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The map label for this gene is panB [H]

Identifier: 193213924

GI number: 193213924

Start: 239529

End: 240371

Strand: Direct

Name: panB [H]

Synonym: Ctha_0205

Alternate gene names: 193213924

Gene position: 239529-240371 (Clockwise)

Preceding gene: 193213923

Following gene: 193213926

Centisome position: 7.27

GC content: 46.38

Gene sequence:

>843_bases
ATGTCAACACGATTGGATATTAAAAAACGACTCGCGCCACAAGTTACCACACGAAAGTTAGTTGAAATGAAAGCGCAAGG
CGAAAAAATCGCAATTCTTACAGCTTACGACTATACGATGGCTCGCATTTTAGATAATTCGGGCATCGATGTGCTGCTCG
TGGGTGATTCGGCTAGCAATGTTTTCGGCGGAAATGAAACGACCTTGCCGATTACAATGGAGGAAATGATCTACCACGCA
AAAGCTGTTTTTCGCGGCGTTCATGCAGCAACAGGACGCGCCATGATCGTGGTCGATATGCCATTTATGAGTTACCAACT
TTCCAGCGAAGACGCGCTGCGCAACGCTGGTAAATTAATGAAAGAAACAGGCTGCCACGCGGTGAAGTTGGAAGGCGGAA
AAGCGATTATTGAAGCCGTCAAAAGAATTACCGATGTAGGCATTCCGGTTATGGGACATTTGGGACTAACGCCGCAAGCG
ATTTATAAATTTGGCAGCTATAAGGTTCGCGCTCGCGAAGAAGAAGAAGCCGAGCAGTTGTTGGAAGATGCAAAGCAACT
TGAAAATGCAGGCGCATTTGCTGTGGTGCTGGAAAAAATTCCGATGGAACTCTCCCAAAAAGTGACAGACAGTCTCCATA
TTCCAACGATCGGGATTGGTGCTGGCGCGGCCTGCGACGGACAAGTGCTGGTTGTGAATGATATGCTTGGGTTCAACACG
GATTTTCATCCGCGATTCGTCAGGAAATATGCAAATTTGGACAACGTCATCGGCACATCCGTTAAAAACTATGTTAATGA
CGTTCGCCAAGGCACATTTCCAAACGAATCAGAAAGTTATTAG

Upstream 100 bases:

>100_bases
AATTTTTCTGGCAAAAAAAAAGCTGCTCACACAAGCGAACCGAATCCTACACTTTTTGTTTTCGTGCACTACATTTTTAC
ACACAAAACCGATTTCAACC

Downstream 100 bases:

>100_bases
GAGCCGTTTTTTAGCGCTGAAGCAAATTAAACGCAATATTTGAACCGTAGCCGTTCATGGCCACATTAATCAAAAGAACG
GCCATCGGTTCAAGATAACG

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSTRLDIKKRLAPQVTTRKLVEMKAQGEKIAILTAYDYTMARILDNSGIDVLLVGDSASNVFGGNETTLPITMEEMIYHA
KAVFRGVHAATGRAMIVVDMPFMSYQLSSEDALRNAGKLMKETGCHAVKLEGGKAIIEAVKRITDVGIPVMGHLGLTPQA
IYKFGSYKVRAREEEEAEQLLEDAKQLENAGAFAVVLEKIPMELSQKVTDSLHIPTIGIGAGAACDGQVLVVNDMLGFNT
DFHPRFVRKYANLDNVIGTSVKNYVNDVRQGTFPNESESY

Sequences:

>Translated_280_residues
MSTRLDIKKRLAPQVTTRKLVEMKAQGEKIAILTAYDYTMARILDNSGIDVLLVGDSASNVFGGNETTLPITMEEMIYHA
KAVFRGVHAATGRAMIVVDMPFMSYQLSSEDALRNAGKLMKETGCHAVKLEGGKAIIEAVKRITDVGIPVMGHLGLTPQA
IYKFGSYKVRAREEEEAEQLLEDAKQLENAGAFAVVLEKIPMELSQKVTDSLHIPTIGIGAGAACDGQVLVVNDMLGFNT
DFHPRFVRKYANLDNVIGTSVKNYVNDVRQGTFPNESESY
>Mature_279_residues
STRLDIKKRLAPQVTTRKLVEMKAQGEKIAILTAYDYTMARILDNSGIDVLLVGDSASNVFGGNETTLPITMEEMIYHAK
AVFRGVHAATGRAMIVVDMPFMSYQLSSEDALRNAGKLMKETGCHAVKLEGGKAIIEAVKRITDVGIPVMGHLGLTPQAI
YKFGSYKVRAREEEEAEQLLEDAKQLENAGAFAVVLEKIPMELSQKVTDSLHIPTIGIGAGAACDGQVLVVNDMLGFNTD
FHPRFVRKYANLDNVIGTSVKNYVNDVRQGTFPNESESY

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=265, Percent_Identity=40.377358490566, Blast_Score=217, Evalue=8e-58,
Organism=Saccharomyces cerevisiae, GI6319653, Length=255, Percent_Identity=36.4705882352941, Blast_Score=184, Evalue=2e-47,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 30658; Mature: 30527

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRLDIKKRLAPQVTTRKLVEMKAQGEKIAILTAYDYTMARILDNSGIDVLLVGDSASN
CCCCCCHHHHHCCHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHCCCCCEEEEECCCCCC
VFGGNETTLPITMEEMIYHAKAVFRGVHAATGRAMIVVDMPFMSYQLSSEDALRNAGKLM
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCHHHHHHHHHHH
KETGCHAVKLEGGKAIIEAVKRITDVGIPVMGHLGLTPQAIYKFGSYKVRAREEEEAEQL
HHCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCEEEECCCHHHHHHH
LEDAKQLENAGAFAVVLEKIPMELSQKVTDSLHIPTIGIGAGAACDGQVLVVNDMLGFNT
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEECCCCCCC
DFHPRFVRKYANLDNVIGTSVKNYVNDVRQGTFPNESESY
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
STRLDIKKRLAPQVTTRKLVEMKAQGEKIAILTAYDYTMARILDNSGIDVLLVGDSASN
CCCCCHHHHHCCHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHCCCCCEEEEECCCCCC
VFGGNETTLPITMEEMIYHAKAVFRGVHAATGRAMIVVDMPFMSYQLSSEDALRNAGKLM
CCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEECCCHHHHHHHHHHH
KETGCHAVKLEGGKAIIEAVKRITDVGIPVMGHLGLTPQAIYKFGSYKVRAREEEEAEQL
HHCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCEEEECCCHHHHHHH
LEDAKQLENAGAFAVVLEKIPMELSQKVTDSLHIPTIGIGAGAACDGQVLVVNDMLGFNT
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEECCCCCCC
DFHPRFVRKYANLDNVIGTSVKNYVNDVRQGTFPNESESY
CCCHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA