Click here to switch to the map view.

The map label for this gene is aqpZ [H]

Identifier: 193212111

GI number: 193212111

Start: 474251

End: 474964

Strand: Direct

Name: aqpZ [H]

Synonym: Cpar_0442

Alternate gene names: 193212111

Gene position: 474251-474964 (Clockwise)

Preceding gene: 193212105

Following gene: 193212116

Centisome position: 20.72

GC content: 60.36

Gene sequence:

>714_bases
ATGAAAAAAAATCTGTTTATCGCCGAAGCAATCGGAACCTTCGCGCTGGTGTTTGCCGGATGCGGAGCCATTGTGGTCAA
CGAAAGTTTCGGGGGAGCGCTCGGGCACCTGGGGGTTTCCACCGTTTTCGGGCTGGTGGTGATGGCCATGATCTATTCGG
TCGGGAACGTTTCTGGCGCGCATCTGAACCCTGCGGTGACGCTCGGCTTCGTGTTCGCAGGCCGTCTGGACAAGCGAAGC
ATTCCGGGGTACATCGGTAGCCAGCTTATCGGGGCTCTTGCCGCAGCCGCCGCACTGCGCCTGCTTTTTCCGGAGAGCGC
CACGCTGGGGTCTACGTTGCCGGGAATTGATCTTGCTCGCGCATTCATCGTCGAGGTGCTGCTTTCGTTTGTGCTGATGT
TCGTCATTCTGAACGTCTCAACGGGCCACATGGAGAAGGGCATCATGGCGGGTGTAGCTGTTGGCGGCACTATTGCGCTC
GAAGCGCTGGTCGGCGGCCCGCTCACCGGAGCGTCGATGAACCCTGCCCGTTCGCTCGCCCCGGCGCTGCTGTCCGGTAA
CCTGTCGTCGATCTGGCTTTACCTGACCGCTCCCGTTGTGGGAACCTGGCTTGCCCATCCGACCTGCCGATGGATCCAGG
GCCCGAACTGCTGTGTTTTGAAGCCGGAGGGTGAATCGTCGGAGGCTGATTGCAACGATAAGTCGTGCGGGTGA

Upstream 100 bases:

>100_bases
TTCAAAGAGCATGTGGGTTGCTATTTTTTTTGAAAGTAATTTTTTCGTTAACCCGCGAGCACTACGAATCAATCTAACTG
GTGTTCAGTTGTATCGAACT

Downstream 100 bases:

>100_bases
GTGTCGAATTTGAATTTTCCTGCTGAGGCGTATTTTTTAAAAATCAGCGGACGATTTTTTGTTCACCCCAACTTTCTGAA
AGCGGACGCTTTAATCGCCG

Product: major intrinsic protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MKKNLFIAEAIGTFALVFAGCGAIVVNESFGGALGHLGVSTVFGLVVMAMIYSVGNVSGAHLNPAVTLGFVFAGRLDKRS
IPGYIGSQLIGALAAAAALRLLFPESATLGSTLPGIDLARAFIVEVLLSFVLMFVILNVSTGHMEKGIMAGVAVGGTIAL
EALVGGPLTGASMNPARSLAPALLSGNLSSIWLYLTAPVVGTWLAHPTCRWIQGPNCCVLKPEGESSEADCNDKSCG

Sequences:

>Translated_237_residues
MKKNLFIAEAIGTFALVFAGCGAIVVNESFGGALGHLGVSTVFGLVVMAMIYSVGNVSGAHLNPAVTLGFVFAGRLDKRS
IPGYIGSQLIGALAAAAALRLLFPESATLGSTLPGIDLARAFIVEVLLSFVLMFVILNVSTGHMEKGIMAGVAVGGTIAL
EALVGGPLTGASMNPARSLAPALLSGNLSSIWLYLTAPVVGTWLAHPTCRWIQGPNCCVLKPEGESSEADCNDKSCG
>Mature_237_residues
MKKNLFIAEAIGTFALVFAGCGAIVVNESFGGALGHLGVSTVFGLVVMAMIYSVGNVSGAHLNPAVTLGFVFAGRLDKRS
IPGYIGSQLIGALAAAAALRLLFPESATLGSTLPGIDLARAFIVEVLLSFVLMFVILNVSTGHMEKGIMAGVAVGGTIAL
EALVGGPLTGASMNPARSLAPALLSGNLSSIWLYLTAPVVGTWLAHPTCRWIQGPNCCVLKPEGESSEADCNDKSCG

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI6912506, Length=202, Percent_Identity=36.6336633663366, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4755125, Length=183, Percent_Identity=32.7868852459016, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI4502181, Length=183, Percent_Identity=32.7868852459016, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI37694062, Length=254, Percent_Identity=29.9212598425197, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI45446752, Length=195, Percent_Identity=29.2307692307692, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4502179, Length=205, Percent_Identity=32.6829268292683, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI4502183, Length=220, Percent_Identity=30, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI157266307, Length=205, Percent_Identity=31.7073170731707, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI86792455, Length=225, Percent_Identity=30.2222222222222, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI22538420, Length=259, Percent_Identity=30.1158301158301, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI4502187, Length=234, Percent_Identity=26.4957264957265, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787101, Length=203, Percent_Identity=36.4532019704434, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790362, Length=207, Percent_Identity=34.2995169082126, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71993722, Length=214, Percent_Identity=30.8411214953271, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17558372, Length=196, Percent_Identity=28.0612244897959, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652747, Length=235, Percent_Identity=34.8936170212766, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45551084, Length=235, Percent_Identity=34.8936170212766, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24762344, Length=206, Percent_Identity=36.4077669902913, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24762346, Length=206, Percent_Identity=36.4077669902913, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24762348, Length=206, Percent_Identity=36.4077669902913, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20130305, Length=206, Percent_Identity=36.4077669902913, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45550503, Length=209, Percent_Identity=34.4497607655502, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24762342, Length=210, Percent_Identity=30, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922038, Length=200, Percent_Identity=33.5, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652751, Length=201, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922828, Length=206, Percent_Identity=29.6116504854369, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 24248; Mature: 24248

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNLFIAEAIGTFALVFAGCGAIVVNESFGGALGHLGVSTVFGLVVMAMIYSVGNVSGA
CCCCEEHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HLNPAVTLGFVFAGRLDKRSIPGYIGSQLIGALAAAAALRLLFPESATLGSTLPGIDLAR
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
AFIVEVLLSFVLMFVILNVSTGHMEKGIMAGVAVGGTIALEALVGGPLTGASMNPARSLA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHH
PALLSGNLSSIWLYLTAPVVGTWLAHPTCRWIQGPNCCVLKPEGESSEADCNDKSCG
HHHHHCCHHHEEEEEHHHHHHHHHCCCCHHEECCCCEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKNLFIAEAIGTFALVFAGCGAIVVNESFGGALGHLGVSTVFGLVVMAMIYSVGNVSGA
CCCCEEHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
HLNPAVTLGFVFAGRLDKRSIPGYIGSQLIGALAAAAALRLLFPESATLGSTLPGIDLAR
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
AFIVEVLLSFVLMFVILNVSTGHMEKGIMAGVAVGGTIALEALVGGPLTGASMNPARSLA
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHH
PALLSGNLSSIWLYLTAPVVGTWLAHPTCRWIQGPNCCVLKPEGESSEADCNDKSCG
HHHHHCCHHHEEEEEHHHHHHHHHCCCCHHEECCCCEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]