Click here to switch to the map view.

The map label for this gene is rnr1 [H]

Identifier: 193212371

GI number: 193212371

Start: 754147

End: 755610

Strand: Direct

Name: rnr1 [H]

Synonym: Cpar_0704

Alternate gene names: 193212371

Gene position: 754147-755610 (Clockwise)

Preceding gene: 193212370

Following gene: 193212373

Centisome position: 32.94

GC content: 55.6

Gene sequence:

>1464_bases
ATGAGCAAAACATTCACGAAAGCCGATATCGTCAATATCGCTGTTGATGCCATGCTGGTTAACGGGTTGGATCCCGATTT
TTCGCCCCAGGCAAAGCAGCAGTTGGGCTCGATGCATGGGCCCACAGAGGGGTATGGTTCGGAGATTCTTGATTTGACCT
CGTTGCTCTGGTGTTCGATTGACAACGACGACTCGCGTGATCTGGACCAGATTACCGCCTGTGAGGTGCTGGATGATTCC
TCCACCATCATTTATGTGGCTATCGCTGACGTCGATACGCTGGTGAAAAAAGGCTCGCCGATCGATGGCCACGCACGGAC
AAATACCACCTCCGTCTATACGTCAGCTAAAGTCTTTCCGATGCTGCCCTTGCGTCTTTCCACCGACCTGACCTCCCTCA
ATCCCGATCAGAACCGGCTGGCCATCGTCACCATCATGAAAATCGGCCCTGATGGCGAGTTGATCAACTCGACGGTCGAG
CGCGCATGGGTGAGGAACAAGGCTCAACTCGCGTATGATTCTGTCTCGGCTTGGATCGATGGTAAAGACGAGCTGCCTGC
GGCTGCAAAGGCCGTTCCGGGGATGGATGAGCAGTTGCGCCGTCAGGATGCTGTGGCGCAAAAATTACGGTTGCAACGGC
ATGCGAAAGGTTCTCTGGAATTCGAGACCTTTCAGCCTCGCGCCGTGTTCGAAGGGGATCGCGTTGTTGGCATCACTCAG
CAGGAGAAGAACCGGGCGCGACAACTGATCGAGGAGTTCATGATTGCCACCAACGCCTGCACCGCCGATTTTCTTGCTGA
AAAGGGTGTTGCGTCGATTCGTCGGGTGGTAAAGTCGCCTGAGCGATGGAAGCGCATTGTGGAGGTGGCCAAGGAGTACG
GCTATTCGCTGCCCGGTGAGCCCGACGGAAAAGCGCTCGAAAAATTCCTAGCCGTGAGGCACAAGGCCGATCCATTGCGT
TTCCCTGACCTTTCGCTCACCATCATCAAGCTTATGGGAGCAGGAGAGTACGTCGTGGAATTTCCGGGGCAGAAACCCAT
CGGGCACTTTGGCCTTGCCGAGCGCGATTACACTCACTCGACGGCACCGAACAGACGCTATCCCGATCTGATTACCCTGA
GAATGACCAAGGCTTTTCTGGCCAACTGCCCGTCCCCGTATGGCGTTGACGAGCTTGAAGAGTTGGCGGTTCATTGCACC
CGCCAGGAGGATGCGGCCCGCAAGGTGGAGCGTCGCGTACGCAAGTCTGAAGCCGCGTTACTTCTGGGAACCATGATCGG
TCAGCACTTCGACGCTGTTGTCTCCGGTCATTCGGAGCGGGGCACGTGGGTGAGGATCCTGACGCCGCCAGCCGAGGGGC
GTCTGGTCAGAACTTACGGGAAAGTCAGCGTTGGTAAAAAGATCAAGGTAAAGCTTGTTTTGGCCGATGTCGAACAGGGG
TTCATTGATTTTGAAAGGATATGA

Upstream 100 bases:

>100_bases
GGTAGGCTGTTTCCGCGGTAAACCTGTATTCTCCCGGAACAAATCTTTCTGTTTTACGGGCTGCCGTGTACATCAAAGAG
GTAAGTATTCGAGGAGCGCT

Downstream 100 bases:

>100_bases
CAACCGGTCATGGTCATTCGCATAACCGGTTGTCAAAAGACAGCTTACCACTCTGAAGAATGTAACCCGACGATCTCCTT
GTACGCAATCGCGGCCGCGC

Product: exoribonuclease II

Products: NA

Alternate protein names: RNase R 1; VacB protein homolog 1 [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MSKTFTKADIVNIAVDAMLVNGLDPDFSPQAKQQLGSMHGPTEGYGSEILDLTSLLWCSIDNDDSRDLDQITACEVLDDS
STIIYVAIADVDTLVKKGSPIDGHARTNTTSVYTSAKVFPMLPLRLSTDLTSLNPDQNRLAIVTIMKIGPDGELINSTVE
RAWVRNKAQLAYDSVSAWIDGKDELPAAAKAVPGMDEQLRRQDAVAQKLRLQRHAKGSLEFETFQPRAVFEGDRVVGITQ
QEKNRARQLIEEFMIATNACTADFLAEKGVASIRRVVKSPERWKRIVEVAKEYGYSLPGEPDGKALEKFLAVRHKADPLR
FPDLSLTIIKLMGAGEYVVEFPGQKPIGHFGLAERDYTHSTAPNRRYPDLITLRMTKAFLANCPSPYGVDELEELAVHCT
RQEDAARKVERRVRKSEAALLLGTMIGQHFDAVVSGHSERGTWVRILTPPAEGRLVRTYGKVSVGKKIKVKLVLADVEQG
FIDFERI

Sequences:

>Translated_487_residues
MSKTFTKADIVNIAVDAMLVNGLDPDFSPQAKQQLGSMHGPTEGYGSEILDLTSLLWCSIDNDDSRDLDQITACEVLDDS
STIIYVAIADVDTLVKKGSPIDGHARTNTTSVYTSAKVFPMLPLRLSTDLTSLNPDQNRLAIVTIMKIGPDGELINSTVE
RAWVRNKAQLAYDSVSAWIDGKDELPAAAKAVPGMDEQLRRQDAVAQKLRLQRHAKGSLEFETFQPRAVFEGDRVVGITQ
QEKNRARQLIEEFMIATNACTADFLAEKGVASIRRVVKSPERWKRIVEVAKEYGYSLPGEPDGKALEKFLAVRHKADPLR
FPDLSLTIIKLMGAGEYVVEFPGQKPIGHFGLAERDYTHSTAPNRRYPDLITLRMTKAFLANCPSPYGVDELEELAVHCT
RQEDAARKVERRVRKSEAALLLGTMIGQHFDAVVSGHSERGTWVRILTPPAEGRLVRTYGKVSVGKKIKVKLVLADVEQG
FIDFERI
>Mature_486_residues
SKTFTKADIVNIAVDAMLVNGLDPDFSPQAKQQLGSMHGPTEGYGSEILDLTSLLWCSIDNDDSRDLDQITACEVLDDSS
TIIYVAIADVDTLVKKGSPIDGHARTNTTSVYTSAKVFPMLPLRLSTDLTSLNPDQNRLAIVTIMKIGPDGELINSTVER
AWVRNKAQLAYDSVSAWIDGKDELPAAAKAVPGMDEQLRRQDAVAQKLRLQRHAKGSLEFETFQPRAVFEGDRVVGITQQ
EKNRARQLIEEFMIATNACTADFLAEKGVASIRRVVKSPERWKRIVEVAKEYGYSLPGEPDGKALEKFLAVRHKADPLRF
PDLSLTIIKLMGAGEYVVEFPGQKPIGHFGLAERDYTHSTAPNRRYPDLITLRMTKAFLANCPSPYGVDELEELAVHCTR
QEDAARKVERRVRKSEAALLLGTMIGQHFDAVVSGHSERGTWVRILTPPAEGRLVRTYGKVSVGKKIKVKLVLADVEQGF
IDFERI

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=455, Percent_Identity=27.6923076923077, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI190014623, Length=352, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI190014625, Length=352, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI219521928, Length=378, Percent_Identity=23.2804232804233, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI19115966, Length=383, Percent_Identity=23.4986945169713, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI87082383, Length=453, Percent_Identity=30.9050772626932, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI1787542, Length=421, Percent_Identity=28.0285035629454, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17553506, Length=405, Percent_Identity=30.8641975308642, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI212645896, Length=379, Percent_Identity=26.1213720316623, Blast_Score=109, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324552, Length=336, Percent_Identity=28.8690476190476, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24649634, Length=341, Percent_Identity=25.8064516129032, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24654592, Length=428, Percent_Identity=25.7009345794392, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19922976, Length=428, Percent_Identity=25.7009345794392, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24654597, Length=428, Percent_Identity=25.7009345794392, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 54004; Mature: 53873

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTFTKADIVNIAVDAMLVNGLDPDFSPQAKQQLGSMHGPTEGYGSEILDLTSLLWCSI
CCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEEC
DNDDSRDLDQITACEVLDDSSTIIYVAIADVDTLVKKGSPIDGHARTNTTSVYTSAKVFP
CCCCCCCHHHHHHHHEECCCCCEEEEEECCHHHHHHCCCCCCCCCCCCCCEEEECCEEEE
MLPLRLSTDLTSLNPDQNRLAIVTIMKIGPDGELINSTVERAWVRNKAQLAYDSVSAWID
ECCEEECCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
GKDELPAAAKAVPGMDEQLRRQDAVAQKLRLQRHAKGSLEFETFQPRAVFEGDRVVGITQ
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCEEEEECH
QEKNRARQLIEEFMIATNACTADFLAEKGVASIRRVVKSPERWKRIVEVAKEYGYSLPGE
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
PDGKALEKFLAVRHKADPLRFPDLSLTIIKLMGAGEYVVEFPGQKPIGHFGLAERDYTHS
CCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCC
TAPNRRYPDLITLRMTKAFLANCPSPYGVDELEELAVHCTRQEDAARKVERRVRKSEAAL
CCCCCCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LLGTMIGQHFDAVVSGHSERGTWVRILTPPAEGRLVRTYGKVSVGKKIKVKLVLADVEQG
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCEEEEEEEEEECCCC
FIDFERI
CCCHHCC
>Mature Secondary Structure 
SKTFTKADIVNIAVDAMLVNGLDPDFSPQAKQQLGSMHGPTEGYGSEILDLTSLLWCSI
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEEC
DNDDSRDLDQITACEVLDDSSTIIYVAIADVDTLVKKGSPIDGHARTNTTSVYTSAKVFP
CCCCCCCHHHHHHHHEECCCCCEEEEEECCHHHHHHCCCCCCCCCCCCCCEEEECCEEEE
MLPLRLSTDLTSLNPDQNRLAIVTIMKIGPDGELINSTVERAWVRNKAQLAYDSVSAWID
ECCEEECCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
GKDELPAAAKAVPGMDEQLRRQDAVAQKLRLQRHAKGSLEFETFQPRAVFEGDRVVGITQ
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCEEEEECH
QEKNRARQLIEEFMIATNACTADFLAEKGVASIRRVVKSPERWKRIVEVAKEYGYSLPGE
HHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
PDGKALEKFLAVRHKADPLRFPDLSLTIIKLMGAGEYVVEFPGQKPIGHFGLAERDYTHS
CCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCC
TAPNRRYPDLITLRMTKAFLANCPSPYGVDELEELAVHCTRQEDAARKVERRVRKSEAAL
CCCCCCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LLGTMIGQHFDAVVSGHSERGTWVRILTPPAEGRLVRTYGKVSVGKKIKVKLVLADVEQG
HHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCEEEEEEEEEECCCC
FIDFERI
CCCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]