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The map label for this gene is yqeC [H]

Identifier: 193212005

GI number: 193212005

Start: 354502

End: 355419

Strand: Direct

Name: yqeC [H]

Synonym: Cpar_0334

Alternate gene names: 193212005

Gene position: 354502-355419 (Clockwise)

Preceding gene: 193212002

Following gene: 193212006

Centisome position: 15.49

GC content: 63.18

Gene sequence:

>918_bases
ATGAAGATAGGATTTATCGGTCTCGGGAAAATGGGATTCAACATGGTCGAGCACTTGCTGGAGCTGGGCCACGAGGTGAC
GGCGTTCGATCTTTCTGCGGAAGCGGTCGCGGCGATTGCTGAAAAAGGGGCGACGGCGGCAAGTTCATTGCAGCACGTTG
TCGGTGATTTGCCGAAACCTCGCGTGGTCTGGATGATGGTTCCGGCGGGCAAGGCGGTCGATGCGGTGCTCGACGGGTTG
CTGCCGTTCCTCGACAAGGGCGACATCGTCATCGACGGCGGGAACTCTCGGTATACCGATTCGGTCGCCCGTGCGGAAAA
GCTCCGTCAGCAAGGCGTCCGGATGCTCGACATCGGTACCAGCGGCGGGCTGGACGGCGCTCGCCACGGTGCGTGCATGA
TGGCCGGCGGCGAGCGTGAGGCGTACGACGTCGTCGAGCCGATGCTGCGCGACCTTTGCGTCGAGAACGGCTACGGCTAC
ATGGGCGCGTCGGGCGCGGGCCACTTCGTCAAAATGGTGCATAACGGCATCGAATACGGCATGATGCAGGCGATCGGTGA
GGGGTTCGATCTGCTTCGCGCCAGCGGCTTCGACCTTGACAACCAGAACGTTGCGCGGGTCTGGTCGAACGGCTCGGTGA
TTCGCGGCTGGCTCATGGACTTGGCGGGCAAGGCATTCGCGCAGGACAACGATCTCGGCTGGCTCGGCAGCAAGGTTGCC
GATTCGGGCGAAGGGCGCTGGACGGTCGAGGCGGCTATCGATCTCGGCGTGGCGGTGCCGATCATCTCCGGCTCTTTGTT
CCGGCGCTTCCGGTCGCAGAGCGAGGAGAATTTTTCGGACAAGGTGGTCGCCGCGTTGCGCCACGAGTTCGGCGGGCACG
CCTATGAGAAACCCGGCGATGGGGAGGGGAAGGCATGA

Upstream 100 bases:

>100_bases
CTGTTCCGGCGATTGTCACGAAATCGTTTCAGAGCGTTTATCGAACGTCGGAACCAATAACGCAACACAGGCGTAAACAC
TGCCAAAAAGGAGATTTCAT

Downstream 100 bases:

>100_bases
ACGGCAAACCGGGCAACTTGACGATCGTCATCTTCGGCGCGGACGGCGATCTTGCGTCGCGCAAGCTCTTTCCCTCGATC
TTCCAGCTCGACCGCTGGGG

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKIGFIGLGKMGFNMVEHLLELGHEVTAFDLSAEAVAAIAEKGATAASSLQHVVGDLPKPRVVWMMVPAGKAVDAVLDGL
LPFLDKGDIVIDGGNSRYTDSVARAEKLRQQGVRMLDIGTSGGLDGARHGACMMAGGEREAYDVVEPMLRDLCVENGYGY
MGASGAGHFVKMVHNGIEYGMMQAIGEGFDLLRASGFDLDNQNVARVWSNGSVIRGWLMDLAGKAFAQDNDLGWLGSKVA
DSGEGRWTVEAAIDLGVAVPIISGSLFRRFRSQSEENFSDKVVAALRHEFGGHAYEKPGDGEGKA

Sequences:

>Translated_305_residues
MKIGFIGLGKMGFNMVEHLLELGHEVTAFDLSAEAVAAIAEKGATAASSLQHVVGDLPKPRVVWMMVPAGKAVDAVLDGL
LPFLDKGDIVIDGGNSRYTDSVARAEKLRQQGVRMLDIGTSGGLDGARHGACMMAGGEREAYDVVEPMLRDLCVENGYGY
MGASGAGHFVKMVHNGIEYGMMQAIGEGFDLLRASGFDLDNQNVARVWSNGSVIRGWLMDLAGKAFAQDNDLGWLGSKVA
DSGEGRWTVEAAIDLGVAVPIISGSLFRRFRSQSEENFSDKVVAALRHEFGGHAYEKPGDGEGKA
>Mature_305_residues
MKIGFIGLGKMGFNMVEHLLELGHEVTAFDLSAEAVAAIAEKGATAASSLQHVVGDLPKPRVVWMMVPAGKAVDAVLDGL
LPFLDKGDIVIDGGNSRYTDSVARAEKLRQQGVRMLDIGTSGGLDGARHGACMMAGGEREAYDVVEPMLRDLCVENGYGY
MGASGAGHFVKMVHNGIEYGMMQAIGEGFDLLRASGFDLDNQNVARVWSNGSVIRGWLMDLAGKAFAQDNDLGWLGSKVA
DSGEGRWTVEAAIDLGVAVPIISGSLFRRFRSQSEENFSDKVVAALRHEFGGHAYEKPGDGEGKA

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=314, Percent_Identity=35.9872611464968, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI23308751, Length=305, Percent_Identity=26.8852459016393, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1788341, Length=310, Percent_Identity=37.741935483871, Blast_Score=196, Evalue=1e-51,
Organism=Escherichia coli, GI145693186, Length=204, Percent_Identity=28.4313725490196, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790315, Length=202, Percent_Identity=28.7128712871287, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17542558, Length=287, Percent_Identity=35.8885017421603, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321695, Length=300, Percent_Identity=35, Blast_Score=168, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6321977, Length=286, Percent_Identity=36.7132867132867, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24639279, Length=283, Percent_Identity=35.3356890459364, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24655230, Length=216, Percent_Identity=28.7037037037037, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19922568, Length=216, Percent_Identity=28.7037037037037, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 32478; Mature: 32478

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGLGKMGFNMVEHLLELGHEVTAFDLSAEAVAAIAEKGATAASSLQHVVGDLPKP
CEEEEEEECHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCCC
RVVWMMVPAGKAVDAVLDGLLPFLDKGDIVIDGGNSRYTDSVARAEKLRQQGVRMLDIGT
EEEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECC
SGGLDGARHGACMMAGGEREAYDVVEPMLRDLCVENGYGYMGASGAGHFVKMVHNGIEYG
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
MMQAIGEGFDLLRASGFDLDNQNVARVWSNGSVIRGWLMDLAGKAFAQDNDLGWLGSKVA
HHHHHHCCHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHCHHHC
DSGEGRWTVEAAIDLGVAVPIISGSLFRRFRSQSEENFSDKVVAALRHEFGGHAYEKPGD
CCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCC
GEGKA
CCCCC
>Mature Secondary Structure
MKIGFIGLGKMGFNMVEHLLELGHEVTAFDLSAEAVAAIAEKGATAASSLQHVVGDLPKP
CEEEEEEECHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCCC
RVVWMMVPAGKAVDAVLDGLLPFLDKGDIVIDGGNSRYTDSVARAEKLRQQGVRMLDIGT
EEEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECC
SGGLDGARHGACMMAGGEREAYDVVEPMLRDLCVENGYGYMGASGAGHFVKMVHNGIEYG
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
MMQAIGEGFDLLRASGFDLDNQNVARVWSNGSVIRGWLMDLAGKAFAQDNDLGWLGSKVA
HHHHHHCCHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHCHHHC
DSGEGRWTVEAAIDLGVAVPIISGSLFRRFRSQSEENFSDKVVAALRHEFGGHAYEKPGD
CCCCCCEEEEEEHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCC
GEGKA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]