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The map label for this gene is dgk [H]

Identifier: 193214182

GI number: 193214182

Start: 543589

End: 544239

Strand: Direct

Name: dgk [H]

Synonym: Ctha_0463

Alternate gene names: 193214182

Gene position: 543589-544239 (Clockwise)

Preceding gene: 193214181

Following gene: 193214183

Centisome position: 16.51

GC content: 40.09

Gene sequence:

>651_bases
TTGTCCTTTGAAGCGCGTCGTTTAAAATACATCGCTATTGAAGGCGTCATCGGGGTCGGAAAAACTTCATTGGCAAAAAA
GCTTTCCGAAAAATGTGGCCATCGCTTGCTGCTTGAAGAATTTGAAGAAAATCCTTTTCTGGCATCTTTTTATCAAAATC
CTCAATGTTTTGCGCTTCCCGCGCAATTATTTTTTCTTCTACGTCGCTACAAGCAACAACACCAAATTTCTGAAATCAGC
CTTGCGGCAAATGGGCTGATTTCAGATTATTCATTTCAGAAGAATGATATTTTTGCCAAAACGACCTTAAACAAAGAGGA
GTTTTCGCTTTATTCAGCCTATGCGGAGATCTTGCAAGCCAATATTCCCAAGCCTGATTTAGTGGTTTATTTGCAGTCCA
CGCCAGAGCGCCTTATAAAAAATATTCACCAACGCGCCCGCCGCTATGAACACTGCATAGAAAGCCCTTATATCAAAAAA
TTGCATGCTGCGTATAATGAGTTTTTTTTCGCGTTTGCGTCCTCAAATCAATGCGTTATTGATGTTTCTCAACTGGATTT
CGTGGAAAATCCCCGAGATTTTGAGCGGCTTTACCGGATTATTTTTTGTGGTGATATGAACGATAAACTCGTGATAAAAA
AACCCGAATAA

Upstream 100 bases:

>100_bases
TTGTGTTCATTAATGGACGCCTTGCTTTCAAATATCATGTTTATGAATTAGAACTAAAGGAACTGCTGCTTTCTGAAATG
TCCTAAAAAGAGCGTGAATT

Downstream 100 bases:

>100_bases
ACGTTCATGCAGTCAAACGTGTGTTAACTAAGTACAGAAAATTTAAACCAGACGAGGCGTATTATGATTCGTTCTATTTT
ATTTTTAATTCTTGGATATT

Product: deoxynucleoside kinase

Products: NA

Alternate protein names: DGUO kinase; dGK [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MSFEARRLKYIAIEGVIGVGKTSLAKKLSEKCGHRLLLEEFEENPFLASFYQNPQCFALPAQLFFLLRRYKQQHQISEIS
LAANGLISDYSFQKNDIFAKTTLNKEEFSLYSAYAEILQANIPKPDLVVYLQSTPERLIKNIHQRARRYEHCIESPYIKK
LHAAYNEFFFAFASSNQCVIDVSQLDFVENPRDFERLYRIIFCGDMNDKLVIKKPE

Sequences:

>Translated_216_residues
MSFEARRLKYIAIEGVIGVGKTSLAKKLSEKCGHRLLLEEFEENPFLASFYQNPQCFALPAQLFFLLRRYKQQHQISEIS
LAANGLISDYSFQKNDIFAKTTLNKEEFSLYSAYAEILQANIPKPDLVVYLQSTPERLIKNIHQRARRYEHCIESPYIKK
LHAAYNEFFFAFASSNQCVIDVSQLDFVENPRDFERLYRIIFCGDMNDKLVIKKPE
>Mature_215_residues
SFEARRLKYIAIEGVIGVGKTSLAKKLSEKCGHRLLLEEFEENPFLASFYQNPQCFALPAQLFFLLRRYKQQHQISEISL
AANGLISDYSFQKNDIFAKTTLNKEEFSLYSAYAEILQANIPKPDLVVYLQSTPERLIKNIHQRARRYEHCIESPYIKKL
HAAYNEFFFAFASSNQCVIDVSQLDFVENPRDFERLYRIIFCGDMNDKLVIKKPE

Specific function: Plays an essential role in generating the deoxyribonucleotide precursors dGTP for DNA metabolism. Highly specific toward deoxyguanosine (dGuo) and deoxyinosine (dIno). Only marginal activity is observed with guanosine. UTP is slightly more efficient as ph

COG id: COG1428

COG function: function code F; Deoxynucleoside kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DCK/DGK family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002624 [H]

Pfam domain/function: PF01712 dNK [H]

EC number: =2.7.1.113 [H]

Molecular weight: Translated: 25196; Mature: 25065

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFEARRLKYIAIEGVIGVGKTSLAKKLSEKCGHRLLLEEFEENPFLASFYQNPQCFALP
CCCCHHHEEEEEEECEECCCHHHHHHHHHHHHCHHHHHHHHCCCCCEEECCCCCCEEEEH
AQLFFLLRRYKQQHQISEISLAANGLISDYSFQKNDIFAKTTLNKEEFSLYSAYAEILQA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHC
NIPKPDLVVYLQSTPERLIKNIHQRARRYEHCIESPYIKKLHAAYNEFFFAFASSNQCVI
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEECCCCEEE
DVSQLDFVENPRDFERLYRIIFCGDMNDKLVIKKPE
EHHHHCCCCCCHHHHHHHHHHEECCCCCCEEEECCC
>Mature Secondary Structure 
SFEARRLKYIAIEGVIGVGKTSLAKKLSEKCGHRLLLEEFEENPFLASFYQNPQCFALP
CCCHHHEEEEEEECEECCCHHHHHHHHHHHHCHHHHHHHHCCCCCEEECCCCCCEEEEH
AQLFFLLRRYKQQHQISEISLAANGLISDYSFQKNDIFAKTTLNKEEFSLYSAYAEILQA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHC
NIPKPDLVVYLQSTPERLIKNIHQRARRYEHCIESPYIKKLHAAYNEFFFAFASSNQCVI
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEECCCCEEE
DVSQLDFVENPRDFERLYRIIFCGDMNDKLVIKKPE
EHHHHCCCCCCHHHHHHHHHHEECCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]