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The map label for this gene is panB

Identifier: 193212478

GI number: 193212478

Start: 886838

End: 887671

Strand: Direct

Name: panB

Synonym: Cpar_0815

Alternate gene names: 193212478

Gene position: 886838-887671 (Clockwise)

Preceding gene: 193212477

Following gene: 193212479

Centisome position: 38.74

GC content: 58.87

Gene sequence:

>834_bases
ATGCCCAACGGTTCCGCCAACAAACTGCCTCACGTTACGACCCGCAGGATGCTCGATATGAAAGAGCGCGGCGAAAAGAT
TGCCGTTCTGACCGCTTACGACTACACGATGGCGCGGATTCTCGACCGCTCGGGAGTCGATGCGATTCTGGTCGGCGATT
CGGCCAGCAACGTCTTTTCGGGCCACAATACCACGCTTCCGATCACGGTCGACGAGATGATCTACCATGCTAAAGCGGTG
GTTCGCGGCGTGCAGGCAGAGACGAGCCGCGCGATGGTGATTGTCGACATGCCCTTCATGAGCTACCAGCTTTCGCCGGA
GGATGCGGTGCGCAACGCGGGCAAAATCATGAAAGAACATGAGTGCGACGCCGTCAAGATGGAGGGCGGCAAGGTGATCG
CTGAAGCGGTCAAACGGATTACCGACATCGGTATTCCTGTAATGGGCCACCTCGGCCTGATGCCGCAGTCGATCTACAAA
TACGGCAGCTACAAGGTGCGGGCCAAGGAGGGCGACGAGGCCGAGCAGCTTATGGAGGATGCCCGCATTCTCGAAGAGTC
CGGGGCGTTCGCCATCGTGCTCGAAAAGATTCCCTCGAAGCTCGCCGGGGAGGTGAGCCGCTCGCTGACTATTCCGACCA
TCGGCATCGGTGCCGGGCCGGAGTGCGACGGCCAGGTGCTGGTGATCAACGACATGCTCGGTCTCAACACCGAGTTCCAC
CCGAGGTTCGTCCGTCGCTATGCCGACCTCTCATCGGTCATTGAAAAGGCTGTGCAGAGTTATGTGGCTGATGTGCGAGC
CAACAGCTTTCCTTCGGAGGATGAAAGCTACTGA

Upstream 100 bases:

>100_bases
CGCCGGAACGTCCGCTGAAGAGGGGGCAAGGGTTCTGAGTCAGGATGACCTTGAACGTTTCGGCGTGTCTCAAGTTTCAA
TCACTTAATGTTTTTCCATC

Downstream 100 bases:

>100_bases
GCTTTGGCTGGTATGCAGCACTCTTTGCTTTTCATGTTGTGATAAATCTTCTATTTTAAAAAACATGCCGGAAATGGCCG
GAGCGTTTTCCGGCCTTGAT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MPNGSANKLPHVTTRRMLDMKERGEKIAVLTAYDYTMARILDRSGVDAILVGDSASNVFSGHNTTLPITVDEMIYHAKAV
VRGVQAETSRAMVIVDMPFMSYQLSPEDAVRNAGKIMKEHECDAVKMEGGKVIAEAVKRITDIGIPVMGHLGLMPQSIYK
YGSYKVRAKEGDEAEQLMEDARILEESGAFAIVLEKIPSKLAGEVSRSLTIPTIGIGAGPECDGQVLVINDMLGLNTEFH
PRFVRRYADLSSVIEKAVQSYVADVRANSFPSEDESY

Sequences:

>Translated_277_residues
MPNGSANKLPHVTTRRMLDMKERGEKIAVLTAYDYTMARILDRSGVDAILVGDSASNVFSGHNTTLPITVDEMIYHAKAV
VRGVQAETSRAMVIVDMPFMSYQLSPEDAVRNAGKIMKEHECDAVKMEGGKVIAEAVKRITDIGIPVMGHLGLMPQSIYK
YGSYKVRAKEGDEAEQLMEDARILEESGAFAIVLEKIPSKLAGEVSRSLTIPTIGIGAGPECDGQVLVINDMLGLNTEFH
PRFVRRYADLSSVIEKAVQSYVADVRANSFPSEDESY
>Mature_276_residues
PNGSANKLPHVTTRRMLDMKERGEKIAVLTAYDYTMARILDRSGVDAILVGDSASNVFSGHNTTLPITVDEMIYHAKAVV
RGVQAETSRAMVIVDMPFMSYQLSPEDAVRNAGKIMKEHECDAVKMEGGKVIAEAVKRITDIGIPVMGHLGLMPQSIYKY
GSYKVRAKEGDEAEQLMEDARILEESGAFAIVLEKIPSKLAGEVSRSLTIPTIGIGAGPECDGQVLVINDMLGLNTEFHP
RFVRRYADLSSVIEKAVQSYVADVRANSFPSEDESY

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family

Homologues:

Organism=Escherichia coli, GI1786326, Length=258, Percent_Identity=40.6976744186046, Blast_Score=207, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6319653, Length=255, Percent_Identity=36.4705882352941, Blast_Score=174, Evalue=1e-44,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PANB_CHLP8 (B3QMS8)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001998431.1
- GeneID:   6419744
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_0815
- HOGENOM:   HBG299908
- OMA:   FPSAHVA
- ProtClustDB:   PRK00311
- GO:   GO:0005737
- HAMAP:   MF_00156
- InterPro:   IPR003700
- InterPro:   IPR015813
- Gene3D:   G3DSA:3.20.20.60
- PANTHER:   PTHR20881
- PIRSF:   PIRSF000388
- TIGRFAMs:   TIGR00222

Pfam domain/function: PF02548 Pantoate_transf; SSF51621 Pyrv/PenolPyrv_Kinase_cat

EC number: =2.1.2.11

Molecular weight: Translated: 30343; Mature: 30212

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: ACT_SITE 195-195 BINDING 96-96 BINDING 126-126

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNGSANKLPHVTTRRMLDMKERGEKIAVLTAYDYTMARILDRSGVDAILVGDSASNVFS
CCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHCCCCCEEEECCCCCCCCC
GHNTTLPITVDEMIYHAKAVVRGVQAETSRAMVIVDMPFMSYQLSPEDAVRNAGKIMKEH
CCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHC
ECDAVKMEGGKVIAEAVKRITDIGIPVMGHLGLMPQSIYKYGSYKVRAKEGDEAEQLMED
CCCEEEECCCHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHCCCEEEEECCCCHHHHHHHH
ARILEESGAFAIVLEKIPSKLAGEVSRSLTIPTIGIGAGPECDGQVLVINDMLGLNTEFH
HHHHHHCCCEEEEHHHHHHHHHHHHHCCEECCEEECCCCCCCCCEEEEEECCCCCCCCCC
PRFVRRYADLSSVIEKAVQSYVADVRANSFPSEDESY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PNGSANKLPHVTTRRMLDMKERGEKIAVLTAYDYTMARILDRSGVDAILVGDSASNVFS
CCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHCCCCCEEEECCCCCCCCC
GHNTTLPITVDEMIYHAKAVVRGVQAETSRAMVIVDMPFMSYQLSPEDAVRNAGKIMKEH
CCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHC
ECDAVKMEGGKVIAEAVKRITDIGIPVMGHLGLMPQSIYKYGSYKVRAKEGDEAEQLMED
CCCEEEECCCHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHCCCEEEEECCCCHHHHHHHH
ARILEESGAFAIVLEKIPSKLAGEVSRSLTIPTIGIGAGPECDGQVLVINDMLGLNTEFH
HHHHHHCCCEEEEHHHHHHHHHHHHHCCEECCEEECCCCCCCCCEEEEEECCCCCCCCCC
PRFVRRYADLSSVIEKAVQSYVADVRANSFPSEDESY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA