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The map label for this gene is proC [H]

Identifier: 193213621

GI number: 193213621

Start: 2187069

End: 2187869

Strand: Direct

Name: proC [H]

Synonym: Cpar_1985

Alternate gene names: 193213621

Gene position: 2187069-2187869 (Clockwise)

Preceding gene: 193213620

Following gene: 193213624

Centisome position: 95.54

GC content: 60.67

Gene sequence:

>801_bases
ATGTCACGACTCTCCATCGGCTTCATCGGCACCGGACGCATCGCCCAGGCCCTGATTTCCGGACTCTCTCACGACCCGAA
CATCGTCATCTGCGGCTACGACAAATCGCACGATGCCCTGCACTCAGTCGCCCTGCAATACAACGTTCAGGCCGAAGAGT
CGATCGAGGGGTTGGCACGCGATGTGAGCATCATCATCCTTTCGGTCAAACCCTATCAGGTGGCTGAAGTGATGGGCGAG
TTGAAGCATGCGCTGCACGGGGAACACCTCATCATCAGCGTGGCTGCAGGTATTTCGACAGGCTTCATCGAAGCGAATGC
GCCTGAAGGCTCGCGCGTCATCAGGGTGATGCCCAACACCCCGGCCTTTGTCGGCGAAGGCATGACTGCCCTCTGCAAAG
GCGCGCATGCGACCGCGGACGACCTGCTTGCTGCGGAACAGATTTTCAACGCCATCGGCAAAACCGCCGTCATCGACGAA
AGTGGCATGGATGCGGCAACGGCCGTCTCGGGCAGCGGACCGGCTTACATGTTCCGCATTATCGACTCGCTGGCCGAAGG
TGGCGAGGAGTGCGGACTGGATCGCCAGACCGCGCAACTGCTCGCTGCCCAGACCATGCTTGGCGCAGCGAAGATGGTTC
TGTCTGGCCGCAAAAGCCCGGAGGATCTGGTTCGCGAAGTAACCACGCCGGGCGGAACGACCGAGGCCGGACTGAAAGCG
ATGGATGAGCACGAAGTGCGCCAGGCGCTCGTCGAAACCGTCAAGGCCGCGGCCAGCCGCTCGAAAGAGTTGATGAAATA
G

Upstream 100 bases:

>100_bases
TCACGCTGCTCCTGCTGCTGGTCATTCTCTTTATCAAACTCCGGTATCAGGACAGCACCGATACCGGCGAGAAATAACCC
AATCTGCAATATCCCCAGTC

Downstream 100 bases:

>100_bases
GTTGAGCTGAAAAAAGGGGAGAGAAAACGACCTGTCACGCGCCAGCAAGCCCTGACAGGTGAAGCGCAATTTCCGGATGG
TCGGTAATGATGCCGTCAAC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSRLSIGFIGTGRIAQALISGLSHDPNIVICGYDKSHDALHSVALQYNVQAEESIEGLARDVSIIILSVKPYQVAEVMGE
LKHALHGEHLIISVAAGISTGFIEANAPEGSRVIRVMPNTPAFVGEGMTALCKGAHATADDLLAAEQIFNAIGKTAVIDE
SGMDAATAVSGSGPAYMFRIIDSLAEGGEECGLDRQTAQLLAAQTMLGAAKMVLSGRKSPEDLVREVTTPGGTTEAGLKA
MDEHEVRQALVETVKAAASRSKELMK

Sequences:

>Translated_266_residues
MSRLSIGFIGTGRIAQALISGLSHDPNIVICGYDKSHDALHSVALQYNVQAEESIEGLARDVSIIILSVKPYQVAEVMGE
LKHALHGEHLIISVAAGISTGFIEANAPEGSRVIRVMPNTPAFVGEGMTALCKGAHATADDLLAAEQIFNAIGKTAVIDE
SGMDAATAVSGSGPAYMFRIIDSLAEGGEECGLDRQTAQLLAAQTMLGAAKMVLSGRKSPEDLVREVTTPGGTTEAGLKA
MDEHEVRQALVETVKAAASRSKELMK
>Mature_265_residues
SRLSIGFIGTGRIAQALISGLSHDPNIVICGYDKSHDALHSVALQYNVQAEESIEGLARDVSIIILSVKPYQVAEVMGEL
KHALHGEHLIISVAAGISTGFIEANAPEGSRVIRVMPNTPAFVGEGMTALCKGAHATADDLLAAEQIFNAIGKTAVIDES
GMDAATAVSGSGPAYMFRIIDSLAEGGEECGLDRQTAQLLAAQTMLGAAKMVLSGRKSPEDLVREVTTPGGTTEAGLKAM
DEHEVRQALVETVKAAASRSKELMK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=276, Percent_Identity=32.9710144927536, Blast_Score=148, Evalue=4e-36,
Organism=Homo sapiens, GI24797095, Length=276, Percent_Identity=32.9710144927536, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI198041662, Length=265, Percent_Identity=32.8301886792453, Blast_Score=147, Evalue=7e-36,
Organism=Homo sapiens, GI21361454, Length=269, Percent_Identity=33.8289962825279, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=33.7121212121212, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17569021, Length=263, Percent_Identity=36.1216730038023, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=32.6164874551971, Blast_Score=117, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6320861, Length=282, Percent_Identity=30.4964539007092, Blast_Score=118, Evalue=8e-28,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=34.8314606741573, Blast_Score=143, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24648116, Length=285, Percent_Identity=36.8421052631579, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24647700, Length=168, Percent_Identity=38.6904761904762, Blast_Score=116, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27866; Mature: 27735

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00521 P5CR ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLSIGFIGTGRIAQALISGLSHDPNIVICGYDKSHDALHSVALQYNVQAEESIEGLAR
CCCEEEEEECCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHH
DVSIIILSVKPYQVAEVMGELKHALHGEHLIISVAAGISTGFIEANAPEGSRVIRVMPNT
CEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCCCCCEEEECCCC
PAFVGEGMTALCKGAHATADDLLAAEQIFNAIGKTAVIDESGMDAATAVSGSGPAYMFRI
CCHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCHHHEECCCCHHHHHHH
IDSLAEGGEECGLDRQTAQLLAAQTMLGAAKMVLSGRKSPEDLVREVTTPGGTTEAGLKA
HHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHH
MDEHEVRQALVETVKAAASRSKELMK
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRLSIGFIGTGRIAQALISGLSHDPNIVICGYDKSHDALHSVALQYNVQAEESIEGLAR
CCEEEEEECCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHH
DVSIIILSVKPYQVAEVMGELKHALHGEHLIISVAAGISTGFIEANAPEGSRVIRVMPNT
CEEEEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEECCCCCCCCEEEECCCC
PAFVGEGMTALCKGAHATADDLLAAEQIFNAIGKTAVIDESGMDAATAVSGSGPAYMFRI
CCHHHCCHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCHHHEECCCCHHHHHHH
IDSLAEGGEECGLDRQTAQLLAAQTMLGAAKMVLSGRKSPEDLVREVTTPGGTTEAGLKA
HHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHH
MDEHEVRQALVETVKAAASRSKELMK
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11844777; 11932238 [H]