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The map label for this gene is gppA [H]

Identifier: 193212148

GI number: 193212148

Start: 510189

End: 511742

Strand: Direct

Name: gppA [H]

Synonym: Cpar_0479

Alternate gene names: 193212148

Gene position: 510189-511742 (Clockwise)

Preceding gene: 193212145

Following gene: 193212149

Centisome position: 22.29

GC content: 59.46

Gene sequence:

>1554_bases
ATGTCAACAGAGAAACTAAGGGTAGCCGCCATCGACCTCGGCACCAACTCCTTTCACATGGTTATTGTCGAGGAGAGCGA
GGCCAAAGGAATCGTCGAGATCGACCGGGTCAAGGATATGATCTGTATCGGCCGGGGCAGCATTTCGACCAAGAAGCTCG
ATAAGGGGGCGATGGAGGCCGGTGTGGCCGCGCTTCGGAACTTCCTGGTGCTGGCGACGCAGCACGAAGTGCCCGTTCGG
AACATCATCGCTTTCGCCACCAGTGCCATTCGCGAGGCTGACAACCGGCAGGAGTTCATCGATATGGTTCGGCGTGAGAC
CGGGCTTGAGGTCAAGATCATCTCCGGCAAGGAGGAGGCGCAGTTCATCTATTACGGCGTGCGCAATGCCGTAACCTTGC
GCGACAAGCCCGATCTGCTGTTCGACATCGGCGGCGGTTCGGTGGAGTTCATCATTGCCGACAAAGGCAAAGCGCATCTG
CTTGAAAGCCGCAAGATCGGCGTGGCGAGGATGATGGAGCGGTTCCTGACCACCGATCCGGTCTCGGAGCACGAACGGAA
GCTTTTGGAGCAGTTTTTTGCTTCCGAGATCTTCGATTCGGCTGAAAAAGCGCGCGAGCTTGGCGTGACCCGCGCGATTG
CCTCTTCCGGCACTGCCGAGAACATCGCCCGCATGATTCGCGCGGGCAAGGATGCCGAGGGCGGGGATGCGCTGAACCAG
ACCGGCTTTACCCGGCAGGAGTTCGAGAATTTCTATAAATCGGTGATCTCGATGGACCGCGCTGCGCGTCGCAAGCTGAC
CGGTCTGGACGAGAAGCGGGTCGATCTGATTGTGCCCGGCCTGATTCTGATCAACGTCATTTTTCGGGAGTTCAACCTCA
GGGAGGTGGTTATTTCCGATTCGGCGTTGCGCGAGGGGATGGTGGTGCACTACATCGCCTCCATGCGTGGGCGAAAGGGG
AGTTGCCCGCTCGATATTCGCCGTCAGAGCGTTATCGAACTGGCCCATCGCTGCAACTGGCACGAGCCGCATTCGCGGCA
GGTGGCGCGGCTGTCGCTGATGCTGTTCGACCAGCTCAAACCGTTGCACGGCCTCAAGCCGCACTACCGCGAGCTGCTCG
AATACGCCGCGCTGCTGCACAATATCGGCGTATTTATCTCGATCTCAGCGCACCACAAGCACTCCCAGTATATCATCATG
AACAGCGATCTCCGTGGCTTTGCGCCGACGGAGATCGATATTATCGGCAACGTCGCTCGCTACCACCGCAAGCAGCCGCC
GACGGAAAAGCATCCGCTCTACAGCCAGCTCAAGCCTTCGCATCGCCGCGCAGTCGATGTGCTGTCGGGGATTTTGCGCG
TGGCCAACGGGCTCGAACGCGGGCACCGGCAGAACGTGCAATCGATTACCATGCGTGACGAGCCGAAGCGCATCGTCATC
AACGCGCTGGCTCGCTATGAACCCGACATCGAGCTGTGGGCGGTGAGCGGCCACAAGGAGTGGCTCGAAGAGGTGCTTGG
CAAGCCGATCGTGATCGAGGCTTCGCTGCAGTGA

Upstream 100 bases:

>100_bases
GAAGTGCGCGAGGATTTCGAGCACTAGCCAACGCAGCAATCGGAGCACGCAACAGGTTTTCAGAGACGTTCGACAGTATC
TCGTTACCATTCTCAACAGC

Downstream 100 bases:

>100_bases
TGGCGCTGTACGATGAGCTTTCCAGACCGGGTTCGCTCTGGTTTGAATCCACCTGTCCGGACGCGCGCTACGGCGAATCC
CTCCTTTTTACCGATCCGGT

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MSTEKLRVAAIDLGTNSFHMVIVEESEAKGIVEIDRVKDMICIGRGSISTKKLDKGAMEAGVAALRNFLVLATQHEVPVR
NIIAFATSAIREADNRQEFIDMVRRETGLEVKIISGKEEAQFIYYGVRNAVTLRDKPDLLFDIGGGSVEFIIADKGKAHL
LESRKIGVARMMERFLTTDPVSEHERKLLEQFFASEIFDSAEKARELGVTRAIASSGTAENIARMIRAGKDAEGGDALNQ
TGFTRQEFENFYKSVISMDRAARRKLTGLDEKRVDLIVPGLILINVIFREFNLREVVISDSALREGMVVHYIASMRGRKG
SCPLDIRRQSVIELAHRCNWHEPHSRQVARLSLMLFDQLKPLHGLKPHYRELLEYAALLHNIGVFISISAHHKHSQYIIM
NSDLRGFAPTEIDIIGNVARYHRKQPPTEKHPLYSQLKPSHRRAVDVLSGILRVANGLERGHRQNVQSITMRDEPKRIVI
NALARYEPDIELWAVSGHKEWLEEVLGKPIVIEASLQ

Sequences:

>Translated_517_residues
MSTEKLRVAAIDLGTNSFHMVIVEESEAKGIVEIDRVKDMICIGRGSISTKKLDKGAMEAGVAALRNFLVLATQHEVPVR
NIIAFATSAIREADNRQEFIDMVRRETGLEVKIISGKEEAQFIYYGVRNAVTLRDKPDLLFDIGGGSVEFIIADKGKAHL
LESRKIGVARMMERFLTTDPVSEHERKLLEQFFASEIFDSAEKARELGVTRAIASSGTAENIARMIRAGKDAEGGDALNQ
TGFTRQEFENFYKSVISMDRAARRKLTGLDEKRVDLIVPGLILINVIFREFNLREVVISDSALREGMVVHYIASMRGRKG
SCPLDIRRQSVIELAHRCNWHEPHSRQVARLSLMLFDQLKPLHGLKPHYRELLEYAALLHNIGVFISISAHHKHSQYIIM
NSDLRGFAPTEIDIIGNVARYHRKQPPTEKHPLYSQLKPSHRRAVDVLSGILRVANGLERGHRQNVQSITMRDEPKRIVI
NALARYEPDIELWAVSGHKEWLEEVLGKPIVIEASLQ
>Mature_516_residues
STEKLRVAAIDLGTNSFHMVIVEESEAKGIVEIDRVKDMICIGRGSISTKKLDKGAMEAGVAALRNFLVLATQHEVPVRN
IIAFATSAIREADNRQEFIDMVRRETGLEVKIISGKEEAQFIYYGVRNAVTLRDKPDLLFDIGGGSVEFIIADKGKAHLL
ESRKIGVARMMERFLTTDPVSEHERKLLEQFFASEIFDSAEKARELGVTRAIASSGTAENIARMIRAGKDAEGGDALNQT
GFTRQEFENFYKSVISMDRAARRKLTGLDEKRVDLIVPGLILINVIFREFNLREVVISDSALREGMVVHYIASMRGRKGS
CPLDIRRQSVIELAHRCNWHEPHSRQVARLSLMLFDQLKPLHGLKPHYRELLEYAALLHNIGVFISISAHHKHSQYIIMN
SDLRGFAPTEIDIIGNVARYHRKQPPTEKHPLYSQLKPSHRRAVDVLSGILRVANGLERGHRQNVQSITMRDEPKRIVIN
ALARYEPDIELWAVSGHKEWLEEVLGKPIVIEASLQ

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=432, Percent_Identity=28.0092592592593, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI48994966, Length=459, Percent_Identity=28.5403050108932, Blast_Score=151, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 58356; Mature: 58225

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEKLRVAAIDLGTNSFHMVIVEESEAKGIVEIDRVKDMICIGRGSISTKKLDKGAMEA
CCCCCEEEEEEEECCCCEEEEEEECCCCCCCEEHHHHHHEEEECCCCCCHHHHHHHHHHH
GVAALRNFLVLATQHEVPVRNIIAFATSAIREADNRQEFIDMVRRETGLEVKIISGKEEA
HHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCCC
QFIYYGVRNAVTLRDKPDLLFDIGGGSVEFIIADKGKAHLLESRKIGVARMMERFLTTDP
EEEEEECCCEEEECCCCCEEEEECCCEEEEEEECCCCHHHHHHCCCCHHHHHHHHHCCCC
VSEHERKLLEQFFASEIFDSAEKARELGVTRAIASSGTAENIARMIRAGKDAEGGDALNQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
TGFTRQEFENFYKSVISMDRAARRKLTGLDEKRVDLIVPGLILINVIFREFNLREVVISD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHHCCCCEEEECC
SALREGMVVHYIASMRGRKGSCPLDIRRQSVIELAHRCNWHEPHSRQVARLSLMLFDQLK
HHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
PLHGLKPHYRELLEYAALLHNIGVFISISAHHKHSQYIIMNSDLRGFAPTEIDIIGNVAR
CCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHH
YHRKQPPTEKHPLYSQLKPSHRRAVDVLSGILRVANGLERGHRQNVQSITMRDEPKRIVI
HHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
NALARYEPDIELWAVSGHKEWLEEVLGKPIVIEASLQ
HHHHHCCCCCEEEEECCHHHHHHHHCCCCEEEEECCC
>Mature Secondary Structure 
STEKLRVAAIDLGTNSFHMVIVEESEAKGIVEIDRVKDMICIGRGSISTKKLDKGAMEA
CCCCEEEEEEEECCCCEEEEEEECCCCCCCEEHHHHHHEEEECCCCCCHHHHHHHHHHH
GVAALRNFLVLATQHEVPVRNIIAFATSAIREADNRQEFIDMVRRETGLEVKIISGKEEA
HHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCCCC
QFIYYGVRNAVTLRDKPDLLFDIGGGSVEFIIADKGKAHLLESRKIGVARMMERFLTTDP
EEEEEECCCEEEECCCCCEEEEECCCEEEEEEECCCCHHHHHHCCCCHHHHHHHHHCCCC
VSEHERKLLEQFFASEIFDSAEKARELGVTRAIASSGTAENIARMIRAGKDAEGGDALNQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
TGFTRQEFENFYKSVISMDRAARRKLTGLDEKRVDLIVPGLILINVIFREFNLREVVISD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHHCCCCEEEECC
SALREGMVVHYIASMRGRKGSCPLDIRRQSVIELAHRCNWHEPHSRQVARLSLMLFDQLK
HHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
PLHGLKPHYRELLEYAALLHNIGVFISISAHHKHSQYIIMNSDLRGFAPTEIDIIGNVAR
CCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHH
YHRKQPPTEKHPLYSQLKPSHRRAVDVLSGILRVANGLERGHRQNVQSITMRDEPKRIVI
HHCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHH
NALARYEPDIELWAVSGHKEWLEEVLGKPIVIEASLQ
HHHHHCCCCCEEEEECCHHHHHHHHCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA