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The map label for this gene is iscS [H]

Identifier: 193211915

GI number: 193211915

Start: 251101

End: 252279

Strand: Direct

Name: iscS [H]

Synonym: Cpar_0241

Alternate gene names: 193211915

Gene position: 251101-252279 (Clockwise)

Preceding gene: 193211914

Following gene: 193211916

Centisome position: 10.97

GC content: 59.63

Gene sequence:

>1179_bases
ATGAAGCCATCAAGACCTGTATATTTTGATCATAATGCCACCACGCCACTGCATCCTGAAGTAAAAAAAGAGATGGTGGC
TGCGATGGAGATGTTCGGCAACCCGTCGAGCATGCACGCTTTCGGGCGTGAGGCGCGGGCCAACGTCGAGGATGCTCGTC
ACCGCGTGGCGGCGTTCATGGGCGCTGAGGCCGAGGAGATTGTGTTTACCGGCAGCGGCTCGGAGGGCAACAACACTGTC
CTTTCGCTGTTCGCGTGTGGCACAAGCCAGTGCTTTCCGGGCATGAAGCCGAAGATCGTGACCAGCCGCATCGAGCATCC
CTGTGTTCTGGAAACCTCCGGGTGCCTGGCACATCGCGGTGTCGATGTGAGTTATCTTGACGTTGACGCTTACGGCAAGA
TCGATCTCGGGCAGCTCGAAGAGTTCCTGAAATCGGGTGGCGTTGGTCTCGTTTCGGTGATGATGGCCAACAACGAGATC
GGCACGCTGCAGGATATTCCGGCAATTACCAAACTCGCTCACCAGTACGGAGCGCTTATGCACACCGACGCCGTACAGGC
GTTCGGCAAAATTCCGGTCGATGTGAACGAGCTCGGCGTCGATTTCCTGACCATTTCCGCGCACAAGATTTACGGGCCGA
AGGGCATTGGCGCGCTGTACGTGCGCAAGAAAACCCCGTACTGCCCCTTCATCCGGGGCGGACATCAGGAGAAGGGGCGC
CGCGCAGGTACCGAAAACACGCTCGGCATCATGGGCCTGGCGATGGCCGTGGATATGCGCAAGGCCGAGATGGAGGCCGA
AGCCGAACGGCTGCTCGGGTTCCGCGAGATGCTGCGCAAGGGCATTTCGGAGCGCATCGAAGACGCACAGTTCAACGGCC
ATCCGACCGACTCGATGCCAAACACGCTCAACGTGTCGTTCCCCGGCGCGGAGGGCGAGTCCATATTACTTTATCTCGAC
CTTGCCGGTATCGCGGTCTCGACCGGGTCGGCCTGCGCGTCCGGCTCGCTCGATCCGTCGCACGTGCTGCTTGCCACGGG
CGTCGATGCCGAGCGGGCGCACGGCTCCATCCGCATCAGCATGGGCCGTTCGACCACCGTCGAAGAGGTCGAATACATGC
TTGACGTCCTGCCGGGCGTCATCGAACGAATCAGAAACATGTCAACAGCTTATATCTAA

Upstream 100 bases:

>100_bases
ATCGCTTTGAGTTCGGCAAAGGCAATAATTTTTCACTGGTGCCGGTAATAACCTTATATTTGTCCTGCTCGATACAAGTT
TCACCGAAATTCAGAAAGCA

Downstream 100 bases:

>100_bases
TAAAGGAGGCGCTCATGCTGCAATCAGGTGAATGGGCATATACGGAAAAGCTCAAGGAGCATTTCGAAAGTCCGAAAAAT
ATTCTTCAGGGTAACGACAC

Product: class V aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKPSRPVYFDHNATTPLHPEVKKEMVAAMEMFGNPSSMHAFGREARANVEDARHRVAAFMGAEAEEIVFTGSGSEGNNTV
LSLFACGTSQCFPGMKPKIVTSRIEHPCVLETSGCLAHRGVDVSYLDVDAYGKIDLGQLEEFLKSGGVGLVSVMMANNEI
GTLQDIPAITKLAHQYGALMHTDAVQAFGKIPVDVNELGVDFLTISAHKIYGPKGIGALYVRKKTPYCPFIRGGHQEKGR
RAGTENTLGIMGLAMAVDMRKAEMEAEAERLLGFREMLRKGISERIEDAQFNGHPTDSMPNTLNVSFPGAEGESILLYLD
LAGIAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRISMGRSTTVEEVEYMLDVLPGVIERIRNMSTAYI

Sequences:

>Translated_392_residues
MKPSRPVYFDHNATTPLHPEVKKEMVAAMEMFGNPSSMHAFGREARANVEDARHRVAAFMGAEAEEIVFTGSGSEGNNTV
LSLFACGTSQCFPGMKPKIVTSRIEHPCVLETSGCLAHRGVDVSYLDVDAYGKIDLGQLEEFLKSGGVGLVSVMMANNEI
GTLQDIPAITKLAHQYGALMHTDAVQAFGKIPVDVNELGVDFLTISAHKIYGPKGIGALYVRKKTPYCPFIRGGHQEKGR
RAGTENTLGIMGLAMAVDMRKAEMEAEAERLLGFREMLRKGISERIEDAQFNGHPTDSMPNTLNVSFPGAEGESILLYLD
LAGIAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRISMGRSTTVEEVEYMLDVLPGVIERIRNMSTAYI
>Mature_392_residues
MKPSRPVYFDHNATTPLHPEVKKEMVAAMEMFGNPSSMHAFGREARANVEDARHRVAAFMGAEAEEIVFTGSGSEGNNTV
LSLFACGTSQCFPGMKPKIVTSRIEHPCVLETSGCLAHRGVDVSYLDVDAYGKIDLGQLEEFLKSGGVGLVSVMMANNEI
GTLQDIPAITKLAHQYGALMHTDAVQAFGKIPVDVNELGVDFLTISAHKIYGPKGIGALYVRKKTPYCPFIRGGHQEKGR
RAGTENTLGIMGLAMAVDMRKAEMEAEAERLLGFREMLRKGISERIEDAQFNGHPTDSMPNTLNVSFPGAEGESILLYLD
LAGIAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRISMGRSTTVEEVEYMLDVLPGVIERIRNMSTAYI

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=395, Percent_Identity=41.5189873417722, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI156713448, Length=422, Percent_Identity=36.0189573459716, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI48994898, Length=396, Percent_Identity=43.1818181818182, Blast_Score=301, Evalue=4e-83,
Organism=Escherichia coli, GI1787970, Length=322, Percent_Identity=29.5031055900621, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789175, Length=417, Percent_Identity=26.6187050359712, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25143064, Length=395, Percent_Identity=40.7594936708861, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17533177, Length=328, Percent_Identity=31.0975609756098, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319831, Length=392, Percent_Identity=41.3265306122449, Blast_Score=287, Evalue=2e-78,
Organism=Drosophila melanogaster, GI20129463, Length=391, Percent_Identity=42.4552429667519, Blast_Score=289, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR017772
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42266; Mature: 42266

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPSRPVYFDHNATTPLHPEVKKEMVAAMEMFGNPSSMHAFGREARANVEDARHRVAAFM
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHH
GAEAEEIVFTGSGSEGNNTVLSLFACGTSQCFPGMKPKIVTSRIEHPCVLETSGCLAHRG
CCCCCEEEEECCCCCCCCEEEEEEECCCHHCCCCCCCHHHHHHCCCCEEEECCCCHHHCC
VDVSYLDVDAYGKIDLGQLEEFLKSGGVGLVSVMMANNEIGTLQDIPAITKLAHQYGALM
CCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
HTDAVQAFGKIPVDVNELGVDFLTISAHKIYGPKGIGALYVRKKTPYCPFIRGGHQEKGR
HHHHHHHHCCCCCCHHHHCCEEEEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHC
RAGTENTLGIMGLAMAVDMRKAEMEAEAERLLGFREMLRKGISERIEDAQFNGHPTDSMP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
NTLNVSFPGAEGESILLYLDLAGIAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRIS
CEEEEEECCCCCCEEEEEEEECCEEEECCCCCCCCCCCCCEEEEEECCCHHHCCCEEEEE
MGRSTTVEEVEYMLDVLPGVIERIRNMSTAYI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPSRPVYFDHNATTPLHPEVKKEMVAAMEMFGNPSSMHAFGREARANVEDARHRVAAFM
CCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHH
GAEAEEIVFTGSGSEGNNTVLSLFACGTSQCFPGMKPKIVTSRIEHPCVLETSGCLAHRG
CCCCCEEEEECCCCCCCCEEEEEEECCCHHCCCCCCCHHHHHHCCCCEEEECCCCHHHCC
VDVSYLDVDAYGKIDLGQLEEFLKSGGVGLVSVMMANNEIGTLQDIPAITKLAHQYGALM
CCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
HTDAVQAFGKIPVDVNELGVDFLTISAHKIYGPKGIGALYVRKKTPYCPFIRGGHQEKGR
HHHHHHHHCCCCCCHHHHCCEEEEEEEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHC
RAGTENTLGIMGLAMAVDMRKAEMEAEAERLLGFREMLRKGISERIEDAQFNGHPTDSMP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
NTLNVSFPGAEGESILLYLDLAGIAVSTGSACASGSLDPSHVLLATGVDAERAHGSIRIS
CEEEEEECCCCCCEEEEEEEECCEEEECCCCCCCCCCCCCEEEEEECCCHHHCCCEEEEE
MGRSTTVEEVEYMLDVLPGVIERIRNMSTAYI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA