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The map label for this gene is gyrA [H]

Identifier: 193213726

GI number: 193213726

Start: 4575

End: 7100

Strand: Direct

Name: gyrA [H]

Synonym: Ctha_0006

Alternate gene names: 193213726

Gene position: 4575-7100 (Clockwise)

Preceding gene: 193213721

Following gene: 193213729

Centisome position: 0.14

GC content: 50.71

Gene sequence:

>2526_bases
ATGCAGCGAGAAAAAATTATTCCGATCAACATTGAAGACGAGATGCGGGATTCGTATCTCGATTATTCCATGTCGGTGAT
TGTCAGTCGTGCTTTGCCAGATGTTAGAGACGGCTTAAAACCCGTGCATCGGCGGGTTCTTTTTGGAATGAACGAGCTTG
GACTTCAAGCCGGGCGGTCGTATAAAAAATCGGCGCGCGTGGTTGGCGAAGTGCTTGGTAAATATCATCCGCATGGTGAC
TCGGCGGTTTATGACTCGATCGTTCGTATGGTTCAGAATTTTTCTTTGCGCTATCCGCTCGTGGACGGACAAGGCAACTT
CGGCTCGGTTGATGGCGACGCCCCAGCGGCGATGCGTTATACCGAAGTTCGCATGATGCGTATTTCGAGTGAAATCCTGC
GCGATTTAGATAAAAATACGATCGATTTCGCCCCGAACTTCGACGATTCGCTTGAAGAGCCCATCGTGCTTCCCGCTGCA
TTCCCCAATTTGCTTATCAATGGCGCTTCTGGCATCGCCGTTGGCATGGCCACCAACATTCCACCGCATAATCTCACCGA
AGTGATCGACGGCGTCATCGCCTACATCAATAATCCTGAGATTACGATCGAAGAATTGATGACCTACATCAAAGCCCCAG
ATTTTCCAACAGCCGGCATTATTTATGGCTACAACGGCGTGCGCGATGCTTACCTCACCGGTCGCGGGAAAATTGTGCTT
CGTGCGAAAGTTCAAGTAGAGGTGACGCCAAAAAATGGCCGCGAGTCCATCATTATCACCGAACTGCCTTATCAGGTCAA
TAAAGCCAGGCTGATCGAAAAAATTGCGGGCTTGGTTCAGCAGAAAAAGGTGGAAGGCATTGCCGACCTGCGCGACGAGT
CCGACCGCGACGGCATGCGCGTGGTCATCGAACTGAAAAAAGATGCCGTTACCCAAGTGGTGATCAATCGGCTGTTCAAA
CTCACGCAGCTCCAAGAAACATTTGGTGTGATTATGCTGGCGCTTGTGGGCGGCATCCCAAGAGTGCTCACGCTGAAAGA
AACGATTCAATATTATGTCAATCATCGGCACGAAGTCATTTTGCGCCGTACCCGCTTTGAGCTGGACGAAGCCGAGCGGC
GCGCGCATATTTTAGAAGGCCTTAAAATCTGCCTGGACAATCTCGATGAAATCATCGCGACCATTCGCCAGTCGCCCGAC
ACAGAAACAGCTCGCGAGCGATTAATGGCAACATTCAGCCTCTCCGACCTGCAAGCCAAAGCGATTTTGGATATGCGGTT
GCAACGCCTCACCGGCCTTGAGCGCCAGAAAATTGAGGACGAATATCTCGAGTTGCTCAAAACCATCGAAGGCCTTCGTG
CGATTCTTGCCAACGAAAAACTCCAGATGCAGCTCATTAAAAAGGAGCTTTTGCAAATTAAGAAAACCTACGGCGATGAA
CGCCGCACGCAAATTGTGTATGAAACAGAGGATTTCTCGGTTGAAGACATGATTGCCGAAGAAGATGTGGTGATCACCAT
TACGCACCAAGGCTACATCAAGCGATTTCCGGTTTCCGGCTACCGGCGCCAAGGTCGTGGCGGACGCGGCATTTCCGGCG
TTAGCGCTCGCGAGGACGATTTCATCGAACATATGTTCATCGCGTCCACGCATCACTACATTCTCTTTTTCACTTCACAT
GGAAAGTGCTATTGGCTCAAGGTGCACGAAATTCCTGAAGCTGGCCGCACCGCACGCGGGCGTTCCATCACCAATTTGAT
CGAATTTGCTACGGGCGAAAAAATCAAGGCGTCCATCAACGTGAAGGAATTCAACGATACACAGTTTATCGTGATGGCCA
CGAAGAACGGCACGATCAAAAAAACACCACTCAGCGAATATTCTAATCCACGCCGCTCGGGCATCATTGCTATTAACATT
ACCGATAACGACGAACTGGTTGGTGCAAGCCTCACCGATGGCAGCCACCAAATCGTGCTCGCCAAAAACACGGGCTACGC
CGTTCGCTTCCCTGAACAAAATGTGAGACCGATGGGCAGAAACTCCATCGGCGTTAAAGGCGCATCGATTAGCGGCGACG
AGGCCATTATTTCTATGGTTTCCACGCCTCGCAACGACGCAACGCTGCTTGCCATCACCGACAATGGCTATGGCAAACGC
AGCGCGATTGAAGATTATCGCATGACCAAGCGCGGCGCAAACGGCGTGATTACGCTCAAGGCCAATGAAAAAGTGGGCAA
GCTGGTCGACATGCTTGAGGTCAATGATGGCGAGGATATTATTATTATCACGAATAAGGGAATCGTCAATCGTCAGCACA
TCGCCGACATTCGCGTGATGGGTCGCAATACTTCCGGCGTTCGTTTGATTCGCTTAGACGAAGACGATTTCGTTTCTGCG
GTTGCTCGTGTGCCAAAAGAAGACACGGAAGAGGAAGAAACACCGGAGGAAAACGACAATCAAATCAGCCTCCCGCTTGA
TTCATCCGACAACAATCCGCAGCCGGAAGACGAAGATCCCGAGTAA

Upstream 100 bases:

>100_bases
AGAAAAGGGGATGATTTTCCCTCTGCCAACGCTCTGAGAAGTTCCGAGTTTTTTGTATCTTGCGCGGTTTTTATGCTTTG
CGATATAACAATATAGATTT

Downstream 100 bases:

>100_bases
GCAATTGAAATACCTACCAAGCAAAGAGCCGCAGATTTTCGCGGCTCTTTTTTTTGACCGATTCTCACAAAATCAACCGC
CCGCGTCCCGACCGTCCATG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 841; Mature: 841

Protein sequence:

>841_residues
MQREKIIPINIEDEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLFGMNELGLQAGRSYKKSARVVGEVLGKYHPHGD
SAVYDSIVRMVQNFSLRYPLVDGQGNFGSVDGDAPAAMRYTEVRMMRISSEILRDLDKNTIDFAPNFDDSLEEPIVLPAA
FPNLLINGASGIAVGMATNIPPHNLTEVIDGVIAYINNPEITIEELMTYIKAPDFPTAGIIYGYNGVRDAYLTGRGKIVL
RAKVQVEVTPKNGRESIIITELPYQVNKARLIEKIAGLVQQKKVEGIADLRDESDRDGMRVVIELKKDAVTQVVINRLFK
LTQLQETFGVIMLALVGGIPRVLTLKETIQYYVNHRHEVILRRTRFELDEAERRAHILEGLKICLDNLDEIIATIRQSPD
TETARERLMATFSLSDLQAKAILDMRLQRLTGLERQKIEDEYLELLKTIEGLRAILANEKLQMQLIKKELLQIKKTYGDE
RRTQIVYETEDFSVEDMIAEEDVVITITHQGYIKRFPVSGYRRQGRGGRGISGVSAREDDFIEHMFIASTHHYILFFTSH
GKCYWLKVHEIPEAGRTARGRSITNLIEFATGEKIKASINVKEFNDTQFIVMATKNGTIKKTPLSEYSNPRRSGIIAINI
TDNDELVGASLTDGSHQIVLAKNTGYAVRFPEQNVRPMGRNSIGVKGASISGDEAIISMVSTPRNDATLLAITDNGYGKR
SAIEDYRMTKRGANGVITLKANEKVGKLVDMLEVNDGEDIIIITNKGIVNRQHIADIRVMGRNTSGVRLIRLDEDDFVSA
VARVPKEDTEEEETPEENDNQISLPLDSSDNNPQPEDEDPE

Sequences:

>Translated_841_residues
MQREKIIPINIEDEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLFGMNELGLQAGRSYKKSARVVGEVLGKYHPHGD
SAVYDSIVRMVQNFSLRYPLVDGQGNFGSVDGDAPAAMRYTEVRMMRISSEILRDLDKNTIDFAPNFDDSLEEPIVLPAA
FPNLLINGASGIAVGMATNIPPHNLTEVIDGVIAYINNPEITIEELMTYIKAPDFPTAGIIYGYNGVRDAYLTGRGKIVL
RAKVQVEVTPKNGRESIIITELPYQVNKARLIEKIAGLVQQKKVEGIADLRDESDRDGMRVVIELKKDAVTQVVINRLFK
LTQLQETFGVIMLALVGGIPRVLTLKETIQYYVNHRHEVILRRTRFELDEAERRAHILEGLKICLDNLDEIIATIRQSPD
TETARERLMATFSLSDLQAKAILDMRLQRLTGLERQKIEDEYLELLKTIEGLRAILANEKLQMQLIKKELLQIKKTYGDE
RRTQIVYETEDFSVEDMIAEEDVVITITHQGYIKRFPVSGYRRQGRGGRGISGVSAREDDFIEHMFIASTHHYILFFTSH
GKCYWLKVHEIPEAGRTARGRSITNLIEFATGEKIKASINVKEFNDTQFIVMATKNGTIKKTPLSEYSNPRRSGIIAINI
TDNDELVGASLTDGSHQIVLAKNTGYAVRFPEQNVRPMGRNSIGVKGASISGDEAIISMVSTPRNDATLLAITDNGYGKR
SAIEDYRMTKRGANGVITLKANEKVGKLVDMLEVNDGEDIIIITNKGIVNRQHIADIRVMGRNTSGVRLIRLDEDDFVSA
VARVPKEDTEEEETPEENDNQISLPLDSSDNNPQPEDEDPE
>Mature_841_residues
MQREKIIPINIEDEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLFGMNELGLQAGRSYKKSARVVGEVLGKYHPHGD
SAVYDSIVRMVQNFSLRYPLVDGQGNFGSVDGDAPAAMRYTEVRMMRISSEILRDLDKNTIDFAPNFDDSLEEPIVLPAA
FPNLLINGASGIAVGMATNIPPHNLTEVIDGVIAYINNPEITIEELMTYIKAPDFPTAGIIYGYNGVRDAYLTGRGKIVL
RAKVQVEVTPKNGRESIIITELPYQVNKARLIEKIAGLVQQKKVEGIADLRDESDRDGMRVVIELKKDAVTQVVINRLFK
LTQLQETFGVIMLALVGGIPRVLTLKETIQYYVNHRHEVILRRTRFELDEAERRAHILEGLKICLDNLDEIIATIRQSPD
TETARERLMATFSLSDLQAKAILDMRLQRLTGLERQKIEDEYLELLKTIEGLRAILANEKLQMQLIKKELLQIKKTYGDE
RRTQIVYETEDFSVEDMIAEEDVVITITHQGYIKRFPVSGYRRQGRGGRGISGVSAREDDFIEHMFIASTHHYILFFTSH
GKCYWLKVHEIPEAGRTARGRSITNLIEFATGEKIKASINVKEFNDTQFIVMATKNGTIKKTPLSEYSNPRRSGIIAINI
TDNDELVGASLTDGSHQIVLAKNTGYAVRFPEQNVRPMGRNSIGVKGASISGDEAIISMVSTPRNDATLLAITDNGYGKR
SAIEDYRMTKRGANGVITLKANEKVGKLVDMLEVNDGEDIIIITNKGIVNRQHIADIRVMGRNTSGVRLIRLDEDDFVSA
VARVPKEDTEEEETPEENDNQISLPLDSSDNNPQPEDEDPE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=340, Percent_Identity=23.8235294117647, Blast_Score=74, Evalue=7e-13,
Organism=Escherichia coli, GI1788562, Length=873, Percent_Identity=50.1718213058419, Blast_Score=869, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=665, Percent_Identity=38.0451127819549, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17535065, Length=364, Percent_Identity=25.5494505494505, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=304, Percent_Identity=27.3026315789474, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=343, Percent_Identity=25.0728862973761, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17136538, Length=354, Percent_Identity=25.7062146892655, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 94410; Mature: 94410

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQREKIIPINIEDEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLFGMNELGLQAGRS
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHCCC
YKKSARVVGEVLGKYHPHGDSAVYDSIVRMVQNFSLRYPLVDGQGNFGSVDGDAPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHH
TEVRMMRISSEILRDLDKNTIDFAPNFDDSLEEPIVLPAAFPNLLINGASGIAVGMATNI
HHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEECCCHHEEECCCCEEEEEECCC
PPHNLTEVIDGVIAYINNPEITIEELMTYIKAPDFPTAGIIYGYNGVRDAYLTGRGKIVL
CCCHHHHHHHHHHEEECCCCEEHHHHHHHHCCCCCCCCCEEECCCCCCCEEEECCCEEEE
RAKVQVEVTPKNGRESIIITELPYQVNKARLIEKIAGLVQQKKVEGIADLRDESDRDGMR
EEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
VVIELKKDAVTQVVINRLFKLTQLQETFGVIMLALVGGIPRVLTLKETIQYYVNHRHEVI
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCHHHEE
LRRTRFELDEAERRAHILEGLKICLDNLDEIIATIRQSPDTETARERLMATFSLSDLQAK
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHH
AILDMRLQRLTGLERQKIEDEYLELLKTIEGLRAILANEKLQMQLIKKELLQIKKTYGDE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
RRTQIVYETEDFSVEDMIAEEDVVITITHQGYIKRFPVSGYRRQGRGGRGISGVSAREDD
HHEEEEEECCCCCHHHHHCCCCEEEEEECCCCEEECCCCCHHHCCCCCCCCCCCCCCCHH
FIEHMFIASTHHYILFFTSHGKCYWLKVHEIPEAGRTARGRSITNLIEFATGEKIKASIN
HHHHHHHCCCCEEEEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEEE
VKEFNDTQFIVMATKNGTIKKTPLSEYSNPRRSGIIAINITDNDELVGASLTDGSHQIVL
EEEECCCEEEEEEECCCCEEECCHHHCCCCCCCCEEEEEECCCCCEEEEEECCCCEEEEE
AKNTGYAVRFPEQNVRPMGRNSIGVKGASISGDEAIISMVSTPRNDATLLAITDNGYGKR
EECCCEEEECCCCCCCCCCCCCCCEECCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCH
SAIEDYRMTKRGANGVITLKANEKVGKLVDMLEVNDGEDIIIITNKGIVNRQHIADIRVM
HHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHEEEEEE
GRNTSGVRLIRLDEDDFVSAVARVPKEDTEEEETPEENDNQISLPLDSSDNNPQPEDEDP
CCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
E
C
>Mature Secondary Structure
MQREKIIPINIEDEMRDSYLDYSMSVIVSRALPDVRDGLKPVHRRVLFGMNELGLQAGRS
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHCCC
YKKSARVVGEVLGKYHPHGDSAVYDSIVRMVQNFSLRYPLVDGQGNFGSVDGDAPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHH
TEVRMMRISSEILRDLDKNTIDFAPNFDDSLEEPIVLPAAFPNLLINGASGIAVGMATNI
HHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEECCCHHEEECCCCEEEEEECCC
PPHNLTEVIDGVIAYINNPEITIEELMTYIKAPDFPTAGIIYGYNGVRDAYLTGRGKIVL
CCCHHHHHHHHHHEEECCCCEEHHHHHHHHCCCCCCCCCEEECCCCCCCEEEECCCEEEE
RAKVQVEVTPKNGRESIIITELPYQVNKARLIEKIAGLVQQKKVEGIADLRDESDRDGMR
EEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
VVIELKKDAVTQVVINRLFKLTQLQETFGVIMLALVGGIPRVLTLKETIQYYVNHRHEVI
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCHHHEE
LRRTRFELDEAERRAHILEGLKICLDNLDEIIATIRQSPDTETARERLMATFSLSDLQAK
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHH
AILDMRLQRLTGLERQKIEDEYLELLKTIEGLRAILANEKLQMQLIKKELLQIKKTYGDE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
RRTQIVYETEDFSVEDMIAEEDVVITITHQGYIKRFPVSGYRRQGRGGRGISGVSAREDD
HHEEEEEECCCCCHHHHHCCCCEEEEEECCCCEEECCCCCHHHCCCCCCCCCCCCCCCHH
FIEHMFIASTHHYILFFTSHGKCYWLKVHEIPEAGRTARGRSITNLIEFATGEKIKASIN
HHHHHHHCCCCEEEEEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEEE
VKEFNDTQFIVMATKNGTIKKTPLSEYSNPRRSGIIAINITDNDELVGASLTDGSHQIVL
EEEECCCEEEEEEECCCCEEECCHHHCCCCCCCCEEEEEECCCCCEEEEEECCCCEEEEE
AKNTGYAVRFPEQNVRPMGRNSIGVKGASISGDEAIISMVSTPRNDATLLAITDNGYGKR
EECCCEEEECCCCCCCCCCCCCCCEECCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCH
SAIEDYRMTKRGANGVITLKANEKVGKLVDMLEVNDGEDIIIITNKGIVNRQHIADIRVM
HHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHEEEEEE
GRNTSGVRLIRLDEDDFVSAVARVPKEDTEEEETPEENDNQISLPLDSSDNNPQPEDEDP
CCCCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]