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The map label for this gene is sppA [H]

Identifier: 193212213

GI number: 193212213

Start: 583639

End: 585375

Strand: Direct

Name: sppA [H]

Synonym: Cpar_0544

Alternate gene names: 193212213

Gene position: 583639-585375 (Clockwise)

Preceding gene: 193212212

Following gene: 193212215

Centisome position: 25.49

GC content: 58.43

Gene sequence:

>1737_bases
GTGGTCGTGCTTTTTGTGCTTCTCATTGGCGGTGTCTGGCTGGCAAGCTCCTGGAGCGACAAGCTGCCCGAACGATTCGT
GCTCAGGGTTCCCGTGAAGGGGCAGATCGAAGAACGTTCGCCGGATTCGGGGCTTTTTTCATTTGGCCAGAGAGCCGAGC
CGCTTTCGCTCGAAGCATTGATGACCATTCTCGACCGGGCGCAGAGCGATAAGCGAGTCGAGTCCGTTTTGCTCGACATC
GACGGGCTCAGCACCTCCACGGCGAAAATCCAGGAGCTGAGCAGTTCGATCGATGCTCTCCGGAAGTCGGGGAAAAAAGT
GACCGCACTGCTGCGCACGCCGGCGGACAAGGACTATCTGCTTGCCGTCGCCTGCGATTCGATTATCGTGCAGAAAAATT
CGTGGATGCAGCTTGACGGTTTCAAGGCTGAACTCTTCTTCTTTGCCGAACCGCTCAAAAAACTTGGCATTGGCTTTCAG
GCTGCGCAGTGGAAAAAGTATAAAAGCGCCATTGAGCCCTATACCAGGAACTCACCGAGTCCGGAGAGCCTCCAAGAGCT
GAACTCCTTGCTCGACGATTCGTGGGCCAACTATCTCGACCAGGTCGCCCGGCGTCGGCATATCGGCAGGGATGCGTTCC
GCGAGGTGATCGACTCGCTGGCCGTCCTGACCCCCGAGCAGGCGCTTGAGCGGAAGCTGATCGATCGCGTGCTCTCCATC
CGGCAGCTTGAAAAGGAGTACCGGAAACGCTTCGGCAAGCCCTTCGATGAGCTGGTGGTCAACGCCGGGAGCTACCTTTC
CTCCACCGGCGACCTGGAGCCTCATGGCACCGGCAATCGCATCGCCGTCATTACCATCAACGGCCTGATTGTCGGCGACA
GTATTGCGGGCATGGGGGATGACGAAGAGATCGATGTCGCTTCGGTTCGCCGGGCGGTTGATGCCGCACTTGATGATTCA
AAGGTCAAGGCAATCGTGCTCAGGATCGACAGCCCGGGCGGTGAGGCATTGGCCGCATCGTCGATGCTCGAACTGCTTGA
GGAGGCCGCACAGAAAAAGCCGCTGGTCGCTTCGATGTCGGGCAGCGCGGCTTCGGGAGGGTACATGGTCGCTCTTGCCG
CCAACAAAATCTACGCCCAGCCGTTGACCGTGACCGGCTCCATTGGCGTGTTCGCCCTCAAGCCGGATTTCAGTGGCCTG
CTCGAAAAAACCGGCATCCACCGTGAGGTGCTGACCCGCGGGCGGTTTGCCGATGCTTACACGCCTTTCAAACCTTTCGA
TGATGCCGCTTTCAGGAAATTTGTCGAAACCACCGGGCACATTTATGAGGACTTCACCGGCAAGGTTGCCAAAAGCCGGC
ATCTGACTGCCGAGCAGGTCGAAGCCGTGGCTGGTGGCCGCGTCTGGAGTGGCAAGCGGGCGGTCGAGGTTGGTCTGGTT
GACGAGATCGGCGGGCTCAATGATGCCGTGCAGGAAGCGAGCCGGCTTGCCAAGCTGAAAAAGGGGACAAAGCCGGAAAT
GCTCTATCTGCCTGCCCGCAAAACCTGGATCGAACGTTTTTTTGATGGAGATGCCGTGCAGGCTGTTGCGGACATGTCCG
ATCATCTGGCCACCCAATCGCTTGCGAGGTTGCTTCCTGTCTCACAGCTTCCCGGTACGGCAACCGTTCGCTTCCTGCTC
CGCACTGAAGAGCCTCAAGTGCTTGCAATCCAGCCGTTTGGGGTTGAGATGAATTGA

Upstream 100 bases:

>100_bases
CACCGGGTGAGCTGTCTGCTTTATCAGTGATTCATCCATGAAATTATGACTGACGCAAAACCAAAAAAAACGGGGCTGTT
TGCTCACAGGATGCCTGACG

Downstream 100 bases:

>100_bases
CCATGGATCGTTGATAATTAGTAGGGGCAGCCCTCGCAGCTGCCCTTCGGAATGGCGAACGACTTCGCTTTTCAATCAGA
CAGATCGGACGGATCGGATC

Product: signal peptide peptidase SppA, 67K type

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MVVLFVLLIGGVWLASSWSDKLPERFVLRVPVKGQIEERSPDSGLFSFGQRAEPLSLEALMTILDRAQSDKRVESVLLDI
DGLSTSTAKIQELSSSIDALRKSGKKVTALLRTPADKDYLLAVACDSIIVQKNSWMQLDGFKAELFFFAEPLKKLGIGFQ
AAQWKKYKSAIEPYTRNSPSPESLQELNSLLDDSWANYLDQVARRRHIGRDAFREVIDSLAVLTPEQALERKLIDRVLSI
RQLEKEYRKRFGKPFDELVVNAGSYLSSTGDLEPHGTGNRIAVITINGLIVGDSIAGMGDDEEIDVASVRRAVDAALDDS
KVKAIVLRIDSPGGEALAASSMLELLEEAAQKKPLVASMSGSAASGGYMVALAANKIYAQPLTVTGSIGVFALKPDFSGL
LEKTGIHREVLTRGRFADAYTPFKPFDDAAFRKFVETTGHIYEDFTGKVAKSRHLTAEQVEAVAGGRVWSGKRAVEVGLV
DEIGGLNDAVQEASRLAKLKKGTKPEMLYLPARKTWIERFFDGDAVQAVADMSDHLATQSLARLLPVSQLPGTATVRFLL
RTEEPQVLAIQPFGVEMN

Sequences:

>Translated_578_residues
MVVLFVLLIGGVWLASSWSDKLPERFVLRVPVKGQIEERSPDSGLFSFGQRAEPLSLEALMTILDRAQSDKRVESVLLDI
DGLSTSTAKIQELSSSIDALRKSGKKVTALLRTPADKDYLLAVACDSIIVQKNSWMQLDGFKAELFFFAEPLKKLGIGFQ
AAQWKKYKSAIEPYTRNSPSPESLQELNSLLDDSWANYLDQVARRRHIGRDAFREVIDSLAVLTPEQALERKLIDRVLSI
RQLEKEYRKRFGKPFDELVVNAGSYLSSTGDLEPHGTGNRIAVITINGLIVGDSIAGMGDDEEIDVASVRRAVDAALDDS
KVKAIVLRIDSPGGEALAASSMLELLEEAAQKKPLVASMSGSAASGGYMVALAANKIYAQPLTVTGSIGVFALKPDFSGL
LEKTGIHREVLTRGRFADAYTPFKPFDDAAFRKFVETTGHIYEDFTGKVAKSRHLTAEQVEAVAGGRVWSGKRAVEVGLV
DEIGGLNDAVQEASRLAKLKKGTKPEMLYLPARKTWIERFFDGDAVQAVADMSDHLATQSLARLLPVSQLPGTATVRFLL
RTEEPQVLAIQPFGVEMN
>Mature_578_residues
MVVLFVLLIGGVWLASSWSDKLPERFVLRVPVKGQIEERSPDSGLFSFGQRAEPLSLEALMTILDRAQSDKRVESVLLDI
DGLSTSTAKIQELSSSIDALRKSGKKVTALLRTPADKDYLLAVACDSIIVQKNSWMQLDGFKAELFFFAEPLKKLGIGFQ
AAQWKKYKSAIEPYTRNSPSPESLQELNSLLDDSWANYLDQVARRRHIGRDAFREVIDSLAVLTPEQALERKLIDRVLSI
RQLEKEYRKRFGKPFDELVVNAGSYLSSTGDLEPHGTGNRIAVITINGLIVGDSIAGMGDDEEIDVASVRRAVDAALDDS
KVKAIVLRIDSPGGEALAASSMLELLEEAAQKKPLVASMSGSAASGGYMVALAANKIYAQPLTVTGSIGVFALKPDFSGL
LEKTGIHREVLTRGRFADAYTPFKPFDDAAFRKFVETTGHIYEDFTGKVAKSRHLTAEQVEAVAGGRVWSGKRAVEVGLV
DEIGGLNDAVQEASRLAKLKKGTKPEMLYLPARKTWIERFFDGDAVQAVADMSDHLATQSLARLLPVSQLPGTATVRFLL
RTEEPQVLAIQPFGVEMN

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=525, Percent_Identity=31.6190476190476, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1787527, Length=224, Percent_Identity=33.4821428571429, Blast_Score=99, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 63285; Mature: 63285

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVLFVLLIGGVWLASSWSDKLPERFVLRVPVKGQIEERSPDSGLFSFGQRAEPLSLEAL
CHHHHHHHHHHHHHHCCHHHCCCCCEEEECCCCCCCCCCCCCCCHHHCCCCCCCCHHHHH
MTILDRAQSDKRVESVLLDIDGLSTSTAKIQELSSSIDALRKSGKKVTALLRTPADKDYL
HHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEE
LAVACDSIIVQKNSWMQLDGFKAELFFFAEPLKKLGIGFQAAQWKKYKSAIEPYTRNSPS
EEEECCHHEEECCCCEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
PESLQELNSLLDDSWANYLDQVARRRHIGRDAFREVIDSLAVLTPEQALERKLIDRVLSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RQLEKEYRKRFGKPFDELVVNAGSYLSSTGDLEPHGTGNRIAVITINGLIVGDSIAGMGD
HHHHHHHHHHHCCCHHHHHHCCCHHHCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCC
DEEIDVASVRRAVDAALDDSKVKAIVLRIDSPGGEALAASSMLELLEEAAQKKPLVASMS
CCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEECC
GSAASGGYMVALAANKIYAQPLTVTGSIGVFALKPDFSGLLEKTGIHREVLTRGRFADAY
CCCCCCCEEEEEECCEEEECCEEEECCCEEEEECCCHHHHHHHCCCHHHHHHCCCCCCCC
TPFKPFDDAAFRKFVETTGHIYEDFTGKVAKSRHLTAEQVEAVAGGRVWSGKRAVEVGLV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEECCCCEEEEECH
DEIGGLNDAVQEASRLAKLKKGTKPEMLYLPARKTWIERFFDGDAVQAVADMSDHLATQS
HHHCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LARLLPVSQLPGTATVRFLLRTEEPQVLAIQPFGVEMN
HHHHCCHHCCCCCCEEEEEEECCCCCEEEEECCCCCCC
>Mature Secondary Structure
MVVLFVLLIGGVWLASSWSDKLPERFVLRVPVKGQIEERSPDSGLFSFGQRAEPLSLEAL
CHHHHHHHHHHHHHHCCHHHCCCCCEEEECCCCCCCCCCCCCCCHHHCCCCCCCCHHHHH
MTILDRAQSDKRVESVLLDIDGLSTSTAKIQELSSSIDALRKSGKKVTALLRTPADKDYL
HHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEE
LAVACDSIIVQKNSWMQLDGFKAELFFFAEPLKKLGIGFQAAQWKKYKSAIEPYTRNSPS
EEEECCHHEEECCCCEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCC
PESLQELNSLLDDSWANYLDQVARRRHIGRDAFREVIDSLAVLTPEQALERKLIDRVLSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
RQLEKEYRKRFGKPFDELVVNAGSYLSSTGDLEPHGTGNRIAVITINGLIVGDSIAGMGD
HHHHHHHHHHHCCCHHHHHHCCCHHHCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCCC
DEEIDVASVRRAVDAALDDSKVKAIVLRIDSPGGEALAASSMLELLEEAAQKKPLVASMS
CCCCCHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEECC
GSAASGGYMVALAANKIYAQPLTVTGSIGVFALKPDFSGLLEKTGIHREVLTRGRFADAY
CCCCCCCEEEEEECCEEEECCEEEECCCEEEEECCCHHHHHHHCCCHHHHHHCCCCCCCC
TPFKPFDDAAFRKFVETTGHIYEDFTGKVAKSRHLTAEQVEAVAGGRVWSGKRAVEVGLV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEECCCCEEEEECH
DEIGGLNDAVQEASRLAKLKKGTKPEMLYLPARKTWIERFFDGDAVQAVADMSDHLATQS
HHHCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LARLLPVSQLPGTATVRFLLRTEEPQVLAIQPFGVEMN
HHHHCCHHCCCCCCEEEEEEECCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]