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The map label for this gene is pyrE

Identifier: 193213627

GI number: 193213627

Start: 2191499

End: 2192080

Strand: Direct

Name: pyrE

Synonym: Cpar_1991

Alternate gene names: 193213627

Gene position: 2191499-2192080 (Clockwise)

Preceding gene: 193213626

Following gene: 193213628

Centisome position: 95.73

GC content: 60.65

Gene sequence:

>582_bases
ATGACCAATTCGGAAACCCTCGCGATGTTCAAATCGAGCGGCGCTTTGCTCGATGGCCATTTCAAACTCACCTCGGGCCG
CCACAGCAACTCTTACTTCCAGTGCGCCAAGGTGTTGCAGTACCCGGAGTACCTGTCGGCGATCTGTGGCGAAATTGCCG
CACACTTCAGGGATTCCGGTATCACGACAGTCATTTCGCCGGCCATCGGCGGCATTGTCGTCGGCACGGAGGTCGGGCGT
CAACTCGGCGTCAAAACCATCTTTGCCGAGCGCAAGGAGGGGACGATGATGATCCGGCGCGGCTTTTCCATCGACCCGTC
CGAGCAGGTACTCGTGGTCGAGGATGTGATCACCACCGGCGGTTCGGTCGTCGAAGTGATGGAGCAAGTCAAGGCTGCCG
GCGCGACGGTTGCCGGTGTCGCTTCGGTGGTTGACCGCAGCAACGGCAAGGTGAAGCTCGCCGATAAGCAGTTTTCGCTG
CTCATGATGGAGGTGGTGAGCTATGCGCCCGAGGAGTGCCCGCTCTGCAAGGAGGGCCTGCCGATTGACGCACCGGGCAG
TCGAAGCAACGCGCAAGGCTGA

Upstream 100 bases:

>100_bases
TTAACTTTTCAAGCAGGCTTCTGTATCTTTACTTTTGGGCATCCCGATAGGCAGTTGCCCTTCATTATCCTTCTCACGCA
TAACTGACCACTGTTCCTCC

Downstream 100 bases:

>100_bases
CACGCGATATGCGGCAAGGCATCCACACCATTTCGTTCATCGGCCTCGGCCTAATCGGCACCTCGTTGATGCAGGCGCTC
AAACACGCCGGTGAAGCAAC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MTNSETLAMFKSSGALLDGHFKLTSGRHSNSYFQCAKVLQYPEYLSAICGEIAAHFRDSGITTVISPAIGGIVVGTEVGR
QLGVKTIFAERKEGTMMIRRGFSIDPSEQVLVVEDVITTGGSVVEVMEQVKAAGATVAGVASVVDRSNGKVKLADKQFSL
LMMEVVSYAPEECPLCKEGLPIDAPGSRSNAQG

Sequences:

>Translated_193_residues
MTNSETLAMFKSSGALLDGHFKLTSGRHSNSYFQCAKVLQYPEYLSAICGEIAAHFRDSGITTVISPAIGGIVVGTEVGR
QLGVKTIFAERKEGTMMIRRGFSIDPSEQVLVVEDVITTGGSVVEVMEQVKAAGATVAGVASVVDRSNGKVKLADKQFSL
LMMEVVSYAPEECPLCKEGLPIDAPGSRSNAQG
>Mature_192_residues
TNSETLAMFKSSGALLDGHFKLTSGRHSNSYFQCAKVLQYPEYLSAICGEIAAHFRDSGITTVISPAIGGIVVGTEVGRQ
LGVKTIFAERKEGTMMIRRGFSIDPSEQVLVVEDVITTGGSVVEVMEQVKAAGATVAGVASVVDRSNGKVKLADKQFSLL
MMEVVSYAPEECPLCKEGLPIDAPGSRSNAQG

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_CHLP8 (B3QLE2)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001999580.1
- ProteinModelPortal:   B3QLE2
- GeneID:   6420943
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_1991
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 20448; Mature: 20317

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 118-118 BINDING 146-146

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSETLAMFKSSGALLDGHFKLTSGRHSNSYFQCAKVLQYPEYLSAICGEIAAHFRDSG
CCCCHHEEEEECCCCEEECEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
ITTVISPAIGGIVVGTEVGRQLGVKTIFAERKEGTMMIRRGFSIDPSEQVLVVEDVITTG
CCEEEHHCCCCEEECHHHHHHHCHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEHHHHCC
GSVVEVMEQVKAAGATVAGVASVVDRSNGKVKLADKQFSLLMMEVVSYAPEECPLCKEGL
CHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCC
PIDAPGSRSNAQG
CCCCCCCCCCCCC
>Mature Secondary Structure 
TNSETLAMFKSSGALLDGHFKLTSGRHSNSYFQCAKVLQYPEYLSAICGEIAAHFRDSG
CCCHHEEEEECCCCEEECEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
ITTVISPAIGGIVVGTEVGRQLGVKTIFAERKEGTMMIRRGFSIDPSEQVLVVEDVITTG
CCEEEHHCCCCEEECHHHHHHHCHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEHHHHCC
GSVVEVMEQVKAAGATVAGVASVVDRSNGKVKLADKQFSLLMMEVVSYAPEECPLCKEGL
CHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCCC
PIDAPGSRSNAQG
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA