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The map label for this gene is adk

Identifier: 193212780

GI number: 193212780

Start: 1243339

End: 1243995

Strand: Direct

Name: adk

Synonym: Cpar_1126

Alternate gene names: 193212780

Gene position: 1243339-1243995 (Clockwise)

Preceding gene: 193212779

Following gene: 193212781

Centisome position: 54.31

GC content: 57.08

Gene sequence:

>657_bases
ATGAGAGTAATCCTGTTGGGCGCACCAGGCGCAGGAAAAGGAACACAAGCACAATACATATCGGAAGCATTCGACATTCC
CCAGATTTCAACCGGCGACATGCTCCGCGCCGCCGTCAAGGCGCAGAGCGAACTGGGTATGGCCGCCAAGAAAGTTATGG
ATGAAGGCGGTCTCGTGCCGGACGACATCATCATCGGCCTCGTCAAGGAGCGCATCGAAGAGGATGATTGCGCGAACGGC
TGCCTGTTCGACGGCTTCCCCCGCACCATCGCCCAGGCAGACGCCCTCAGAACCGAAGGTATCCGCATCGACAACATCAT
CGAAATCGACGTTCCCGACGAAGAGATCATCAAACGCATGAGCGGTCGCCGTGTGCATCCTGCTTCGGGCCGTACCTATC
ACATCGTCTTCAATCCTCCGGCCGTCGAGGGCAAGGATGACGTCACCGGCGAAGACCTGGTGCAGCGCGACGACGACACC
GAAGAAACTGTACGCAAACGCCTCAAGGTCTATCACGATCAGACCGAACCGCTGGTGGGCTACTATCGCAATCTCGCCAT
TGAAGGATCTGATGATGCGCCGAAGTACAGCTGCATCAACGGCATCGGCCAGGTCGAGCAGATCAAGCAGGATATTATCG
CTGCACTGAAGCAGTGA

Upstream 100 bases:

>100_bases
GAAACTCCGGCATCAACTGGTCAGGAAGAGGCTAAAAAGCCATCACGACCGAAAATTACCGTTGTCTCCCTGAAAAAAAA
TTCATAAAGGAAAGCGTTTC

Downstream 100 bases:

>100_bases
TCGCCAAACAGAGCATCAGGAAAAAAGCCAGTTGTTATGACTGGCTTTTTTTGTTTATATGACAACGATCGAACTCTCTT
TTTGCTGATGAAACATCCGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MRVILLGAPGAGKGTQAQYISEAFDIPQISTGDMLRAAVKAQSELGMAAKKVMDEGGLVPDDIIIGLVKERIEEDDCANG
CLFDGFPRTIAQADALRTEGIRIDNIIEIDVPDEEIIKRMSGRRVHPASGRTYHIVFNPPAVEGKDDVTGEDLVQRDDDT
EETVRKRLKVYHDQTEPLVGYYRNLAIEGSDDAPKYSCINGIGQVEQIKQDIIAALKQ

Sequences:

>Translated_218_residues
MRVILLGAPGAGKGTQAQYISEAFDIPQISTGDMLRAAVKAQSELGMAAKKVMDEGGLVPDDIIIGLVKERIEEDDCANG
CLFDGFPRTIAQADALRTEGIRIDNIIEIDVPDEEIIKRMSGRRVHPASGRTYHIVFNPPAVEGKDDVTGEDLVQRDDDT
EETVRKRLKVYHDQTEPLVGYYRNLAIEGSDDAPKYSCINGIGQVEQIKQDIIAALKQ
>Mature_218_residues
MRVILLGAPGAGKGTQAQYISEAFDIPQISTGDMLRAAVKAQSELGMAAKKVMDEGGLVPDDIIIGLVKERIEEDDCANG
CLFDGFPRTIAQADALRTEGIRIDNIIEIDVPDEEIIKRMSGRRVHPASGRTYHIVFNPPAVEGKDDVTGEDLVQRDDDT
EETVRKRLKVYHDQTEPLVGYYRNLAIEGSDDAPKYSCINGIGQVEQIKQDIIAALKQ

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=197, Percent_Identity=47.7157360406091, Blast_Score=200, Evalue=8e-52,
Organism=Homo sapiens, GI7524346, Length=197, Percent_Identity=47.7157360406091, Blast_Score=200, Evalue=9e-52,
Organism=Homo sapiens, GI19923437, Length=183, Percent_Identity=45.9016393442623, Blast_Score=177, Evalue=6e-45,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=42.3913043478261, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=42.3913043478261, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=42.3913043478261, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=42.3913043478261, Blast_Score=157, Evalue=5e-39,
Organism=Homo sapiens, GI22749187, Length=202, Percent_Identity=26.7326732673267, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI4502011, Length=198, Percent_Identity=27.7777777777778, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI28144897, Length=187, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI28144899, Length=187, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=27.3381294964029, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI237858799, Length=138, Percent_Identity=27.536231884058, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786680, Length=212, Percent_Identity=61.7924528301887, Blast_Score=268, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI17552384, Length=199, Percent_Identity=43.21608040201, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17537943, Length=219, Percent_Identity=33.7899543378995, Blast_Score=123, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=215, Percent_Identity=29.7674418604651, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320432, Length=198, Percent_Identity=48.4848484848485, Blast_Score=206, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321018, Length=194, Percent_Identity=42.7835051546392, Blast_Score=152, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=28.9617486338798, Blast_Score=83, Evalue=3e-17,
Organism=Drosophila melanogaster, GI22026816, Length=219, Percent_Identity=44.2922374429224, Blast_Score=190, Evalue=6e-49,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=45.0549450549451, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=45.0549450549451, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI17647141, Length=215, Percent_Identity=26.9767441860465, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24663208, Length=215, Percent_Identity=26.9767441860465, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221459597, Length=214, Percent_Identity=26.1682242990654, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356893, Length=214, Percent_Identity=26.1682242990654, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CHLP8 (B3QNN0)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001998733.1
- GeneID:   6420057
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_1126
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23937; Mature: 23937

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVILLGAPGAGKGTQAQYISEAFDIPQISTGDMLRAAVKAQSELGMAAKKVMDEGGLVP
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DDIIIGLVKERIEEDDCANGCLFDGFPRTIAQADALRTEGIRIDNIIEIDVPDEEIIKRM
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHCCEEECCEEEEECCHHHHHHHH
SGRRVHPASGRTYHIVFNPPAVEGKDDVTGEDLVQRDDDTEETVRKRLKVYHDQTEPLVG
CCCEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHH
YYRNLAIEGSDDAPKYSCINGIGQVEQIKQDIIAALKQ
HHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVILLGAPGAGKGTQAQYISEAFDIPQISTGDMLRAAVKAQSELGMAAKKVMDEGGLVP
CEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
DDIIIGLVKERIEEDDCANGCLFDGFPRTIAQADALRTEGIRIDNIIEIDVPDEEIIKRM
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHCCEEECCEEEEECCHHHHHHHH
SGRRVHPASGRTYHIVFNPPAVEGKDDVTGEDLVQRDDDTEETVRKRLKVYHDQTEPLVG
CCCEECCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHH
YYRNLAIEGSDDAPKYSCINGIGQVEQIKQDIIAALKQ
HHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA