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The map label for this gene is proA

Identifier: 193213210

GI number: 193213210

Start: 1711962

End: 1713224

Strand: Direct

Name: proA

Synonym: Cpar_1565

Alternate gene names: 193213210

Gene position: 1711962-1713224 (Clockwise)

Preceding gene: 193213205

Following gene: 193213211

Centisome position: 74.78

GC content: 61.68

Gene sequence:

>1263_bases
ATGACCGAACACGAAGCCATCGTCCAGCACCTCCAGGCCGTCCAGAACGCCAGCCGCAAGATCGTCACGCTCGATGAAGA
TGCTATCAACGCTCTGCTCAACGATCTCGCCGACCGAATTCCCGACGCCGCTGAAACGATTCTCGAAGCCAACCGCAAGG
ACCTCGAACGGATGGATCCGGCCGACCCGCGCTACGACCGCCTGCTCCTAAACGAATCTCGCCTGAACTCGATCGCTTCC
GACCTGCGCAACGTGGCCGCACTCCCTTCGCCGCTCGACCGCGTGCTCGAAGAGCGCACGCTGCCCAACGGGCTGGAGCT
GCGCAAGGTCTCGGTGCCACTCGGCGTGATCGGCATCATCTACGAATCGCGCCCGAACGTGACGTTTGACGTCTTCGCGC
TCTGCCTGAAATCGGGCAACGCCACCGTGCTGAAAGGCGGCAGTGACGCGGCCTTCTCAAACATCGCCATCGTCGAGCTG
ATCCAGACGGTCATCCGTGATCGCGGCCTCGATCCCGAGATGATCTACCTGCTGCCTGCTGAACGCGAGGCGGCACACAT
TCTGCTCAACGCAGTCGGCTATATCGACGTCATCATTCCGCGCGGCAGCCAGGCGCTGATCGACTTCGCCCGCAAGCACT
CCACCGTACCGGTCATCGAAACCGGCGCGGGCATCGTGCACACCTACTTCGATGAGAGCGGCGACCTGGCGATGGGTCGC
GACATCATCTTCAACGCCAAAACCCGCCGTCCGAGCGTCTGCAACGCGCTCGATACGCTGATTGTGCACAAAAGCCGCAT
CGACGACCTACCGGTGCTGGTCGAGCAGCTCGAAGAAAAGCTGGTGCAGATTTTTGCCGACGAACCAGCCTATTACAAGC
TGCTGAACCGCTATCCGGACGAACTGCTTCAGATCGCCACGCCTGAGAATTTCGGCACGGAGTACCTGTCGCTGAAGATG
TCGATCAAGACCGTTGAGACCTTCGAAGAAGCGCTCGACCACATCGCGCACCACAGCTCGAAGCACAGCGAAGCGATCGT
CGCATCGGATCAGGCGACCATCGACGCCTTCATGAAGCGAGTGGACGCGGCGGCGGTGTACGCCAACACCTCGACCGCCT
TCACCGACGGCGCGCAGTTCGGTCTCGGCGCGGAGATCGGCATCAGCACGCAGAAGCTGCACGCGCGTGGCCCGATGGCG
CTCAAGGAGCTGTGCACCTACAAATGGCTGATCGAAGGCCAGGGACAGGTGAGGCCCGCCTGA

Upstream 100 bases:

>100_bases
CGGCCCGCCGCGCCCGAGACAATTGCAAGGGTTGGCAAAGAATGACTATCTTTCGGTCACTTCAAAATTCTGACAATCCC
CTTTCAAGGAGCCCGCGTCC

Downstream 100 bases:

>100_bases
TGCTCGAAGCCCGCAAGCTCGTCAAATCCTACGCCCTGCCCGGCCAGCCGCCCCTGCGCATTCTCGACGGCATCGACCTC
TCGGTCGCGCCGGGCGAAAT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTEHEAIVQHLQAVQNASRKIVTLDEDAINALLNDLADRIPDAAETILEANRKDLERMDPADPRYDRLLLNESRLNSIAS
DLRNVAALPSPLDRVLEERTLPNGLELRKVSVPLGVIGIIYESRPNVTFDVFALCLKSGNATVLKGGSDAAFSNIAIVEL
IQTVIRDRGLDPEMIYLLPAEREAAHILLNAVGYIDVIIPRGSQALIDFARKHSTVPVIETGAGIVHTYFDESGDLAMGR
DIIFNAKTRRPSVCNALDTLIVHKSRIDDLPVLVEQLEEKLVQIFADEPAYYKLLNRYPDELLQIATPENFGTEYLSLKM
SIKTVETFEEALDHIAHHSSKHSEAIVASDQATIDAFMKRVDAAAVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMA
LKELCTYKWLIEGQGQVRPA

Sequences:

>Translated_420_residues
MTEHEAIVQHLQAVQNASRKIVTLDEDAINALLNDLADRIPDAAETILEANRKDLERMDPADPRYDRLLLNESRLNSIAS
DLRNVAALPSPLDRVLEERTLPNGLELRKVSVPLGVIGIIYESRPNVTFDVFALCLKSGNATVLKGGSDAAFSNIAIVEL
IQTVIRDRGLDPEMIYLLPAEREAAHILLNAVGYIDVIIPRGSQALIDFARKHSTVPVIETGAGIVHTYFDESGDLAMGR
DIIFNAKTRRPSVCNALDTLIVHKSRIDDLPVLVEQLEEKLVQIFADEPAYYKLLNRYPDELLQIATPENFGTEYLSLKM
SIKTVETFEEALDHIAHHSSKHSEAIVASDQATIDAFMKRVDAAAVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMA
LKELCTYKWLIEGQGQVRPA
>Mature_419_residues
TEHEAIVQHLQAVQNASRKIVTLDEDAINALLNDLADRIPDAAETILEANRKDLERMDPADPRYDRLLLNESRLNSIASD
LRNVAALPSPLDRVLEERTLPNGLELRKVSVPLGVIGIIYESRPNVTFDVFALCLKSGNATVLKGGSDAAFSNIAIVELI
QTVIRDRGLDPEMIYLLPAEREAAHILLNAVGYIDVIIPRGSQALIDFARKHSTVPVIETGAGIVHTYFDESGDLAMGRD
IIFNAKTRRPSVCNALDTLIVHKSRIDDLPVLVEQLEEKLVQIFADEPAYYKLLNRYPDELLQIATPENFGTEYLSLKMS
IKTVETFEEALDHIAHHSSKHSEAIVASDQATIDAFMKRVDAAAVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMAL
KELCTYKWLIEGQGQVRPA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=415, Percent_Identity=36.8674698795181, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI21361368, Length=415, Percent_Identity=36.8674698795181, Blast_Score=252, Evalue=5e-67,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=41.8269230769231, Blast_Score=307, Evalue=8e-85,
Organism=Caenorhabditis elegans, GI17569967, Length=415, Percent_Identity=34.4578313253012, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17569969, Length=415, Percent_Identity=34.4578313253012, Blast_Score=229, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=34.8946135831382, Blast_Score=238, Evalue=1e-63,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=35.3808353808354, Blast_Score=231, Evalue=6e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_CHLP8 (B3QPW0)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001999163.1
- ProteinModelPortal:   B3QPW0
- GeneID:   6420507
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_1565
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- ProtClustDB:   PRK00197
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 46312; Mature: 46181

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHEAIVQHLQAVQNASRKIVTLDEDAINALLNDLADRIPDAAETILEANRKDLERMDP
CCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHCCC
ADPRYDRLLLNESRLNSIASDLRNVAALPSPLDRVLEERTLPNGLELRKVSVPLGVIGII
CCCCHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCCEEEEEE
YESRPNVTFDVFALCLKSGNATVLKGGSDAAFSNIAIVELIQTVIRDRGLDPEMIYLLPA
EECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
EREAAHILLNAVGYIDVIIPRGSQALIDFARKHSTVPVIETGAGIVHTYFDESGDLAMGR
CCHHHHHHHHHHCEEEEEECCCCHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCEEECC
DIIFNAKTRRPSVCNALDTLIVHKSRIDDLPVLVEQLEEKLVQIFADEPAYYKLLNRYPD
EEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCH
ELLQIATPENFGTEYLSLKMSIKTVETFEEALDHIAHHSSKHSEAIVASDQATIDAFMKR
HHHEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHH
VDAAAVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMALKELCTYKWLIEGQGQVRPA
HHHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHEEEEECCCCCCCC
>Mature Secondary Structure 
TEHEAIVQHLQAVQNASRKIVTLDEDAINALLNDLADRIPDAAETILEANRKDLERMDP
CCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHCCC
ADPRYDRLLLNESRLNSIASDLRNVAALPSPLDRVLEERTLPNGLELRKVSVPLGVIGII
CCCCHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEECCCEEEEEE
YESRPNVTFDVFALCLKSGNATVLKGGSDAAFSNIAIVELIQTVIRDRGLDPEMIYLLPA
EECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
EREAAHILLNAVGYIDVIIPRGSQALIDFARKHSTVPVIETGAGIVHTYFDESGDLAMGR
CCHHHHHHHHHHCEEEEEECCCCHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCEEECC
DIIFNAKTRRPSVCNALDTLIVHKSRIDDLPVLVEQLEEKLVQIFADEPAYYKLLNRYPD
EEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCH
ELLQIATPENFGTEYLSLKMSIKTVETFEEALDHIAHHSSKHSEAIVASDQATIDAFMKR
HHHEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHH
VDAAAVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMALKELCTYKWLIEGQGQVRPA
HHHHHEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA