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The map label for this gene is cysM [H]

Identifier: 193213770

GI number: 193213770

Start: 63367

End: 64311

Strand: Direct

Name: cysM [H]

Synonym: Ctha_0051

Alternate gene names: 193213770

Gene position: 63367-64311 (Clockwise)

Preceding gene: 193213769

Following gene: 193213771

Centisome position: 1.92

GC content: 48.15

Gene sequence:

>945_bases
ATGTTAGTTACTCATCAAGCTGTAGTTGAAAAGCACATTTTTTCCCTGATCGGAAACACGCCACTCATTCGCATCAAAAA
ATTGGCACGCGAGTGGGGCATTAACGACAATGTGGAAGTTTATGGAAAAGCGGAATGGATGAACCCGGGCGGCAGCGTTA
AGGATCGCGCGGCACTGAATATCATTGAAACAGCTGAAGCTCGCGGCGATTTGACTCACGATAAAATTTTGCTTGATGCC
ACCAGCGGAAATACCGGCATTGCCTATGCCATGATTTGCGCCGTGAAGGGCTACCGTGTCACGCTTTGCCTTCCTGAATC
TGCCTCAAAAGAGCGTAAAGAAATTTTGCAAGCTTATGGCGCAACGCTGGTCGAAACGCCGGCATCCGAGTCGAGCGATG
GTGCGATTCTGAAAGCCATTGAGATGTACAAGAACAACCCTGACCTTTATTATTATGCCGACCAATACAGCAACGATGCG
AATTGGCAGGCGCATTACCACTCGACTGGCATTGAAATTTATGAACAGACTCACGGGAAAATCACGCATTTCGTCACGGC
AATTGGCACAAGCGGGACATTCGTGGGAACAACCCGCCGGTTGAAAACTTACAATCCTGATATAAAATGCATCGCCGCGC
AGCCAGATGTAGCCGTTCATGGCATCGAAGGTATTAAGCATTTGGAATCGGCAATGGTGCCCAAAATTTATGACCCCGCT
TTATCCGATCGCCTGCTTGAGATCTCAACGGAAACCGCCTATGAATATGCCCGAAAATTGGCACGAGTCGAAGGCTTATT
GGTTGGCATTTCAGCAGCGGCCAACCTTTTTGCGACGCTCACTATCGCCAAGGAAGTTTCCGACAGTGGCAAGAATGGCG
TGATTGTGACCGTGCTTTGCGACAATGGCATGAAATATCTTTCCGAACCATTTTGGATACAATAA

Upstream 100 bases:

>100_bases
TGGTAAAGCTTTTCCAAACGAATTTTTCCTTGCGTTAGGCGGTTTATCTGAAAACTCCTCTTTAGGCAATGGGTCGTGGG
ACTCTAAATATAATAGGCGC

Downstream 100 bases:

>100_bases
TCTCGAATACTTTTCACTTAAATCTTTTCTTTATAGAAATGGGTTTTATGCCAGAACACTAACGGTTATTTTAAGGTTGA
ATGTAAAACCAGAAAAAAGC

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MLVTHQAVVEKHIFSLIGNTPLIRIKKLAREWGINDNVEVYGKAEWMNPGGSVKDRAALNIIETAEARGDLTHDKILLDA
TSGNTGIAYAMICAVKGYRVTLCLPESASKERKEILQAYGATLVETPASESSDGAILKAIEMYKNNPDLYYYADQYSNDA
NWQAHYHSTGIEIYEQTHGKITHFVTAIGTSGTFVGTTRRLKTYNPDIKCIAAQPDVAVHGIEGIKHLESAMVPKIYDPA
LSDRLLEISTETAYEYARKLARVEGLLVGISAAANLFATLTIAKEVSDSGKNGVIVTVLCDNGMKYLSEPFWIQ

Sequences:

>Translated_314_residues
MLVTHQAVVEKHIFSLIGNTPLIRIKKLAREWGINDNVEVYGKAEWMNPGGSVKDRAALNIIETAEARGDLTHDKILLDA
TSGNTGIAYAMICAVKGYRVTLCLPESASKERKEILQAYGATLVETPASESSDGAILKAIEMYKNNPDLYYYADQYSNDA
NWQAHYHSTGIEIYEQTHGKITHFVTAIGTSGTFVGTTRRLKTYNPDIKCIAAQPDVAVHGIEGIKHLESAMVPKIYDPA
LSDRLLEISTETAYEYARKLARVEGLLVGISAAANLFATLTIAKEVSDSGKNGVIVTVLCDNGMKYLSEPFWIQ
>Mature_314_residues
MLVTHQAVVEKHIFSLIGNTPLIRIKKLAREWGINDNVEVYGKAEWMNPGGSVKDRAALNIIETAEARGDLTHDKILLDA
TSGNTGIAYAMICAVKGYRVTLCLPESASKERKEILQAYGATLVETPASESSDGAILKAIEMYKNNPDLYYYADQYSNDA
NWQAHYHSTGIEIYEQTHGKITHFVTAIGTSGTFVGTTRRLKTYNPDIKCIAAQPDVAVHGIEGIKHLESAMVPKIYDPA
LSDRLLEISTETAYEYARKLARVEGLLVGISAAANLFATLTIAKEVSDSGKNGVIVTVLCDNGMKYLSEPFWIQ

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=320, Percent_Identity=33.75, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI295821200, Length=320, Percent_Identity=33.75, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI4557415, Length=320, Percent_Identity=33.75, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI2367138, Length=292, Percent_Identity=40.0684931506849, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1788754, Length=313, Percent_Identity=37.3801916932907, Blast_Score=171, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=37.9084967320261, Blast_Score=197, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI32566674, Length=301, Percent_Identity=36.2126245847176, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=35.2941176470588, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI115535073, Length=308, Percent_Identity=37.012987012987, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=33.9869281045752, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17534315, Length=325, Percent_Identity=30.1538461538462, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32566672, Length=218, Percent_Identity=33.0275229357798, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25147552, Length=315, Percent_Identity=30.1587301587302, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321594, Length=328, Percent_Identity=34.4512195121951, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=34.5345345345345, Blast_Score=146, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24643623, Length=329, Percent_Identity=31.6109422492401, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI20129101, Length=329, Percent_Identity=31.6109422492401, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34460; Mature: 34460

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVTHQAVVEKHIFSLIGNTPLIRIKKLAREWGINDNVEVYGKAEWMNPGGSVKDRAALN
CEECHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCHHHHH
IIETAEARGDLTHDKILLDATSGNTGIAYAMICAVKGYRVTLCLPESASKERKEILQAYG
HHHHHHHCCCCCCCEEEEEECCCCCCHHHHEEECCCCCEEEEECCCCCCHHHHHHHHHHC
ATLVETPASESSDGAILKAIEMYKNNPDLYYYADQYSNDANWQAHYHSTGIEIYEQTHGK
CEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCEEEEECCCCC
ITHFVTAIGTSGTFVGTTRRLKTYNPDIKCIAAQPDVAVHGIEGIKHLESAMVPKIYDPA
EEEEEEEECCCCEEEECCCEEEECCCCEEEEECCCCEEEECHHHHHHHHHHCCCCCCCHH
LSDRLLEISTETAYEYARKLARVEGLLVGISAAANLFATLTIAKEVSDSGKNGVIVTVLC
HHCCEEEEHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
DNGMKYLSEPFWIQ
CCCHHHHCCCCCCC
>Mature Secondary Structure
MLVTHQAVVEKHIFSLIGNTPLIRIKKLAREWGINDNVEVYGKAEWMNPGGSVKDRAALN
CEECHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCHHHHH
IIETAEARGDLTHDKILLDATSGNTGIAYAMICAVKGYRVTLCLPESASKERKEILQAYG
HHHHHHHCCCCCCCEEEEEECCCCCCHHHHEEECCCCCEEEEECCCCCCHHHHHHHHHHC
ATLVETPASESSDGAILKAIEMYKNNPDLYYYADQYSNDANWQAHYHSTGIEIYEQTHGK
CEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCEEEEECCCCC
ITHFVTAIGTSGTFVGTTRRLKTYNPDIKCIAAQPDVAVHGIEGIKHLESAMVPKIYDPA
EEEEEEEECCCCEEEECCCEEEECCCCEEEEECCCCEEEECHHHHHHHHHHCCCCCCCHH
LSDRLLEISTETAYEYARKLARVEGLLVGISAAANLFATLTIAKEVSDSGKNGVIVTVLC
HHCCEEEEHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
DNGMKYLSEPFWIQ
CCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]