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The map label for this gene is pepD [H]

Identifier: 193212668

GI number: 193212668

Start: 1120288

End: 1121748

Strand: Direct

Name: pepD [H]

Synonym: Cpar_1013

Alternate gene names: 193212668

Gene position: 1120288-1121748 (Clockwise)

Preceding gene: 193212666

Following gene: 193212669

Centisome position: 48.94

GC content: 56.61

Gene sequence:

>1461_bases
ATGACCACTACCATTCCTGAGCTGGAGCCCCGTGCGCTTTGGAGGCATTTTTATAACCTGACGCAAATCCCACGACCATC
CGGCCACGAGCAACAGATCAGGGAGTACGTTGCTGATTTTGGCCGACGGCTCGGGTTGAAAAGCCTGATCGATGAGGCAG
GCAATGTCATCATCAGAAAGCCTGCCAAGAAAGGCATGGAGCAGCGCAAAGGCGTCATCCTTCAGGCGCATCTCGACATG
GTGCCGCAGAAGAATGCGGACAGCCATCACGATTTTGAGCGAGATCCGATCGAAGCTTACTTCGAGAAGGGTTGGGTTCG
TGCCCGAGGCACAACGCTCGGGGCCGACAATGGCATCGGCGTCGCCGCAGCGCTGGCAGTGCTGGAGTCGGAATCGCTAT
CACATGGGCCACTCGAAGCGCTGTTCACAGCCAATGAGGAGGCCGGAATGACCGGGGCAATGGGGTTGAAGCCGGAGGTT
CTTGAGGGAGAAATTCTTCTGAACCTCGACTCCGAAGATGAGGGTGAACTGTTCATCGGGTGCGCCGGTGGGCTTGATGG
CACGATGACGTTCAGGTACAGCGAAGCATCGCTTCCTCCCGACTATGCCGGATTTGAGATCAGGGTTTCAGGACTGAAAG
GTGGGCATAGCGGTTTGGATATTCATCTTGGTCGGGGCAACGCCAACAAGATCATGAACAGGCTGTTGCAAGCTGGCCAC
GACTGTTGCAGCTTGCGGTTGGCCTCGATTGATGGCGGAAGCCTGCGCAACGCAATTCCCCGTGAATCAACGTCACTCGT
CACGCTTCCATCCGATCGCGCTGAGCTTTTTGTCGAAACGCTCAAGCGCCTTGGGGCAACAATCGCGGAAGAACTGGCGG
CGGTTGACCCGGATTTGCGTATCGAGATTAGAGCTGCTGAGATTCCGGATACGGTTATCGATAACGAATCTTTCGGGCGC
CTCCTCCAGGCCGTTGCCGACTGCCCGAATGGTGTCGTGCGAATGAGCGGCGAAATGGATGGCGTGGTTGAAACGTCGAA
CAATCTGGCGAGGGTGAAATCGAACGCCGGAAGCATTGCTGTCGAGTGCCTGCTCAGAAGCTCCGTTGATTCGTCGCTTG
AAGAGCTTGCGACGAGCATCCAGAGCGTCGCTGATCGTGTTGGTGCGACCTCTTCGTTCACCGGCGGCTACCCTGGCTGG
AAACCAGATCCGGATTCGCCTATCCTGAGCCTGATGCAGCGCATCTATCAACAACGTTTCGGAAAAGCTCCGGAAGTCAA
GGCTATTCACGCCGGGCTGGAGTGCGGCATCATCGGCGGTATCTATCCCGGGCTCGACATGATTTCGTTCGGGCCGACGA
TTCGTTTTCCTCACTCGCCTGACGAAAAGGTCGAATGCGCGTCGGTCCAGAAATTCTGGGACTTCCTCGTCGATGTGCTG
GCCGATATTCCGGCAAAGTGA

Upstream 100 bases:

>100_bases
CGGGGAACATCGTTGACTTTATGCAGCGCTTTTTTATTCTCTCAAATTATGGTGATACTATAACAATCAGTTTGTCGCAG
AAACGTTGAATCTGGAGATT

Downstream 100 bases:

>100_bases
GCCGTTCATTGATGTTCATGTCCTGTCGGCAAGCGGGATAACCGCACGGGAGTGCTATCTTCTATTTTGCTTTAATTTCG
CCGATCCGCACCAGTGAAAA

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTTTIPELEPRALWRHFYNLTQIPRPSGHEQQIREYVADFGRRLGLKSLIDEAGNVIIRKPAKKGMEQRKGVILQAHLDM
VPQKNADSHHDFERDPIEAYFEKGWVRARGTTLGADNGIGVAAALAVLESESLSHGPLEALFTANEEAGMTGAMGLKPEV
LEGEILLNLDSEDEGELFIGCAGGLDGTMTFRYSEASLPPDYAGFEIRVSGLKGGHSGLDIHLGRGNANKIMNRLLQAGH
DCCSLRLASIDGGSLRNAIPRESTSLVTLPSDRAELFVETLKRLGATIAEELAAVDPDLRIEIRAAEIPDTVIDNESFGR
LLQAVADCPNGVVRMSGEMDGVVETSNNLARVKSNAGSIAVECLLRSSVDSSLEELATSIQSVADRVGATSSFTGGYPGW
KPDPDSPILSLMQRIYQQRFGKAPEVKAIHAGLECGIIGGIYPGLDMISFGPTIRFPHSPDEKVECASVQKFWDFLVDVL
ADIPAK

Sequences:

>Translated_486_residues
MTTTIPELEPRALWRHFYNLTQIPRPSGHEQQIREYVADFGRRLGLKSLIDEAGNVIIRKPAKKGMEQRKGVILQAHLDM
VPQKNADSHHDFERDPIEAYFEKGWVRARGTTLGADNGIGVAAALAVLESESLSHGPLEALFTANEEAGMTGAMGLKPEV
LEGEILLNLDSEDEGELFIGCAGGLDGTMTFRYSEASLPPDYAGFEIRVSGLKGGHSGLDIHLGRGNANKIMNRLLQAGH
DCCSLRLASIDGGSLRNAIPRESTSLVTLPSDRAELFVETLKRLGATIAEELAAVDPDLRIEIRAAEIPDTVIDNESFGR
LLQAVADCPNGVVRMSGEMDGVVETSNNLARVKSNAGSIAVECLLRSSVDSSLEELATSIQSVADRVGATSSFTGGYPGW
KPDPDSPILSLMQRIYQQRFGKAPEVKAIHAGLECGIIGGIYPGLDMISFGPTIRFPHSPDEKVECASVQKFWDFLVDVL
ADIPAK
>Mature_485_residues
TTTIPELEPRALWRHFYNLTQIPRPSGHEQQIREYVADFGRRLGLKSLIDEAGNVIIRKPAKKGMEQRKGVILQAHLDMV
PQKNADSHHDFERDPIEAYFEKGWVRARGTTLGADNGIGVAAALAVLESESLSHGPLEALFTANEEAGMTGAMGLKPEVL
EGEILLNLDSEDEGELFIGCAGGLDGTMTFRYSEASLPPDYAGFEIRVSGLKGGHSGLDIHLGRGNANKIMNRLLQAGHD
CCSLRLASIDGGSLRNAIPRESTSLVTLPSDRAELFVETLKRLGATIAEELAAVDPDLRIEIRAAEIPDTVIDNESFGRL
LQAVADCPNGVVRMSGEMDGVVETSNNLARVKSNAGSIAVECLLRSSVDSSLEELATSIQSVADRVGATSSFTGGYPGWK
PDPDSPILSLMQRIYQQRFGKAPEVKAIHAGLECGIIGGIYPGLDMISFGPTIRFPHSPDEKVECASVQKFWDFLVDVLA
DIPAK

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=490, Percent_Identity=45.1020408163265, Blast_Score=453, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 52542; Mature: 52411

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTIPELEPRALWRHFYNLTQIPRPSGHEQQIREYVADFGRRLGLKSLIDEAGNVIIRK
CCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEC
PAKKGMEQRKGVILQAHLDMVPQKNADSHHDFERDPIEAYFEKGWVRARGTTLGADNGIG
HHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCCCCCCCCH
VAAALAVLESESLSHGPLEALFTANEEAGMTGAMGLKPEVLEGEILLNLDSEDEGELFIG
HHHHHHHHHHCCCCCCCCHHHEECCCCCCCCCCCCCCCCEECCEEEEEECCCCCCCEEEE
CAGGLDGTMTFRYSEASLPPDYAGFEIRVSGLKGGHSGLDIHLGRGNANKIMNRLLQAGH
EECCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHCCC
DCCSLRLASIDGGSLRNAIPRESTSLVTLPSDRAELFVETLKRLGATIAEELAAVDPDLR
HHHEEEEEECCCCHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IEIRAAEIPDTVIDNESFGRLLQAVADCPNGVVRMSGEMDGVVETSNNLARVKSNAGSIA
EEEEECCCCCHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHCCCCHHH
VECLLRSSVDSSLEELATSIQSVADRVGATSSFTGGYPGWKPDPDSPILSLMQRIYQQRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GKAPEVKAIHAGLECGIIGGIYPGLDMISFGPTIRFPHSPDEKVECASVQKFWDFLVDVL
CCCCCCHHHHCCCCCCEECCCCCCCHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHH
ADIPAK
HHCCCC
>Mature Secondary Structure 
TTTIPELEPRALWRHFYNLTQIPRPSGHEQQIREYVADFGRRLGLKSLIDEAGNVIIRK
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEC
PAKKGMEQRKGVILQAHLDMVPQKNADSHHDFERDPIEAYFEKGWVRARGTTLGADNGIG
HHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCEEECCCCCCCCCCCH
VAAALAVLESESLSHGPLEALFTANEEAGMTGAMGLKPEVLEGEILLNLDSEDEGELFIG
HHHHHHHHHHCCCCCCCCHHHEECCCCCCCCCCCCCCCCEECCEEEEEECCCCCCCEEEE
CAGGLDGTMTFRYSEASLPPDYAGFEIRVSGLKGGHSGLDIHLGRGNANKIMNRLLQAGH
EECCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHCCC
DCCSLRLASIDGGSLRNAIPRESTSLVTLPSDRAELFVETLKRLGATIAEELAAVDPDLR
HHHEEEEEECCCCHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IEIRAAEIPDTVIDNESFGRLLQAVADCPNGVVRMSGEMDGVVETSNNLARVKSNAGSIA
EEEEECCCCCHHCCCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHCCCCHHH
VECLLRSSVDSSLEELATSIQSVADRVGATSSFTGGYPGWKPDPDSPILSLMQRIYQQRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
GKAPEVKAIHAGLECGIIGGIYPGLDMISFGPTIRFPHSPDEKVECASVQKFWDFLVDVL
CCCCCCHHHHCCCCCCEECCCCCCCHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHH
ADIPAK
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]