, Length=245, Percent_Identity=36.3265306122449, Blast_Score=138, Evalue=5e-33,
Organism=Homo sapiens, GI66932972, Length=213, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI66932970, Length=222, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=4e-24,
Organism=Escherichia coli, GI1788476, Length=203, Percent_Identity=54.1871921182266, Blast_Score=211, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17560486, Length=225, Percent_Identity=37.3333333333333, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321706, Length=198, Percent_Identity=40.4040404040404, Blast_Score=139, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24656791, Length=186, Percent_Identity=37.0967741935484, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24656796, Length=186, Percent_Identity=37.0967741935484, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24656782, Length=186, Percent_Identity=37.0967741935484, Blast_Score=110, Evalue=7e-25,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 26835; Mature: 26835

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHAEKSLTDARNGHRTATSFIDAVTEEIGDEHISTSVDTPIRPDAFDQDDELKMELIAE
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
HFEKIMLILGLDLKDDSLRGTPKRVAKMYVKEIFSGLNPANKPKVALFDNSYKYNEMLIE
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHH
KDIIVHSTCEHHFVPILGKAHVGYISSGKVIGLSKINRIVQYYAKRPQVQERMTMQIVKE
HHHHEECCCCCCCCEEECCCCCCEECCCCEECHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LKETLQTEDVAVVIDARHLCVSVRGVEDVASSTVTSSYNGKFLNEQTRNEFLKHIYG
HHHHHCCCCEEEEEEHHHHHEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKHAEKSLTDARNGHRTATSFIDAVTEEIGDEHISTSVDTPIRPDAFDQDDELKMELIAE
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHH
HFEKIMLILGLDLKDDSLRGTPKRVAKMYVKEIFSGLNPANKPKVALFDNSYKYNEMLIE
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHH
KDIIVHSTCEHHFVPILGKAHVGYISSGKVIGLSKINRIVQYYAKRPQVQERMTMQIVKE
HHHHEECCCCCCCCEEECCCCCCEECCCCEECHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LKETLQTEDVAVVIDARHLCVSVRGVEDVASSTVTSSYNGKFLNEQTRNEFLKHIYG
HHHHHCCCCEEEEEEHHHHHEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA