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The map label for this gene is pqqL [C]

Identifier: 193213779

GI number: 193213779

Start: 70222

End: 71511

Strand: Direct

Name: pqqL [C]

Synonym: Ctha_0060

Alternate gene names: 193213779

Gene position: 70222-71511 (Clockwise)

Preceding gene: 193213773

Following gene: 193213780

Centisome position: 2.13

GC content: 46.9

Gene sequence:

>1290_bases
ATGGAACTACGGCGTGAGGAGTCCGGCGAGGCTCAAAACAGCGCAGCATCGTGTGTTCAAAAAACGGTGCTGCCTAACGG
ATTAACGGTCATTACCGAACATGTGCCTGGTGTGCGAAGCCTTTCCGTTGGACTTTGGACAAACACCGGCTCCCGAGATG
AAACGCCGGAAAATAATGGCGCGGCGCATTTCATCGAACACATGGTTTTCAAAGGCACAAGCAAACGCGACTATATTCAA
ATTTCAAAAAGTTTGGAGAGCGTTGGCGGCTATTTGAATGCGTTTACCACCAAAGAACATACCTGTTTTTACGCTCGCAG
CCTTGCTGAGCATTTGAAAATCACCATCGATGTTTTAACCGACTTGGTCTTTCGCCCGACTTTTCCAGAAGAAGAATTGG
AAAAGGAAAAAGACGTCATTATCGAGGAAATCAAAAGCACGGAAGACACGCCCGACGATTTGATCTTTGATGATTTTGAT
AAATTTTTGTTCGAAAGTCATCCGCTTGGCTTGCCTATCGCTGGCACGGAAGAATCGGTCGACGCATTAACGCGCAACGA
CACTATCGCTTTTCTGAAAGCTTGTTATCGACCCGAAAAAATGTTGCTCGTCGGGACGGGCAATCTAACGCACGACGCGC
TTCTGAATTTCGCCGAATGCTTTGTGCCAAAGCGAAAAACCAAACCGAAATCCGTGCGCCAAACTTACGATTTTGGGCAA
TACCAGCCATTTACGAAAGAAATCGCCAAGCCCATTCAGCAAGCGCATATTCTCATTGGCGCGCCGTACATTCGCGACGA
TAAAAATTATTTCTCCGCCATTTTGCTCAACACGCTGCTCGGCGGCGGCATGAGCAGCCGACTGAATTTATCGCTCAGGG
AAAAACATGGGCTGGTTTATTCCGTTTTTTCCAGCATTTCTACCTTCGACGAAATCAACACGTTTTCCATTTACGCCGGC
ACAGACAAAGATAAGGTCAAGAAAACCGTTGCGCTCATTCACGAAGAACTTGGGCAACTTTTGGGAAAAAATGTGCCAAA
ACGAGAATTGGATTTGGCAAAAGCACAACTCAAAGGCGCGGTGATTATGGGGCAAGAAAGCGTTTCGAAGCGGCAATCGC
ATTTGGCTCGCGATCATTATTATTTTGGCCGCGACTTTTCATTTGACGAATTAATCGAGATGGTCGAAAGCGTTTCGGCA
AAAGATATTCGTTCGGTTGCCGAGCAAATGCTGGATGCCTCAAAATTCTCCACGCTCATCTATCAACCGAAACGACGGGG
AAAAGCGTAA

Upstream 100 bases:

>100_bases
ATGCTGTTTATTGTATTTTAACAGGCTCTTGCGTGAATTTACAAATTTTAAACCGGAAGAGCGGATAACTTTTGCAATTT
GTAAGCGACTTTGTTTAAGC

Downstream 100 bases:

>100_bases
TTCCAAAATAGGTGGATACACAGTTAAAAAGTCAATTCGAGCAACGAGAACTTTTATTATTCTGAAAAGTATACATGCTT
TGGATTGAAATAAAATTGTT

Product: processing peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MELRREESGEAQNSAASCVQKTVLPNGLTVITEHVPGVRSLSVGLWTNTGSRDETPENNGAAHFIEHMVFKGTSKRDYIQ
ISKSLESVGGYLNAFTTKEHTCFYARSLAEHLKITIDVLTDLVFRPTFPEEELEKEKDVIIEEIKSTEDTPDDLIFDDFD
KFLFESHPLGLPIAGTEESVDALTRNDTIAFLKACYRPEKMLLVGTGNLTHDALLNFAECFVPKRKTKPKSVRQTYDFGQ
YQPFTKEIAKPIQQAHILIGAPYIRDDKNYFSAILLNTLLGGGMSSRLNLSLREKHGLVYSVFSSISTFDEINTFSIYAG
TDKDKVKKTVALIHEELGQLLGKNVPKRELDLAKAQLKGAVIMGQESVSKRQSHLARDHYYFGRDFSFDELIEMVESVSA
KDIRSVAEQMLDASKFSTLIYQPKRRGKA

Sequences:

>Translated_429_residues
MELRREESGEAQNSAASCVQKTVLPNGLTVITEHVPGVRSLSVGLWTNTGSRDETPENNGAAHFIEHMVFKGTSKRDYIQ
ISKSLESVGGYLNAFTTKEHTCFYARSLAEHLKITIDVLTDLVFRPTFPEEELEKEKDVIIEEIKSTEDTPDDLIFDDFD
KFLFESHPLGLPIAGTEESVDALTRNDTIAFLKACYRPEKMLLVGTGNLTHDALLNFAECFVPKRKTKPKSVRQTYDFGQ
YQPFTKEIAKPIQQAHILIGAPYIRDDKNYFSAILLNTLLGGGMSSRLNLSLREKHGLVYSVFSSISTFDEINTFSIYAG
TDKDKVKKTVALIHEELGQLLGKNVPKRELDLAKAQLKGAVIMGQESVSKRQSHLARDHYYFGRDFSFDELIEMVESVSA
KDIRSVAEQMLDASKFSTLIYQPKRRGKA
>Mature_429_residues
MELRREESGEAQNSAASCVQKTVLPNGLTVITEHVPGVRSLSVGLWTNTGSRDETPENNGAAHFIEHMVFKGTSKRDYIQ
ISKSLESVGGYLNAFTTKEHTCFYARSLAEHLKITIDVLTDLVFRPTFPEEELEKEKDVIIEEIKSTEDTPDDLIFDDFD
KFLFESHPLGLPIAGTEESVDALTRNDTIAFLKACYRPEKMLLVGTGNLTHDALLNFAECFVPKRKTKPKSVRQTYDFGQ
YQPFTKEIAKPIQQAHILIGAPYIRDDKNYFSAILLNTLLGGGMSSRLNLSLREKHGLVYSVFSSISTFDEINTFSIYAG
TDKDKVKKTVALIHEELGQLLGKNVPKRELDLAKAQLKGAVIMGQESVSKRQSHLARDHYYFGRDFSFDELIEMVESVSA
KDIRSVAEQMLDASKFSTLIYQPKRRGKA

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=404, Percent_Identity=26.2376237623762, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI46593007, Length=200, Percent_Identity=35.5, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI24308013, Length=422, Percent_Identity=25.5924170616114, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI50592988, Length=412, Percent_Identity=19.6601941747573, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71999683, Length=413, Percent_Identity=25.90799031477, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17553678, Length=407, Percent_Identity=24.0786240786241, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17510601, Length=440, Percent_Identity=24.0909090909091, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323192, Length=400, Percent_Identity=29.25, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6321813, Length=410, Percent_Identity=22.6829268292683, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319426, Length=204, Percent_Identity=25.9803921568627, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357875, Length=404, Percent_Identity=26.4851485148515, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24646943, Length=404, Percent_Identity=26.4851485148515, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI19921772, Length=438, Percent_Identity=25.5707762557078, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 48219; Mature: 48219

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRREESGEAQNSAASCVQKTVLPNGLTVITEHVPGVRSLSVGLWTNTGSRDETPENNG
CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCC
AAHFIEHMVFKGTSKRDYIQISKSLESVGGYLNAFTTKEHTCFYARSLAEHLKITIDVLT
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
DLVFRPTFPEEELEKEKDVIIEEIKSTEDTPDDLIFDDFDKFLFESHPLGLPIAGTEESV
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHH
DALTRNDTIAFLKACYRPEKMLLVGTGNLTHDALLNFAECFVPKRKTKPKSVRQTYDFGQ
HHHHCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
YQPFTKEIAKPIQQAHILIGAPYIRDDKNYFSAILLNTLLGGGMSSRLNLSLREKHGLVY
CCCHHHHHHHHHHHHHEEEECCEEECCHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCHHH
SVFSSISTFDEINTFSIYAGTDKDKVKKTVALIHEELGQLLGKNVPKRELDLAKAQLKGA
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCE
VIMGQESVSKRQSHLARDHYYFGRDFSFDELIEMVESVSAKDIRSVAEQMLDASKFSTLI
EEECHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
YQPKRRGKA
CCCHHCCCC
>Mature Secondary Structure
MELRREESGEAQNSAASCVQKTVLPNGLTVITEHVPGVRSLSVGLWTNTGSRDETPENNG
CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCC
AAHFIEHMVFKGTSKRDYIQISKSLESVGGYLNAFTTKEHTCFYARSLAEHLKITIDVLT
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
DLVFRPTFPEEELEKEKDVIIEEIKSTEDTPDDLIFDDFDKFLFESHPLGLPIAGTEESV
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHH
DALTRNDTIAFLKACYRPEKMLLVGTGNLTHDALLNFAECFVPKRKTKPKSVRQTYDFGQ
HHHHCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCC
YQPFTKEIAKPIQQAHILIGAPYIRDDKNYFSAILLNTLLGGGMSSRLNLSLREKHGLVY
CCCHHHHHHHHHHHHHEEEECCEEECCHHHHHHHHHHHHHCCCCCCCEEEEEHHHCCHHH
SVFSSISTFDEINTFSIYAGTDKDKVKKTVALIHEELGQLLGKNVPKRELDLAKAQLKGA
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCE
VIMGQESVSKRQSHLARDHYYFGRDFSFDELIEMVESVSAKDIRSVAEQMLDASKFSTLI
EEECHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
YQPKRRGKA
CCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]